Melatonin prevents diabetes‐associated cognitive dysfunction from microglia‐mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway

Melatonin Enhances Cisplatin and Radiation Cytotoxicity in Head and Neck Squamous Cell Carcinoma by Stimulating Mitochondrial ROS Generation, Apoptosis, and Autophagy

(2019) Beatriz I. Fernandez-Gil et al.   Oxidative Medicine and Cellular Longevity

Oxidative and endoplasmic reticulum stresses are involved in palmitic acid-induced H9c2 cell apoptosis

(2019) Lei Yang et al.   BIOSCIENCE REPORTS

Pharmacological doses of melatonin impede cognitive decline in tau‐related Alzheimer models, once tauopathy is initiated, by restoring the autophagic flux

(2019) Enrique Luengo et al.   JOURNAL OF PINEAL RESEARCH

The Association of Late-Life Diabetes Status and Hyperglycemia With Incident Mild Cognitive Impairment and Dementia: The ARIC Study

(2019) Andreea M. Rawlings et al.   DIABETES CARE

Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice

(2019) Kexin Wang et al.   MEDIATORS OF INFLAMMATION

Early-life high-fat diet-induced obesity programs hippocampal development and cognitive functions via regulation of gut commensal Akkermansia muciniphila

(2019) Youjun Yang et al.   NEUROPSYCHOPHARMACOLOGY

Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes

(2018) Mark A. Espeland et al.   Alzheimers & Dementia

Autophagy and Inflammation

(2018) Yu Matsuzawa-Ishimoto et al.   Annual Review of Immunology

Neuroprotective effects of INT-777 against Aβ 1–42 -induced cognitive impairment, neuroinflammation, apoptosis, and synaptic dysfunction in mice

(2018) Xian Wu et al.   BRAIN BEHAVIOR AND IMMUNITY

Melatonin induces mechanisms of brain resilience against neurodegeneration

(2018) Rubén Corpas et al.   JOURNAL OF PINEAL RESEARCH

Activation of the STING-IRF3 pathway promotes hepatocyte inflammation, apoptosis and induces metabolic disorders in nonalcoholic fatty liver disease

(2018) J.T. Qiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Palmitic acid induces human osteoblast-like Saos-2 cell apoptosis via endoplasmic reticulum stress and autophagy

(2018) Lei Yang et al.   CELL STRESS & CHAPERONES

Gender differences in the association between melatonin secretion and diabetes in elderly: The HEIJO-KYO cohort

(2018) Kenji Obayashi et al.   CLINICAL ENDOCRINOLOGY

Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition

(2018) Shanjie Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TLR4 (toll-like receptor 4) activation suppresses autophagy through inhibition of FOXO3 and impairs phagocytic capacity of microglia

(2018) Ji-Won Lee et al.   Autophagy

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Effects of Melatonin on Glucose Homeostasis, Antioxidant Ability, and Adipokine Secretion in ICR Mice with NA/STZ-Induced Hyperglycemia

(2017) Chung-Cheng Lo et al.   Nutrients

Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury

(2016) Yue Hu et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus

(2016) Alexandra Kautzky-Willer et al.   ENDOCRINE REVIEWS

Modulation of Diabetes-Induced Oxidative Stress, Apoptosis, and Ca2+ Entry Through TRPM2 and TRPV1 Channels in Dorsal Root Ganglion and Hippocampus of Diabetic Rats by Melatonin and Selenium

(2016) Mehmet Cemal Kahya et al.   MOLECULAR NEUROBIOLOGY

Interleukin-1β-induced memory reconsolidation impairment is mediated by a reduction in glutamate release and zif268 expression and α-melanocyte-stimulating hormone prevented these effects

(2015) Ivana Machado et al.   BRAIN BEHAVIOR AND IMMUNITY

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice

(2015) Juliane Zemdegs et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autophagy and apoptosis in liver injury

(2015) Kewei Wang   CELL CYCLE

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

(2015) Mythily Srinivasan et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Evaluating the Oxidative Stress in Inflammation: Role of Melatonin

(2015) Aroha Sánchez et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic intestinal inflammation alters hippocampal neurogenesis

(2015) Svetlana Zonis et al.   Journal of Neuroinflammation

Diabetes in Midlife and Cognitive Change Over 20 Years

(2014) Andreea M. Rawlings et al.   ANNALS OF INTERNAL MEDICINE

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells

(2013) Hye-Eun Han et al.   Biomolecules & Therapeutics

Impact of Metabolic Syndrome on Cognition and Brain

(2012) Kathy F. Yates et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death

(2012) Guillaume Robert et al.   Autophagy

TLR2-dependent selective autophagy regulates NF-κB lysosomal degradation in hepatoma-derived M2 macrophage differentiation

(2012) C-P Chang et al.   CELL DEATH AND DIFFERENTIATION

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

(2012) Mi-Zhen Xia et al.   JOURNAL OF PINEAL RESEARCH

AMPK activation inhibits apoptosis and tau hyperphosphorylation mediated by palmitate in SH-SY5Y cells

(2011) Juhae Kim et al.   BRAIN RESEARCH

Oxidative stress, insulin signaling, and diabetes

(2010) Justin L. Rains et al.   FREE RADICAL BIOLOGY AND MEDICINE

Autophagy: cellular and molecular mechanisms

(2010) Danielle Glick et al.   JOURNAL OF PATHOLOGY

Astrogliosis in CNS Pathologies: Is There A Role for Microglia?

(2010) Dan Zhang et al.   MOLECULAR NEUROBIOLOGY

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE