Article
Biochemistry & Molecular Biology
Yongqi Zhang, Jia Man, Jiali Wang, Jianing Liu, Xinzhong Song, Xiaohan Yu, Jianyong Li, Ruijian Li, Yinghua Qiu, Jianfeng Li, Yuguo Chen
Summary: This study developed heparinized surfaces on PVC substrates using plasma treatment technology and chemical grafting method. The heparinized surfaces not only reduced thrombosis but also decreased side effects of anticoagulants. Sodium alginate and carboxymethyl chitosan interlayers significantly increased the graft density of heparin, improving its anticoagulant effects and hemocompatibility. The CCS/low-molecular-weight heparin surface showed the best anticoagulant properties. The heparinized surfaces prepared in this study have great potential in anticoagulant treatment for medical devices.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biotechnology & Applied Microbiology
Xiao Sheng, Ao Wang, Zhonghan Wang, He Liu, Jincheng Wang, Chen Li
Summary: This article discusses the principles, processes, and challenges of surface modification of 3D printed titanium alloy implants. Future research directions, such as the combination of multiple modification technologies and the coordination of the structure and composition of composite coatings, are also presented.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Tianqi Guo, Saso Ivanovski, Karan Gulati
Summary: The study evaluates nanostructure self-ordering on clinically relevant curved/micro-rough Ti, contributing to an improved understanding of implant nanoengineering.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Physical
Xiaojian Cao, Jiangpei Zhu, Fei Gao, Zhu Gao
Summary: Through ultrasonic surface impact, nanograins were achieved in the surfaces of titanium alloys Ti6Al4V and Ti3Zr2Sn3Mo25Nb, leading to improvements in mechanical properties such as hardness, residual stress, and roughness. The rotating-bending fatigue limits of the alloys were found to increase significantly after ultrasonic impact treatment, with an effect on crack initiation.
Article
Materials Science, Biomaterials
Hongwei Shao, Shi Cheng, Mengyu Yao, Xiongfa Ji, Hua Zhong, Donghui Wang, Xiujuan Fan, Qian Li, Jielong Zhou, Yu Zhang, Feng Peng
Summary: The multifunctional mussel-inspired film on Mg alloy exhibits excellent photothermal effect and controlled release of doxorubicin, enabling it to kill bone tumors in vitro and inhibit tumor growth in nude mice. The material supports extracellular matrix mineralization and gene expression, showing promising potential for the therapy of primary malignant bone tumors.
REGENERATIVE BIOMATERIALS
(2021)
Article
Multidisciplinary Sciences
Tahereh Tayebi, Alireza Baradaran-Rafii, Abbas Hajifathali, Azam Rahimpour, Hakimeh Zali, Alireza Shaabani, Hassan Niknejad
Summary: A biodegradable transparent scaffold for culturing corneal endothelial cells was constructed by incorporating chitosan nanoparticles into chitosan/polycaprolactone membranes. The scaffold showed improved transparency and surface wettability, was non-toxic to cells, promoted cell proliferation, and was suitable for corneal endothelial regeneration.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Physical
Raphael C. Costa, Bruna E. Nagay, Martinna Bertolini, Barbara E. Costa-Oliveira, Aline A. Sampaio, Belen Retamal-Valdes, Jamil A. Shibli, Magda Feres, Valentim A. R. Barao, Joao Gabriel S. Souza
Summary: There is currently no consensus on the best Ti surface to reduce bacterial colonization on dental implants. Emerging smart release or on-demand activation surface coatings may be the most effective alternative for reducing microbial colonization on Ti surfaces, and future studies should focus on these technologies.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Jingjing Bian, Tong Wu, Qiyue Zhou, Haifeng Xie, Chen Chen
Summary: This study aimed to improve the osseointegration of titanium implants in a diabetic microenvironment by developing a local drug delivery system using antioxidants and osteogenic substances. The researchers successfully constructed a coating with good biocompatibility and excellent performance, which promoted cell adhesion and proliferation and improved mitochondrial function.
APPLIED SURFACE SCIENCE
(2023)
Review
Biotechnology & Applied Microbiology
Chuang Hou, Jing An, Duoyi Zhao, Xiao Ma, Weilin Zhang, Wei Zhao, Meng Wu, Zhiyu Zhang, Fusheng Yuan
Summary: This article reviews the application and characteristics of titanium processing methods, explores the effects of technology on the surface characteristics of titanium-based implants, and proposes future research directions and the characteristics of ideal titanium-based implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Hui Wang, Changyong Yuan, Kaili Lin, Rui Zhu, Shilei Zhang
Summary: This study demonstrated that a polydopamine (PDA) coating on 3D-printed implants improved their hydrophilicity, enhanced the adhesion, propagation, and osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs), and improved osteointegration performance in vivo. This suggests that PDA coating could be a feasible strategy for optimizing 3D-printed implant surfaces and provides a basis for future research on immobilizing bioactive factors on these surfaces.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Maohua Chen, Menghuan Li, Xijiao Ren, Fei Zhou, Yanan Li, Lu Tan, Zhong Luo, Kaiyong Cai, Yan Hu
Summary: A nanoengineered composite coating was developed to improve the in situ osseointegration of a Ti implant for osteoporotic fracture repair. The coating inhibited STING in endothelial cells to stimulate the formation of Type H vessels. Galvanotaxis recruited endothelial cells and mesenchymal stem cells to the implant surface, where released narigenin upregulated eNOS in recruited endothelial cells under ROS stimulation, leading to enhanced local angiogenesis. Coordinately released DNFzns abolished STING expression in endothelial cells to transform the newly formed vessels into Type H vessels, thereby promoting the osseointegration of Ti implants.
Article
Automation & Control Systems
Michela Sanguedolce, Giovanna Rotella, Federica Curcio, Riccardo Pelaccia, Vincenzina Siciliani, Roberta Cassano, Leonardo Orazi, Luigino Filice
Summary: Biomedical implants can cause significant perturbation to the human body, but functionalizing and coating implant surfaces can improve biocompatibility and provide additional functions such as corrosion protection, osteointegration, and drug delivery. In this study, a composite of chitosan and bioactive glass nanoparticles was used to coat Ti6Al4V alloy samples processed with different methods. Experiments were conducted to investigate the relationship between substrate surface conditions and the effectiveness of the coating in terms of scratch resistance, aiming to provide guidelines for improving substrate-coating performances.
INTERNATIONAL JOURNAL OF ADVANCED MANUFACTURING TECHNOLOGY
(2023)
Article
Materials Science, Coatings & Films
Donata Kuczynska-Zemla, Agata Sotniczuk, Marcin Pisarek, Adrian Chlanda, Halina Garbacz
Summary: This paper discusses the corrosion behavior of Titanium Grade 2 after non-contact laser functionalization using Direct Laser Interference Lithography (DLIL). The results show that laser-textured surfaces improve titanium corrosion resistance in physiological saline, with a more stable passive layer. The enhanced corrosion resistance in DLIL samples is mainly attributed to changes in surface topography, chemical composition, and oxide film thickness.
SURFACE & COATINGS TECHNOLOGY
(2021)
Article
Polymer Science
Guillaume Conzatti, Farouk Ayadi, Sandrine Cavalie, Marion Castel-Moliere, Audrey Tourrette
Summary: The study explores a method of hydrophobizing alginate/chitosan PECs to enhance their applicability, revealing that the hydrophobization treatment is effective but reduces the swelling abilities of PECs. The research found that the PCL layer is not resistant to the enzymatic environment, while PLA provides impermeability to the PECs.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yangyang Duan, You Wu, Ru Yan, Meng Lin, Shengjun Sun, Houyi Ma
Summary: In this study, a self-strengthening coating was successfully constructed using silver nanoparticles, chitosan, and sodium alginate, which exhibited enhanced corrosion resistance and antibacterial properties. The coating continuously strengthened in corrosive medium, showing high protection efficiency.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Engineering, Biomedical
Hsin-Yi Lin, Shin-Hung Chen, Shih-Hsin Chang, Sheng-Tung Huang
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2015)
Article
Engineering, Biomedical
Hsin-Yi Lin, Zhao-Xiang Peng
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2017)
Article
Engineering, Biomedical
Hsin-Yi Lin, Tsang-Wen Chang, Tie-Kun Peng
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2018)
Article
Chemistry, Analytical
T. S. T. Balamurugan, Veerappan Mani, Chang-Che Hsieh, Sheng-Tung Huang, Tie-Kun Peng, Hsin-Yi Lin
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Biology
Hsin-Yi Lin, Yu-Jen Lin
BIOELECTROMAGNETICS
(2011)
Article
Engineering, Biomedical
Hsin-Yi Lin, Yu-Jen Kuo, Shih-Hsin Chang, Tsung-Sheng Ni
BIOMEDICAL MATERIALS
(2013)
Article
Engineering, Biomedical
Hsin-Yi Lin, Hsin-Hung Chen, Shih-Hsin Chang, Tsung-Sheng Ni
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2013)
Article
Engineering, Biomedical
Hsin-Yi Lin, Chih-Wei Peng, Wei-Wen Wu
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2014)
Article
Chemistry, Multidisciplinary
Huang-Sheng Liao, Josephine W. Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Cheng-Wen Tsao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai, Yih Ho
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
(2012)
Article
Materials Science, Biomaterials
Chih-Wei Peng, Hsin-Yi Lin, Hsin-Wei Wang, Wei-Wen Wu
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2012)
Article
Chemistry, Analytical
Jiun-An Gu, Yu-Jen Lin, Yu-Ming Chia, Hsin-Yi Lin, Sheng-Tung Huang
Article
Engineering, Biomedical
I-Hsin Liu, Shih-Hsin Chang, Hsin-Yi Lin
BIOMEDICAL MATERIALS
(2015)
Article
Engineering, Biomedical
Hsin-Yi Lin, Chih-Tsung Yeh
BIO-MEDICAL MATERIALS AND ENGINEERING
(2012)
Article
Cell Biology
Shin-Hua Lu, Josephine W. Wu, Hsuan-Liang Liu, Jian-Hua Zhao, Kung-Tien Liu, Chih-Kuang Chuang, Hsin-Yi Lin, Wei-Bor Tsai, Yih Ho
JOURNAL OF BIOMEDICAL SCIENCE
(2011)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
