Neuronal Trafficking of the Amyloid Precursor Protein—What Do We Really Know?

Amyloid-beta mediates homeostatic synaptic plasticity

(2021) Christos Galanis et al.   JOURNAL OF NEUROSCIENCE

The Journey of the Synaptic Autophagosome: A Cell Biological Perspective

(2020) Sarah E. Hill et al.   NEURON

Depletion of the AD Risk Gene SORL1 Selectively Impairs Neuronal Endosomal Traffic Independent of Amyloidogenic APP Processing

(2020) Allison Knupp et al.   Cell Reports

Endosomal recycling reconciles the Alzheimer’s disease paradox

(2020) Scott A. Small et al.   Science Translational Medicine

The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease

(2019) Jing Zhi A. Tan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

Trafficking and proteolytic processing of amyloid precursor protein and secretases in Alzheimer's disease development: An up-to-date review

(2019) Melike Yuksel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity

(2019) Tamar Farfel-Becker et al.   Cell Reports

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Interaction of microtubules and actin during the post-fusion phase of exocytosis

(2019) M. Tabitha Müller et al.   Scientific Reports

Kinesin light chain-1 serine-460 phosphorylation is altered in Alzheimer’s disease and regulates axonal transport and processing of the amyloid precursor protein

(2019) Gábor M. Mórotz et al.   Acta Neuropathologica Communications

Tau filaments in neurodegenerative diseases

(2018) Michel Goedert   FEBS LETTERS

Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons

(2018) Xiu-Tang Cheng et al.   JOURNAL OF CELL BIOLOGY

Degradation of dendritic cargos requires Rab7-dependent transport to somatic lysosomes

(2018) Chan Choo Yap et al.   JOURNAL OF CELL BIOLOGY

Crosstalk between endoplasmic reticulum stress and brain inflammation in Alzheimer's disease

(2018) Luis E. Santos et al.   NEUROPHARMACOLOGY

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

(2018) André M. Miranda et al.   Nature Communications

Rotation of endosomes demonstrates coordination of molecular motors during axonal transport

(2018) Luke Kaplan et al.   Science Advances

Neuronal endosomes to lysosomes: A journey to the soma

(2018) Vineet Vinay Kulkarni et al.   JOURNAL OF CELL BIOLOGY

The interplay between exosomes and autophagy – partners in crime

(2018) Jing Xu et al.   JOURNAL OF CELL SCIENCE

Autophagosome maturation: An epic journey from the ER to lysosomes

(2018) Yan G. Zhao et al.   JOURNAL OF CELL BIOLOGY

Impaired JIP3-dependent axonal lysosome transport promotes amyloid plaque pathology

(2017) Swetha Gowrishankar et al.   JOURNAL OF CELL BIOLOGY

The Retromer Supports AMPA Receptor Trafficking During LTP

(2017) Paul Temkin et al.   NEURON

An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

(2017) Ebbe T. Poulsen et al.   Frontiers in Molecular Neuroscience

Functional Roles of the Interaction of APP and Lipoprotein Receptors

(2017) Theresa Pohlkamp et al.   Frontiers in Molecular Neuroscience

ER Stress-Mediated Apoptotic Pathway Induced by Aβ Peptide Requires the Presence of Functional Mitochondria

(2017) Rui O. Costa et al.   JOURNAL OF ALZHEIMERS DISEASE

Dynein Dysfunction Reproduces Age-Dependent Retromer Deficiency

(2016) Nobuyuki Kimura et al.   AMERICAN JOURNAL OF PATHOLOGY

Sorting receptor SORLA: cellular mechanisms and implications for disease

(2016) Vanessa Schmidt et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neurotrophin signaling endosomes: biogenesis, regulation, and functions

(2016) Naoya Yamashita et al.   CURRENT OPINION IN NEUROBIOLOGY

Lipids implicated in the journey of a secretory granule: from biogenesis to fusion

(2016) Emeline Tanguy et al.   JOURNAL OF NEUROCHEMISTRY

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

The Dynamic Localization of Cytoplasmic Dynein in Neurons Is Driven by Kinesin-1

(2016) Alison E. Twelvetrees et al.   NEURON

A molecular dynamics study of the binary complexes of APP, JIP1, and the cargo binding domain of KLC

(2016) Cooper A. Taylor et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

α-Tubulin Tyrosination and CLIP-170 Phosphorylation Regulate the Initiation of Dynein-Driven Transport in Neurons

(2016) Jeffrey J. Nirschl et al.   Cell Reports

Super-resolution microscopy reveals γ-secretase at both sides of the neuronal synapse

(2016) Sophia Schedin-Weiss et al.   Acta Neuropathologica Communications

Extracellular association of APP and tau fibrils induces intracellular aggregate formation of tau

(2015) Muneaki Takahashi et al.   ACTA NEUROPATHOLOGICA

Secretory autophagy

(2015) Marisa Ponpuak et al.   CURRENT OPINION IN CELL BIOLOGY

Amyloid-β precursor protein: Multiple fragments, numerous transport routes and mechanisms

(2015) Virgil Muresan et al.   EXPERIMENTAL CELL RESEARCH

Distinct Functions for Anterograde and Retrograde Sorting of SORLA in Amyloidogenic Processes in the Brain

(2015) S. B. Dumanis et al.   JOURNAL OF NEUROSCIENCE

An atomic structure of human γ-secretase

(2015) Xiao-chen Bai et al.   NATURE

Structural basis for amyloidogenic peptide recognition by sorLA

(2015) Yu Kitago et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

(2015) Swetha Gowrishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP–SorLA Interaction

(2015) Luca Rosario La Rosa et al.   Frontiers in Cellular Neuroscience

Structural basis for amyloidogenic peptide recognition by sorLA

(2015) Yu Kitago et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

(2015) Weihao Tang et al.   Molecular Brain

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

(2014) Per Nilsson et al.   BIOESSAYS

Quantitative analysis of APP axonal transport in neurons: role of JIP1 in enhanced APP anterograde transport

(2014) Kyoko Chiba et al.   MOLECULAR BIOLOGY OF THE CELL

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Axonal Transport: Cargo-Specific Mechanisms of Motility and Regulation

(2014) Sandra Maday et al.   NEURON

Aβ-induced Golgi fragmentation in Alzheimer’s disease enhances Aβ production

(2014) Gunjan Joshi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of c-Jun N-terminal kinase-interacting protein-1 does not affect axonal transport of the amyloid precursor protein or Aβ production

(2013) Alessio Vagnoni et al.   HUMAN MOLECULAR GENETICS

JIP1 regulates the directionality of APP axonal transport by coordinating kinesin and dynein motors

(2013) Meng-meng Fu et al.   JOURNAL OF CELL BIOLOGY

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

(2013) C. Gustafsen et al.   JOURNAL OF NEUROSCIENCE

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Correction: The Pathogenic Aβ43 Is Enriched in Familial and Sporadic Alzheimer Disease

(2013) Anna Sandebring et al.   PLoS One

Retrograde Traffic from the Golgi to the Endoplasmic Reticulum

(2013) A. Spang   Cold Spring Harbor Perspectives in Biology

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates A  production

(2012) A. Vagnoni et al.   HUMAN MOLECULAR GENETICS

Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons

(2012) Sandra Maday et al.   JOURNAL OF CELL BIOLOGY

Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

(2012) A. W. Fjorback et al.   JOURNAL OF NEUROSCIENCE

The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

(2012) Akhil Bhalla et al.   NEUROBIOLOGY OF DISEASE

JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides

(2012) Sung Ok Yoon et al.   NEURON

Amyloid Precursor Protein Is Trafficked and Secreted via Synaptic Vesicles

(2011) Teja W. Groemer et al.   PLoS One

Dementia incidence continues to increase with age in the oldest old: The 90+ study

(2009) María M. Corrada et al.   ANNALS OF NEUROLOGY

Aβ43 is more frequent than Aβ40 in amyloid plaque cores from Alzheimer disease brains

(2009) Hedvig Welander et al.   JOURNAL OF NEUROCHEMISTRY

Calsyntenins Mediate TGN Exit of APP in a Kinesin-1-Dependent Manner

(2009) Alexander Ludwig et al.   TRAFFIC

Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons

(2008) A. Schneider et al.   JOURNAL OF NEUROSCIENCE

Loss of LR11/SORLA Enhances Early Pathology in a Mouse Model of Amyloidosis: Evidence for a Proximal Role in Alzheimer's Disease

(2008) S. E. Dodson et al.   JOURNAL OF NEUROSCIENCE

VPS10P-domain receptors — regulators of neuronal viability and function

(2008) Thomas E. Willnow et al.   NATURE REVIEWS NEUROSCIENCE

Role of Endoplasmic Reticulum, Endosomal-Lysosomal Compartments, and Microtubules in Amyloid Precursor Protein Metabolism of Human Neurons

(2003) Andréa C. LeBlanc et al.   JOURNAL OF NEUROCHEMISTRY