Review
Oncology
Tiantian Wu, Wannian Yang, Aiqin Sun, Zhixiao Wei, Qiong Lin
Summary: CXC chemokines are small chemotactic and secreted cytokines that are dysregulated in multiple types of cancer and closely correlated with tumor progression. They play crucial roles in promoting angiogenesis, stimulating inflammatory responses, and facilitating tumor metastases. They have the potential to serve as diagnostic and prognostic biomarkers, as well as therapeutic targets for cancer treatment.
Article
Critical Care Medicine
Julie Goswami, Taleen MacArthur, Kent Bailey, Grant Spears, Rosemary A. Kozar, Matthew Auton, Jing-Fei Dong, Nigel S. Key, Stephanie Heller, Erica Loomis, Nathan W. Hall, Andrea L. Johnstone, Myung S. Park
Summary: This pilot study found that trauma patients exhibit increased NETosis, elevated syndecan-1 shedding, and accelerated thrombin generation kinetics early after injury. Levels of H3NUC and H3Free were significantly higher in trauma patients and showed positive correlations with syndecan-1 levels.
Article
Biochemistry & Molecular Biology
Daiane Boff, Remo Castro Russo, Helena Crijns, Vivian Louise Soares de Oliveira, Matheus Silverio Mattos, Pedro Elias Marques, Gustavo Batista Menezes, Angelica Thomaz Vieira, Mauro Martins Teixeira, Paul Proost, Flavio Almeida Amaral
Summary: This study tested the anti-inflammatory effect of CXCL9(74-103) in Klebsiella pneumoniae-induced pneumonia. The treatment with CXCL9(74-103) reduced neutrophil migration, decreased the production of IL-1 beta, and improved lung function in infected mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Amin Ullah, Mei-Jiao Wang, Ying-Xiong Wang, Bairong Shen
Summary: Reproductive health is particularly important for women during their reproductive age. Female reproductive problems such as polycystic ovary syndrome (PCOS) and endometriosis affect about 10% of women, negatively impacting their health, fertility, and quality of life. CXC chemokines, small chemotactic and secreted cytokines, are found to be dysregulated in both PCOS and endometriosis, playing a critical role in the development and progression of these diseases. Studies have shown that CXC chemokines promote inflammation and are involved in angiogenesis and inflammatory responses. Overexpression of CXC chemokines is associated with poor survival and prognosis. The levels of CXC chemokines significantly impact the circumstances of PCOS and endometriosis patients, indicating their potential as diagnostic and prognostic biomarkers and therapeutic targets. The molecular mechanisms underlying how CXC chemokines promote inflammation and the development of PCOS and endometriosis are currently unknown. This article aims to discuss the functions of CXC chemokines in the promotion, development, and therapy of PCOS and endometriosis, as well as future research directions. The current state and future prospects of CXC chemokine-based therapeutic strategies in managing PCOS and endometriosis are also highlighted.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Immunology
Heejeong Hong, Hyun-Kuk Song, Bohee Jang, Eunhye Park, Dong Soo Han, Seong-Eun Kim, Eok-Soo Oh
Summary: The study found that chronic inflammation induces shedding of Syndecan-2, and the mechanism involves the site-specific colocalization of Syndecan-2 with MMP-7 in the distal colon.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Cell Biology
Amin Ullah, Jing Zhao, Rajeev K. Singla, Bairong Shen
Summary: This review discusses the role of CXC and CX3CL1 chemokines and their receptors in the pathophysiology of preeclampsia and gestational diabetes mellitus (GDM) and investigates the potential of CXC-based therapies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Giselle Santos Magalhaes, Juliana Fabiana Gregorio, Arthur Tonani Pereira Cancado Ribeiro, Isis Felippe Baroni, Ana Victoria de Oliveira Vasconcellos, Gabriela Pansanato Nakashima, Isabel Fusaro Aguiar Oliveira, Natalia Alves de Matos, Thalles de Freitas Castro, Frank Silva Bezerra, Ruben D. Sinisterra, Vanessa Pinho, Mauro Martins Teixeira, Robson Augusto Souza Santos, Maria Gloria Rodrigues-Machado, Maria Jose Campagnole-Santos
Summary: This study investigated the therapeutic action of Ang-(1-7) in an asthma model and found that oral administration of Ang-(1-7) improved behavior, restored lung function, reduced inflammatory cell content, and decreased airway mucus deposition. These results suggest the potential value of Ang-(1-7) in the treatment of asthma.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Miguel Camba-Gomez, Laura Arosa, Oreste Gualillo, Javier Conde-Aranda
Summary: Despite the benefits of current therapeutic options, there is a need for novel pharmacological targets to improve the treatment of inflammatory bowel disease (IBD). Chemokine and chemokine receptors have emerged as appealing options, as they regulate leukocyte trafficking and other processes related to intestinal inflammation development.
DRUG DISCOVERY TODAY
(2022)
Article
Critical Care Medicine
Hyung-Geun Moon, Seung-jae Kim, Ki-Hyun Kim, Young-Mee Kim, Jalees Rehman, Hyun Lee, Yi-Chien Wu, Steve Seung-Young Lee, John W. Christman, Steven J. Ackerman, Minhyung Kim, Sungyoung You, Gye Young Park
Summary: This study aims to investigate the cellular mechanism of tissue-resident macrophages involved in the resolution process of eosinophilic lung inflammation. Using mass cytometry, single-cell RNA sequencing, and biophysical and immunological analyses, it was found that the CCL26-CX3CR1 pathway plays a crucial role in resolving eosinophilic allergic lung inflammation.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Franciel Batista Felix, Julia Dias, Juliana Priscila Vago, Debora Gonzaga Martins, Vinicius Amorim Beltrami, Debora de Oliveira Fernandes, Anna Clara Paiva Menezes dos Santos, Celso Martins Queiroz, Lirlandia Pires de Sousa, Flavio Almeida Amaral, Frederico Marianetti Soriani, Mauro Martins Teixeira, Vanessa Pinho
Summary: Inflammation resolution involves cellular events such as apoptosis and efferocytosis, and the HGF/MET axis plays a crucial role in determining the progression and severity of inflammatory and immune-mediated disorders. Blocking the HGF/MET signalling pathway by PF-04217903 has been shown to promote the resolution of neutrophilic inflammation in models of gout and LPS-induced pleurisy, leading to reduced neutrophil accumulation, increased neutrophil apoptosis and efferocytosis, enhanced expression of Annexin A1, and decreased levels of inflammation markers. These findings suggest that blocking HGF/MET signalling could be a potential therapeutic strategy for resolving neutrophilic inflammatory responses.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Flavia A. Graca, Anna Stephan, Benjamin A. Minden-Birkenmaier, Abbas Shirinifard, Yong-Dong Wang, Fabio Demontis, Myriam Labelle
Summary: Skeletal muscle regeneration requires coordinated interactions between different cell types. Platelet-rich plasma has been widely used as an aid for muscle repair, but the specific role of platelets in regeneration remains unknown. This study shows that platelet-released chemokines play a crucial role in muscle repair by recruiting neutrophils to injured muscles in mice. The depletion of platelets reduces the levels of neutrophil chemoattractants, resulting in impaired neutrophil infiltration and compromised muscle regeneration.
NATURE COMMUNICATIONS
(2023)
Review
Endocrinology & Metabolism
Amin Ullah, Ahmad Ud Din, Wen Ding, Zheng Shi, Sadaf Pervaz, Bairong Shen
Summary: Adipose tissue in obese individuals develops lipids, aberrant adipokines, chemokines, and pro-inflammatory cytokines, leading to low-grade systemic inflammation. This inflammation can result in insulin resistance and metabolic complications like type 2 diabetes and nonalcoholic fatty liver disease. The role of CXC chemokines and chemokine receptors in the development of obesity-related metabolic diseases is still unclear. This review aims to provide an update on the connection between CXC chemokines, obesity, and obesity-related metabolic diseases, exploring their migratory potential, immunomodulatory effects, and potential as a therapeutic predictor.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Cell Biology
Despina Siolas, Emily Vucic, Emma Kurz, Cristina Hajdu, Dafna Bar-Sagi
Summary: Tumor genotype can influence the immune microenvironment in pancreatic cancer, leading to changes in immune cell populations and affecting treatment outcomes. Depletion of neutrophils in CRISPR Kras(G12D/+);Trp53(R172H/+) tumors can enhance the efficacy of CD40 immunotherapy and chemotherapy.
Article
Biochemistry & Molecular Biology
Junwen Han, Yuanyuan Shi, Gareth Willis, Jewel Imani, Min-Young Kwon, Gu Li, Ehab Ayaub, Sailaja Ghanta, Julie Ng, Narae Hwang, Konstantin Tsoyi, Souheil El-Chemaly, Stella Kourembanas, S. Alex Mitsialis, Ivan O. Rosas, Xiaoli Liu, Mark A. Perrella
Summary: The study highlights the importance of SDC2 in the cellular and paracrine function of human MSCs during sepsis. Silencing SDC2 in MSCs resulted in decreased bacterial clearance, increased tissue injury and mortality, as well as impaired resolution of inflammation. MSCs with silenced SDC2 also showed reduced ability to promote phagocytosis of apoptotic neutrophils and convert macrophages into a proresolution phenotype.