The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

Unraveling estrogen action in osteoporosis

(2011) Susan A. Krum et al.   CELL CYCLE

The P2Y6Receptor Stimulates Bone Resorption by Osteoclasts

(2011) Isabel R. Orriss et al.   ENDOCRINOLOGY

The V-ATPase a3 subunit mutation R740S is dominant negative and results in osteopetrosis in mice

(2011) Noelle Ochotny et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

Bone remodelling at a glance

(2011) J. C. Crockett et al.   JOURNAL OF CELL SCIENCE

A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX®

(2011) J. A. Kanis et al.   OSTEOPOROSIS INTERNATIONAL

Integrins, growth factors, and the osteoclast cytoskeleton

(2010) Wei Zou et al.   Annals of the New York Academy of Sciences

Acidosis, hypoxia and bone

(2010) Timothy R. Arnett   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Armus Is a Rac1 Effector that Inactivates Rab7 and Regulates E-Cadherin Degradation

(2010) Marieke A.M. Frasa et al.   CURRENT BIOLOGY

Purinergic signalling and bone remodelling☆

(2010) Isabel R Orriss et al.   CURRENT OPINION IN PHARMACOLOGY

Rapid publication: Impairment of macrophage colony-stimulating factor production and lack of resident bone marrow macrophages in the osteopetrotic op/op Mouse

(2010) R. Felix et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Osteoclast formation in vitro from progenitor cells present in the adult mouse circulation

(2010) Miep H. Helfrich et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD

(2010) Lishu Zhang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP)

(2010) Takashi Nishida et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mitf Induction by RANKL Is Critical for Osteoclastogenesis

(2010) Ssu-Yi Lu et al.   MOLECULAR BIOLOGY OF THE CELL

Strontium Ranelate Decreases Receptor Activator of Nuclear Factor- B Ligand-Induced Osteoclastic Differentiation In Vitro: Involvement of the Calcium-Sensing Receptor

(2010) A. Caudrillier et al.   MOLECULAR PHARMACOLOGY

Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone

(2010) Omar M E Albagha et al.   NATURE GENETICS

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis

(2010) J. C. Crockett et al.   OSTEOPOROSIS INTERNATIONAL

Structure-based development of a receptor activator of nuclear factor- B ligand (RANKL) inhibitor peptide and molecular basis for osteopetrosis

(2010) H. M. Ta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloma cell-induced disruption of bone remodelling compartments leads to osteolytic lesions and generation of osteoclast-myeloma hybrid cells

(2009) Thomas L. Andersen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transcription factor C/EBPβ isoform ratio regulates osteoclastogenesis through MafB

(2009) Jeske J Smink et al.   EMBO JOURNAL

Osteoclast migration on phosphorylated osteopontin is regulated by endogenous tartrate-resistant acid phosphatase

(2009) Barbro Ek-Rylander et al.   EXPERIMENTAL CELL RESEARCH

Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate

(2009) Olivia Fromigué et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Defective co-activator recruitment in osteoclasts frommicrophthalmia-oak ridgemutant mice

(2009) Sudarshana M. Sharma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

c-Cbl and Cbl-b Act Redundantly to Protect Osteoclasts from Apoptosis and to Displace HDAC6 from β-Tubulin, Stabilizing Microtubules and Podosomes

(2009) Enkhtsetseg Purev et al.   MOLECULAR BIOLOGY OF THE CELL

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

Osteoimmunology and the effects of the immune system on bone

(2009) Hiroshi Takayanagi   Nature Reviews Rheumatology

Expression, signaling, and function of P2X7 receptors in bone

(2009) Matthew W. Grol et al.   Purinergic Signalling

Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis

(2009) Kazuhisa Nozawa et al.   ARTHRITIS RESEARCH & THERAPY

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Infantile Malignant, Autosomal Recessive Osteopetrosis: The Rich and The Poor

(2008) Anna Villa et al.   CALCIFIED TISSUE INTERNATIONAL

Synaptotagmin VII Regulates Bone Remodeling by Modulating Osteoclast and Osteoblast Secretion

(2008) Haibo Zhao et al.   DEVELOPMENTAL CELL

Podosome-type adhesions and focal adhesions, so alike yet so different

(2008) M BLOCK et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The Calcium-sensing Receptor Is Involved in Strontium Ranelate-induced Osteoclast Apoptosis

(2008) Anne S. Hurtel-Lemaire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide suppresses RANK gene expression in macrophages by down-regulating PU.1 and MITF

(2008) Junko Ishii et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Vesicular trafficking in osteoclasts

(2008) Fraser P. Coxon et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Bone remodeling: Multiple cellular interactions required for coupling of bone formation and resorption

(2008) Natalie A. Sims et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Tyrosine Kinase Activity of c-Src Regulates Actin Dynamics and Organization of Podosomes in Osteoclasts

(2007) Olivier Destaing et al.   MOLECULAR BIOLOGY OF THE CELL

The Microphthalmia Transcription Factor Regulates Expression of the Tartrate-Resistant Acid Phosphatase Gene During Terminal Differentiation of Osteoclasts

(2006) Alex Luchin et al.   JOURNAL OF BONE AND MINERAL RESEARCH