Molecular determination of claudin-15 organization and channel selectivity

A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations

(2017) Giulio Alberini et al.   PLoS One

The intestinal epithelial barrier: a therapeutic target?

(2016) Matthew A. Odenwald et al.   Nature Reviews Gastroenterology & Hepatology

Tight junctions: from simple barriers to multifunctional molecular gates

(2016) Ceniz Zihni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Water and ion permeability of a claudin model: A computational study

(2016) Rozita Laghaei et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular basis of claudin-17 anion selectivity

(2015) Marcel P. Conrad et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Simulating Current–Voltage Relationships for a Narrow Ion Channel Using the Weighted Ensemble Method

(2015) Joshua L. Adelman et al.   Journal of Chemical Theory and Computation

Model for the Architecture of Claudin-Based Paracellular Ion Channels through Tight Junctions

(2015) Hiroshi Suzuki et al.   JOURNAL OF MOLECULAR BIOLOGY

Molecular Architecture of the Blood Brain Barrier Tight Junction Proteins–A Synergistic Computational and In Vitro Approach

(2015) Flaviyan Jerome Irudayanathan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure-Directing Behaviors of Tetraethylammonium Cations toward Zeolite Beta Revealed by the Evolution of Aluminosilicate Species Formed during the Crystallization Process

(2015) Takaaki Ikuno et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biochemical and biophysical analyses of tight junction permeability made of claudin-16 and claudin-19 dimerization

(2015) Yongfeng Gong et al.   MOLECULAR BIOLOGY OF THE CELL

Assembly and function of claudins: Structure–function relationships based on homology models and crystal structures

(2015) G. Krause et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Conceptual barriers to understanding physical barriers

(2015) Amulya Lingaraju et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structural Refinement of Proteins by Restrained Molecular Dynamics Simulations with Non-interacting Molecular Fragments

(2015) Rong Shen et al.   PLoS Computational Biology

Claudin-3 and Claudin-5 Protein Folding and Assembly into the Tight Junction Are Controlled by Non-conserved Residues in the Transmembrane 3 (TM3) and Extracellular Loop 2 (ECL2) Segments

(2014) Jan Rossa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive Cysteine-scanning Mutagenesis Reveals Claudin-2 Pore-lining Residues with Different Intrapore Locations

(2014) Jiahua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of a Claudin Provides Insight into the Architecture of Tight Junctions

(2014) H. Suzuki et al.   SCIENCE

Claudin-2 pore function requires an intramolecular disulfide bond between two conserved extracellular cysteines

(2013) Jiahua Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Molecular dynamics simulations of membrane proteins under asymmetric ionic concentrations

(2013) Fatemeh Khalili-Araghi et al.   JOURNAL OF GENERAL PHYSIOLOGY

Occludin OCEL-domain interactions are required for maintenance and regulation of the tight junction barrier to macromolecular flux

(2013) Mary M. Buschmann et al.   MOLECULAR BIOLOGY OF THE CELL

Claudins and the Modulation of Tight Junction Permeability

(2013) Dorothee Günzel et al.   PHYSIOLOGICAL REVIEWS

Optimization of the Additive CHARMM All-Atom Protein Force Field Targeting Improved Sampling of the Backbone ϕ, ψ and Side-Chain χ1 and χ2 Dihedral Angles

(2012) Robert B. Best et al.   Journal of Chemical Theory and Computation

Constant electric field simulations of the membrane potential illustrated with simple systems

(2011) James Gumbart et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ouabain Binding Site in a Functioning Na+/K+ATPase

(2011) Walter Sandtner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules

(2010) Christian Piehl et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Claudin-2 Forms Homodimers and Is a Component of a High Molecular Weight Protein Complex

(2010) Christina M. Van Itallie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Claudin-2, a component of the tight junction, forms a paracellular water channel

(2010) R. Rosenthal et al.   JOURNAL OF CELL SCIENCE

Update of the CHARMM All-Atom Additive Force Field for Lipids: Validation on Six Lipid Types

(2010) Jeffery B. Klauda et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structure of the Ethylammonium Nitrate Surface: An X-ray Reflectivity and Vibrational Sum Frequency Spectroscopy Study

(2010) Petru Niga et al.   LANGMUIR

Principles of conduction and hydrophobic gating in K+ channels

(2010) M. O. Jensen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Function Studies of Claudin Extracellular Domains by Cysteine-scanning Mutagenesis

(2009) Susanne Angelow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields

(2009) K. Vanommeslaeghe et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Physiology and Function of the Tight Junction

(2009) J. M. Anderson et al.   Cold Spring Harbor Perspectives in Biology

Probing effects of pH change on dynamic response of Claudin-2 mediated adhesion using single molecule force spectroscopy

(2008) Tong Seng Lim et al.   EXPERIMENTAL CELL RESEARCH

Molecular Basis for Cation Selectivity in Claudin-2–based Paracellular Pores: Identification of an Electrostatic Interaction Site

(2008) Alan S.L. Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Kinetics of Adhesion Mediated by Extracellular Loops of Claudin-2 as Revealed by Single-Molecule Force Spectroscopy

(2008) Tong Seng Lim et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and function of claudins

(2007) Gerd Krause et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Formation of tight junction: determinants of homophilic interaction between classic claudins

(2007) Jörg Piontek et al.   FASEB JOURNAL