Article
Materials Science, Characterization & Testing
Meixin Li, Lei Xu, Fenbo Ma, Bin Tang, Chenghe Qin
Summary: Researchers have synthesized a biofunctional composite combining carboxymethyl-chitosan and strontium chondroitin sulfate for bone regeneration. The composites showed porous structures, good swelling capacity, and the ability to promote osteogenic activity and suppress inflammatory responses. These findings suggest that the developed composites have potential as skeletal candidates for regenerative engineering applications.
Article
Chemistry, Applied
Liangyu Guo, Hao Chen, Yuanli Li, Juan Zhou, Jinghua Chen
Summary: In this study, microspheres were integrated into 3D-printed frameworks to form composite scaffolds for bone repair. The frameworks composed of Gel-MA and nHAP provided strong support for cell growth, while microspheres made of Gel-MA and CSA acted as bridges that facilitated cell migration. CSA released from the microspheres promoted osteoblast migration and enhanced bone formation. The composite scaffolds effectively repaired skull defects in mice and improved osteogenic differentiation.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Multidisciplinary
Jiarui Lu, Ruoman Xu, Yanan Chen, Laiting Chan, Xin Feng, Lichieh Lin, Yichen Yao, Xiaoli Hu, Xiaolei Zhang
Summary: This study developed a thermosensitive hybrid hydrogel scaffold based on collagen and chondroitin sulfate, which showed promising results in promoting bone regeneration. In both in vitro and in vivo evaluations, the presence of the hydrogel enhanced osteogenic differentiation and mineralization, leading to improved healing of bone defects, even in the case of genetically impaired osteogenesis.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Zhe Zheng, Liqiu Hu, Yongmei Ge, Jianchao Qi, Qili Sun, Zhenjian Li, Lijun Lin, Bin Tang
Summary: In this study, strontium chondroitin sulfate was successfully introduced into the surface of poly(ether ether ketone) (PEEK) through a simple chemical grafting method. The modified PEEK material exhibited improved cell compatibility, osteogenic activity, and angiogenic activity, while reducing inflammation.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Ming-Kai Hsieh, Chi-Yun Wang, Chia-Jung Wu, Ying-Cen Chen, Shinn-Chih Wu, Wei-Hsing Tuan, Po-Liang Lai
Summary: The study aimed to design a novel strontium sintered calcium sulfate anhydrate scaffold for controlled release and in vivo bone regeneration. In vitro experiments showed positive effects on osteogenic differentiation with Sr2+ concentrations below 10(-4) M, and enhanced cell viability, osteogenic profiles, and bone mineralization in 1% and 5% weight ratios of strontium-substituted scaffolds. In vivo experiments demonstrated acceptable biodegradability and improved bone regeneration with the 1% weight ratio of strontium sintered calcium sulfate scaffolds, suggesting potential for bone tissue engineering applications.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Xiang Li, Xiaonan Tang, Yufei Wang, Changwei Chai, Zhehui Zhao, Haijing Zhang, Ying Peng, Lianqiu Wu
Summary: CS-semi5 showed positive effects on collagen-induced arthritis in mice, alleviating main pathologies and reducing inflammation and bone loss through NF-kappa B deactivation.
CS-semi5 treatment decreased TNF-alpha and IL-1 beta production in activated macrophages and inhibited osteoclast differentiation from macrophages.
Therefore, CS-semi5 may effectively ameliorate symptoms of rheumatoid arthritis by modulating the immune pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Chenhui Wu, Yunkang Ma, Lihua Chen
Summary: In this study, a low-cost, portable, and reusable biosensor was developed for the rapid and selective quantization of tuberculosis gene in early-stage serum samples. The biosensor exhibited antifouling properties and could be used for complex biological systems. The biosensor, based on DNA double strand reversible bonding, showed a fast response with good linear concentration dependence on the target DNA. Furthermore, the biosensor could be reused after regeneration, reducing the overall cost.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Siyu Chen, Rui Zhao, Zhengyi Xing, Tieliang Shang, Xiao Yang, Xiangdong Zhu, Xingdong Zhang
Summary: The study showed that implantation of bioceramics with SrRAN systematic treatment is more effective in promoting new bone formation and osteointegration in repairing critical-sized osteoporotic bone defects compared to pure Sr doping.
APPLIED MATERIALS TODAY
(2021)
Article
Materials Science, Characterization & Testing
N. Rashidi, M. Tamaddon, C. Liu, J. Czernuszka
Summary: This study aimed to improve the application of chondroitin sulfate (CS) in tissue engineering and drug delivery devices by polymerizing it into a higher molecular weight polymer (PCS). The physicochemical properties of PCS were characterized and compared with CS, showing significant improvements in diameter and viscoelastic properties. These results suggest a great potential for using PCS in regenerative medicine devices.
Article
Chemistry, Applied
Qingshan Shen, Chunhui Zhang, Xiaojie Qin, Hongru Zhang, Zhiqiang Zhang, Aurore Richel
Summary: The study showed that the dietary intervention of chondroitin sulfate calcium complex (CSCa) could improve bone mineral density and microstructure in osteoporosis rats, as well as alter the composition of gut microbiota and metabolite profiles. This suggests that CSCa may have the potential to alleviate osteoporosis and related symptoms through the modulation of gut microbiota and metabolites.
CARBOHYDRATE POLYMERS
(2021)
Article
Pharmacology & Pharmacy
Ting Guan, Liu-Gang Ding, Bao-Yuan Lu, Jia-Yi Guo, Mei-Yin Wu, Zhi-Qun Tan, Shao-Zhen Hou
Summary: This study found that the combined administration of curcumin and chondroitin sulfate has better repair effects on cartilage injury in rat models of arthritis. This research offers a promising avenue for discovering potential drugs to treat osteoarthritis and improving treatment options.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Shan Shan Qi, Meng Li Shao, Ze Sun, Si Min Chen, Ying Jun Hu, Xin Sheng Li, De Jing Chen, Hong Xing Zheng, Tian Li Yue
Summary: Chondroitin sulfate can prevent diabetic osteoporosis by reducing blood glucose, improving bone density and microstructure, alleviating inflammation and oxidative stress, and regulating bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Applied
Qingshan Shen, Chunhui Zhang, Haizhen Mo, Hongru Zhang, Xiaojie Qin, Juan Li, Zhiqiang Zhang, Aurore Richel
Summary: The study fabricated a chondroitin sulfate-calcium complex and found that calcium ions could bind with chondroitin sulfate, forming a complex with good biological activity promoting chondrocyte proliferation.
CARBOHYDRATE POLYMERS
(2021)
Review
Cell Biology
Kazuma Sakamoto, Tomoya Ozaki, Kenji Kadomatsu
Summary: Glycan, like nucleic acid and protein, plays crucial roles in cellular processes by regulating protein folding, extracellular matrix organization, and membrane trafficking. While cell-surface glycans are utilized by viruses as entry receptors, their roles as ligands to specific surface receptors are not well understood except for a few exceptions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Wei Zhang, Jikang Han, Zhiwen Jiang, Yanfei Peng, Xiaorui Sun, Baoqin Han
Summary: In this study, CS oligosaccharides (CSOs) were enzymatically prepared and their therapeutic potential for postmenopausal osteoporosis was explored. The results showed that CS and CSOs could effectively alleviate osteoporosis induced by ovariectomy in rats. CSOs exhibited a more significant alleviating effect compared to CS. These findings suggest that CSOs have great potential as daily interventions for delaying the progression of postmenopausal osteoporosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Ling Guo, Chunhong Cui, Kuo Zhang, Jiaxin Wang, Yilin Wang, Yixuan Lu, Ka Chen, Jifan Yuan, Guozhi Xiao, Bin Tang, Ying Sun, Chuanyue Wu
NATURE COMMUNICATIONS
(2019)
Article
Orthopedics
Cheng-He Qin, Chun-Hao Zhou, Ying Ren, Guo-Yun Cheng, Hong-An Zhang, Jia Fang, Rui Tao
FOOT AND ANKLE SURGERY
(2020)
Article
Chemistry, Applied
Zhen Li, Zhenjian Li, Sijing Li, Kui Wang, Fenbo Ma, Bin Tang
MICROPOROUS AND MESOPOROUS MATERIALS
(2020)
Article
Engineering, Biomedical
L. J. Lin, Y. M. Ge, Y. Tian, N. Liu, X. H. Luo, Y. T. Xue, Y. Z. B. Xue, C. Y. Wen, B. Tang
CLINICAL BIOMECHANICS
(2020)
Article
Orthopedics
Chun-Hao Zhou, Ying Ren, Abdulnassir Ali, Xiang-Qing Meng, Hong-An Zhang, Jia Fang, Cheng-He Qin
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2020)
Article
Orthopedics
Chun-Hao Zhou, Ying Ren, Hui-Juan Song, Abdulnassir Adem Ali, Xiang-Qing Meng, Lei Xu, Hong-An Zhang, Jia Fang, Cheng-He Qin
Summary: One-stage radical debridement and bone transport has been proven to be a safe and effective method for treating static (or near static) lower limb osteomyelitis.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Orthopedics
Cheng-he Qin, Rui Tao, Ji-wei Luo, Liang Hong, Lei Xu, Jia Fang, Chun-hao Zhou
Summary: Hematogenous osteomyelitis in infancy is unique in its severity and rapid progression, with the transition from acute to chronic form occurring within just 7 days. The presented case of chronic hematogenous osteomyelitis in a 2-month-old girl is the youngest reported case to date.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Orthopedics
Lei Xu, Huijuan Song, Ying Ren, Jia Fang, Chunhao Zhou, Hongan Zhang, Xiangqing Meng, Guoyun Cheng, Ribo Zhuo, Chenghe Qin
Summary: This study suggests that both antibiotic-impregnated calcium sulfate and irrigation-suction after careful and thorough surgical debridement are generally effective in treating chronic calcaneal osteomyelitis. Antibiotic-impregnated calcium sulfate achieved a higher single-staged cure rate but was associated with an increased postoperative wound exudate.
FOOT & ANKLE INTERNATIONAL
(2022)
Article
Materials Science, Biomaterials
Xiangchao Pang, Caijie Yuan, Rui Sun, Kui Wang, Bin Tang
Summary: The study revealed that the unfolding processes of apo-azurin and holo-azurin are different, with holo-azurin requiring a stronger force to unfold. The copper cluster significantly impacts the stability and folding process of holoazurin, with the copper ion leaving the unfolded azurin during the process. Rarely reported in previous studies, the mechanical strength of the Cu-N(His) bond of the copper cluster was found in this research, providing new insights for azurin's anticancer activity extension.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Review
Crystallography
Xianfang Zhou, Yansong Wang, Chuangye Ge, Bin Tang, Haoran Lin, Xintao Zhang, Yun Huang, Quanyao Zhu, Hanlin Hu
Summary: Lead-free perovskite single crystals have attracted significant attention due to their outstanding properties and potential applications in various fields, despite facing challenges that limit their performance.
Article
Materials Science, Biomaterials
Yang Liu, Qihao Yang, Yue Wang, Minmin Lin, Yanrong Tong, Hanwei Huang, Chengyu Yang, Jianqun Wu, Bin Tang, Jiaming Bai, Chao Liu
Summary: The development of precision manufacturing has allowed the creation of small pores in metallic scaffolds. This study investigates the impact of pore geometry on cellular response, specifically in terms of osteogenesis and angiogenesis. The results show that triangular pores can enhance osteogenic differentiation and promote angiogenesis. The findings contribute to the understanding of the interaction between orthopedic implants and cells.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Guofeng Wu, Fenbo Ma, Zhengwei Liu, Jiayi Liu, Yizhebang Xue, Mengdi Zhang, Chunyi Wen, Bin Tang, Lijun Lin
Summary: The alteration of extracellular matrix (ECM) homeostasis is crucial in the development of osteoarthritis (OA). This study developed magnesium-containing glycosaminoglycans (Mg-GAGs) to improve ECM conditions, promote cartilage regeneration, and alleviate OA. The results showed positive effects of Mg-GAGs on chondrocyte proliferation, upregulating chondrogenic genes, suppressing inflammation, and protecting subchondral bone in an OA rabbit model. This study provides new insights into ECM-based therapies and novel approaches for OA treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Orthopedics
Hong-An Zhang, Chun-Hao Zhou, Xiang-Qing Meng, Jia Fang, Cheng-He Qin
BMC MUSCULOSKELETAL DISORDERS
(2020)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)
