Galectins at a glance

Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions

(2018) Fredrik R. Zetterberg et al.   ChemMedChem

The roles and mechanisms of homogalacturonan and rhamnogalacturonan I pectins on the inhibition of cell migration

(2018) Yuying Fan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Galectin-3: One Molecule for an Alphabet of Diseases, from A to Z

(2018) Salvatore Sciacchitano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A myopic perspective on the future of protein diagnostics

(2018) Ulf Landegren et al.   New Biotechnology

Members of the Galectin Network with Deviations from the Canonical Sequence Signature. 2. Galectin-Related Protein (GRP)

(2018) Joachim C. Manning et al.   TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY

Members of the Galectin Network with Deviations from the Canonical Sequence Signature. 1. Galectin-Related Inter-Fiber Protein (GRIFIN)

(2018) Gabriel García Caballero et al.   TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY

Galectin-3 in Heart Failure

(2018) Carolin Gehlken et al.   Heart Failure Clinics

A genome-wide CRISPR screen reconciles the role of N-linked glycosylation in galectin-3 transport to the cell surface

(2017) Sarah E. Stewart et al.   JOURNAL OF CELL SCIENCE

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Galectin-3 Inhibits Galectin-8/Parkin-Mediated Ubiquitination of Group A Streptococcus

(2017) Yi-Lin Cheng et al.   mBio

Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration

(2017) Monica Gordon-Alonso et al.   Nature Communications

Impaired endo-lysosomal membrane integrity accelerates the seeding progression of α-synuclein aggregates

(2017) Peizhou Jiang et al.   Scientific Reports

Spindle pole cohesion requires glycosylation-mediated localization of NuMA

(2017) Jérémy Magescas et al.   Scientific Reports

Galectin-3 is a non-classic RNA binding protein that stabilizes the mucin MUC4 mRNA in the cytoplasm of cancer cells

(2017) Lucie Coppin et al.   Scientific Reports

E-cadherin dynamics is regulated by galectin-7 at epithelial cell surface

(2017) Tamara Advedissian et al.   Scientific Reports

Galectins and Immune Responses—Just How Do They Do Those Things They Do?

(2016) Sandra Thiemann et al.   Annual Review of Immunology

Galectin-3 interacts with components of the nuclear ribonucleoprotein complex

(2016) Katharina Fritsch et al.   BMC CANCER

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

(2016) Pingping Li et al.   CELL

Glycosylation-Dependent IFN-γR Partitioning in Lipid and Actin Nanodomains Is Critical for JAK Activation

(2016) Cédric M. Blouin et al.   CELL

Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition

(2016) Tamara Delaine et al.   CHEMBIOCHEM

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Intra- and intermolecular interactions of human galectin-3: assessment by full-assignment-based NMR

(2016) Hans Ippel et al.   GLYCOBIOLOGY

Synthetic glycoconjugates inhibitors of tumor-related galectin-3: an update

(2016) Vanessa Leiria Campo et al.   GLYCOCONJUGATE JOURNAL

Low or No Inhibitory Potency of the Canonical Galectin Carbohydrate-binding Site by Pectins and Galactomannans

(2016) John Stegmayr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Selective Galactose–Coumarin-Derived Galectin-3 Inhibitor Demonstrates Involvement of Galectin-3-glycan Interactions in a Pulmonary Fibrosis Model

(2016) Vishal K. Rajput et al.   JOURNAL OF MEDICINAL CHEMISTRY

Glycolipids and Lectins in Endocytic Uptake Processes

(2016) Ludger Johannes et al.   JOURNAL OF MOLECULAR BIOLOGY

A 10S galectin-3–U1 snRNP complex assembles into active spliceosomes

(2016) Kevin C. Haudek et al.   NUCLEIC ACIDS RESEARCH

Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis

(2016) Ramray Bhat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key regulators of galectin-glycan interactions

(2016) Nourine A. Kamili et al.   PROTEOMICS

Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain

(2016) Hyeok Gu Kang et al.   Oncotarget

Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering

(2016) Olga Blaževitš et al.   Scientific Reports

Interaction of the Oncofetal Thomsen–Friedenreich Antigen with Galectins in Cancer Progression and Metastasis

(2016) Paulina Sindrewicz et al.   Frontiers in Oncology

Sensitive detection of lysosomal membrane permeabilization by lysosomal galectin puncta assay

(2015) Sonja Aits et al.   Autophagy

Re-wiring regulatory cell networks in immunity by galectin-glycan interactions

(2015) Ada G. Blidner et al.   FEBS LETTERS

Binding of polysaccharides to human galectin-3 at a noncanonical site in its carbohydrate recognition domain

(2015) Michelle C Miller et al.   GLYCOBIOLOGY

The galectin lattice at a glance

(2015) I. R. Nabi et al.   JOURNAL OF CELL SCIENCE

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

(2015) Anders Wittrup et al.   NATURE BIOTECHNOLOGY

Galectin 2 (gal-2) expression is downregulated on protein and mRNA level in placentas of preeclamptic (PE) patients

(2015) S. Hutter et al.   PLACENTA

Many Light Touches Convey the Message

(2015) James W. Dennis   TRENDS IN BIOCHEMICAL SCIENCES

B-cell precursor acute lymphoblastic leukemia and stromal cells communicate through Galectin-3

(2015) Fei Fei et al.   Oncotarget

Galectin-3 leads to attenuation of apoptosis through Bax heterodimerization in human thyroid carcinoma cells

(2015) Yosuke Harazono et al.   Oncotarget

A Short Treatment with Galactomannan GM-CT-01 Corrects the Functions of Freshly Isolated Human Tumor-Infiltrating Lymphocytes

(2014) N. Demotte et al.   CLINICAL CANCER RESEARCH

Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6

(2014) Sheng-Fan Wang et al.   GLYCOBIOLOGY

Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers

(2014) Ramya Lakshminarayan et al.   NATURE CELL BIOLOGY

Basal foot MTOC organizes pillar MTs required for coordination of beating cilia

(2014) Daniel K. Clare et al.   Nature Communications

Ligand binding and complex formation of galectin-3 is modulated by pH variations

(2013) Tobias von Mach et al.   BIOCHEMICAL JOURNAL

Why anti-Bcl-2 clinical trials fail: a solution

(2013) Y. Harazono et al.   CANCER AND METASTASIS REVIEWS

The role of ‘eat-me’ signals and autophagy cargo receptors in innate immunity

(2013) Keith B. Boyle et al.   CURRENT OPINION IN MICROBIOLOGY

Phosphorylation and externalization of galectin-4 is controlled by Src family kinases

(2013) Hiroko Ideo et al.   GLYCOBIOLOGY

Galectin-3 Guides Intracellular Trafficking of Some Human Serotransferrin Glycoforms

(2013) Michael C. Carlsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression Patterns Suggest that Despite Considerable Functional Redundancy, Galectin-4 and -6 Play Distinct Roles in Normal and Damaged Mouse Digestive Tract

(2013) Denis Houzelstein et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Neuronal Galectin-4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering

(2013) Silvia Velasco et al.   JOURNAL OF NEUROCHEMISTRY

Density-dependent Lectin–Glycan Interactions as a Paradigm for Conditional Regulation by Posttranslational Modifications

(2013) James W. Dennis et al.   MOLECULAR & CELLULAR PROTEOMICS

Therapy of Experimental NASH and Fibrosis with Galectin Inhibitors

(2013) Peter G. Traber et al.   PLoS One

Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy

(2013) S. Li et al.   Science Signaling

pH-Dependent Recycling of Galectin-3 at the Apical Membrane of Epithelial Cells

(2013) Tamara Straube et al.   TRAFFIC

Structural basis for recognition of autophagic receptor NDP52 by the sugar receptor galectin-8

(2013) Byeong-Won Kim et al.   Nature Communications

Ligand Induced Galectin-3 Protein Self-association

(2012) Adriana Lepur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Galectin-3 Regulates Intracellular Trafficking of EGFR through Alix and Promotes Keratinocyte Migration

(2012) Wei Liu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Spatiotemporal Dynamics of Adenovirus Membrane Rupture and Endosomal Escape

(2012) O. Maier et al.   JOURNAL OF VIROLOGY

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

(2012) Teresa L. M. Thurston et al.   NATURE

Galectin fingerprinting detects differences in expression profiles between bovine endometrium and placentomes as well as early and late gestational stages

(2012) R. Froehlich et al.   PLACENTA

When Galectins Recognize Glycans: From Biochemistry to Physiology and Back Again

(2011) Santiago Di Lella et al.   BIOCHEMISTRY

Structural features for α-galactomannan binding to galectin-1

(2011) Michelle C Miller et al.   GLYCOBIOLOGY

Galectin secretion and binding to adult Fasciola hepatica during chronic liver fluke infection of sheep

(2011) Anna R. Young et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Monovalent Interactions of Galectin-1

(2010) Emma Salomonsson et al.   BIOCHEMISTRY

Trafficking of galectin-3 through endosomal organelles of polarized and non-polarized cells

(2010) Dominik Schneider et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mutational Tuning of Galectin-3 Specificity and Biological Function

(2010) Emma Salomonsson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomics Analysis of Bladder Cancer Exosomes

(2010) Joanne L. Welton et al.   MOLECULAR & CELLULAR PROTEOMICS

Galectin-9 trafficking regulates apical-basal polarity in Madin–Darby canine kidney epithelial cells

(2010) Rashmi Mishra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of galectin-3 in the nucleus and cytoplasm

(2009) Kevin C. Haudek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking

(2009) Willy Morelle et al.   BIOLOGICAL CHEMISTRY

Galectin-3, a marker for vacuole lysis by invasive pathogens

(2009) Irit Paz et al.   CELLULAR MICROBIOLOGY

The  -galactomannan Davanat binds galectin-1 at a site different from the conventional galectin carbohydrate binding domain

(2009) M. C Miller et al.   GLYCOBIOLOGY

A novel form of cell type-specific partial IFN-γR1 deficiency caused by a germ line mutation of the IFNGR1 initiation codon

(2009) Xiao-Fei Kong et al.   HUMAN MOLECULAR GENETICS

Galectin-3, a Novel Centrosome-associated Protein, Required for Epithelial Morphogenesis

(2009) Annett Koch et al.   MOLECULAR BIOLOGY OF THE CELL

A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death

(2009) N. G. Than et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse

(2009) H.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Galectin-4-Regulated Delivery of Glycoproteins to the Brush Border Membrane of Enterocyte-Like Cells

(2009) Laurence Stechly et al.   TRAFFIC

Adaptive Regulation at the Cell Surface byN-Glycosylation

(2009) James W. Dennis et al.   TRAFFIC

K-Ras Nanoclustering Is Subverted by Overexpression of the Scaffold Protein Galectin-3

(2008) R. Shalom-Feuerstein et al.   CANCER RESEARCH

Modified citrus pectin anti-metastatic properties: one bullet, multiple targets

(2008) Vladislav V. Glinsky et al.   CARBOHYDRATE RESEARCH

Lgals6, a 2-Million-Year-Old Gene in Mice: A Case of Positive Darwinian Selection and Presence/Absence Polymorphism

(2008) D. Houzelstein et al.   GENETICS

Functional characterization of an eosinophil-specific galectin, ovine galectin-14

(2008) Anna R. Young et al.   GLYCOCONJUGATE JOURNAL

Ligand Reduces Galectin-1 Sensitivity to Oxidative Inactivation by Enhancing Dimer Formation

(2008) Sean R. Stowell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY