Deficiency in T follicular regulatory cells promotes autoimmunity

A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers

(2017) James Badger Wing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-21 restricts T follicular regulatory T cell proliferation through Bcl-6 mediated inhibition of responsiveness to IL-2

(2017) Christoph Jandl et al.   Nature Communications

Store-Operated Ca 2+ Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity

(2016) Martin Vaeth et al.   IMMUNITY

Suppression by TFR cells leads to durable and selective inhibition of B cell effector function

(2016) Peter T Sage et al.   NATURE IMMUNOLOGY

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

(2016) Meryem Aloulou et al.   Nature Communications

Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation

(2016) Xindong Liu et al.   Cell Reports

Strategically Localized Dendritic Cells Promote Rapid T Cell Responses to Lymph-Borne Particulate Antigens

(2015) Michael Y. Gerner et al.   IMMUNITY

Immune homeostasis enforced by co-localized effector and regulatory T cells

(2015) Zhiduo Liu et al.   NATURE

Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging

(2015) Peter T. Sage et al.   Cell Reports

Th17 cells play a critical role in the development of experimental Sjögren's syndrome

(2014) Xiang Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulatory T Cells Control Antigen-Specific Expansion of Tfh Cell Number and Humoral Immune Responses via the Coreceptor CTLA-4

(2014) James Badger Wing et al.   IMMUNITY

The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells

(2014) Peter T. Sage et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Circulating T follicular regulatory and helper cells have memory-like properties

(2014) Peter T. Sage et al.   JOURNAL OF CLINICAL INVESTIGATION

Follicular regulatory T cells control humoral autoimmunity via NFAT2-regulated CXCR5 expression

(2014) Martin Vaeth et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development

(2014) Xindong Liu et al.   NATURE

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

(2014) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas

(2012) G. D. Victora et al.   BLOOD

Bcl6 expression specifies the T follicular helper cell program in vivo

(2012) Xindong Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood

(2012) Peter T Sage et al.   NATURE IMMUNOLOGY

The development and fate of follicular helper T cells defined by an IL-21 reporter mouse

(2012) Katja Lüthje et al.   NATURE IMMUNOLOGY

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Follicular helper T cells poise immune responses to the development of autoimmune pathology

(2010) Diana Gómez-Martín et al.   AUTOIMMUNITY REVIEWS

Germinal Center Dynamics Revealed by Multiphoton Microscopy with a Photoactivatable Fluorescent Reporter

(2010) Gabriel D. Victora et al.   CELL

IL-21 regulates germinal center B cell differentiation and proliferation through a B cell–intrinsic mechanism

(2010) Dimitra Zotos et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Cytokine-secreting follicular T cells shape the antibody repertoire

(2009) R Lee Reinhardt et al.   NATURE IMMUNOLOGY

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE