ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

(2018) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain Pericytes ABCA1 Expression Mediates Cholesterol Efflux but not Cellular Amyloid-β Peptide Accumulation

(2018) Julien Saint-Pol et al.   JOURNAL OF ALZHEIMERS DISEASE

ABCG2- and ABCG4-Mediated Efflux of Amyloid-β Peptide 1-40 at the Mouse Blood-Brain Barrier

(2018) Tuan Minh Do et al.   JOURNAL OF ALZHEIMERS DISEASE

Disease-Induced Alterations in Brain Drug Transporters in Animal Models of Alzheimer’s Disease

(2017) Kati-Sisko Vellonen et al.   PHARMACEUTICAL RESEARCH

Apical-to-Basolateral Transport of Amyloid-β Peptides through Blood-Brain Barrier Cells is Mediated by the Receptor for Advanced Glycation End-Products and is Restricted by P-Glycoprotein

(2017) Pietra Candela et al.   JOURNAL OF ALZHEIMERS DISEASE

Expression and function of Abcg4 in the mouse blood-brain barrier: role in restricting the brain entry of amyloid-β peptide

(2017) Agnès Dodacki et al.   Scientific Reports

Abca7 deletion does not affect adult neurogenesis in the mouse

(2016) H. Li et al.   BIOSCIENCE REPORTS

Imbalanced cholesterol metabolism in Alzheimer's disease

(2016) Zhao Xue-shan et al.   CLINICA CHIMICA ACTA

ABCA7 Mediates Phagocytic Clearance of Amyloid-β in the Brain

(2016) YuHong Fu et al.   JOURNAL OF ALZHEIMERS DISEASE

Modulation of Amyloid-β1–40 Transport by ApoA1 and ApoJ Across an in vitro Model of the Blood-Brain Barrier

(2016) Cristina Merino-Zamorano et al.   JOURNAL OF ALZHEIMERS DISEASE

ABCA7 Deficiency Accelerates Amyloid-β Generation and Alzheimer's Neuronal Pathology

(2016) Nobutaka Sakae et al.   JOURNAL OF NEUROSCIENCE

Loss of Mrp1 Potentiates Doxorubicin-Induced Cytotoxicity in Neonatal Mouse Cardiomyocytes and Cardiac Fibroblasts

(2016) Wei Zhang et al.   TOXICOLOGICAL SCIENCES

β-Cyclodextrins Decrease Cholesterol Release and ABC-Associated Transporter Expression in Smooth Muscle Cells and Aortic Endothelial Cells

(2016) Caroline Coisne et al.   Frontiers in Physiology

The impairment of cholesterol metabolism in Huntington disease

(2015) Valerio Leoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

In vitro discrimination of the role of LRP1 at the BBB cellular level: Focus on brain capillary endothelial cells and brain pericytes

(2015) Pietra Candela et al.   BRAIN RESEARCH

ATP-binding Cassette Transporter A7 (ABCA7) Loss of Function Alters Alzheimer Amyloid Processing

(2015) Kanayo Satoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease

(2015) Stacy Steinberg et al.   NATURE GENETICS

27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain

(2015) D.-D. Zhang et al.   NEUROSCIENCE

Oxysterols decrease apical-to-basolateral transport of Aß peptides via an ABCB1-mediated process in an in vitro Blood-brain barrier model constituted of bovine brain capillary endothelial cells

(2013) Julien Saint-Pol et al.   BRAIN RESEARCH

Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier

(2013) Fabien Gosselet et al.   Current Alzheimer Research

Dyslipidemia and the Risk of Alzheimer’s Disease

(2013) Christiane Reitz   Current Atherosclerosis Reports

Deletion of Abca7 Increases Cerebral Amyloid-  Accumulation in the J20 Mouse Model of Alzheimer's Disease

(2013) W. S. Kim et al.   JOURNAL OF NEUROSCIENCE

Transient oxygen–glucose deprivation sensitizes brain capillary endothelial cells to rtPA at 4h of reoxygenation

(2013) Mélanie Kuntz et al.   MICROVASCULAR RESEARCH

Apolipoprotéine E et intégrité de la barrière hémato-encéphalique

(2012) Fabien Gosselet   M S-MEDECINE SCIENCES

Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood–Brain Barrier Model

(2012) Sumio Ohtsuki et al.   MOLECULAR PHARMACEUTICS

Correction: Effects of Deletion of Macrophage ABCA7 on Lipid Metabolism and the Development of Atherosclerosis in the Presence and Absence of ABCA1

(2012) Illiana Meurs et al.   PLoS One

Role of Abca7 in Mouse Behaviours Relevant to Neurodegenerative Diseases

(2012) Warren Logge et al.   PLoS One

Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice

(2011) Markus Krohn et al.   JOURNAL OF CLINICAL INVESTIGATION

Pitavastatin Increases ABCA1 Expression by Dual Mechanisms: SREBP2-Driven Transcriptional Activation and PPARα-Dependent Protein Stabilization but Without Activating LXR in Rat Hepatoma McARH7777 Cells

(2011) Takashi Maejima et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Direct evidence of abca1-mediated efflux of cholesterol at the mouse blood–brain barrier

(2011) Tuan Minh Do et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-  in a Mouse Model of Alzheimer's Disease

(2010) A. M. S. Hartz et al.   MOLECULAR PHARMACOLOGY

LRP1 mediates bidirectional transcytosis of amyloid-β across the blood-brain barrier

(2010) Thorsten Pflanzner et al.   NEUROBIOLOGY OF AGING

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Peroxisome Proliferator-Activated Receptor-α Activation Protects Brain Capillary Endothelial Cells from Oxygen-Glucose Deprivation-Induced Hyperpermeability in the Blood-Brain Barrier

(2009) Caroline Mysiorek et al.   CURRENT NEUROVASCULAR RESEARCH

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

P-Glycoprotein and Breast Cancer Resistance Protein Restrict Apical-to-Basolateral Permeability of Human Brain Endothelium to Amyloid-β

(2009) Leon M Tai et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease

(2009) Ian J. Martins et al.   JOURNAL OF NEUROCHEMISTRY

ABCG2 Is Upregulated in Alzheimer's Brain with Cerebral Amyloid Angiopathy and May Act as a Gatekeeper at the Blood-Brain Barrier for A 1-40 Peptides

(2009) H. Xiong et al.   JOURNAL OF NEUROSCIENCE

Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function

(2009) J. M. Karasinska et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Transcriptional profiles of receptors and transporters involved in brain cholesterol homeostasis at the blood–brain barrier: Use of an in vitro model

(2008) Fabien Gosselet et al.   BRAIN RESEARCH

ATP-binding cassette transporter A7 regulates processing of amyloid precursor proteinin vitro

(2008) Sharon L. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Role of ATP-binding cassette transporters in brain lipid transport and neurological disease

(2008) Woojin Scott Kim et al.   JOURNAL OF NEUROCHEMISTRY

ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

(2007) Nan Wang et al.   FASEB JOURNAL