Identification of a metabolic disposal route for the oncometaboliteS-(2-succino)cysteine inBacillus subtilis

Discovery of a widespread prokaryotic 5-oxoprolinase that was hiding in plain sight

(2017) Thomas D. Niehaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

(2017) Julie Adam et al.   Cell Reports

Construction and Analysis of Two Genome-Scale Deletion Libraries for Bacillus subtilis

(2017) Byoung-Mo Koo et al.   Cell Systems

A computational analysis of S-(2-succino)cysteine sites in proteins

(2016) Gianluca Miglio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome

(2015) Gerardo G. Piroli et al.   MOLECULAR & CELLULAR PROTEOMICS

MS-DIAL: data-independent MS/MS deconvolution for comprehensive metabolome analysis

(2015) Hiroshi Tsugawa et al.   NATURE METHODS

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors

(2015) Attje S. Hoekstra et al.   Oncotarget

Identification of protein succination as a novel modification of tubulin

(2014) Gerardo G. Piroli et al.   BIOCHEMICAL JOURNAL

Identification of host genes that affect acquisition of an integrative and conjugative element inBacillus subtilis

(2014) Christopher M. Johnson et al.   MOLECULAR MICROBIOLOGY

The Free Radical Theory of Aging Is Dead. Long Live the Damage Theory!

(2013) Vadim N. Gladyshev   ANTIOXIDANTS & REDOX SIGNALING

Monitoring bacterial growth using tunable resistive pulse sensing with a pore-based technique

(2013) Allen C. S. Yu et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Paralogous metabolism: S-alkyl-cysteine degradation inBacillus subtilis

(2013) Che-Man Chan et al.   ENVIRONMENTAL MICROBIOLOGY

Identification and characterization of serine acetyltransferase encoded by the Mycobacterium tuberculosis Rv2335 gene

(2013) JUANJUAN QIU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Crystallographic Study To Determine the Substrate Specificity of an L-Serine-Acetylating Enzyme Found in the D-Cycloserine Biosynthetic Pathway

(2013) K. Oda et al.   JOURNAL OF BACTERIOLOGY

Oncometabolites: linking altered metabolism with cancer

(2013) Ming Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

The succinated proteome

(2013) Eric D. Merkley et al.   MASS SPECTROMETRY REVIEWS

Uterine smooth muscle tumors with features suggesting fumarate hydratase aberration: detailed morphologic analysis and correlation with S-(2-succino)-cysteine immunohistochemistry

(2013) Carolina Reyes et al.   MODERN PATHOLOGY

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Metabolite damage and its repair or pre-emption

(2013) Carole L Linster et al.   Nature Chemical Biology

Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency

(2013) Nicola Ternette et al.   Cell Reports

Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity

(2012) Norma Frizzell et al.   BIOCHEMICAL JOURNAL

A fast, lock-free approach for efficient parallel counting of occurrences of k-mers

(2011) Guillaume Marçais et al.   BIOINFORMATICS

Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling

(2011) Julie Adam et al.   CANCER CELL

Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

(2011) Chiara Bardella et al.   JOURNAL OF PATHOLOGY

Tissue Distribution of S-(2-Succino)cysteine (2SC), a Biomarker of Mitochondrial Stress in Obesity and Diabetes

(2011) Sonia A. Thomas et al.   Obesity

A high-throughput colorimetric assay to characterize the enzyme kinetic and cellular activity of spermidine/spermine N1-acetyltransferase 1

(2010) Han-Jia Lin et al.   ANALYTICAL BIOCHEMISTRY

Succination of proteins in diabetes

(2010) Norma Frizzell et al.   FREE RADICAL RESEARCH

Cells need safety valves

(2009) Antoine Danchin   BIOESSAYS

Succination of Thiol Groups in Adipose Tissue Proteins in Diabetes

(2009) Norma Frizzell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succination of Proteins by Fumarate

(2008) Matthew Blatnik et al.   Annals of the New York Academy of Sciences