Article
Oncology
Dmitry Namgaladze, Bernhard Bruene
Summary: Pharmacological activation of tumor suppressor p53 demonstrates anti-inflammatory effects in differentiating human macrophages.
Review
Biochemistry & Molecular Biology
Haina Zhang, Yeling Wang, Hongbo Men, Wenqian Zhou, Shanshan Zhou, Quan Liu, Lu Cai
Summary: CARD9 is a crucial adaptor protein involved in the pathogenesis of cardiovascular diseases, including inflammation, apoptosis, and autophagy. By regulating signaling pathways and cytokine production, CARD9 plays a significant role in the development of CVDs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xishuai Tong, Gengsheng Yu, Xiaohui Fu, Ruilong Song, Jianhong Gu, Zongping Liu
Summary: Osteoclastogenesis is regulated by endogenous and exogenous factors, and is closely related to autophagy, inflammation, and immunity. Studies on osteoclastogenesis induced by different regulatory aspects have provided new directions for osteoclast differentiation and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
Yanlin Guo, Dong Huang, Mingzhu Pan, Mengxi Yang, Kai Luo, Jiahuan Liu, Chenglong Wu, Wenbing Zhang, Kangsen Mai
Summary: A 100-day feeding trial was conducted to investigate the effects of dietary lipid levels on abalone immunity and mechanism, finding that high levels of dietary lipid (67.19 g/kg) decreased abalone immunity, potentially due to increased inflammation and apoptosis, as well as decreased anti-oxidative capacity through specific signaling pathways.
AQUACULTURE NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Ewa Trybus, Teodora Krol, Wojciech Trybus
Summary: The study investigates the mechanisms of action of azelastine hydrochloride in cancer treatment. The results demonstrate that azelastine can induce degradation processes, increase autophagy activity, and activate apoptosis, leading to anti-proliferative, cytotoxic, autophagic, and apoptotic effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yixin Cui, Mengmeng Yang, Yilin Wang, Jianmin Ren, Peng Lin, Chen Cui, Jia Song, Qin He, Huiqing Hu, Kexin Wang, Yu Sun
Summary: This study found that MLT has a certain therapeutic effect on improving cognitive dysfunction in type 2 diabetic mice, possibly by activating the TLR4/Akt/mTOR pathway to regulate autophagy, thereby reducing neuroinflammation and microglial apoptosis.
Article
Environmental Sciences
Simeng Wang, Yilong Yang, Dan Luo, Lingling Zhai, Yinglong Bai, Wei Wei, Qi Sun, Lihong Jia
Summary: The study found that BPA can induce inflammatory response in the lungs, possibly through the TLR4/NF-kappa B signaling pathway and mTOR-mediated autophagy. Inhibition of autophagy can weaken the inflammatory response.
Article
Medicine, Research & Experimental
Yi Ying, Chun-bin Sun, Si-qi Zhang, Bo-jun Chen, Jing-ze Yu, Fei-yu Liu, Jing Wen, Jiong Hou, Si-si Han, Jin-yuan Yan, Zhong-shan Yang, Lei Xiong
Summary: ASIV, extracted from Astragalus membranaceus, shows significant anti-inflammatory effects on CSE-exposed cells by promoting autophagy and inhibiting the TLR4/NF-κB signaling pathway, thus alleviating inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Sutian Wang, Kunli Zhang, Xuting Song, Qiuyan Huang, Sen Lin, Shoulong Deng, Meiyu Qi, Yecheng Yang, Qi Lu, Duowei Zhao, Fanming Meng, Jianhao Li, Zhengxing Lian, Chenglong Luo, Yuchang Yao
Summary: Gram-negative bacterial infections pose a significant threat to public health. Toll-like receptor 4 (TLR4) plays a crucial role in recognizing bacterial lipopolysaccharide (LPS) and mediating innate immune responses, autophagy, and apoptosis. However, the role of TLR4 in large mammals, such as sheep, remains unknown.
Article
Medicine, Research & Experimental
Liang-Hsuan Chien, Jeng-Shyan Deng, Wen-Ping Jiang, Ya-Ni Chou, Jaung-Geng Lin, Guan-Jhong Huang
Summary: This study used a bleomycin-induced IPF mouse model to demonstrate the potential benefits of SS in ameliorating IPF. The results showed that SS reduced tissue damage and fibrosis expression, and regulated various pathways involved in IPF.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Neurosciences
Jingxiang Wu, Xin Li, Xiaoxuan Zhang, Wei Wang, Xingji You
Summary: This article summarizes the role and mechanisms of the cGAS-STING pathway in chronic pain. By considering its involvement in sensory neurons and glial cells, it provides new insights into the potential mechanisms of pain, including inflammation, immunity, apoptosis, and autophagy, and offers a new perspective for pain treatment.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Zihao Li, Ziyu Huang, Lunhao Bai
Summary: Osteoarthritis is a common joint disease, where cartilage instability leads to cell death and inflammatory factor release, resulting in cartilage degradation. The P2X7 receptor plays a crucial role in cell death and inflammatory reactions, potentially serving as a therapeutic target for OA treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Safura Pournajaf, Leila Dargahi, Mohammad Javan, Mohammad Hossein Pourgholami
Summary: Fingolimod is an effective therapy for disease progression, reducing T-cell numbers, suppressing inflammation, and potentially treating various pathological conditions. It modulates multiple molecular pathways and has shown potential therapeutic effects in immunomodulatory diseases, CNS injuries, Alzheimer's disease, Parkinson's disease, epilepsy, and cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Environmental Sciences
Shanshan Zhu, Yingwei Liu, Yangwei Li, Jiangnan Yi, Bijing Yang, Yuanliang Li, Zhuanxu Ouyang, Bingxian Liu, Peng Shang, Khalid Mehmood, Rao Zahid Abbas, Shakeel Ahmed, Yung-Fu Chang, Jianying Guo, Jiaqiang Pan, Lianmei Hu, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: Exposure to Butachlor can cause cancer, lymphocyte aberration, and immunotoxic effects, leading to toxic effects on the spleen of mice and triggering an immune response by targeting the CYTC/BCL2/M-TOR pathway and caspase cascading activation of spleen autophagy and apoptosis pathways.
Article
Environmental Sciences
Dan Song, Chao Xu, Askild L. Holck, Rong Liu
Summary: ACR exposure has been shown to cause neurotoxicity, reproductive toxicity, and carcinogenicity, but the exact mechanism of its toxicity remains unknown. In this study, it was demonstrated that ACR inhibited autophagic flux, increased ROS content, and led to apoptosis and inflammatory responses. Metabolomic analysis revealed significant differences in metabolic profiles between ACR treated and control cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Clinical Neurology
Ilhan Elmaci, Meric A. Altinoz, Burcu Eylem Kahraman Ozlu, Ramazan Sari, Ozlem Er, Ayca Ersen Danyeli, Ercan Karaarslan
Summary: Benign metastatic leiomyomas (BML) are slowly growing metastatic tumors commonly associated with uterine leiomyomas in women of reproductive ages. Despite their benign pathological features, these tumors can cause significant morbidity and even mortality. Treatment options include hysterectomy and GnRH modifier therapies, with the potential for systemic estrogen antagonists to provide better tumor control.
NEUROSURGICAL REVIEW
(2021)
Review
Biochemistry & Molecular Biology
Meric A. Altinoz, Ilhan Elmaci, Ahmet Hacimuftuoglu, Alp Ozpinar, Emily Hacker, Aysel Ozpinar
Summary: This review study focuses on the potential benefits of the transcription factor PPAR? and its ligand erucic acid (EA) in the management of neuroectodermal tumors and Parkinson's Disease, suggesting that they may play a positive role in these conditions.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Obstetrics & Gynecology
Ozlem Naciye Sahin, Aysel Ozpinar, Muhittin Serdar
Summary: The study evaluated levels of MMP-1, TIMP-1, leptin, IL-6, and fatty acids in breastmilk from women who consumed omega-3. It found that MMP-1 levels were significantly lower in breastmilk from omega users, and positively correlated with omega 6:3 ratio, IL-6, and leptin levels. Maternal omega use may modify MMP-1 levels in breastmilk, impacting extracellular matrix remodelling and metabolic programming in early infancy.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Clinical Neurology
Ilhan Elmaci, Meric A. Altinoz, Gokhan Akdemir, Ramazan Sari, Ozdil Baskan, Alp Ozpinar, Emily Hacker, Aydin Sav
Summary: IHSP is a relatively novel entity of hypertrophic pachymeningitis that may present with neurological deficits and spinal compression, treatment involves medication and surgery for management.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Biochemistry & Molecular Biology
Hande Karpuzoglu, Yasemin Ucal, Pinar Kumru, Murat Muhcu, Mustafa Eroglu, Muhittin Serdar, Mustafa Serteser, Aysel Ozpinar
Summary: This study aimed to investigate the correlation between maternal serum leptin concentration during the third trimester of pregnancy and newborn screening-TSH levels. The results suggest that high leptin levels in the third trimester of pregnancy influence maternal thyroid functions and might cause an increase in newborn TSH levels.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Meric A. Altinoz, Sinan Guloksuz, Aysel Ozpinar
Summary: Noscapine is a versatile alkaloid with various pharmacological effects that can be used to treat neurodegenerative and psychiatric diseases such as multiple sclerosis, Parkinson's Disease, Amyotrophic Lateral Sclerosis, stroke, anxiety, depression, and Alzheimer's Disease.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Biochemistry & Molecular Biology
Merve Kilic, Aysel Ozpinar, Mustafa Serteser, Meltem Kilercik, Muhittin Serdar
Summary: This meta-analysis study suggests that reticulocyte hemoglobin content (CHr) is a more effective biomarker than routinely used parameters for diagnosing iron deficiency anemia (IDA). Routine testing using CHr is important for the pre-diagnosis of IDA.
JOURNAL OF MEDICAL BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Meltem Kilercik, Yasemin Ucal, Muhittin Serdar, Mustafa Serteser, Aysel Ozpinar, Florian J. Schweigert
Summary: ZnPP may be an important indicator of anemia in COVID-19 patients, and the ZnPP/L ratio may serve as a valid prognostic marker for the severity of the disease.
Review
Medicine, Research & Experimental
Meric A. Altinoz, Aysel Ozpinar
Summary: Oxamate is a potential drug for the treatment of refractory cancers and brain tumors. It blocks LDHA activity and induces mitochondrial apoptosis, inhibiting tumor growth. Combination with phenformin enhances anticancer efficacy and reduces side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Clinical Neurology
Meric A. Altinoz, Alp Ozpinar, Emily Hacker, Aysel Ozpinar
Summary: Meperidine has unique anticancer properties by inhibiting specific receptors and enzymes, while tamoxifen enhances the anticancer effect by blocking proteins and regulating lipid levels. The combination of meperidine and tamoxifen may have a synergistic relationship in the treatment of glioblastoma.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Endocrinology & Metabolism
I. Orcun Olcay, Berkay Akcay, Mustafa Bahceci, Aydin Arici, Kubra Boynukalin, Cengiz Yakicier, Aysel Ozpinar, Murat Basar
Summary: Assisted reproduction technology faces challenges of low success rates and multiple pregnancies. This study suggests that analyzing the amino acid metabolism profile in the spent culture media may help discriminate between euploid and aneuploid human preimplantation embryos. The findings provide a potential noninvasive method for embryo selection, contributing to the improvement of assisted reproduction techniques.
GYNECOLOGICAL ENDOCRINOLOGY
(2022)
Article
Oncology
Ilhan Elmaci, Meric A. Altinoz, Eylem Burcu Kahraman Ozlu, Ramazan Sari, Ozlem Er, Cumhur Gokhan Ekmekci, Burcu Turkgenc, Alp Ozpinar, Emily Hacker, Aysel Ozpinar
Summary: There are fewer studies on the association between MGMT enzyme biochemistry and glial carcinogenesis compared to the effect of MGMT gene methylation on temozolomide's antineoplasticity in glioblastoma patients. MGMT is involved in various malignancies associated with carcinogens, but its interactions with these carcinogens in gliomagenesis are not yet studied. In the future, MGMT sequencing could be used in high-risk populations to develop preventive strategies. Additionally, a polymorphism in MGMT may modify the risk of gliomas and enhance temozolomide cytotoxicity in both marrow and tumor cells.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2022)
Article
Immunology
Meric A. Altinoz, Alp Ozpinar, Emily Hacker, Aysel Ozpinar
Summary: This article proposes a triple approach for immune treatment of GBM, involving the preparation of tumor lysates, the application of levamisole, and the injection of CAR-T cells. It aims to activate the immune system through cell-cell interactions to eradicate GBM.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Abdurrahman Coskun, Cumhur Yegen, Serap Arbak, Wafi Attaallah, Omer Gunal, Merve Acikel Elmas, Yasemin Ucal, Ozge Can, Banu Bas, Zeynep Yildirim, Ismail Seckin, Sibel Demirci, Mustafa Serteser, Aysel Ozpinar, Ahmet Belce, Gulcin Basdemir, Derya Emel Moldur, Ecenur Izzete Derelioglu, Tahir Koray Yozgatli, Yigit Erdemgil, Ibrahim Unsal
Summary: Transplantation is the most effective treatment for end-stage organ failure, but the functional preservation of organs prior to transplantation is limited to a few hours. In this study, a modified UW solution supplemented with components from the HTK solution, as well as melatonin and glucosamine, was found to effectively protect renal tissue for up to 72 hours at low temperature.