Review
Biochemistry & Molecular Biology
Ziwei Ouyang, Lei Dong, Feng Yao, Ke Wang, Yong Chen, Shufang Li, Renpeng Zhou, Yingjie Zhao, Wei Hu
Summary: Collagen plays an important role in maintaining the mechanical properties of articular cartilage and the stability of the extracellular matrix. The degradation of collagen is involved in the progressive destruction of cartilage in diseases such osteoarthritis and rheumatoid arthritis. Collagen degradation can generate new biochemical markers and collagen can also be used as a biomaterial with excellent properties. This review provides a comprehensive understanding of collagen and its role in cartilage repair, offering insights and techniques for clinical diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yue Fan, Dalong Gao, Yingang Zhang, Jiaqiang Zhu, Feng Zhang, Lu Wang, Yan Wen, Xiong Guo, Shiquan Sun
Summary: Kashin-Beck disease (KBD) and osteoarthritis (OA) exhibit significant differences in molecular mechanisms, with KBD-associated DMRs having a higher proportion than OA-associated DMRs, and genes related to cartilage/skeletal processes are enriched in skeletal system and limb-associated pathways.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Mehdi Najar, Sami G. Alsabri, Gadid G. Guedi, Makram Merimi, Frederic Lavoie, Detlev Grabs, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi
Summary: This study explored the transcriptional regulation of the prostaglandin D2 receptor DP1 in cartilage and found that the transcription factor Sp1 and DNA methylation play important roles in DP1 expression. Additionally, it was discovered that the methylation status and expression level of DP1 remain unchanged in osteoarthritis cartilage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Md Shafiullah Shajib, Kathryn Futrega, Travis Jacob Klein, Ross W. Crawford, Michael Robert Doran
Summary: Achieving high-quality integration between repair tissue and native cartilage is a major challenge in cartilage defect repair. Enzyme treatment of the tissue interface has been explored to facilitate remodeling and integration, but simpler models are needed to evaluate its effectiveness.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Chemistry, Medicinal
Zara Ahmed, Lydia C. Powell, Navid Matin, Andrew Mearns-Spragg, Catherine A. Thornton, Ilyas M. Khan, Lewis W. Francis
Summary: The study found that jellyfish collagen exhibited comparable scaffold structural properties and stability to mammalian collagen, and showed similar immunogenic responses in vitro. Jellyfish collagen supported invasion of bovine chondroprogenitor cells in scaffold structures, promoting chondrogenesis in the presence of TGF beta 1, highlighting its potential as a safe and biocompatible biomaterial.
Article
Cell Biology
Sami G. Alsabri, Gadid G. Guedi, Mehdi Najar, Makram Merimi, Frederic Lavoie, Detlev Grabs, Julio Fernandes, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Mohamed Benderdour, Hassan Fahmi
Summary: The expression level of 15-LOX-1 is elevated in osteoarthritis (OA) cartilage, but it is not associated with the methylation status of its promoter.
INFLAMMATION RESEARCH
(2023)
Review
Biology
Hope C. Ball, Andrew L. Alejo, Trinity K. Samson, Amanda M. Alejo, Fayez F. Safadi
Summary: This review provides an updated overview of the epigenetic factors involved in osteoarthritis, discussing their impact on the onset and development of the disease, and exploring current therapeutic options targeting aberrant epigenetic regulation.
Article
Food Science & Technology
Chengcheng Ma, Mingxiao Yu, Zhoujin Huang, Jingfeng Wang, Xue Zhao, Chunmei Kang, Hao Xu, Yanchao Wang, Hu Hou
Summary: The study demonstrates that administration of chicken sternal cartilage hydrolysates (CCH) can effectively prevent osteoarthritis by inhibiting abnormal subchondral bone formation, preventing osteophyte formation, and ameliorating cartilage damage through improving collagen metabolism.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Review
Cell Biology
Francesca Veronesi, Viviana Costa, Daniele Bellavia, Valentina Basoli, Gianluca Giavaresi
Summary: Osteoarthritis (OA) is a joint disorder characterized by cartilage degeneration, chondrocyte hypertrophy, apoptosis, and inflammation. The identification of specific biomarkers for OA is an urgent need in clinical practice. The role of microRNAs (miRNAs) in OA has been investigated, and it has been found that the epigenetic regulation of miRNA methylation plays a significant role in OA progression. Future research should focus on understanding the mechanism by which different epigenetic modifications of miRNAs drive the aggressiveness of OA.
Article
Orthopedics
Tomoyuki Kamenaga, Jie Shen, May Wu, Robert H. H. Brophy, John C. C. Clohisy, Regis J. J. O'Keefe, Cecilia Pascual-Garrido
Summary: This study examined the catabolic state of articular chondrocytes and the expression of DNMT3B and ABAT during the progression of osteoarthritis (OA) in hip femoroacetabular impingement (FAI). The findings showed that early-FAI and late-FAI-OA patients exhibited a histological OA phenotype and increased expression of catabolic markers. DNMT3B was underexpressed and ABAT was overexpressed in advanced disease. IL1 beta stimulus further accentuated catabolic marker overexpression through ABAT promoter hypomethylation, while TGF beta normalized these alterations. Suppression of ABAT through methylation control could be a potential therapeutic target for preventing OA progression in hip FAI.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Orthopedics
Benjamin Andress, Jason H. Kim, Hattie C. Cutcliffe, Annunziato Amendola, Adam P. Goode, Shyni Varghese, Louis E. DeFrate, Amy L. McNulty
Summary: The study established baseline expression profiles and dedifferentiation patterns of inner and outer zone primary meniscus cells, and evaluated the utility of PEGDA and GelMA polymer hydrogels to reverse dedifferentiation trends for long-term meniscus cell culture. The results showed that expression levels of meniscus cell phenotype genes were significantly modulated by varying the ratio of polymer components in the hydrogels, allowing for tunable materials for phenotype restoration, meniscus cell culture, and tissue engineering applications.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Engineering, Biomedical
Mathaeus Tschaikowsky, Sofia Brander, Vanessa Barth, Ralf Thomann, Bernd Rolauffs, Bizan N. Balzer, Thorsten Hugel
Summary: This study reveals changes in the thickness and composition of collagen fibers at the onset of osteoarthritis. Fibrocartilage-like tissue rich in type I collagen is formed in intact cartilage during the early stages of the disease, while thick fibers are completely absent in advanced osteoarthritis. The findings provide insights into the understanding of other native biological tissues and the development of sustainable biomaterials.
ACTA BIOMATERIALIA
(2022)
Article
Environmental Sciences
Zhuang Ke, Shen Wang, Wenqi Zhu, Fu Zhang, Wenjing Qiao, Jiandong Jiang, Kai Chen
Summary: This study demonstrates the efficient removal of triclocarban from wastewater using genetic bioaugmentation with Pseudomonas putida KT2440, which harbors a transferable triclocarban-catabolic plasmid. The study also provides insights into the horizontal transfer and proliferation of the plasmid in the wastewater bacterial community, and identifies potential recipients of the plasmid in the community. Isolation of transconjugants with triclocarban-degrading abilities further confirms the effectiveness of the bioaugmentation method.
ENVIRONMENTAL RESEARCH
(2022)
Article
Orthopedics
Emma N. Luke, Pahweenvaj Ratnatilaka Na Bhuket, Seungju M. Yu, Jeffrey A. Weiss
Summary: The objective of this study was to investigate the potential of collagen hybridizing peptides (CHPs) to extend the retention time of near-infrared fluorophores (NIRF) following intra-articular injection in rat knee joints. The study found that CHPs were retained within the joint for the full study period and significantly extended the retention time of NIRFs by binding to multiple collagenous tissues in the joint. These results support further research to develop CHP based therapeutics for the treatment of osteoarthritis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Medicine, General & Internal
Xiaowei Zhang, Shili Wu, Yong Zhu, Cong-Qiu Chu
Summary: The long-term in vivo study demonstrated that scSOX9 in combination with microfracture could induce reparative tissue with features of hyaline cartilage, showing durable effects in the prevention of progression to osteoarthritis in a rabbit model.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Fu Li, Minghua Lei, Junye Xie, Shujun Guo, Weicai Li, Xiujuan Ren, Teng Wang, Songxiong Lin, Qiuling Xie, Xiaojia Chen
Summary: In this study, degradation experiments were conducted on a peptide called SAIF, derived from sharks. A truncated peptide sequence was identified from the degradation fragments and expressed as a novel cyclic peptide called ctSAIF. ctSAIF demonstrated high anti-HCC activity, enhanced enzymatic stability, and showed antitumor activity and good biocompatibility in a HCC xenograft model. This study discovered and characterized a shark-derived cyclic peptide with antitumor activity, laying a foundation for its development as an antitumor drug candidate, and providing a new solution for peptide drug development.
BIOENGINEERING-BASEL
(2023)
Article
Engineering, Environmental
Shun-Shun Chen, Xu-Xiu Chen, Tian-Yu Yang, Li Chen, Zheng Guo, Xing-Jiu Huang
Summary: A temperature-modulated sensing strategy was proposed to identify and determine BTEX compounds. Highly effective identification of BTEX was achieved using linear discrimination and convolutional neural network analyses. Additionally, quantitative analysis of concentration was accomplished by establishing the relationship between concentration and response.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Myungkyung Noh, Jeong Yeon Sim, Jisung Kim, Jee Hwan Ahn, Hye-Young Min, Jong-Uk Lee, Jong-Sook Park, Ji Yun Jeong, Jae Young Lee, Shin Yup Lee, Hyo-Jong Lee, Choon-Sik Park, Ho-Young Lee
Summary: This study reveals that chronic exposure to PM induces chronic inflammation and development of COPD by dysregulating NAD+ metabolism and subsequent SIRT1 deficiency in pulmonary macrophages. Activation of SIRT1 by resveratrol effectively mitigates PM-induced inflammation and COPD development. Targeting metabolic and epigenetic reprogramming in macrophages induced by PM is a promising strategy for COPD treatment.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Yu Liu, Linlin Qin, Yiming Qin, Tong Yang, Haoran Lu, Yulong Liu, Qiqi Zhang, Wenyan Liang
Summary: Co/NC/PAC electrode was prepared by compounding ZIF-67 with powder-activated carbon for the electrocatalytic treatment of nitrogen-containing heterocyclic compounds. The degradation efficiency of the four compounds reached 90.2-93.7% under optimal conditions, and the degradation order was pyridazine < pyrimidine < pyrazine < pyridine.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Julien Couturier, Pierre Tamba Oulare, Blanche Collin, Claire Lallemand, Isabelle Kieffer, Julien Longerey, Perrine Chaurand, Jerome Rose, Daniel Borschneck, Bernard Angeletti, Steven Criquet, Renaud Podor, Hamed Pourkhorsandi, Guilhem Arrachart, Clement Levard
Summary: This study analyzes the properties of bauxite residue samples and explores the influence of bauxite ore origin, storage conditions, and storage time. The results show that the speciation of yttrium is related to the origin of bauxite ore, while no significant variation was observed with storage conditions or aging of the residues.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Sakthinarenderan Saikumar, Ravi Mani, Mirunalini Ganesan, Inbakandan Dhinakarasamy, Thavamani Palanisami, Dharani Gopal
Summary: Microplastic contamination in marine ecosystems poses a growing concern due to its trophic transfer and negative effects on marine organisms. This study investigates the transfer and impacts of polystyrene microplastics in an estuarine food chain. The results show that microplastics can be transferred through the food chain, although the transfer rates are low. The exposed organisms exhibit stress responses, suggesting the potential risk of microplastics reaching humans through the food chain.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Review
Engineering, Environmental
Yan-Jiao Li, Ying Yuan, Wen-Bing Tan, Bei-Dou Xi, Hui Wang, Kun-Long Hui, Jia-Bao Chen, Yi-Fan Zhang, Lian-Feng Wang, Ren-Fei Li
Summary: This review investigated and analyzed the distribution, composition, and abundance of heavy metals and antibiotic resistance genes (ARGs) in landfill. The results showed that heavy metals have lasting effects on ARGs, and complexes of heavy metals and organic matter are common in landfill. This study provides a new basis to better understand the horizontal gene transfer (HGT) of ARGs in landfill.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Jessy Joseph, Ari Vaisanen, Ajay B. Patil, Manu Lahtinen
Summary: Efficient and environmentally friendly porous hybrid adsorbent beads have been developed for the removal of arsenic from drinking water. The structural tuning of the adsorbents has been shown to have a significant impact on their adsorption performance, with high crystallinity leading to increased adsorption capacity and selectivity towards As5+.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Yangyang Liu, Minhua Xiao, Kaiqin Huang, Juntao Cui, Hongli Liu, Yingxin Yu, Shengtao Ma, Xihong Liu, Meiqing Lin
Summary: This study measured the levels of phthalate metabolites in breast milk collected from mothers in southern China. The results showed that phthalates are still prevalent in the region, and breastfeeding contributes to phthalate intake in infants. However, the levels detected do not pose significant health risks to infants based on dietary exposure. The increasing exposure to certain phthalates calls for further research into their sources and potential risks.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Zhiqiang Wu, Jianxing Sun, Liting Xu, Hongbo Zhou, Haina Cheng, Zhu Chen, Yuguang Wang, Jichao Yang
Summary: Ocean depth affects microbial diversity, composition, and co-occurrence patterns of microplastic microbial communities. Deterministic processes dominate the assembly of mesopelagic plastisphere microbial communities, while stochastic processes shape the assembly of bathypelagic microbial communities. The relationships between microorganisms in the mesopelagic layer are more complex and stable, with Proteobacteria and Actinobacteriota playing important roles.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Tingting Xiao, Renjie Chen, Chen Cai, Shijie Yuan, Xiaohu Dai, Bin Dong, Zuxin Xu
Summary: Based on the efficiency of catalytic ozonation techniques in enhancing sludge dewaterability, this study investigated its effectiveness in simultaneous reduction of antibiotics and antibiotic resistance genes. The results showed that catalytic ozonation conditioning changed the distribution of antibiotics and achieved high degradation rates. It also significantly reduced the abundance of ARGs, inhibited horizontal gene transfer, and decreased the signal transduction of typical ARGs host bacteria.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Yang Deng, Xiaohong Guan
Summary: This article discusses two different development approaches for ferrate(VI) technology in water treatment, arguing that process integration is a promising method that can drive technological innovation and revolution in water treatment, achieving higher treatment efficiency, reduced costs and energy consumption, and a smaller physical footprint.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Zhe Zhang, Lu Zhang, Zhihao Huang, Yuxin Xu, Qingqing Zhao, Hongju Wang, Meiqing Shi, Xiangnan Li, Kai Jiang, Dapeng Wu
Summary: In this study, a floating catalytic foam was designed and prepared to enhance the mass transfer in immobilized photocatalysts for wastewater treatment. The floating catalytic foam could float on the water surface and establish a temperature gradient, effectively promoting the diffusion and adsorption of target molecules during the photocatalytic process.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Muhammad Nafees, Adiba Khan Sehrish, Sarah Owdah Alomrani, Linlin Qiu, Aasim Saeed, Shoaib Ahmad, Shafaqat Ali, Hongyan Guo
Summary: The accumulation of cadmium and antibiotics in edible plants and fertile soil is a worldwide problem. This study investigated the potential of zinc oxide nanoparticles to alleviate the toxicity of both cadmium and antibiotics and promote spinach growth.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Lurui Wan, Kai Wang, Yuan Chen, Zhiyong Xu, Wenbo Zhao
Summary: In this study, a low viscosity and high thermal stability SO2 absorbent with dual interacting sites was successfully synthesized. The absorbent showed the highest absorption enthalpy change and entropy change values among reported SO2 absorbents, and exhibited lower viscosity and comparable thermal stability to ILs.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Engineering, Environmental
Zhengwei Zhou, Guojie Ye, Yang Zong, Zhenyu Zhao, Deli Wu
Summary: This study utilized Mo powder and STPP to enhance the performance of the sodium percarbonate system in pollutant degradation. The presence of Mo and STPP resulted in a higher degradation rate of the model pollutant SMX, with low oxidant consumption. The system generated multiple active species through a series of chain reactions at different pH values, exhibiting excellent performance towards electron-rich pollutants. Furthermore, Mo demonstrated excellent stability and reusability.
JOURNAL OF HAZARDOUS MATERIALS
(2024)