Specific bioactive collagen peptides (PETAGILE®) as supplement for horses with osteoarthritis: A two-centred study

The aim of the study was to evaluate the clinical efficacy of specific bioactive collagen peptides (BCP), here administered orally as PETAGILE((R)), on horses with mild to moderate, naturally occurring osteoarthritis. Data from a two-centred pilot study were used for the meta-analysis. Thirty-eight privately owned horses of various breeds were available. In one centre, 18 of these patients (6 +/- 3years; 519 +/- 100kg BW) received either 25g (n=6) or 50g (n=12) BCP/day orally for 12weeks. In the second centre, 20 horses (18 +/- 4years; 413 +/- 94kg BW) received either a placebo (control; n=10) or 25g BCP/day. The attending veterinarians performed an orthopaedic examination including flexion tests and evaluated the degree of lameness, rotation pain, step length and arc of foot flight during trot (8 parameters) at the beginning and after 6 and 12weeks. The horse owners answered a weekly questionnaire about their perception of lameness, mobility and the horses' willingness to run. In the 50g BCP group, in six of eight parameters, a strong effect (Cohen's r>.5) was detected with two parameters (lameness and flexion pain) significantly improved already after 6weeks. In the 25g BCP group, a moderate effect (Cohen's r=.3-0.5) was seen in six parameters, with three parameters improved already after 6weeks. The owners reported a strong effect for mobility and willingness to run (Cohen's r=.69 and .62, respectively) and a moderate effect (Cohen's r=.49 and 0.41) for the development of lameness in the 50g and 25g BCP group in comparison with the placebo treatment. This study revealed promising effects of the safe oral-specific BCP supplementation on symptoms of osteoarthritis in horses already after 3months. The higher dosage of 50g BCP/day had superior impact. Further long-term investigations on specific BCP efficacy in horses with osteoarthritis, preferably in blinded and placebo-controlled studies, should be performed to confirm these first positive results.