Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer's Disease Therapy

Intelligent lesion blood brain barrier targeting nano-missiles for Alzheimer's disease treatment by anti-neuroinflammation and neuroprotection

(2022) Xueqin He et al.   Acta Pharmaceutica Sinica B

Rethinking CRITID Procedure of Brain Targeting Drug Delivery: Circulation, Blood Brain Barrier Recognition, Intracellular Transport, Diseased Cell Targeting, Internalization, and Drug Release

(2021) Shaobo Ruan et al.   Advanced Science

Intranasal delivery of nanostructured lipid carriers, solid lipid nanoparticles and nanoemulsions: A current overview of in vivo studies

(2021) Cláudia Pina Costa et al.   Acta Pharmaceutica Sinica B

Recent advances in nano delivery systems for blood-brain barrier (BBB) penetration and targeting of brain tumors

(2021) Shriya Reddy et al.   DRUG DISCOVERY TODAY

A nanocleaner specifically penetrates the blood‒brain barrier at lesions to clean toxic proteins and regulate inflammation in Alzheimer’s disease

(2021) Ting Lei et al.   Acta Pharmaceutica Sinica B

A review on advances of treatment modalities for Alzheimer's disease

(2021) Ewen Se Thoe et al.   LIFE SCIENCES

The construction of in vitro nasal cavity-mimic M-cell model, design of M cell-targeting nanoparticles and evaluation of mucosal vaccination by nasal administration

(2020) Xiaotong Yang et al.   Acta Pharmaceutica Sinica B

Endo/Lysosome‐Escapable Delivery Depot for Improving BBB Transcytosis and Neuron Targeted Therapy of Alzheimer's Disease

(2020) Lulu Cai et al.   ADVANCED FUNCTIONAL MATERIALS

The development of advanced structural framework as multi-target-directed ligands for the treatment of Alzheimer’s disease

(2020) Zhipei Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease

(2020) Jing Zhao et al.   Frontiers in Molecular Neuroscience

Detection of amyloid-beta by Fmoc-KLVFF self-assembled fluorescent nanoparticles for Alzheimer’s disease diagnosis

(2020) Dingchang Liu et al.   CHINESE CHEMICAL LETTERS

Discovery of a novel small molecule PT109 with multi-targeted effects against Alzheimer's disease in vitro and in vivo

(2020) Qiuhe Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Escape from abluminal LRP1-mediated clearance for boosted nanoparticle brain delivery and brain metastasis treatment

(2020) Naveed Ullah Khan et al.   Acta Pharmaceutica Sinica B

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Biodegradable PEG-poly(ω-pentadecalactone- co - p -dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors

(2018) Evan M. Chen et al.   BIOMATERIALS

The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease

(2018) Harald Hampel et al.   BRAIN

Systemic delivery of BACE1 siRNA through neuron-targeted nanocomplexes for treatment of Alzheimer's disease

(2018) Pengzhen Wang et al.   JOURNAL OF CONTROLLED RELEASE

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

(2018) Mukta Agrawal et al.   JOURNAL OF CONTROLLED RELEASE

A self-destructive nanosweeper that captures and clears amyloid β-peptides

(2018) Qiang Luo et al.   Nature Communications

TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

(2018) Ji-Won Lee et al.   Autophagy

Nanocomposites Inhibit the Formation, Mitigate the Neurotoxicity, and Facilitate the Removal of β-Amyloid Aggregates in Alzheimer’s Disease Mice

(2018) Yu Zhao et al.   NANO LETTERS

Altered γ-Secretase Processing of APP Disrupts Lysosome and Autophagosome Function in Monogenic Alzheimer’s Disease

(2018) Christy O.Y. Hung et al.   Cell Reports

Rapamycin suppresses Aβ 25–35 - or LPS-induced neuronal inflammation via modulation of NF-κB signaling

(2017) Ying-Chun Liu et al.   NEUROSCIENCE

Brain-targeted co-delivery of therapeutic gene and peptide by multifunctional nanoparticles in Alzheimer's disease mice

(2016) Yang Liu et al.   BIOMATERIALS

Autophagy and Alzheimer’s Disease

(2016) Qian Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Development and application of a novel recombinantAleuria aurantialectin with enhanced core fucose binding for identification of glycoprotein biomarkers of hepatocellular carcinoma

(2016) Pamela Norton et al.   PROTEOMICS

Early etiology of Alzheimer’s disease: tipping the balance toward autophagy or endosomal dysfunction?

(2015) Aleksandar Peric et al.   ACTA NEUROPATHOLOGICA

Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor

(2013) D. T. Wiley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Can we do better in developing new drugs for Alzheimer's disease?

(2009) Serge Gauthier et al.   Alzheimers & Dementia

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of a high affinity binding site in recombinant Aleuria aurantia lectin

(2008) Johan Olausson et al.   GLYCOCONJUGATE JOURNAL