The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors

Targeting the NS5A protein of HCV: An emerging option

(2014) D.G. Cordek et al.   DRUGS OF THE FUTURE

Novel Spiroketal Pyrrolidine GSK2336805 Potently Inhibits Key Hepatitis C Virus Genotype 1b Mutants: From Lead to Clinical Compound

(2014) Wieslaw M. Kazmierski et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Development of Hepatitis C Virus NS5A Replication Complex Inhibitors

(2014) Makonen Belema et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and evaluation of non-dimeric HCV NS5A inhibitors

(2013) Franck Amblard et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insights into the Complexity and Functionality of Hepatitis C Virus NS5A Phosphorylation

(2013) D. Ross-Thriepland et al.   JOURNAL OF VIROLOGY

Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life

(2013) J. Guedj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterizations of HCV NS5A replication complex inhibitors

(2013) Donald R. O'Boyle II et al.   VIROLOGY

Towards automated crystallographic structure refinement withphenix.refine

(2012) Pavel V. Afonine et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Impact of a baseline polymorphism on the emergence of resistance to the hepatitis C virus nonstructural protein 5a replication complex inhibitor, BMS-790052

(2012) Jin-Hua Sun et al.   HEPATOLOGY

Small molecule inhibitors of the hepatitis C virus-encoded NS5A protein

(2012) Oscar Belda et al.   VIRUS RESEARCH

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization

(2011) D. Qiu et al.   JOURNAL OF GENERAL VIROLOGY

New targets for antiviral therapy of chronic hepatitis C

(2011) Sandra Bühler et al.   LIVER INTERNATIONAL

Treatment of chronic hepatitis C - are interferons really necessary?

(2011) Peter Ferenci   LIVER INTERNATIONAL

Perspective: Miles to go before we sleep

(2011) Charles Rice   NATURE

Introduction: A smouldering public-health crisis

(2011) Lauren Gravitz   NATURE

Inhibitors of HCV NS5A: From Iminothiazolidinones to Symmetrical Stilbenes

(2011) Jeffrey L. Romine et al.   ACS Medicinal Chemistry Letters

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Development of novel therapies for hepatitis C

(2010) Stanley M. Lemon et al.   ANTIVIRAL RESEARCH

All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding

(2010) T. L. Foster et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins

(2010) J. Hwang et al.   JOURNAL OF VIROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Domain 3 of non-structural protein 5A from hepatitis C virus is natively unfolded

(2009) Xavier Hanoulle et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of Hepatitis C Virus NS5A Inhibitors

(2009) J. A. Lemm et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY

Protein-protein crystal-packing contacts

(2009) Oliviero Carugo et al.   PROTEIN SCIENCE