TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation

(2012) S McComb et al.   CELL DEATH AND DIFFERENTIATION

TAK1 Negatively Regulates NF-κB and p38 MAP Kinase Activation in Gr-1+CD11b+ Neutrophils

(2012) Adebusola Alagbala Ajibade et al.   IMMUNITY

Myeloid Takl Acts as a Negative Regulator of the LPS Response and Mediates Resistance to Endotoxemia

(2012) Christina Eftychi et al.   PLoS One

A novel role for RIP1 kinase in mediating TNFα production

(2012) D E Christofferson et al.   Cell Death & Disease

Inhibition of Cathepsin K for Treatment of Osteoporosis

(2012) Steven Boonen et al.   Current Osteoporosis Reports

Rac deletion in osteoclasts causes severe osteopetrosis

(2011) M. Croke et al.   JOURNAL OF CELL SCIENCE

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

(2011) David J Mellis et al.   JOURNAL OF ENDOCRINOLOGY

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

(2011) William J. Kaiser et al.   NATURE

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

(2011) Andrew Oberst et al.   NATURE

The Prevalence of TNFα-Induced Necrosis over Apoptosis Is Determined by TAK1-RIP1 Interplay

(2011) Seda Çöl Arslan et al.   PLoS One

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

(2010) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

zVAD-induced necroptosis in L929 cells depends on autocrine production of TNFα mediated by the PKC–MAPKs–AP-1 pathway

(2010) Y-T Wu et al.   CELL DEATH AND DIFFERENTIATION

Virus Inhibition of RIP3-Dependent Necrosis

(2010) Jason W. Upton et al.   Cell Host & Microbe

Bone histomorphometry: Standardization of nomenclature, symbols, and units: Report of the asbmr histomorphometry nomenclature committee

(2010) A. Michael Parfitt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The p38 MAPK pathway is essential for skeletogenesis and bone homeostasis in mice

(2010) Matthew B. Greenblatt et al.   JOURNAL OF CLINICAL INVESTIGATION

Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization

(2010) Yuji Ito et al.   JOURNAL OF CLINICAL INVESTIGATION

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis

(2010) Yoshiteru Miyauchi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NIK Stabilization in Osteoclasts Results in Osteoporosis and Enhanced Inflammatory Osteolysis

(2010) Chang Yang et al.   PLoS One

The Role of the Kinases RIP1 and RIP3 in TNF-Induced Necrosis

(2010) P. Vandenabeele et al.   Science Signaling

A critical role of TAK1 in B-cell receptor–mediated nuclear factor κB activation

(2009) James Schuman et al.   BLOOD

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Expression and regulation of cathepsin K in skin fibroblasts

(2009) Maria J. Quintanilla-Dieck et al.   EXPERIMENTAL DERMATOLOGY

Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation

(2009) Yihui Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E2 interaction and dimerization in the crystal structure of TRAF6

(2009) Qian Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

(2008) Junichi Hitomi et al.   CELL

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

(2008) Betty Lamothe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity

(2008) Emily Omori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Osteoclastogenesis by IKKβ-null Precursors Is a Result of Receptor Activator of NF-κB Ligand (RANKL)-induced JNK-dependent Apoptosis and Impaired Differentiation

(2008) Jesse E. Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology