Common signalling pathways in macrophage and osteoclast multinucleation

Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss

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Ca2+-Dependent Regulation of NFATc1 via KCa3.1 in Inflammatory Osteoclastogenesis

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T Cell-Macrophage Fusion Triggers Multinucleated Giant Cell Formation for HIV-1 Spreading

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SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts

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E-cadherin is important for cell differentiation during osteoclastogenesis

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The Alternative Faces of Macrophage Generate Osteoclasts

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Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases

(2016) Colleen M. McClean et al.   Pathogens and Disease

Examination of the foreign body response to biomaterials by nonlinear intravital microscopy

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Involvement of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-induced Incomplete Cytokinesis in the Polyploidization of Osteoclasts

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KCNK1 inhibits osteoclastogenesis by blocking the Ca2+ oscillation and JNK-NFATc1 signaling axis

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CCL2 and CCR2 are Essential for the Formation of Osteoclasts and Foreign Body Giant Cells

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Different Blood-Borne Human Osteoclast Precursors Respond in Distinct Ways to IL-17A

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DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine–producing metabolic pathway

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CD44 deficiency inhibits unloading-induced cortical bone loss through downregulation of osteoclast activity

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Multinucleated Giant Cells Are Specialized for Complement-Mediated Phagocytosis and Large Target Destruction

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Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

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The Foreign Body Giant Cell Cannot Resorb Bone, But Dissolves Hydroxyapatite Like Osteoclasts

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Absence of Dap12 and the αvβ3 integrin causes severe osteopetrosis

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Integrating Phosphoproteome and Transcriptome Reveals New Determinants of Macrophage Multinucleation

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Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation

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Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease

(2014) Heeseog Kang et al.   Cell Reports

Foreign body giant cells and osteoclasts are TRAP positive, have podosome-belts and both require OC-STAMP for cell fusion

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Osteopetrosis: genetics, treatment and new insights into osteoclast function

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Membrane Localization of Membrane Type 1 Matrix Metalloproteinase by CD44 Regulates the Activation of Pro-Matrix Metalloproteinase 9 in Osteoclasts

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Osteoclasts: New Insights

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Granuloma Formation in Pulmonary Sarcoidosis

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Osteoclast Fusion and Fission

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An Essential Role for STAT6-STAT1 Protein Signaling in Promoting Macrophage Cell-Cell Fusion

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Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells

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TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TREM2 and  -Catenin Regulate Bone Homeostasis by Controlling the Rate of Osteoclastogenesis

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Clinical features of polymyalgia rheumatica and giant cell arteritis

(2012) Carlo Salvarani et al.   Nature Reviews Rheumatology

Increased Generation of TRAP Expressing Multinucleated Giant Cells in Patients with Granulomatosis with Polyangiitis

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P2X7 receptor drives osteoclast fusion by increasing the extracellular adenosine concentration

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Absence of MCP-1 leads to elevated bone mass via impaired actin ring formation

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The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

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The Pathogenesis of Rheumatoid Arthritis

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TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages

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Nomenclature of monocytes and dendritic cells in blood

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MT1-MMP Is Required for Myeloid Cell Fusion via Regulation of Rac1 Signaling

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TREM2- and DAP12-Dependent Activation of PI3K Requires DAP10 and Is Inhibited by SHIP1

(2010) Q. Peng et al.   Science Signaling

Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes

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Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation

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Distinct roles for tetraspanins CD9, CD63 and CD81 in the formation of multinucleated giant cells

(2009) Varadarajan Parthasarathy et al.   IMMUNOLOGY

The scavenger receptor CD36 plays a role in cytokine-induced macrophage fusion

(2009) L. Helming et al.   JOURNAL OF CELL SCIENCE

Myeloid blasts are the mouse bone marrow cells prone to differentiate into osteoclasts

(2009) Teun J. de Vries et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tetraspanin Proteins Regulate Membrane Type-1 Matrix Metalloproteinase-dependent Pericellular Proteolysis

(2009) Marc A. Lafleur et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mediators of macrophage fusion

(2009) Laura Helming et al.   TRENDS IN CELL BIOLOGY

Tartrate-resistant acid phosphatase (TRAP) and the osteoclast/immune cell dichotomy

(2008) Alison R. Hayman   AUTOIMMUNITY

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE

Giant cell formation in sarcoidosis: cell fusion or proliferation with non-division?

(2008) T. C. M. Th. van Maarsseveen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Elie Metchnikoff: Father of natural immunity

(2008) Siamon Gordon   EUROPEAN JOURNAL OF IMMUNOLOGY

Myoblasts and macrophages share molecular components that contribute to cell–cell fusion

(2008) Kostandin V. Pajcini et al.   JOURNAL OF CELL BIOLOGY

Activation of P2X7receptors induces CCL3 production in microglial cells through transcription factor NFAT

(2008) Ayako Kataoka et al.   JOURNAL OF NEUROCHEMISTRY

Viral membrane fusion

(2008) Stephen C Harrison   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Essential Role of DAP12 Signaling in Macrophage Programming into a Fusion-Competent State

(2008) L. Helming et al.   Science Signaling

Foreign body reaction to biomaterials

(2008) James M. Anderson et al.   SEMINARS IN IMMUNOLOGY