期刊
NATURE COMMUNICATIONS
卷 7, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ncomms10579
关键词
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资金
- AVENIR INSERM
- Conseil Regional Midi-Pyrenees
- Institut National contre le Cancer (INCa) [PLBIO10-195, INCA-6530]
- Biotechnology and Biological Sciences Research Council
- European Research Council [637801 TWILIGHT]
- ARSEP
- NIHR
- BBSRC [BBS/E/B/000C0409, BBS/E/B/000C0407] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0407, BBS/E/B/000C0409] Funding Source: researchfish
- National Institute for Health Research [ACF-2014-14-003] Funding Source: researchfish
T follicular regulatory (Tfr) cells are a subset of Foxp3(+) regulatory T (Treg) cells that form in response to immunization or infection, which localize to the germinal centre where they control the magnitude of the response. Despite an increased interest in the role of Tfr cells in humoral immunity, many fundamental aspects of their biology remain unknown, including whether they recognize self-or foreign antigen. Here we show that Tfr cells can be specific for the immunizing antigen, irrespective of whether it is a self- or foreign antigen. We show that, in addition to developing from thymic derived Treg cells, Tfr cells can also arise from Foxp3(-) precursors in a PD-L1-dependent manner, if the adjuvant used is one that supports T-cell plasticity. These findings have important implications for Tfr cell biology and for improving vaccine efficacy by formulating vaccines that modify the Tfr:Tfh cell ratio.
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