标题
Amyloid assembly and disassembly
作者
关键词
-
出版物
JOURNAL OF CELL SCIENCE
Volume 131, Issue 8, Pages jcs189928
出版商
The Company of Biologists
发表日期
2018-04-13
DOI
10.1242/jcs.189928
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Protein-Based Inheritance: Epigenetics beyond the Chromosome
- (2018) Zachary H. Harvey et al. MOLECULAR CELL
- Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks
- (2018) Michael P. Hughes et al. SCIENCE
- Phase separation of a yeast prion protein promotes cellular fitness
- (2018) Titus M. Franzmann et al. SCIENCE
- Galectin-8–mediated selective autophagy protects against seeded tau aggregation
- (2017) Benjamin Falcon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination
- (2017) Kyota Yasuda et al. JOURNAL OF CELL BIOLOGY
- Prying into the Prion Hypothesis for Parkinson's Disease
- (2017) Patrik Brundin et al. JOURNAL OF NEUROSCIENCE
- A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
- (2017) K. Adam Bohnert et al. NATURE
- Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes
- (2017) Wei Qiang et al. NATURE
- Cryo-EM structures of tau filaments from Alzheimer’s disease
- (2017) Anthony W. P. Fitzpatrick et al. NATURE
- Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
- (2017) Zhuohao He et al. NATURE MEDICINE
- Variant Creutzfeldt–Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129
- (2017) Tzehow Mok et al. NEW ENGLAND JOURNAL OF MEDICINE
- SUMOylation and ubiquitination reciprocally regulate α-synuclein degradation and pathological aggregation
- (2017) Ruth Rott et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inhibition of curli assembly andEscherichia colibiofilm formation by the human systemic amyloid precursor transthyretin
- (2017) Neha Jain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril
- (2017) Einav Tayeb-Fligelman et al. SCIENCE
- Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104
- (2017) Stephanie N. Gates et al. SCIENCE
- A bacterial global regulator forms a prion
- (2017) Andy H. Yuan et al. SCIENCE
- Liquid phase condensation in cell physiology and disease
- (2017) Yongdae Shin et al. SCIENCE
- Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients
- (2017) Joseph D. Schonhoft et al. Science Translational Medicine
- Evolution of an intricate J-protein network driving protein disaggregation in eukaryotes
- (2017) Nadinath B Nillegoda et al. eLife
- Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity
- (2017) Pascal Krotee et al. eLife
- Semen amyloids participate in spermatozoa selection and clearance
- (2017) Nadia R Roan et al. eLife
- Protein-Remodeling Factors As Potential Therapeutics for Neurodegenerative Disease
- (2017) Meredith E. Jackrel et al. Frontiers in Neuroscience
- Distinct conformers of transmissible misfolded SOD1 distinguish human SOD1-FALS from other forms of familial and sporadic ALS
- (2016) Jacob I. Ayers et al. ACTA NEUROPATHOLOGICA
- Conformational Dynamics of the Human Islet Amyloid Polypeptide in a Membrane Environment: Toward the Aggregation Prone Form
- (2016) Katrine Kirkeby Skeby et al. BIOCHEMISTRY
- Mechanisms of neuronal homeostasis: Autophagy in the axon
- (2016) Sandra Maday BRAIN RESEARCH
- Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease
- (2016) Zachary M. March et al. BRAIN RESEARCH
- A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas
- (2016) Alice Soragni et al. CANCER CELL
- UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
- (2016) Roland Hjerpe et al. CELL
- Coexisting Liquid Phases Underlie Nucleolar Subcompartments
- (2016) Marina Feric et al. CELL
- The amyloid hypothesis of Alzheimer's disease at 25 years
- (2016) Dennis J Selkoe et al. EMBO Molecular Medicine
- Mechanistic Insights into Hsp104 Potentiation
- (2016) Mariana P. Torrente et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Amyloid formation: functional friend or fearful foe?
- (2016) P. Bergman et al. JOURNAL OF INTERNAL MEDICINE
- Mechanistic and Structural Insights into the Prion-Disaggregase Activity of Hsp104
- (2016) Elizabeth A. Sweeny et al. JOURNAL OF MOLECULAR BIOLOGY
- Compartment-Specific Regulation of Autophagy in Primary Neurons
- (2016) Sandra Maday et al. JOURNAL OF NEUROSCIENCE
- Dynamic Assembly and Disassembly of Functional β-Endorphin Amyloid Fibrils
- (2016) Nadezhda Nespovitaya et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils
- (2016) Michael T. Colvin et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Systemic amyloidosis
- (2016) Ashutosh D Wechalekar et al. LANCET
- Engineering therapeutic protein disaggregases
- (2016) James Shorter MOLECULAR BIOLOGY OF THE CELL
- Decoding ALS: from genes to mechanism
- (2016) J. Paul Taylor et al. NATURE
- Structure of aggregates revealed
- (2016) Robert Tycko NATURE
- The activities of amyloids from a structural perspective
- (2016) Roland Riek et al. NATURE
- Phasing in and out
- (2016) James Shorter Nature Chemistry
- Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters
- (2016) Timothy J. Nott et al. Nature Chemistry
- Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation
- (2016) Adam L Yokom et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Amyloid fibrils from the N-terminal prion protein fragment are infectious
- (2016) Jin-Kyu Choi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril
- (2016) Marielle Aulikki Wälti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Heat shock protein–based therapy as a potential candidate for treating the sphingolipidoses
- (2016) Thomas Kirkegaard et al. Science Translational Medicine
- ALS Mutations Disrupt Phase Separation Mediated by α-Helical Structure in the TDP-43 Low-Complexity C-Terminal Domain
- (2016) Alexander E. Conicella et al. STRUCTURE
- Cross-β Polymerization of Low Complexity Sequence Domains
- (2016) Masato Kato et al. Cold Spring Harbor Perspectives in Biology
- The HET-S/s Prion Motif in the Control of Programmed Cell Death
- (2016) Roland Riek et al. Cold Spring Harbor Perspectives in Biology
- ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function
- (2016) Aarti Sharma et al. Nature Communications
- Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation
- (2016) Adam L Yokom et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
- (2016) Marcus D Tuttle et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Biology and Pathobiology of TDP-43 and Emergent Therapeutic Strategies
- (2016) Lin Guo et al. Cold Spring Harbor Perspectives in Medicine
- Ex vivomammalian prions are formed of paired double helical prion protein fibrils
- (2016) Cassandra Terry et al. Open Biology
- Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics
- (2016) Andisheh Abedini et al. eLife
- Amyloid formation of growth hormone in presence of zinc: Relevance to its storage in secretory granules
- (2016) Reeba S. Jacob et al. Scientific Reports
- Aβ43 is neurotoxic and primes aggregation of Aβ40 in vivo
- (2015) Sylvie Burnouf et al. ACTA NEUROPATHOLOGICA
- Prion-like propagation of mutant SOD1 misfolding and motor neuron disease spread along neuroanatomical pathways
- (2015) Jacob I. Ayers et al. ACTA NEUROPATHOLOGICA
- Personalized medicine approach for optimizing the dose of tafamidis to potentially ameliorate wild-type transthyretin amyloidosis (cardiomyopathy)
- (2015) Younhee Cho et al. AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS
- Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization
- (2015) Amandine Molliex et al. CELL
- A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation
- (2015) Avinash Patel et al. CELL
- Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection
- (2015) Laura M. Castellano et al. CHEMISTRY & BIOLOGY
- Nuclear bodies: the emerging biophysics of nucleoplasmic phases
- (2015) Lian Zhu et al. CURRENT OPINION IN CELL BIOLOGY
- The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation
- (2015) Tina Ho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagosome dynamics in neurodegeneration at a glance
- (2015) Y. C. Wong et al. JOURNAL OF CELL SCIENCE
- Chaperones in Neurodegeneration
- (2015) I. Lindberg et al. JOURNAL OF NEUROSCIENCE
- The Hsp104 N-Terminal Domain Enables Disaggregase Plasticity and Potentiation
- (2015) Elizabeth A. Sweeny et al. MOLECULAR CELL
- Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils
- (2015) Xuechao Gao et al. MOLECULAR CELL
- It’s Raining Liquids: RNA Tunes Viscoelasticity and Dynamics of Membraneless Organelles
- (2015) Lin Guo et al. MOLECULAR CELL
- Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins
- (2015) Yuan Lin et al. MOLECULAR CELL
- Residue-by-Residue View of In Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II
- (2015) Kathleen A. Burke et al. MOLECULAR CELL
- Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles
- (2015) Timothy J. Nott et al. MOLECULAR CELL
- α-Synuclein strains cause distinct synucleinopathies after local and systemic administration
- (2015) W. Peelaerts et al. NATURE
- Structure of the toxic core of α-synuclein from invisible crystals
- (2015) Jose A. Rodriguez et al. NATURE
- Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation
- (2015) Nadinath B. Nillegoda et al. NATURE
- Determinants of amyloid fibril degradation by the PDZ protease HTRA1
- (2015) Simon Poepsel et al. Nature Chemical Biology
- Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling
- (2015) Natura Myeku et al. NATURE MEDICINE
- Proteostasis and aging
- (2015) Susmita Kaushik et al. NATURE MEDICINE
- Polymer physics of intracellular phase transitions
- (2015) Clifford P. Brangwynne et al. Nature Physics
- Targeting protein aggregation for the treatment of degenerative diseases
- (2015) Yvonne S. Eisele et al. NATURE REVIEWS DRUG DISCOVERY
- The Persistence of Hippocampal-Based Memory Requires Protein Synthesis Mediated by the Prion-like Protein CPEB3
- (2015) Luana Fioriti et al. NEURON
- ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
- (2015) Tetsuro Murakami et al. NEURON
- RAN Translation in Huntington Disease
- (2015) Monica Bañez-Coronel et al. NEURON
- Exogenous Hsp70 delays senescence and improves cognitive function in aging mice
- (2015) Natalia V. Bobkova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Differential effects of Ydj1 and Sis1 on Hsp70-mediated clearance of stress granules inSaccharomyces cerevisiae
- (2015) Robert W. Walters et al. RNA
- Pharmacological chaperone for -crystallin partially restores transparency in cataract models
- (2015) L. N. Makley et al. SCIENCE
- Coupling of Ribostasis and Proteostasis: Hsp70 Proteins in mRNA Metabolism
- (2015) Robert W. Walters et al. TRENDS IN BIOCHEMICAL SCIENCES
- Trafficking and degradation pathways in pathogenic conversion of prions and prion-like proteins in neurodegenerative diseases
- (2015) Guiliana Soraya Victoria et al. VIRUS RESEARCH
- Ubiquitin-specific protease 14 modulates degradation of cellular prion protein
- (2015) Takujiro Homma et al. Scientific Reports
- SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3
- (2015) Bettina Drisaldi et al. Cell Reports
- The CPEB3 Protein Is a Functional Prion that Interacts with the Actin Cytoskeleton
- (2015) Joseph S. Stephan et al. Cell Reports
- A molecular tweezer antagonizes seminal amyloids and HIV infection
- (2015) Edina Lump et al. eLife
- Promiscuous interactions and protein disaggregases determine the material state of stress-inducible RNP granules
- (2015) Sonja Kroschwald et al. eLife
- Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils
- (2015) L. M. Castellano et al. Biology Open
- Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?
- (2015) Shynrye Lee et al. Experimental Neurobiology
- Chaperone-mediated autophagy: dedicated saviour and unfortunate victim in the neurodegeneration arena: Figure 1
- (2015) Jaime L. Schneider et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
- (2014) Mi-Hyang Cho et al. Autophagy
- Specific aromatic foldamers potently inhibit spontaneous and seeded Aβ42 and Aβ43 fibril assembly
- (2014) Katelyn M. Seither et al. BIOCHEMICAL JOURNAL
- Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events
- (2014) Meredith E. Jackrel et al. CELL
- Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway
- (2014) Sandra Maday et al. DEVELOPMENTAL CELL
- Infectious prion diseases in humans: Cannibalism, iatrogenicity and zoonoses
- (2014) Stéphane Haïk et al. INFECTION GENETICS AND EVOLUTION
- A Cellular System that Degrades Misfolded Proteins and Protects against Neurodegeneration
- (2014) Lili Guo et al. MOLECULAR CELL
- Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
- (2014) Sami J Barmada et al. Nature Chemical Biology
- Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
- (2014) Jing L Guo et al. NATURE MEDICINE
- The amyloid state and its association with protein misfolding diseases
- (2014) Tuomas P. J. Knowles et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations
- (2014) Nael H. Alami et al. NEURON
- Protoporphyrins Enhance Oligomerization and Enzymatic Activity of HtrA1 Serine Protease
- (2014) Hakryul Jo et al. PLoS One
- The metazoan protein disaggregase and amyloid depolymerase system
- (2014) Mariana P Torrente et al. Prion
- Differences in nucleation behavior underlie the contrasting aggregation kinetics of the Aβ40 and Aβ42 peptides
- (2014) Georg Meisl et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Solution conditions determine the relative importance of nucleation and growth processes in -synuclein aggregation
- (2014) A. K. Buell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prion-like aggregation of mutant p53 in cancer
- (2014) Jerson L. Silva et al. TRENDS IN BIOCHEMICAL SCIENCES
- A loss of FUS/TLS function leads to impaired cellular proliferation
- (2014) C L Ward et al. Cell Death & Disease
- Direct visualization of HIV-enhancing endogenous amyloid fibrils in human semen
- (2014) Shariq M. Usmani et al. Nature Communications
- Chemical Induction of Hsp70 Reduces α-Synuclein Aggregation in Neuroglioma Cells
- (2013) Kiri Kilpatrick et al. ACS Chemical Biology
- Inclusions in frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), but not FTLD with FUS proteinopathy (FTLD-FUS), have properties of amyloid
- (2013) Eileen H. Bigio et al. ACTA NEUROPATHOLOGICA
- Structure of Inclusions of Huntington’s Disease Brain Revealed by Synchrotron Infrared Microspectroscopy: Polymorphism and Relevance to Cytotoxicity
- (2013) William André et al. ANALYTICAL CHEMISTRY
- Systemic Amyloidoses
- (2013) Luis M. Blancas-Mejía et al. Annual Review of Biochemistry
- Semen-Derived Enhancer of Viral Infection (SEVI) Binds Bacteria, Enhances Bacterial Phagocytosis by Macrophages, and Can Protect against Vaginal Infection by a Sexually Transmitted Bacterial Pathogen
- (2013) David Easterhoff et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Allosteric Heat Shock Protein 70 Inhibitors Rapidly Rescue Synaptic Plasticity Deficits by Reducing Aberrant Tau
- (2013) Jose Abisambra et al. BIOLOGICAL PSYCHIATRY
- Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue
- (2013) Jun-Xia Lu et al. CELL
- Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
- (2013) Jing L. Guo et al. CELL
- Coordination of Translational Control and Protein Homeostasis during Severe Heat Stress
- (2013) Valeria Cherkasov et al. CURRENT BIOLOGY
- Islet Amyloid Polypeptide and Diabetes
- (2013) Gunilla Westermark et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Caudo-rostral brain spreading of α-synuclein through vagal connections
- (2013) Ayse Ulusoy et al. EMBO Molecular Medicine
- Hsp110 Is aBona FideChaperone Using ATP to Unfold Stable Misfolded Polypeptides and Reciprocally Collaborate with Hsp70 to Solubilize Protein Aggregates
- (2013) Rayees U. H. Mattoo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phase transitions and size scaling of membrane-less organelles
- (2013) Clifford P. Brangwynne JOURNAL OF CELL BIOLOGY
- Stress granules as crucibles of ALS pathogenesis
- (2013) Yun R. Li et al. JOURNAL OF CELL BIOLOGY
- Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy
- (2013) Teresa Coelho et al. JOURNAL OF NEUROLOGY
- Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
- (2013) Hong Joo Kim et al. NATURE
- Self-propagation of pathogenic protein aggregates in neurodegenerative diseases
- (2013) Mathias Jucker et al. NATURE
- Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease
- (2013) Usman A Khan et al. NATURE NEUROSCIENCE
- State of play in amyotrophic lateral sclerosis genetics
- (2013) Alan E Renton et al. NATURE NEUROSCIENCE
- The changing scene of amyotrophic lateral sclerosis
- (2013) Wim Robberecht et al. NATURE REVIEWS NEUROSCIENCE
- SUMO and Alzheimer’s Disease
- (2013) Linda Lee et al. NEUROMOLECULAR MEDICINE
- Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
- (2013) Shuo-Chien Ling et al. NEURON
- PMEL: a pigment cell-specific model for functional amyloid formation
- (2013) Brenda Watt et al. Pigment Cell & Melanoma Research
- Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS
- (2013) M. I. Ivanova et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Islet amyloid polypeptide toxicity and membrane interactions
- (2013) P. Cao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells
- (2013) L. Rochin et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy
- (2013) P. K. Chan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism
- (2013) S. I. A. Cohen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation
- (2013) Jacqueline Gire O’Rourke et al. Cell Reports
- Genetics of Parkinson's Disease
- (2013) C. Klein et al. Cold Spring Harbor Perspectives in Medicine
- Hsp104 Suppresses Polyglutamine-Induced Degeneration Post Onset in a Drosophila MJD/SCA3 Model
- (2013) Mimi Cushman-Nick et al. PLoS Genetics
- Disease to Dirt: The Biology of Microbial Amyloids
- (2013) David A. Hufnagel et al. PLoS Pathogens
- Molecular chaperones and protein folding as therapeutic targets in Parkinson’s disease and other synucleinopathies
- (2013) Darius Ebrahimi-Fakhari et al. Acta Neuropathologica Communications
- TDP-43 skeins show properties of amyloid in a subset of ALS cases
- (2012) John L. Robinson et al. ACTA NEUROPATHOLOGICA
- Autophagosome assembly and cargo capture in the distal axon
- (2012) Sandra Maday et al. Autophagy
- The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease
- (2012) Oliver D. King et al. BRAIN RESEARCH
- Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients
- (2012) Morgan E. DeSantis et al. CELL
- Cell-free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers within Hydrogels
- (2012) Masato Kato et al. CELL
- Sumoylation in neurodegenerative diseases
- (2012) Petranka Krumova et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Architecture and regulation of HtrA-family proteins involved in protein quality control and stress response
- (2012) Guido Hansen et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Hsp104 Drives “Protein-Only” Positive Selection of Sup35 Prion Strains Encoding Strong [PSI+]
- (2012) Morgan E. DeSantis et al. CHEMISTRY & BIOLOGY
- Metazoan Hsp70 machines use Hsp110 to power protein disaggregation
- (2012) Heike Rampelt et al. EMBO JOURNAL
- Imbalance of Hsp70 family variants fosters tau accumulation
- (2012) Umesh K. Jinwal et al. FASEB JOURNAL
- Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis
- (2012) Julien Couthouis et al. HUMAN MOLECULAR GENETICS
- Human High Temperature Requirement Serine Protease A1 (HTRA1) Degrades Tau Protein Aggregates
- (2012) Annette Tennstaedt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
- (2012) Sandra Maday et al. JOURNAL OF CELL BIOLOGY
- Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
- (2012) Stefan M. Gehrig et al. NATURE
- Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
- (2012) Adrienne M Wang et al. Nature Chemical Biology
- The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
- (2012) Iryna Benilova et al. NATURE NEUROSCIENCE
- Tafamidis for transthyretin familial amyloid polyneuropathy: A randomized, controlled trial
- (2012) T. Coelho et al. NEUROLOGY
- CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
- (2012) J.- M. Lee et al. NEUROLOGY
- Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
- (2012) Alix de Calignon et al. NEURON
- Conserved features of intermediates in amyloid assembly determine their benign or toxic states
- (2012) R. Krishnan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antiparallel -sheet architecture in Iowa-mutant -amyloid fibrils
- (2012) W. Qiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
- (2012) C. E. Bulawa et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans
- (2012) Martin L. Duennwald et al. PLOS BIOLOGY
- Alfy-dependent elimination of aggregated proteins by macroautophagy
- (2011) Ai Yamamoto et al. Autophagy
- Rapamycin treatment augments motor neuron degeneration in SOD1G93Amouse model of amyotrophic lateral sclerosis
- (2011) Xiaojie Zhang et al. Autophagy
- Neuralized1 Activates CPEB3: A Function for Nonproteolytic Ubiquitin in Synaptic Plasticity and Memory Storage
- (2011) Elias Pavlopoulos et al. CELL
- Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions
- (2011) Heidi Olzscha et al. CELL
- Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection
- (2011) Nadia R. Roan et al. Cell Host & Microbe
- Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene
- (2011) Henrik Karring et al. EXPERIMENTAL EYE RESEARCH
- Processing-independent analysis of peptide hormones and prohormones in plasma
- (2011) Jens Peter Goetze Frontiers in Bioscience-Landmark
- Heat shock protein 104 inhibited the fibrillization of prion peptide 106–126 and disassembled prion peptide 106–126 fibrils in vitro
- (2011) Ying-Hui Liu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- A Seeding Reaction Recapitulates Intracellular Formation of Sarkosyl-insoluble Transactivation Response Element (TAR) DNA-binding Protein-43 Inclusions
- (2011) Yoshiaki Furukawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Sumoylation inhibits α-synuclein aggregation and toxicity
- (2011) Petranka Krumova et al. JOURNAL OF CELL BIOLOGY
- α-Synuclein oligomers oppose long-term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases
- (2011) Zane S. Martin et al. JOURNAL OF NEUROCHEMISTRY
- A New Structural Model of Aβ40Fibrils
- (2011) Ivano Bertini et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Naturally Occurring Fragments from Two Distinct Regions of the Prostatic Acid Phosphatase Form Amyloidogenic Enhancers of HIV Infection
- (2011) F. Arnold et al. JOURNAL OF VIROLOGY
- Familial amyloid polyneuropathy
- (2011) Violaine Planté-Bordeneuve et al. LANCET NEUROLOGY
- Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
- (2011) Jie Xu et al. Nature Chemical Biology
- Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
- (2011) Jiyong Lee et al. Nature Chemical Biology
- Nanomechanics of functional and pathological amyloid materials
- (2011) Tuomas P. J. Knowles et al. Nature Nanotechnology
- Potent amyloidogenicity and pathogenicity of Aβ43
- (2011) Takashi Saito et al. NATURE NEUROSCIENCE
- HTRA proteases: regulated proteolysis in protein quality control
- (2011) Tim Clausen et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
- (2011) Edward B. Lee et al. NATURE REVIEWS NEUROSCIENCE
- Substrate-induced remodeling of the active site regulates human HTRA1 activity
- (2011) Linda Truebestein et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Familial Parkinson disease mutations influence α-synuclein assembly
- (2011) Kenjiro Ono et al. NEUROBIOLOGY OF DISEASE
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Huntington's disease: a clinical review
- (2011) Raymund A.C. Roos Orphanet Journal of Rare Diseases
- Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus
- (2011) Per Westermark et al. PHYSIOLOGICAL REVIEWS
- The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System
- (2011) James Shorter PLoS One
- A yeast functional screen predicts new candidate ALS disease genes
- (2011) J. Couthouis et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells
- (2011) Christian Münch et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS
- (2011) Zhihui Sun et al. PLOS BIOLOGY
- Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form
- (2010) Aaron Kerman et al. ACTA NEUROPATHOLOGICA
- Applying Hsp104 to protein-misfolding disordersThis paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.
- (2010) Shilpa Vashist et al. Biochemistry and Cell Biology
- Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations
- (2010) Ju-Hyun Lee et al. CELL
- ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import
- (2010) Dorothee Dormann et al. EMBO JOURNAL
- Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules
- (2010) Daryl A. Bosco et al. HUMAN MOLECULAR GENETICS
- Prion-like disorders: blurring the divide between transmissibility and infectivity
- (2010) M. Cushman et al. JOURNAL OF CELL SCIENCE
- Emergence and natural selection of drug-resistant prions
- (2010) James Shorter Molecular BioSystems
- The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy
- (2010) Maria Filimonenko et al. MOLECULAR CELL
- Enhancement of proteasome activity by a small-molecule inhibitor of USP14
- (2010) Byung-Hoon Lee et al. NATURE
- Hsp70 stabilizes lysosomes and reverts Niemann–Pick disease-associated lysosomal pathology
- (2010) Thomas Kirkegaard et al. NATURE
- Superoxide Dismutase 1 and tgSOD1G93A Mouse Spinal Cord Seed Fibrils, Suggesting a Propagative Cell Death Mechanism in Amyotrophic Lateral Sclerosis
- (2010) Ruth Chia et al. PLoS One
- Identifying the amylome, proteins capable of forming amyloid-like fibrils
- (2010) Lukasz Goldschmidt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity
- (2010) Jan Bieschke et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generating a Prion with Bacterially Expressed Recombinant Prion Protein
- (2010) F. Wang et al. SCIENCE
- Lewy body pathology in fetal grafts
- (2009) Yaping Chu et al. Annals of the New York Academy of Sciences
- The Interplay of Catalysis and Toxicity by Amyloid Intermediates on Lipid Bilayers: Insights from Type II Diabetes
- (2009) James A. Hebda et al. Annual Review of Biophysics
- Evidence for Novel β-Sheet Structures in Iowa Mutant β-Amyloid Fibrils
- (2009) Robert Tycko et al. BIOCHEMISTRY
- A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins
- (2009) Simon Alberti et al. CELL
- Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy
- (2009) Seth Love Frontiers in Bioscience-Landmark
- N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils
- (2009) Brenda Watt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity
- (2009) Brian S. Johnson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 is recruited to stress granules in conditions of oxidative insult
- (2009) Claudia Colombrita et al. JOURNAL OF NEUROCHEMISTRY
- Transmission and spreading of tauopathy in transgenic mouse brain
- (2009) Florence Clavaguera et al. NATURE CELL BIOLOGY
- A synergistic small-molecule combination directly eradicates diverse prion strain structures
- (2009) Blake E Roberts et al. Nature Chemical Biology
- Prions: Protein Aggregation and Infectious Diseases
- (2009) Adriano Aguzzi et al. PHYSIOLOGICAL REVIEWS
- Distinct conformations of in vitro and in vivo amyloids of huntingtin-exon1 show different cytotoxicity
- (2009) Y. Nekooki-Machida et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Design and construction of diverse mammalian prion strains
- (2009) D. W. Colby et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Natural and synthetic prion structure from X-ray fiber diffraction
- (2009) H. Wille et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Analytical Solution to the Kinetics of Breakable Filament Assembly
- (2009) T. P. J. Knowles et al. SCIENCE
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules
- (2009) S. K. Maji et al. SCIENCE
- Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
- (2009) Marco D Mukrasch et al. PLOS BIOLOGY
- The unfoldomics decade: an update on intrinsically disordered proteins
- (2008) A Keith Dunker et al. BMC GENOMICS
- Transthyretin and Amyloid in the Islets of Langerhans in Type-2 Diabetes
- (2008) Gunilla T. Westermark et al. Experimental Diabetes Research
- Hsp104 antagonizes α-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease
- (2008) Christophe Lo Bianco et al. JOURNAL OF CLINICAL INVESTIGATION
- Escaping amyloid fate
- (2008) Blake E Roberts et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs
- (2008) H. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular structural basis for polymorphism in Alzheimer's -amyloid fibrils
- (2008) A. K. Paravastu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Amyloid Fibrils of the HET-s(218-289) Prion Form a Solenoid with a Triangular Hydrophobic Core
- (2008) C. Wasmer et al. SCIENCE
- Adapting Proteostasis for Disease Intervention
- (2008) William E. Balch et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now