Review
Medicine, Research & Experimental
Feng Chen, Qiongwei Ke, Wenyan Wei, Lili Cui, Yan Wang
Summary: ApoE is a crucial protein involved in lipid metabolism and cholesterol homeostasis, and plays a critical role in viral infection. ApoE4 is associated with increased susceptibility to certain viral infections, while offering protection against others. This polymorphism is partly related to structural differences in ApoE. This review summarizes the relationship between ApoE and viral infection, discusses potential mechanisms, and identifies future research directions.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Editorial Material
Virology
Syeda Kanza Kazmi, Fatima Muhammad Asad Khan, Valentino Natoli, Reem Hunain, Zarmina Islam, Ana Carla dos Santos Costa, Shoaib Ahmad, Mohammad Yasir Essar
Summary: Hepatitis is a significant cause of mortality worldwide, with around 1.34 million deaths annually. Africa is not immune to this issue, with an estimated 100 million individuals infected with Hepatitis B or C. The continent, already fragile, is further burdened by the onset of the COVID-19 pandemic, which could potentially worsen the threat from viral diseases like Hepatitis. Strengthening prevention policies is essential for Africa to build resilience against such threats.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Gastroenterology & Hepatology
Maria B. Pisano, Cecilia G. Giadans, Diego M. Flichman, Viviana E. Re, Maria Preciado, Pamela Valva
Summary: Viral hepatitis caused by different viruses remains a significant public health issue with many unresolved problems, including pathogenesis, treatment, and vaccine development. This review focuses on key issues such as epidemiology, diagnostic methodology, and therapy of viral hepatitis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Norah A. Terrault, Miriam T. Levy, Ka Wang Cheung, Gonzague Jourdain
Summary: The management of viral hepatitis in pregnancy requires special consideration due to the unique characteristics of each hepatitis virus and their impact on maternal and infant outcomes. Preventing mother-to-child transmission is crucial in reducing the global burden of chronic viral hepatitis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Cell Biology
Xuan Tan, Kun Cai, Jiajia Li, Zhen Yuan, Ruifeng Chen, Hurong Xiao, Chuanrui Xu, Bing Hu, Yali Qin, Binbin Ding
Summary: This article examines how coronaviruses hijack ER-phagy to promote viral replication and reveals the underlying molecular mechanisms. The study shows that the viral protein ORF8 binds to p62 and disrupts ER-phagy, leading to viral double-membrane vesicle formation.
Article
Multidisciplinary Sciences
Lars E. Clark, Sarah A. Clark, ChieYu Lin, Jianying Liu, Adrian Coscia, Katherine G. Nabel, Pan Yang, Dylan Neel, Hyo Lee, Vesna Brusic, Iryna Stryapunina, Kenneth S. Plante, Asim A. Ahmed, Flaminia Catteruccia, Tracy L. Young-Pearse, Isaac M. Chiu, Paula Montero Llopis, Scott C. Weaver, Jonathan Abraham
Summary: The study reveals the mechanism of alphavirus infection in different hosts, with VLDLR identified as the receptor for Semliki forest virus. It also shows that invertebrate receptor orthologues can serve as functional alphavirus receptors.
Review
Gastroenterology & Hepatology
Patricia Holanda Almeida, Celso E. L. Matielo, Lilian A. Curvelo, Rodrigo A. Rocco, Guilherme Felga, Bianca Della Guardia, Yuri L. Boteon
Summary: Significant progress has been made in the treatment of viral hepatitis, including curative therapies for hepatitis C and advancements in vaccination for hepatitis A, B, and E. There is currently no cure for hepatitis B, but targeted antiviral drugs show promise in eradicating the virus. High vaccination coverage and large-scale test-and-treat programs may ultimately eliminate viral hepatitis and reduce the burden on health systems.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Review
Virology
Hui-Chun Li, Chee-Hing Yang, Shih-Yen Lo
Summary: The life cycle of the hepatitis C virus can be divided into several stages, including viral entry, protein translation, RNA replication, viral assembly, and release. The replication of HCV genomic RNA is regulated by various factors and has led to the development of direct-acting antivirals targeting the replication complex.
Article
Health Care Sciences & Services
Gina Gheorghe, Camelia Cristina Diaconu, Vlad Ionescu, Gabriel Constantinescu, Nicolae Bacalbasa, Simona Bungau, Mihnea-Alexandru Gaman, Madalina Stan-Ilie
Summary: Pancreatic cancer is a highly aggressive malignant tumor with varying incidence and mortality rates depending on geographical location. Early diagnosis and screening strategies are crucial for improving the prognosis of patients. The risk factors for pancreatic cancer can be categorized into extrinsic (such as alcohol consumption, smoking, and viral infections) and intrinsic factors. Further research is needed to fully understand the pathophysiological mechanisms linking viral liver infections and pancreatic cancer development.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Immunology
Pierre Cappy, Quentin Lucas, Nakourogou Kankarafou, Camille Sureau, Syria Laperche
Summary: Following a study demonstrating the role of hepatitis C virus (HCV) in transmitting hepatitis D virus (HDV) in a liver-humanized mouse model, a large cohort of HCV-positive blood donors were screened for HDV markers. However, no evidence of HCV-assisted propagation of HDV in humans was found.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Honglin Han, Yuexuan Wang, Suifeng Xu, Chengzong Han, Qiwei Qin, Shina Wei
Summary: Lipid metabolism, particularly high-density lipoprotein (HDL), plays a crucial role in viral infections. This study investigates the role of Epinephelus coioides SR-B1 (Ec-SR-B1) in red-spotted grouper nervous necrosis virus (RGNNV) infection and reveals that Ec-SR-B1 can promote RGNNV infection. The study also demonstrates the involvement of HDL in facilitating RGNNV entry and the interaction between Ec-SR-B1 and RGNNV's capsid protein (CP).
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Oncology
Marco Y. W. Zaki, Ahmed M. Fathi, Samara Samir, Nardeen Eldafashi, Kerolis Y. William, Maiiada Hassan Nazmy, Moustafa Fathy, Upkar S. Gill, Shishir Shetty
Summary: HBV and HCV infections are the most common risk factors for hepatocellular carcinoma (HCC), and their distribution affects the global prevalence of this type of liver cancer. Hepatitis infections elicit immune responses within the liver microenvironment, and persistent viral infection leads to chronic liver inflammation and carcinogenesis.
Article
Public, Environmental & Occupational Health
Samina Ejaz, Iqra Abdullah, Waqas Nazir Malik, Shazia Anjum, Muhammad Ashraf, Naveed Akhtar, Aurangzeb Khan, Yasir Hameed, Muhammad Usman, Usman Cheema, Safeena Sidiq
Summary: This study aims to investigate the prevalence and associated risk factors of hepatitis among students and employees in Pakistan and implement measures to make IUB hepatitis free. The study found that hepatitis is more prevalent in men and is associated with sharing of needles and certain behavioral and medical factors.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Huangcan Li, Xiong Wang, Yiran Wang, Yichen Li, Ying Chen, Yin-Ting Wong, Jufang He, Ming-Liang He
Summary: The proteases of SARS-CoV-2 and EV71 upregulate the expression and secretion of LRPAP1, which binds with IFNAR1 to trigger receptor degradation and enhance viral infection. A peptide derived from LRPAP1 can cause IFNAR1 degradation and enhance viral infections, while an LRPAP1 inhibitor stabilizes IFNAR1 and arrests virus infections. This study reveals a novel mechanism used by viruses to evade host immunity and provides a potential strategy for developing pan-antiviral drugs.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Cell Biology
Andreas Till, Rintaro Saito, Daria Merkurjev, Jing-Jing Liu, Gulam Hussain Syed, Martin Kolnik, Aleem Siddiqui, Martin Glas, Bjoern Scheffler, Trey Ideker, Suresh Subramani
Review
Biochemistry & Molecular Biology
Mohsin Khan, Gulam Hussain Syed, Seong-Jun Kim, Aleem Siddiqui
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2015)
Article
Microbiology
Mohsin Khan, Gulam Hussain Syed, Seong-Jun Kim, Aleem Siddiqui
Article
Virology
Gulam H. Syed, Mohsin Khan, Song Yang, Aleem Siddiqui
JOURNAL OF VIROLOGY
(2017)
Review
Cell Biology
Seong-Jun Kim, Dae-Gyun Ahn, Gulam H. Syed, Aleem Siddiqui
Article
Biochemistry & Molecular Biology
Kautilya Kumar Jena, Srinivasa Prasad Kolapalli, Subhash Mehto, Parej Nath, Biswajit Das, Pradyumna Kumar Sahoo, Abdul Ahad, Gulam Hussain Syed, Sunil K. Raghav, Shantibhusan Senapati, Swati Chauhan, Santosh Chauhan
Article
Microbiology
Sunil Raghav, Arup Ghosh, Jyotirmayee Turuk, Sugandh Kumar, Atimukta Jha, Swati Madhulika, Manasi Priyadarshini, Viplov K. Biswas, P. Sushree Shyamli, Bharati Singh, Neha Singh, Deepika Singh, Ankita Datey, Kiran Avula, Shuchi Smita, Jyotsnamayee Sabat, Debdutta Bhattacharya, Jaya Singh Kshatri, Dileep Vasudevan, Amol Suryawanshi, Rupesh Dash, Shantibhushan Senapati, Tushar K. Beuria, Rajeeb Swain, Soma Chattopadhyay, Gulam Hussain Syed, Anshuman Dixit, Punit Prasad, Sanghamitra Pati, Ajay Parida
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Cell Biology
Swagatika Panda, Suchismita Behera, Mohd Faraz Alam, Gulam Hussain Syed
Summary: Calcium ions serve as secondary messengers in cellular processes, with ER and mitochondria relying on Ca2+ for their function. Viruses exploit Ca2+ signaling to establish infection and evade host immune defenses, highlighting the significance of this interplay on viral life cycles and disease pathogenesis.
Article
Biochemistry & Molecular Biology
Voddu Suresh, Varshasnata Mohanty, Kiran Avula, Arup Ghosh, Bharati Singh, Rajendra Kumar Reddy, Deepti Parida, Amol Ratnakar Suryawanshi, Sunil Kumar Raghav, Soma Chattopadhyay, Punit Prasad, Rajeeb Kumar Swain, Rupesh Dash, Ajay Parida, Gulam Hussain Syed, Shantibhusan Senapati
Summary: This study confirmed the infectivity of a local SARS-CoV-2 isolate in a hamster model, showing similar lung pathology to COVID-19 patients and other hamsters. The lung-associated pathological changes were prominent on the 4th day post-infection and mostly resolved by 14 dpi. Proteomic analysis identified 68 significantly altered proteins between infected groups, with highlighted pathways including complement and coagulation cascade, platelet activation, ferroptosis, and focal adhesion. Additionally, altered expression of pulmonary surfactant-associated proteins Sftpd and Sftpb was observed, suggesting their potential role in SARS-CoV-2 pathogenesis and disease progression.
Review
Microbiology
Kiran Avula, Bharati Singh, Preethy Kumar, Gulam H. Syed
Summary: Viruses rely on host lipid metabolism to replicate and spread, utilizing specific lipid membrane compositions for membrane rearrangement and establishing replication complexes. By manipulating host lipid transfer proteins, viruses enrich membrane compartments with specific lipids to facilitate various aspects of the viral life cycle.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Sanchari Chatterjee, Ankita Datey, Soumya Sengupta, Arup Ghosh, Atimukta Jha, Safal Walia, Sharad Singh, Sandhya Suranjika, Gargee Bhattacharya, Eshna Laha, Supriya Suman Keshry, Amrita Ray, Sweta Smita Pani, Amol Ratnakar Suryawanshi, Rupesh Dash, Shantibhusan Senapati, Tushar K. Beuria, Gulam Hussain Syed, Punit Prasad, Sunil Kumar Raghav, Satish Devadas, Rajeeb K. Swain, Soma Chattopadhyay, Ajay Parida
Summary: This study investigated SARS-CoV-2 patients in India, revealing that symptomatic patients had elevated levels of CRP, LDH, SGPT, SGOT, and ferritin. Symptomatic patients were mainly with comorbidities, especially type 2 diabetes. Virological estimation showed no significant difference in viral load between oropharyngeal samples, but higher viral load in plasma and serum samples of symptomatic patients. They also developed sufficient antibodies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Anshu Agarwal, Mohd. Faraz Alam, Brohmomoy Basu, Sabyasachi Pattanayak, Shailendra Asthana, Gulam Hussain Syed, Manjula Kalia, Sudhanshu Vrati
Summary: During JEV infection, there is dysregulation of mitochondrial quality control mediated largely by the NS4A protein.
MICROBIOLOGY SPECTRUM
(2022)
Article
Virology
Kiran Avula, Bharati Singh, Subhashish Samantaray, Gulam Hussain Syed
Summary: This article investigates the components of the early secretory pathway in the HCV life cycle and finds that these components are not only essential for HCV release, but also play important roles in the early stages of the HCV life cycle.
JOURNAL OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sugandh Kumar, Bharati Singh, Pratima Kumari, Preethy Kumar, Geetanjali Agnihotri, Shaheerah Khan, Tushar Kant Beuria, Gulam Hussain Syed, Anshuman Dixit
Summary: This study utilized bioinformatics techniques to screen FDA approved drugs against SARS-CoV2 proteins and identified 74 molecules that can bind to various SARS-CoV2 and human host proteins, with some showing good activity against SARS-CoV2. Experimental validation using vero E6 cells infected with SARS-CoV2 virus showed promising results, suggesting that these studies may help in developing new therapeutic options for COVID-19 treatment.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Endocrinology & Metabolism
Emma Borgeson, Ville Wallenius, Gulam H. Syed, Manjula Darshi, Juan Lantero Rodriguez, Christina Biorserud, Malin Ragnmark Ek, Per Bjorklund, Marianne Quiding-Jarbrink, Lars Fandriks, Catherine Godson, Kumar Sharma