Article
Nanoscience & Nanotechnology
Ramin Jafari, Maryam Tohidi, Banafsheh Rastegari, Sedigheh Zeinali
Summary: This study explores the potential application of BioMIL-4, a biological metal-organic framework, and its composite with chitosan and alginate as natural polymers, for bone tissue engineering. The biomimetic mineralization of BioMIL-4 on chitosan nanofibers enhances the scaffold's degradation rate and mechanical strength, while the incorporation of chitosan particles and alginate solutions further improves the scaffold's performance.
ACS APPLIED NANO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Zhengyue Li, Xiuqiong Chen, Chaoling Bao, Chang Liu, Chunyang Liu, Dongze Li, Huiqiong Yan, Qiang Lin
Summary: The combination of alginate with bacterial cellulose nanocrystals-chitosan-gelatin composite scaffolds showed regular 3D morphologies and well-developed pore structures, with the addition of BCNs effectively controlling the swelling and biodegradation behavior. This composite scaffold exhibited good cytocompatibility, making it potentially suitable for bone tissue engineering applications.
Article
Polymer Science
Satar Yousefiasl, Hamed Manoochehri, Esmaeel Sharifi
Summary: Critical-sized bone damage impairs self-repair capacity and conventional therapies have limitations. In this study, strontium-doped mesoporous silica nanoparticles were successfully incorporated into chitosan/alginate scaffolds. The scaffolds showed improved biocompatibility and osteogenic differentiation, making them promising for bone repair and regeneration applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Engineering, Biomedical
Caroline D. Hoemann, Javier Rodriguez Gonzalez, Jessica Guzman-Morales, Gaoping Chen, Ebrahim Jalali Dil, Basil D. Favis
Summary: This study found that non-inflammatory chitosan coatings promoted cartilage infiltration into and over a bioplastic scaffold, and were compatible with trabecular bone integration. Compared to drill-only defects, the 83-99-PCL scaffold induced angiogenesis and slight bone resorption, with the smallest change in bone volume fraction.
BIOACTIVE MATERIALS
(2022)
Review
Chemistry, Applied
Amol D. Gholap, Satish Rojekar, Harshad S. Kapare, Nikhar Vishwakarma, Sarjana Raikwar, Atul Garkal, Tejal A. Mehta, Harsh Jadhav, Mahendra Kumar Prajapati, Uday Annapure
Summary: Chitosan, a natural polysaccharide derived from chitin, holds great potential as a biomaterial in various biomedical applications due to its biocompatibility, biodegradability, antibacterial activity, and ease of modification. This review provides an overview of the use of chitosan scaffolds in tissue engineering, regenerative medicine, and drug delivery systems. It highlights the structural and biological properties of chitosan and explores different fabrication methods, such as gelation, electrospinning, and 3D printing. The review emphasizes the role of chitosan scaffolds in promoting cell adhesion, proliferation, and differentiation for tissue regeneration, as well as their potential in wound healing and infection management. Additionally, it discusses the challenges and future objectives in scaffold design, mechanical properties, and understanding interactions with host tissues.
CARBOHYDRATE POLYMERS
(2024)
Review
Biochemistry & Molecular Biology
L. Roshini Yadav, S. Viji Chandran, K. Lavanya, N. Selvamurugan
Summary: Conventional bone grafting techniques have limitations, highlighting the need for novel approaches to overcome challenges. The combination of bone tissue engineering and 3D-printing technology offers the potential to create tissue-like scaffolds with natural bone characteristics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Zhikang Zhu, Fang He, Huawei Shao, Jiaming Shao, Qiong Li, Haitao Ren, Chuangang You, Zhongtao Zhang, Chunmao Han
Summary: Burn injury is a devastating burden on global public health, and inflammation often leads to delayed healing. In this study, chitosan/alginate nanoparticles (EsA-CS/ALG-NPs) were constructed and impregnated into a collagen/chitosan scaffold (EsA-CS/ALG-NPs@CCS), successfully improving the stability and reducing toxicity of EsA, which may contribute to the treatment of burn wounds.
ACS APPLIED NANO MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
R. Bharathi, S. Shree Ganesh, G. Harini, Kumari Vatsala, R. Anushikaa, S. Aravind, S. Abinaya, N. Selvamurugan
Summary: The bone tissue engineering approach becomes necessary for treating large bone defects when the tissue damage exceeds the body's inherent regenerative ability. Chitosan is a promising bone scaffold material that supports cell attachment, proliferation, and mineralization of the bone matrix. Smart drug delivery scaffolds based on chitosan have been developed to respond to environmental stimuli and provide localized sustained drug delivery in the area of large bone defects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Dong Yang, Keyi Gao, Yang Bai, Lei Lei, Tongtong Jia, Kaidi Yang, Chaohua Xue
Summary: This study utilized a microfluidic approach to synthesize magnetic alginate microparticles and chitosan-coated magnetic alginate microparticles, achieving controlled drug release. By investigating the model drug amoxicillin, it was found that particle size affects drug release rate, while chitosan coating extended drug release time by two times.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Analytical
Xin Shi, Beibei Ma, Hongyu Chen, Wei Tan, Shiqing Ma, Guorui Zhu
Summary: This paper presents the development of a microfluidic/chitosan device for drug release to inhibit infections and guide bone regeneration. The device offers controlled drug release, flexible clinical use, low cost, and excellent antibacterial performance and biocompatibility.
Article
Chemistry, Applied
Amitava Bhattacharyya, Hyeong-wook Ham, JiAe Sonh, Marla Gunbayar, R. Jeffy, R. Nagarajan, Mst Rita Khatun, Insup Noh
Summary: Controlled in situ 3D bioprinting of hydrogel without toxic crosslinker is achieved using an advanced pen-type extruder, allowing for tissue regeneration by distributing reinforcing agent during fabrication of large area and complex tissue engineering scaffolds. The addition of kaolin to the alginate-chitosan bioink improves mechanical properties and printability, while also promoting uniform cell growth and proliferation throughout the bioprinted gel matrix. The advanced pen-type extruder ensures better mixing effectiveness and suitability for in vitro tissue regeneration.
CARBOHYDRATE POLYMERS
(2023)
Review
Materials Science, Multidisciplinary
Yiyuan Li, Yufeng Meng, Yuning Wang, Yun Wang, Zuolin Wang
Summary: Chitosan is a natural cationic polysaccharide with excellent biological properties and potential applications. Mineralized chitosan scaffolds, as ideal biomaterials for repairing hard tissue defects, have made significant progress in the past decade. This study summarizes the structures, properties, preparation methods, and applications of mineralized chitosan scaffolds, and discusses their defects and possible improvement measures.
Article
Biochemistry & Molecular Biology
Bruno Zwingenberger, Corina Vater, Roland L. Bell, Julia Bolte, Elisabeth Mehnert, Ronny Bruenler, Dilbar Aibibu, Stefan Zwingenberger
Summary: The study found that CHS scaffolds exhibited higher osteogenic properties in vitro, but resulted in lower bone-healing outcomes compared to CBA and MCM in vivo. Future improvements on CHS scaffolds are needed for better mechanical stability and osteoconductivity.
Article
Chemistry, Applied
Lei Xu, Fenbo Ma, Frankie K. L. Leung, Chenghe Qin, William W. Lu, Bin Tang
Summary: Bone defects caused by trauma are increasingly common in aged populations, and repairing bone defects in the elderly remains challenging due to decreased bone healing capacity compared to young adults. Developing effective biomaterials targeted at bone defects in the elderly is crucial for bone-tissue engineering strategies, and more attention is needed for bone regeneration in the elderly.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Physical
Junhyung Kim, Seoyun Lee, Yonghyun Choi, Jonghoon Choi, Byung-Jae Kang
Summary: BMP-2 encapsulated alginate microbeads (AM) and VEGF-adsorbing Apt-HA were used to enhance bone regeneration, with AM showing sustained release of BMP-2. The combination of BMP-2-encapsulated Apt-HA + AM showed significantly improved bone regeneration.
Article
Engineering, Biomedical
Hsin-Yi Lin, Shin-Hung Chen, Shih-Hsin Chang, Sheng-Tung Huang
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2015)
Article
Engineering, Biomedical
Hsin-Yi Lin, Zhao-Xiang Peng
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2017)
Article
Chemistry, Analytical
T. S. T. Balamurugan, Veerappan Mani, Chang-Che Hsieh, Sheng-Tung Huang, Tie-Kun Peng, Hsin-Yi Lin
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Engineering, Biomedical
Hsin-Yi Lin, Yu-Jen Kuo, Shih-Hsin Chang, Tsung-Sheng Ni
BIOMEDICAL MATERIALS
(2013)
Article
Chemistry, Applied
Hsin-Yi Lin, Jing-Huei Chen
CARBOHYDRATE POLYMERS
(2013)
Article
Engineering, Biomedical
Hsin-Yi Lin, Hsin-Hung Chen, Shih-Hsin Chang, Tsung-Sheng Ni
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2013)
Article
Engineering, Biomedical
Hsin-Yi Lin, Chih-Wei Peng, Wei-Wen Wu
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2014)
Article
Chemistry, Multidisciplinary
Huang-Sheng Liao, Josephine W. Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Cheng-Wen Tsao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai, Yih Ho
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2012)
Article
Engineering, Chemical
Yeh-Fon Lin, Jian-Hua Zhao, Hsuan-Liang Liu, Josephine W. Wu, Chih-Kuang Chuang, Kung-Tien Liu, Hsin-Yi Lin, Wei-Bor Tsai, Yih Ho
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2011)
Article
Materials Science, Biomaterials
Chih-Wei Peng, Hsin-Yi Lin, Hsin-Wei Wang, Wei-Wen Wu
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2012)
Article
Chemistry, Analytical
Jiun-An Gu, Yu-Jen Lin, Yu-Ming Chia, Hsin-Yi Lin, Sheng-Tung Huang
Article
Engineering, Biomedical
I-Hsin Liu, Shih-Hsin Chang, Hsin-Yi Lin
BIOMEDICAL MATERIALS
(2015)
Article
Engineering, Biomedical
Hsin-Yi Lin, Chih-Tsung Yeh
BIO-MEDICAL MATERIALS AND ENGINEERING
(2012)
Article
Cell Biology
Shin-Hua Lu, Josephine W. Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai, Yih Ho
JOURNAL OF BIOMEDICAL SCIENCE
(2011)