Expansion of DUB functionality generated by alternative isoforms – USP35, a case study

A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

(2018) Kirill Bersuker et al.   DEVELOPMENTAL CELL

USP35 regulates mitotic progression by modulating the stability of Aurora B

(2018) Jinyoung Park et al.   Nature Communications

Mechanisms of regulation and diversification of deubiquitylating enzyme function

(2017) Pawel Leznicki et al.   JOURNAL OF CELL SCIENCE

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

(2016) Xinping Yang et al.   CELL

USP9X stabilizes XIAP to regulate mitotic cell death and chemoresistance in aggressive B‐cell lymphoma

(2016) Katharina Engel et al.   EMBO Molecular Medicine

The deubiquitinase Usp27x stabilizes the BH3‐only protein Bim and enhances apoptosis

(2016) Arnim Weber et al.   EMBO REPORTS

Unconventional secretion of misfolded proteins promotes adaptation to proteasome dysfunction in mammalian cells

(2016) Jin-Gu Lee et al.   NATURE CELL BIOLOGY

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

USP8 suppresses death receptor-mediated apoptosis by enhancing FLIPL stability

(2016) M Jeong et al.   ONCOGENE

Tunable protein synthesis by transcript isoforms in human cells

(2016) Stephen N Floor et al.   eLife

Deubiquitinating enzymes regulate PARK2-mediated mitophagy

(2015) Yuqing Wang et al.   Autophagy

DUBs, the regulation of cell identity and disease

(2015) Johanna Heideker et al.   BIOCHEMICAL JOURNAL

USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics

(2015) E-W Lee et al.   CELL DEATH AND DIFFERENTIATION

Expanding Roles for Lipid Droplets

(2015) Michael A. Welte   CURRENT BIOLOGY

BioID-based Identification of Skp Cullin F-box (SCF)β-TrCP1/2E3 Ligase Substrates

(2015) Etienne Coyaud et al.   MOLECULAR & CELLULAR PROTEOMICS

Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46

(2015) Jianping Yin et al.   STRUCTURE

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

USP35 activated by miR let-7a inhibits cell proliferation and NF-κB activation through stabilization of ABIN-2

(2015) Chunyan Liu et al.   Oncotarget

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

Mass-spectrometry-based draft of the human proteome

(2014) Mathias Wilhelm et al.   NATURE

ProteomeXchange provides globally coordinated proteomics data submission and dissemination

(2014) Juan A Vizcaíno et al.   NATURE BIOTECHNOLOGY

Ubiquitination in disease pathogenesis and treatment

(2014) Doris Popovic et al.   NATURE MEDICINE

Cotranslational folding inhibits translocation from within the ribosome–Sec61 translocon complex

(2014) Brian J Conti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis

(2014) M. Lu et al.   SCIENCE

The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis

(2013) C-S Yang et al.   CELL DEATH AND DIFFERENTIATION

SAINTexpress: Improvements and additional features in Significance Analysis of INTeractome software

(2013) Guoci Teo et al.   Journal of Proteomics

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

(2012) Jeffrey M. Axten et al.   JOURNAL OF MEDICINAL CHEMISTRY

Refined Preparation and Use of Anti-diglycine Remnant (K-ε-GG) Antibody Enables Routine Quantification of 10,000s of Ubiquitination Sites in Single Proteomics Experiments

(2012) Namrata D. Udeshi et al.   MOLECULAR & CELLULAR PROTEOMICS

Tissue-Specific Alternative Splicing Remodels Protein-Protein Interaction Networks

(2012) Jonathan D. Ellis et al.   MOLECULAR CELL

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

(2012) Guillaume Thibault et al.   MOLECULAR CELL

Data processing and analysis with theautoPROCtoolbox

(2011) Clemens Vonrhein et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Membrane Protein Insertion at the Endoplasmic Reticulum

(2011) Sichen Shao et al.   Annual Review of Cell and Developmental Biology

De-ubiquitinating protease USP2a targets RIP1 and TRAF2 to mediate cell death by TNF

(2011) A-L Mahul-Mellier et al.   CELL DEATH AND DIFFERENTIATION

The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types

(2011) Alex C. Faesen et al.   CHEMISTRY & BIOLOGY

Dual Role of Ancient Ubiquitous Protein 1 (AUP1) in Lipid Droplet Accumulation and Endoplasmic Reticulum (ER) Protein Quality Control

(2011) Elizabeth J. Klemm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The USP19 Deubiquitinase Regulates the Stability of c-IAP1 and c-IAP2

(2011) Yide Mei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

(2011) Thanyarat Promlek et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Ancient Ubiquitous Protein 1 (AUP1) Localizes to Lipid Droplets and Binds the E2 Ubiquitin Conjugase G2 (Ube2g2) via Its G2 Binding Region

(2010) Johanna Spandl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bat3 promotes the membrane integration of tail-anchored proteins

(2010) P. Leznicki et al.   JOURNAL OF CELL SCIENCE

Endoplasmic reticulum stress and atherosclerosis

(2010) Gökhan S Hotamisligil   NATURE MEDICINE

Caspase-3 cleaves XIAP in a positive feedback loop to sensitize melanoma cells to TRAIL-induced apoptosis

(2010) M Hörnle et al.   ONCOGENE

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

(2009) Gerco C Hassink et al.   EMBO REPORTS

A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover

(2009) Scott W. Eastman et al.   JOURNAL OF CELL BIOLOGY

Dissection of USP catalytic domains reveals five common insertion points

(2009) Yu Ye et al.   Molecular BioSystems

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

(2009) Martin Schwickart et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Lipid-Induced ER Stress: Synergistic Effects of Sterols and Saturated Fatty Acids

(2009) Ludovic Pineau et al.   TRAFFIC

Final Stages of Cytokinesis and Midbody Ring Formation Are Controlled by BRUCE

(2008) Christian Pohl et al.   CELL

Identification of a novel N-terminal hydrophobic sequence that targets proteins to lipid droplets

(2008) J. K. Zehmer et al.   JOURNAL OF CELL SCIENCE

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY