Review
Biochemistry & Molecular Biology
Latifa Alketbi, Abeer Al-Ali, Iman M. Talaat, Qutayba Hamid, Khuloud Bajbouj
Summary: Colorectal cancer (CRC) is a common malignancy worldwide, ranked fourth in cancer-related deaths. Mutations in oncogenes, tumor suppressor genes, and DNA repair genes contribute to the development of CRC. Chemoresistance is one of the major challenges in CRC treatment, and the overexpression of ATP-binding cassette (ABC) transporters has been identified as a facilitating mechanism for chemoresistance. ABC transporters are involved in lipid transport and homeostasis, which play a crucial role in tumor development and progression. Altered expression of ABCA transporters in CRC is associated with poor prognosis and overall survival. This minireview suggests that ABCA transporters could serve as potential diagnostic and therapeutic targets in CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Daniela Passarella, Maurizio Ronci, Valentina Di Liberto, Mariachiara Zuccarini, Giuseppa Mudo, Carola Porcile, Monica Frinchi, Patrizia Di Iorio, Henning Ulrich, Claudio Russo
Summary: Recent studies have found that cerebral cholesterol formation is primarily controlled by astrocytes, which synthesize cholesterol and deliver it to neurons and oligodendrocytes through specific lipoprotein receptors. Various proteins and carbohydrates modulate the cholesterol shuttle, affecting lipoprotein receptor activity, function, and signaling. Purine receptors, particularly subtypes P2Y(2), P2X(7), and A(2A), play a role in neurodegenerative diseases such as Alzheimer's and Niemann-Pick C diseases by regulating brain cholesterol homeostasis. The precise mechanisms of these interactions are not well understood, but further research in the cholesterol-purine reciprocal control is warranted.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Kelly M. Stanton, Vivian Kienzle, Donna Lee M. Dinnes, Irina Kotchetkov, Wendy Jessup, Leonard Kritharides, David S. Celermajer, Kerry-Anne Rye
Summary: Exercise is associated with a reduced risk of cardiovascular disease, with increased HDL-C levels playing a key role. Controlled studies show that moderate intensity exercise improves HDL function, lipid/lipoprotein profile, fitness, and body composition. A sequential moderate followed by high-intensity exercise program yields sustained or incremental benefits in these parameters.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Hong Y. Choi, Isabelle Ruel, Shiwon Choi, Jacques Genest
Summary: Comparison of THP-1 macrophage subtypes with varying degrees of differentiation provided new insights into cholesterol metabolism and identified DSC1 as a viable target for promoting cholesterol efflux in differentiated macrophages. Pharmacological strategies targeting DSC1, such as docetaxel, may hold significant potential for reducing atherogenic cholesterol deposition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Medicinal
Yingnan Zhao, Yanping Li, Qinhui Liu, Qin Tang, Zijing Zhang, Jinhang Zhang, Cuiyuan Huang, Hui Huang, Guorong Zhang, Jian Zhou, Jiamin Yan, Yan Xia, Zhiyong Zhang, Jinhan He
Summary: The research shows that Cana can facilitate cholesterol efflux in the liver and intestine by activating AMPK to increase the expression of ABC transporters ABCG5 and ABCG8, leading to increased biliary and fecal cholesterol excretion. This may be a partial reason for improving cardiovascular disease.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Silpa Narayanan, Nehaben A. Gujarati, Jing-Quan Wang, Zhuo-Xun Wu, Jagadish Koya, Qingbin Cui, Vijaya L. Korlipara, Charles R. Ashby, Zhe-Sheng Chen
Summary: The study showed that the novel benzamide derivative VKNG-2 can reverse MDR caused by overexpression of ABCG2 transporter in colon cancer cells; VKNG-2 significantly improves the efficacy of anticancer drugs in vitro and works by inhibiting the efflux function of the ABCG2 transporter.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Zhijuan Liang, Wei Jiao, Liping Wang, Yuanbin Chen, Dan Li, Zhao Zhang, Zhilei Zhang, Ye Liang, Haitao Niu
Summary: CYP27A1 plays a regulatory role in the proliferation and migration of ccRCC, by activating LXRs/ABCA1 to regulate cholesterol homeostasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Meekha George, Magdalena Lang, Chaitanya Chakravarthi Gali, Joshua Adekunle Babalola, Carmen Tam-Amersdorfer, Anika Stracke, Herbert Strobl, Robert Zimmermann, Ute Panzenboeck, Christian Wadsack
Summary: Oxysterols, such as 7-ketocholesterol and 7 beta-hydroxycholesterol, contribute to placental inflammation by activating TLR-4 signaling. Activation of LXR reduces the inflammatory response induced by oxysterols in fetal placental endothelial cells.
Article
Public, Environmental & Occupational Health
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Shoaib Afzal, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: Genetic variants in ABCA1 associated with high HDL cholesterol concentrations are also associated with higher risk of AMD, suggesting a role for ABCA1 in AMD pathogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Patrick T. Ronaldson, Thomas P. Davis
Summary: Ischemic stroke is a major cause of morbidity and mortality globally. Despite positive results in preclinical studies, only one compound has advanced to Phase III clinical trial evaluation. This may be due to the neglect of transport mechanisms at the blood-brain barrier and neurovascular unit. This review highlights the role of BBB transporters in drug delivery and their expression in different brain cell types.
Article
Biology
Hanzhi Zhang, Ching-Shin Huang, Xinchao Yu, Jonas Lee, Amit Vaish, Qing Chen, Mingyue Zhou, Zhulun Wang, Xiaoshan Min
Summary: The study presents the cryo-EM structure of ABC transporters ABCG5/G8 with Fab fragments from two monoclonal antibodies, providing insights into the transport cycle and potential therapeutic interventions. The high-resolution structure reveals a unique dimer interface and novel epitopes for potential therapeutic interventions.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Sukriti Sacher, Abhishek Mukherjee, Arjun Ray
Summary: Atherosclerosis is a major cause of cardiovascular disease, and cholesterol-loaded foam cells play a crucial role in the formation of atherosclerotic plaques. Efforts to induce cholesterol efflux and reverse cholesterol transport (RCT) as a treatment for CVD have been unsuccessful due to a lack of understanding about the relationship between HDL function and RCT. This review examines the structure-function relationships and genetic mutations that impact RCT, highlighting the need for further studies.
BIOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Jing Ge, Yan Huang, MeiWei Lv, Cong Zhang, Milton Talukder, JinYang Li, JinLong Li
Summary: Cadmium is a toxic heavy metal that poses a threat to food safety and human health. This study investigated the mechanisms of cadmium-induced kidney damage and the detoxification response. The results showed that cadmium exposure caused renal injuries and affected detoxification enzyme activities. These findings contribute to our understanding of the toxicity and detoxification mechanisms of cadmium.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Jinfan Liu, Lu Fu, Fei Yin, Li Yin, Xiaomei Song, Hong Guo, Jianhui Liu
Summary: Crohn's disease (CD) is a chronic inflammatory bowel disease caused by dysfunction in the barrier function formed by polarized monolayer of epithelial cells. Diosmetin has been found to increase cell viability, maintain barrier integrity, and decrease the protein content of ABCG2 in Caco-2 cells and CD mice. Mechanistically, diosmetin attenuates the phosphorylation of AMPK, PI3K/AKT, and CREB, while AMPK inhibitor prevents the effect of diosmetin on tight junction proteins. These findings suggest that diosmetin improves barrier dysfunction in CD through the AMPK/AKT/CREB-mediated expression of ABCG2.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Camille Tisnerat, Alexandra Dassonville-Klimpt, Fabien Gosselet, Pascal Sonnet
Summary: Malaria is a tropical disease caused by Plasmodium parasites, resulting in 409,000 deaths in 2019. The spread of drug resistant parasites from Southeast Asia has further complicated the mortality and morbidity. The emergence of artemisinin-resistant Plasmodium in Africa, where most cases occur, has highlighted the urgent need for new medicines. This review focuses on the ongoing search for new antimalarial drugs, particularly in terms of medicinal chemistry and the development of promising candidates in clinical and preclinical phases.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Camille Menaceur, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol
Summary: The construction and maintenance of the blood-brain barrier (BBB) relies on cell-cell communication processes between endothelial cells, pericytes, glial cells (mainly astrocytes), and neurons. Understanding these communication pathways is crucial for studying the physiology and pathophysiology of the BBB.
Article
Pharmacology & Pharmacy
Elisa L. J. Moya, Sonia M. Lombardo, Elodie Vandenhaute, Marc Schneider, Caroline Mysiorek, Akif E. Tuereli, Takashi Kanda, Fumitaka Shimizu, Yasuteru Sano, Nathalie Maubon, Fabien Gosselet, Nazende Guenday-Tuereli, Marie-Pierre Dehouck
Summary: In this study, functionalized polymeric nanoparticles coated with surfactants PS80 and P188 were tested on a human in vitro model to evaluate their uptake profiles and transport mechanisms in crossing the human blood-brain barrier. The results showed that both formulations were able to be internalized by the cells and exhibited different uptake profiles, making them potential drug delivery systems for crossing the blood-brain barrier.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Oncology
Sarah Trouvilliez, Julien Cicero, Romain Leveque, Leo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Volkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jerome de Ruyck, Veronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon
Summary: Our study revealed that CD44v3 forms a complex with TrkA in response to NGF stimulation in breast cancer, and a CD44v3 mimetic peptide can inhibit tumor growth and metastasis, suggesting a potential therapeutic option for triple-negative breast cancers.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Medicinal
Ophelie Da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, Caroline Coisne, Andre-Guilhem Calas, Fabien Gosselet, Charlotte Courageux, Anne-Julie Gastellier, Marilene Trancart, Rachid Baati, Marie-Pierre Dehouck, Ludovic Jean, Florian Nachon, Pierre-Yves Renard, Jose Dias
Summary: Recent events have highlighted the serious threat posed by organophosphorus nerve agents to civilian and military populations. This study proposes the use of glucoconjugated oximes without permanent charge as potential central nervous system reactivators, aiming to overcome the current limitations in therapy. The study evaluates the effectiveness of these compounds, their structural characteristics, and their permeability through the blood-brain barrier.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Toxicology
Sara Wellens, Fabien Gosselet, Maxime Culot
Summary: The blood-brain barrier is a tight barrier at the brain microvascular endothelial cells that restricts access to the brain. Human in vitro BBB models are needed to assess neurotoxicity and drug uptake in the brain. Different protocols for differentiating induced pluripotent stem cells into BBB cells have emerged in the past decade, but further characterization is important.
TOXICOLOGY IN VITRO
(2022)
Article
Cell Biology
Marie-Pierre Dehouck, Masanori Tachikawa, Yutaro Hoshi, Kotaro Omori, Claude-Alain Maurage, Guillaume Strecker, Lucie Dehouck, Marie-Christine Boucau, Yasuo Uchida, Fabien Gosselet, Tetsuya Terasaki, Yannis Karamanos
Summary: This study compared the protein expression levels of human brain-like endothelial cells (hBLECs) and human brain microvessels (hBMVs) using quantitative targeted absolute proteomics. The results showed that hBLECs had higher protein levels of CD144, CD147, MRP4, Annexin A6, and caveolin-1 compared to hBMVs, while the protein levels of MCT1, Connexin 43, TfR1, and claudin-5 were relatively lower. Furthermore, BCRP was found to be more expressed than MDR1 in hBLECs. These findings contribute to a better understanding of the characteristics of hBLECs and demonstrate the equivalence of in vitro BBB models with in vivo models in terms of transport properties.
Review
Biochemistry & Molecular Biology
Maria Abou Diwan, Marwa Lahimer, Veronique Bach, Fabien Gosselet, Hafida Khorsi-Cauet, Pietra Candela
Summary: Accumulating evidence suggests that chronic exposure to low levels of pesticides in the diet affects the gut-microbiota-blood-brain barrier axis. This axis describes the connection between the microbiota, intestinal barrier, and blood-brain barrier. Preclinical observations have shown that pesticides cause gut microbiota alteration, or dysbiosis, which is associated with gastrointestinal disorders and diseases affecting distant organs like the blood-brain barrier. However, the interaction between pesticides, microbiota, intestinal barrier, and blood-brain barrier is not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shiraz Dib, Rodrigo Azevedo Loiola, Emmanuel Sevin, Julien Saint-Pol, Fumitaka Shimizu, Takashi Kanda, Jens Pahnke, Fabien Gosselet
Summary: Neuroinflammation and brain lipid imbalances are observed in individuals with Alzheimer's disease. The tumor necrosis factor-a (TNFa) and liver X receptor (LXR) signaling pathways are involved in both processes, but their relationships in human brain pericytes (HBP) of the neurovascular unit are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Camille Menaceur, Johan Hachani, Shiraz Dib, Sophie Duban-Deweer, Yannis Karamanos, Fumitaka Shimizu, Takashi Kanda, Fabien Gosselet, Laurence Fenart, Julien Saint-Pol
Summary: This study investigates the proteome differences between brain pericytes (BPs) cultured alone (hBP-solo) and in co-culture with brain microvessel endothelial cells (ECs) (hBP-coc) to model the human blood-brain barrier (BBB) in vitro. The results show that hBP-solo has 51 proteins related to cell proliferation, contractility, adhesion, and extracellular matrix elements, indicating an immature cell state. On the other hand, hBP-coc has 90 proteins associated with reduced contractile activities and enhanced metabolic functions, particularly in mitochondrial activities and sterol metabolism, suggesting mature pericytes. This study highlights the role of ECs in promoting the maturation and metabolic switch of BPs during barriergenesis.
Article
Pharmacology & Pharmacy
Erik Melander, Camilla Eriksson, Sara Wellens, Kimia Hosseini, Robert Fredriksson, Fabien Gosselet, Maxime Culot, Ulf Goransson, Margareta Hammarlund-Udenaes, Irena Loryan
Summary: The blood-brain barrier poses challenges to drug delivery to the CNS. CD4, γδT cells, mononuclear phagocytes, mononuclear phagocytes-like antigen-presenting cells, NK cells, NKT cells, resident macrophage-like cells, and neutrophils in the CNS are mainly involved in the innate immune response, while B cells, macrophage-like cells, and T cells play a key role in the acquired immune response.The above findings suggest that cCPPs can serve as potential CNS drug delivery scaffolds, and the differences in their transport across the BBB and cellular uptake abilities are important factors to consider in the development of peptide-based drug delivery systems.
Review
Pharmacology & Pharmacy
Solene Masloh, Maxime Culot, Fabien Gosselet, Anne Chevrel, Leonardo Scapozza, Magali Zeisser Labouebe
Summary: Recombinant biological molecules, due to progress in biotechnology and understanding of subcellular processes, have become cutting-edge in biomedical research. They are increasingly used as drugs for various diseases. However, their limited bioavailability when orally delivered has led to the development of accurate models to determine their capacity to cross the intestinal mucosa. Additionally, strategies to enhance their intestinal permeability and stability have been explored.
Article
Biochemistry & Molecular Biology
Romain Versele, Emmanuel Sevin, Fabien Gosselet, Laurence Fenart, Pietra Candela
Summary: The blood-brain barrier is a crucial barrier for maintaining brain homeostasis, and cytokine-induced neuroinflammation may play a role in BBB dysfunction and contribute to the progression of Alzheimer's disease. Cytokines like TNF-alpha and IL-1 beta can modulate BBB permeability, leading to amyloid-beta peptide accumulation and potentially influencing the progression of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
