Review
Chemistry, Applied
Biswajita Pradhan, Laxmidhar Rout, Jang-Seu Ki
Summary: Porphyran, a polysaccharide found in red seaweeds, has immunomodulatory, anti-inflammatory, and anti-cancer effects by boosting immunity and targeting apoptotic molecules, making it a potential chemotherapeutic or chemopreventive drug.
CARBOHYDRATE POLYMERS
(2023)
Article
Medicine, Research & Experimental
Dima W. Alhamad, Sara M. Elgendy, Fatema Hersi, Hesham R. El-Seedi, Hany A. Omar
Summary: The study found differences in autophagy regulation in resistant hepatocellular carcinoma cells, and demonstrated that the combination of an autophagy inhibitor and a chemotherapeutic agent can promote cell death, reduce drug resistance, and increase reactive oxygen species production and apoptosis induction.
Review
Cell Biology
Zihao Li, Ziyu Huang, Lunhao Bai
Summary: Osteoarthritis is a common joint disease, where cartilage instability leads to cell death and inflammatory factor release, resulting in cartilage degradation. The P2X7 receptor plays a crucial role in cell death and inflammatory reactions, potentially serving as a therapeutic target for OA treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Shanshan Zhu, Yingwei Liu, Yangwei Li, Jiangnan Yi, Bijing Yang, Yuanliang Li, Zhuanxu Ouyang, Bingxian Liu, Peng Shang, Khalid Mehmood, Rao Zahid Abbas, Shakeel Ahmed, Yung-Fu Chang, Jianying Guo, Jiaqiang Pan, Lianmei Hu, Zhaoxin Tang, Ying Li, Hui Zhang
Summary: Exposure to Butachlor can cause cancer, lymphocyte aberration, and immunotoxic effects, leading to toxic effects on the spleen of mice and triggering an immune response by targeting the CYTC/BCL2/M-TOR pathway and caspase cascading activation of spleen autophagy and apoptosis pathways.
Article
Environmental Sciences
Dan Song, Chao Xu, Askild L. Holck, Rong Liu
Summary: ACR exposure has been shown to cause neurotoxicity, reproductive toxicity, and carcinogenicity, but the exact mechanism of its toxicity remains unknown. In this study, it was demonstrated that ACR inhibited autophagic flux, increased ROS content, and led to apoptosis and inflammatory responses. Metabolomic analysis revealed significant differences in metabolic profiles between ACR treated and control cells.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Fisheries
Hao Chen, Xin Chen, Jun Ma
Summary: This study investigates the protective effects of hesperidin (HDN), a flavonoid found in citrus fruits, on cell damage caused by deoxynivalenol (DON) toxicity. The results show that HDN can reduce inflammation, autophagy, and apoptosis induced by DON exposure in grass carp liver cells. This research provides insights into the biological threats faced by fish under DON exposure and highlights the potential application of HDN in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ze Fu, Peng-Yue Zhao, Xing-Peng Yang, Hao Li, Shi-Dong Hu, Ying-Xin Xu, Xiao-Hui Du
Summary: Cannabidiol (CBD), a natural terpenoid in plants, has been used as a purified compound for the treatment of mental disorders due to its antidepressant, anxiolytic, and antiepileptic effects. CBD has the ability to regulate various pathophysiological processes, including autophagy, cytokine secretion, apoptosis, and immune responses. However, contradictory findings have been reported regarding the effects of CBD on autophagy and apoptosis, which may be attributed to differences in experimental conditions. This review focuses on the regulation of autophagy and apoptosis by CBD in the context of inflammatory response and cancer, and discusses the potential use of CBD as an anti-inflammatory agent and in cancer therapy in the future.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yazhuo Wang, Yang Xu, Jingrui Tan, Jiaxue Ye, Weizhen Cui, Jie Hou, Peiyu Liu, Jianwei Li, Shiyuan Wang, Qingyang Zhao
Summary: This study confirms the effectiveness of Qingre-Huazhuo-Jiangsuan-Recipe (QHJR), a modified formulation of Si-Miao-San (SMS), in treating Acute Gouty Arthritis (AGA). QHJR, as a traditional Chinese medicine formula, offers advantages such as minimal safety concerns and potential long-term use. The study suggests that QHJR may alleviate AGA by activating the AMPK/mTOR/ULK1 pathway, regulating autophagy levels and reducing inflammation. These findings provide new therapeutic approaches and ideas for the clinical treatment of AGA.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Fatemeh Yarmohammadi, Ramin Rezaee, A. Wallace Haye, Gholamreza Karimi
Summary: Doxorubicin is a chemotherapeutic agent with dose-dependent cardiotoxicity, which can lead to arrhythmia and heart failure. Studies have shown that induction of endoplasmic reticulum stress signaling pathways may contribute to cardiac complications induced by Doxorubicin.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Jin-yan Dong, Hong-Lin Yin, Hao Hao, Yang Liu
Summary: Autophagy is a highly conserved process that maintains cell stability and function, and helps resist pathogen invasion. It plays a role in various diseases, including lung diseases like acute lung injury (ALI). Traditional Chinese medicine has been used to regulate autophagy and improve ALI symptoms. This paper introduces the molecular mechanism and common pathways of autophagy regulation, as well as the relationship between autophagy and ALI, and summarizes the active ingredients of traditional Chinese medicine that improve ALI symptoms by regulating autophagy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Cihan Gur, Fatih Mehmet Kandemir, Cuneyt Caglayan, Emine Satici
Summary: This study found that hesperidin has a protective effect against paclitaxel-induced hepatorenal toxicity by reducing oxidative stress, inflammation, apoptosis, and autophagy, and improving liver and kidney functions.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Medical Laboratory Technology
Yong-Zhen Li, Yan-Yue Wang, Liang Huang, Yu-Yan Zhao, Lin-Hui Chen, Chi Zhang
Summary: Atherosclerosis, a chronic vascular pathology, is influenced by the AnxA family proteins.
CLINICA CHIMICA ACTA
(2022)
Article
Environmental Sciences
Yu Wang, Hongjing Zhao, Yachen Liu, Jingyan Li, Xiaopan Nie, Puyi Huang, Mingwei Xing
Summary: This study revealed the therapeutic effect of Lycopene (LYC) on sulfamethoxazole (SMZ)-induced intestinal injury in grass carp, showing that LYC can suppress intestinal damage, oxidative stress, inflammation, and apoptosis, as well as reduce autophagy activation caused by SMZ.
ENVIRONMENTAL POLLUTION
(2021)
Review
Biochemistry & Molecular Biology
Moussa Omorou, Yiwei Huang, Meng Gao, Chenxi Mu, Weijing Xu, Yuchun Han, Hui Xu
Summary: Forkhead box O3 (FOXO3) is a protein encoded by the FOXO3 gene expressed throughout the body and could play a crucial role in longevity and various pathologies. This study comprehensively reviews the expression of FOXO3 under ischemia and reperfusion (IR) conditions and its molecular mechanisms. The expression level of FOXO3 is tissue-specific, with increased expression in lung and intestinal epithelial cells after IR but downregulation in the kidney after IR and skeletal muscles following ischemia. FOXO3 expression in the brain, liver, and heart following IR can be both increased and decreased, contributing to ischemia and reperfusion injury. Controlling FOXO3 expression genetically or pharmacologically may help prevent or treat IR damage.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Immunology
Yurou Wang, Minmin Zeng, Lin Xia, Chinasa Valerie Olovo, Zhaoliang Su, Ying Zhang
Summary: The bacterial type VI secretion system (T6SS) is used by bacteria to infect the host, but bacteria have developed strategies to evade the host immune system. T6SS and its secreted effector proteins play an important role in the interaction between bacteria and host immune system, and can be used to develop vaccines. This review mainly discusses the impact of T6SS effector proteins on inflammation, autophagy, and apoptosis in the host immune system, as well as T6SS-based vaccines.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mozhgan Alipour, Behnam Hajipour-Verdom, Parviz Abdolmaleki, Mohammad Javan
Summary: This study investigated the transfer mechanism of Ca2+ in the TRPV2 channel and identified the crucial role of electrostatic interactions and specific residues in ion permeation through the channel.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Nanoscience & Nanotechnology
Sahar Farhangi, Elham Karimi, Khosro Khajeh, Saman Hosseinkhani, Mohammad Javan
Summary: Drug development for multiple sclerosis (MS) clinical management is challenging due to various factors. This study demonstrated the potential of a specific peptide in targeting and treating MS lesions, leading to enhanced myelin content and reduced astrocyte/microglia activation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Sareh Pandamooz, Benjamin Jurek, Mehdi Dianatpour, Silke Haerteis, Katharina Limm, Peter J. Oefner, Leila Dargahi, Afshin Borhani-Haghighi, Jaleel A. Miyan, Mohammad Saied Salehi
Summary: This study demonstrates that chick embryo extract (CEE) enhances the migration and proliferation of rat hair follicle stem cells, and promotes their differentiation towards Schwann cells. The effective factors in CEE, such as AP-1, TCTP, and CAMKII, may regulate the fate and function of these stem cells.
CELL PROLIFERATION
(2023)
Article
Neurosciences
Nasrin Jangjoo Ghalat, Koroush Shahpasand, Mohammad Javan
Summary: In this study, we found increased levels of cis-phosphorylated tau (cis-p-tau) in a lyso-phosphatidylcholine-induced demyelination model, especially in axons and microglia. Clearance of cis-p-tau using an antibody resulted in decreased gliosis, protected myelin, and reduced axon degeneration, improving visual acuity and the integrity of the optic pathway.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Neurosciences
Seyedeh Masoumeh Seyedhosseini Tamijani, Elmira Beirami, Saina Dargahi, Abolhassan Ahmadiani, Leila Dargahi
Summary: Thyroid hormones (THs) protect primary hippocampal neurons (PHNs) against methamphetamine (MA) neurotoxicity by activating integrin alpha v83 cell surface receptors. Targeting integrin alpha v83 receptors or using THs can be considered as promising therapeutic strategies to overcome MA neurotoxicity.
NEUROSCIENCE LETTERS
(2023)
Article
Medicine, General & Internal
Sanaz Pournajaf, Rocco Salvatore Calabro, Antonino Naro, Michela Goffredo, Irene Aprile, Federica Tamburella, Serena Filoni, Andreas Waldner, Stefano Mazzoleni, Antonella Focacci, Francesco Ferraro, Donatella Bonaiuti, Marco Franceschini
Summary: This study investigated the efficacy of stationary robot-assisted gait rehabilitation in comparison to conventional overground gait training for subacute stroke survivors. The results showed that robot-assisted training improved walking ability better than conventional training, with significant improvements in walking speed observed.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Azam Abedi, Tahereh Foroutan, Leila Mohaghegh Shalmani, Leila Dargahi
Summary: This study investigates the effects of long-term high-fat diet on brain glucose metabolism and memory performance, finding that only male rats on the high-fat diet showed impairment in memory retrieval and spatial working memory.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Medicine, General & Internal
Matteo Cioeta, Sanaz Pournajaf, Michela Goffredo, Giuseppe Giovannico, Marco Franceschini
Summary: This case report describes a 57-year-old woman who suffered from neck pain for 15 months. After poor compliance with traditional physiotherapy treatments, home exercise training through virtual reality was proposed to improve patient adherence to the treatment plan. The personalized treatment allowed the patient to quickly resolve her problem and return to a peaceful life with her family.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Michela Goffredo, Chiara Pagliari, Andrea Turolla, Cristina Tassorelli, Sonia Di Tella, Sara Federico, Sanaz Pournajaf, Johanna Jonsdottir, Roberto De Icco, Leonardo Pellicciari, Rocco Salvatore Calabro, Francesca Baglio, Marco Franceschini
Summary: This study aimed to expand the research on the impact of telerehabilitation on quality of life to a larger sample of neurological patients, including those with Parkinson's Disease. The results showed that telerehabilitation positively affected static and dynamic balance and gait in people with Parkinson's Disease and Multiple Sclerosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Sanaz Pournajaf, Giovanni Morone, Sofia Straudi, Michela Goffredo, Maria Rosaria Leo, Rocco Salvatore Calabro, Giorgio Felzani, Stefano Paolucci, Serena Filoni, Andrea Santamato, Marco Franceschini
Summary: This study aims to investigate the clinical effects of an exoskeleton robotic system for upper limb rehabilitation compared with conventional therapy in people with subacute stroke. It also aims to identify patient characteristics that can predict better recovery after robotic-assisted therapy and whether it could elicit greater brain stimulation. A total of 84 subacute stroke patients will be randomly allocated to either the control group or experimental group, and the outcomes will be recorded at different time points.
Article
Health Care Sciences & Services
Peppino Tropea, Francesco Infarinato, Irma Sterpi, Marco Ottaviani, Paola Antoniotti, Paola Romano, Michela Picardi, Michela Goffredo, Riccardo Re, Sanaz Pournajaf, Agnese Seregni, Antonio Caronni, Marco Franceschini, Massimo Corbo
Summary: This study aims to investigate the effectiveness of action observation treatment (AOT) in patients with stroke, with a particular focus on the predictive value of neurophysiological biomarkers. A 3-arm, assessor-blinded, randomized controlled trial will be conducted, enrolling chronic stroke patients for 15 sessions of AOT, with different protocols. The primary outcome will be assessed using the Fugl-Meyer Assessment-Upper Extremity scores.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Neurosciences
Zohreh Tavassoli, Mohammad Javan, Narges Hosseinmardi, Yaghoub Fathollahi
Summary: This study investigated the effects of electrical stimulation of the ventral tegmental area (VTA) and the locus coeruleus (LC) on hippocampal-dependent learning and neurogenesis in mice. Phasic LC modulation improved behavioral acquisition and cell proliferation in the dorsal dentate gyrus, while tonic VTA stimulation enhanced passive avoidance acquisition and increased cell proliferation in the intermediate dentate gyrus. The findings suggest that electrical impulses from the LC and VTA can modulate cell proliferation along the adult mouse dentate gyrus in a learning-dependent manner.
IBRO NEUROSCIENCE REPORTS
(2023)
Review
Clinical Neurology
Akram Mokhtarzadeh Khanghahi, Atefeh Rayatpour, Hossein Baharvand, Mohammad Javan
Summary: Multiple sclerosis (MS) is a chronic autoimmune and demyelinating disease of the central nervous system (CNS) which leads to focal demyelinated lesions in the brain and spinal cord. Understanding the events occurring during the demyelination and remyelination processes can offer new strategies for MS treatment.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Forough Foolad, Zahra Samadi-Bahrami, Fariba Khodagholi, Seyed Massood Nabavi, G. R. Wayne Moore, Mohammad Javan
Summary: This study suggests that mitochondrial dysfunction and alterations in some epigenetics and metabolism modifying factors in the CNS and peripheral blood cells may contribute to or correlate with the progression of multiple sclerosis.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Surgery
Mitra Rezapour, Mehdi Akbari, Leila Dargahi, Mohammad Ismail Zibaii, Ali Shahbazi
Summary: In this study, the auditory brainstem response (ABR) electrophysiological test was used to diagnose salicylate-induced tinnitus, providing a more accurate evaluation of tinnitus. The results showed an increase in hearing threshold and a decrease in latency ratio due to salicylate-induced tinnitus. Furthermore, the ABR test demonstrated the function of the auditory brainstem, while the GPIAS test depended on brainstem circuits and the auditory cortex.
INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
(2023)