Article
Biochemistry & Molecular Biology
Roberta Dal Magro, Agostina Vitali, Stefano Fagioli, Alberto Casu, Andrea Falqui, Beatrice Formicola, Lorenzo Taiarol, Valeria Cassina, Claudia Adriana Marrano, Francesco Mantegazza, Umberto Anselmi-Tamburini, Patrizia Sommi, Francesca Re
Summary: Vascular oxidative stress exacerbates the progression of Alzheimer's disease, but antioxidant compounds like cerium oxide nanoparticles may help improve vascular function. CNP restored ROS levels and increased uptake in brain cells exposed to A beta, potentially offering protection against neurotoxicity.
Article
Hematology
Felecia M. Marottoli, Hui Zhang, Eden Flores-Barrera, Emilce Artur de la Villarmois, Frederick C. Damen, Anabel M. M. Miguelez Fernandez, Hannah V. Blesson, Rohan Chaudhary, Anthony L. Nguyen, Amanda E. Nwokeji, Ruju Talati, Ashwin S. John, Kushi Madadakere, Sarah E. Lutz, Kejia Cai, Kuei Y. Tseng, Leon M. Tai
Summary: The loss of endothelial cell APOE3 expression leads to neurovascular dysfunction and abnormalities in neural function. This finding supports the importance of endothelial cell APOE3 in neurovascular regulation, neural circuit function, and behavior.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Clinical Neurology
Dovile Poceviciute, Cristina Nunez-Diaz, Bodil Roth, Shorena Janelidze, Andreas Giannisis, Oskar Hansson, Malin Wennstrom
Summary: Alzheimer's disease is characterized by Aβ plaques, NFT, and neuroinflammation, but recent studies suggest that peripheral inflammation might also play a role. This study found that plasma IgA levels were higher in AD patients, especially in APOE ε4 non-carriers, and these levels were associated with cognitive decline and neuropathology. This suggests that the relationship between AD pathology and plasma IgA levels may be influenced by APOE allele status.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Ahmad Sait, Cristian Angeli, Andrew J. Doig, Philip J. R. Day
Summary: Alzheimer's disease is characterized by the presence of beta-amyloid plaques and neurofibrillary tangles in the brain. Despite the increasing prevalence, the causative agent for AD remains unknown. Evidence of pathogens in the brains of AD patients and controls exists, suggesting further investigation is needed to understand the relationship.
ACS CHEMICAL NEUROSCIENCE
(2021)
Review
Cell Biology
Yan-Li Zhang, Juan Wang, Zhi-Na Zhang, Qiang Su, Jun-Hong Guo
Summary: Neurovascular dysfunction plays an important role in the development and progression of chronic neurodegenerative processes in Alzheimer's disease. The blood-brain barrier (BBB) pathway is crucial for the clearance of amyloid-beta (A beta) in the brain, and endothelial cells are key players in A beta transport. Dysregulation of A beta clearance is considered the main reason for its accumulation in the brain. Understanding the interactions between A beta and brain capillary endothelial cells, including their receptors and transporters, may provide new therapeutic strategies for A beta clearance in Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Review
Cell Biology
Yan-Li Zhang, Juan Wang, Zhi-Na Zhang, Qiang Su, Jun-Hong Guo
Summary: Neurovascular dysfunction plays an important role in the onset and progression of Alzheimer's disease, and the blood-brain barrier pathway is a key pathway for amyloid-beta (Aβ) clearance in the brain. Brain capillary endothelial cells are crucial for Aβ clearance mediated by the blood-brain barrier. Dysregulation of Aβ clearance leads to its accumulation in the brain parenchyma. Understanding the interactions between Aβ and brain capillary endothelial cells and developing new therapeutic strategies could improve Aβ clearance in Alzheimer's disease.
NEURAL REGENERATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qian Yue, Xinhua Zhou, Zaijun Zhang, Maggie Pui Man Hoi
Summary: The study found that murine sA beta (1-42) oligomers had moderate toxicity on an endothelial and astrocyte co-culture, leading to endothelial barrier disruptions induced by deleterious soluble factors released from astrocytes which disrupted endothelial VEGFR2 signaling and perturbed cell survival and barrier stabilization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tao Sun, Qiaoqiao Shi, Yongzhi Zhang, Chanikarn Power, Camilla Hoesch, Shawna Antonelli, Maren K. Schroeder, Barbara J. Caldarone, Nadine Taudte, Mathias Schenk, Thore Hettmann, Stephan Schilling, Nathan J. McDannold, Cynthia A. Lemere
Summary: The use of focused ultrasound (FUS) with microbubbles enhanced the delivery of an Fc-competent anti-pGlu3 Aβ monoclonal antibody to the brain, resulting in improved cognitive function and reduced plaque burden in aged Alzheimer's disease-like model mice. Additionally, the combination of antibody treatment with FUS-BBBD led to greater monocyte infiltration to plaques, suggesting a potential novel mechanism for enhancing immunotherapy efficacy in Alzheimer's disease.
JOURNAL OF CONTROLLED RELEASE
(2021)
Review
Pharmacology & Pharmacy
Satyam Pati, Avtar Singh Gautam, Mangaldeep Dey, Aman Tiwari, Rakesh Kumar Singh
Summary: Inflammation and cell death processes controlled by RIPK1 play a crucial role in maintaining organ homeostasis. Inhibiting RIPK1 has shown promising effects in preventing neuronal cell death, leading to a potential reduction in neurodegeneration and neuroinflammation. Therefore, RIPK1 has emerged as an important therapeutic target for Alzheimer's disease.
DRUG DISCOVERY TODAY
(2023)
Review
Cell Biology
Qian Yue, Maggie Pui Man Hoi
Summary: In the early stages of Alzheimer's disease, there is disruption of the blood-brain barrier. Recent studies have shown a link between blood-brain barrier dysfunction and cognitive decline, and this dysfunction may accelerate Alzheimer's disease progression. Astrocytes, the most abundant glial cells, play crucial roles in maintaining the integrity of the blood-brain barrier. This review summarizes the existing literature on the relevance of astrocyte alteration in blood-brain barrier dysfunction and discusses the potential therapeutic implications.
NEURAL REGENERATION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Qin Ouyang, Kai Liu, Qubo Zhu, Huiyin Deng, Yuan Le, Wen Ouyang, Xiaoxin Yan, Wenhu Zhou, Jianbin Tong
Summary: Alzheimer's disease (AD) is a common form of dementia in elderly individuals, with no effective treatment currently available. This study presents a novel DNA nanoflowers-based delivery system for AD therapy, which allows exogenous supplementation of miR-124 to ameliorate AD-like pathology. The nanosystem demonstrates promising results in increasing miR-124 levels in the brain and achieving robust therapeutic efficacy in a mouse model of AD.
Article
Clinical Neurology
Bruna Bellaver, Albert Puig-Pijoan, Joao Pedro Ferrari-Souza, Douglas T. Leffa, Firoza Z. Lussier, Pamela C. L. Ferreira, Cecile Tissot, Guilherme Povala, Joseph Therriault, Andrea L. Benedet, Nicholas J. Ashton, Stijn Servaes, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Marie Vermeiren, Arthur C. Macedo, Aida Fernandez-Lebrero, Greta Garcia-Escobar, Irene Navalpotro-Gomez, Oscar Lopez, Dana L. Tudorascu, Ann Cohen, Victor L. Villemagne, William E. Klunk, Serge Gauthier, Eduardo R. Zimmer, Thomas K. Karikari, Kaj Blennow, Henrik Zetterberg, Marc Suarez-Calvet, Pedro Rosa-Neto, Tharick A. Pascoal
Summary: The permeability of the blood-brain barrier (BBB) may affect the levels of brain-derived proteins in the blood, which in turn can impact the relationship between brain and blood biomarkers. The study found that BBB permeability influenced the relationship between plasma A beta(42/40) and CSF A beta(42/40) as well as A beta-PET positivity, but did not significantly impact the relationship between brain and plasma p-tau levels.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Qing-Qing Tao, Rong-Rong Lin, Yi-He Chen, Zhi-Ying Wu
Summary: Alzheimer's disease is the most common neurodegenerative disease characterized by the accumulation of Aβ and tau in the brain. The dysfunction of the blood brain barrier (BBB) is increasingly recognized as a causative factor of cognitive impairment, but its role in the pathogenesis of AD is still not fully understood. Additional research is needed to determine the underlying mechanisms between BBB dysfunction and AD, as well as explore new therapies for BBB regulation to treat AD in the future.
Article
Biochemistry & Molecular Biology
Can-Can Zhou, Xu-Jie Wang, Zi-Chen Li, Wen-Jie Lu, Yun-Ting Zhang, Fu-Ming Shen, Dong-Jie Li
Summary: The study showed that developmental lead exposure increased cell apoptosis in rat choroid plexus and microvessels, upregulated pro-inflammatory factors, and disrupted the expression of key proteins, affecting Aβ transportation. These pathological changes resulted in Aβ deposition within BCSFB and BBB, leading to dysfunction of these vascularized structures.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qiuling Liu, Tujing Song, Bing Chen, Jingjing Zhang, Wen Li
Summary: Hypoxia is crucial for the development of various disorders, especially hypoxic cerebropathy. The damage to the blood-brain barrier (BBB) caused by hypoxia is well known. This study explored the correlation between endothelial ferroptosis and hypoxia-induced BBB damage using in vivo zebrafish and in vitro bEnd.3 cells. The results showed that hypoxic treatment could induce BBB disruption by down-regulating claudin-5 (CLDN5) expression in both zebrafish cerebrovascular endothelial cells and bEnd.3 cells.
Article
Cardiac & Cardiovascular Systems
Jorge Pagola, Jesus Juega, Jaume Francisco-Pascual, Maite Rodriguez, Laura Dorado, Raquel Martinez, Mercedes De Lera-Alfonso, Juan F. Arenillas, Juan Antonio Cabezas, Francisco Moniche, Reyes de Torres, Joan Montaner, Marian Muchada, Sandra Boned, Manuel Requena, Alvaro Garcia-Tornel, Noelia Rodriguez-Villatoro, David Rodriguez-Luna, Matias Deck, Marta Olive, Marta Rubiera, Marc Ribo, Jose Alvarez-Sabin, Carlos A. Molina
Summary: The feasibility of 90-day cardiac monitoring with an external Holter device was demonstrated in stroke patients, with a high percentage of pAF detected. Older patients and those with enlarged left atria benefited more from the monitoring.
Article
Economics
Elizabeth Parody-Rua, Alejandro Bustamante, Joan Montaner, Maria Rubio-Valera, David Serrano, Soledad Perez-Sanchez, Alba Sanchez-Vinas, Cesar Guevara-Cuellar, Antoni Serrano-Blanco
Summary: This study evaluates the cost-effectiveness of a blood biomarker test to guide pre-hospital treatment with tPA in patients with suspected stroke, compared with standard hospital management.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Neurosciences
Laura Ramiro, Julia Faura, Alba Simats, Paula Garcia-Rodriguez, Feifei Ma, Luna Martin, Francesc Canals, Anna Rosell, Joan Montaner
Summary: Ischemic stroke is a leading cause of death and disability globally, but translating promising pre-clinical neuroprotective agents into clinical settings has been unsuccessful. This may be due to the use of animal models that don't accurately represent the stroke-affected population, as most pre-clinical studies are conducted on healthy young male mice. In this study, we investigated the proteomic and transcriptomic changes during the hyperacute phase of cerebral ischemia in different groups of mice based on age, sex, and comorbidities. We found that the response to cerebral ischemia varied depending on sex, age, and comorbidities, highlighting the importance of including animals with diverse phenotypes in future stroke research.
Article
Surgery
Soledad Perez-Sanchez, Ana Barragan Prieto, Miguel Angel Gamero Garcia, Francisco Moniche, Alejandro Tomasello, Fernando Delgado-Acosta, Alejandro Gonzalez, Joan Montaner
Summary: This study aims to explore independent risk factors for cerebrovascular events following CAS. The main findings indicate that female sex and diabetes are strong predictors for the development of complications after symptomatic CAS.
JOURNAL OF ENDOVASCULAR THERAPY
(2023)
Review
Nutrition & Dietetics
Ana M. Najar, Marina Romero-Bernal, Carmen del Rio, Joan Montaner
Summary: There is a growing interest in consuming halophytes as a healthy food. Salicornia ramosissima is a Mediterranean halophyte with a rich profile of bioactive compounds, including over 60 identified polyphenols with various biological activities. These polyphenols have shown potential protective effects against brain ischemia, mainly through reducing oxidative stress and inflammation, inhibiting cell death pathways, and preserving vascular function. Although most of these compounds have been found to be neuroprotective, human studies on their effects are still limited. Considering the safe profile of polyphenols in S. ramosissima, this halophyte could be a valuable source of bioactive compounds for the nutraceutical industry.
Article
Cell Biology
Nea Korvenlaita, Mireia Gomez-Budia, Flavia Scoyni, Cristiana Pistono, Luca Giudice, Shaila Eamen, Sanna Loppi, Ana Hernandez de Sande, Benjamin Huremagic, Maria Bouvy-Liivrand, Merja Heinaniemi, Minna U. Kaikkonen, Lesley Cheng, Andrew F. Hill, Katja M. Kanninen, Guido W. Jenster, Martin E. van Royen, Laura Ramiro, Joan Montaner, Tereza Batkova, Robert Mikulik, Rosalba Giugno, Jukka Jolkkonen, Paula Korhonen, Tarja Malm
Summary: Hypoxia induces changes in the secretion of extracellular vesicles (EVs) in non-neuronal cells and pathological conditions. The secretion of miR-21-5p in EVs is increased under hypoxia. Neuronal EVs and miR-21-5p secretion may be altered under hypoxia, and miR-21-5p in EVs may serve as a potential biomarker for stroke recovery.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Clinical Neurology
Manuel Medina-Rodriguez, Francisco Moniche, Asier De Alboniga-Chindurza, Joaquin Ortega-Quintanilla, Leire Ainz-Gomez, Blanca Pardo-Galiana, Juan Antonio Cabezas-Rodriguez, Marta Aguilar-Perez, Aynara Zamora, Fernando Delgado-Acosta, Elvira Jimenez-Gomez, Isabel Bravo Rey, Rafael Oteros Fernandez, Maria del Mar Freijo Guerrero, Eva Gonzalez Diaz, Irene Escudero-Martinez, Lluis Morales Caba, Isabel Vielba-Gomez, Sonia Mosteiro, Maria del Mar Castellanos Rodrigo, Laura Amaya Pascasio, Carlos Hidalgo, Luis Fernandez Prudencio, Jose Maria Ramirez Moreno, Jose Diaz Perez, Gema Sanz-Fernandez, Pablo Baena-Palomino, Miguel Angel Gamero-Garcia, Silvia Jimenez Jorge, Clara Rosso Fernandez, Joan Montaner, Alejandro Gonzalez Garcia, Elena Zapata-Arriaza
Summary: The ATILA trial aims to compare the efficacy of low-dose intravenous tirofiban and intravenous aspirin in preventing in-stent thrombosis in patients with acute ischemic stroke due to tandem lesions. The primary outcomes include the proportion of patients with carotid in-stent thrombosis within 24 hours and the rate of symptomatic intracranial hemorrhage.
EUROPEAN STROKE JOURNAL
(2023)
Article
Clinical Neurology
Tim Honegger, Juliane Schweizer, Antonela Bicvic, Laura P. Westphal, Valerie Schuetz, Corinne Inauen, Thomas Pokorny, Katja Bracher, Marcel Arnold, Urs Fischer, Leo H. Bonati, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Carlo Cereda, Georg Kaegi, Joan Montaner, Alejandro Bustamante, Elena Pala, George Ntaios, Christian Foerch, Andreas Luft, Katharina Spanaus, Lanja Saleh, Arnold von Eckardstein, Markus Arnold, Mira Katan
Summary: In this study, the prognostic value of serum S-100B for the development of symptomatic intracranial hemorrhage and symptomatic brain edema in acute ischemic stroke patients was assessed. The results indicated that serum S-100B levels measured within 24 hours after symptom onset were independently associated with the development of these complications. Adding S-100B to the clinical prediction model improved the accuracy of early risk stratification for stroke complications.
EUROPEAN STROKE JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Maria Abou Diwan, Marwa Lahimer, Veronique Bach, Fabien Gosselet, Hafida Khorsi-Cauet, Pietra Candela
Summary: Accumulating evidence suggests that chronic exposure to low levels of pesticides in the diet affects the gut-microbiota-blood-brain barrier axis. This axis describes the connection between the microbiota, intestinal barrier, and blood-brain barrier. Preclinical observations have shown that pesticides cause gut microbiota alteration, or dysbiosis, which is associated with gastrointestinal disorders and diseases affecting distant organs like the blood-brain barrier. However, the interaction between pesticides, microbiota, intestinal barrier, and blood-brain barrier is not yet fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shiraz Dib, Rodrigo Azevedo Loiola, Emmanuel Sevin, Julien Saint-Pol, Fumitaka Shimizu, Takashi Kanda, Jens Pahnke, Fabien Gosselet
Summary: Neuroinflammation and brain lipid imbalances are observed in individuals with Alzheimer's disease. The tumor necrosis factor-a (TNFa) and liver X receptor (LXR) signaling pathways are involved in both processes, but their relationships in human brain pericytes (HBP) of the neurovascular unit are not well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Elena Zapata-Arriaza, Manuel Medina-Rodriguez, Joaquin Ortega-Quintanilla, Asier De Alboniga-Chindurza, Leire Ainz-Gomez, Blanca Pardo-Galiana, Juan Antonio Cabezas-Rodriguez, Lucia Lebrato-Herandez, Ana Barragan-Prieto, Soledad Perez-Sanchez, Aynara Zamora, Joan Montaner, Alejandro Gonzalez Garcia, Francisco Moniche
Summary: A retrospective analysis showed that carotid reocclusion after mechanical thrombectomy in acute ischemic stroke was associated with worse clinical outcomes. Factors such as recanalization grade, presence of pial collateral circulation, use of a stent, and use of general anesthesia were identified as independent predictors. This study provides important guidance for clinical treatment.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2023)
Article
Clinical Neurology
John J. McCabe, Cathal Walsh, Sarah Gorey, Katie Harris, Pablo Hervella, Ramon Iglesias-Rey, Christina Jern, Linxin Li, Nobukazu Miyamoto, Joan Montaner, Annie Pedersen, Francisco Purroy, Peter M. Rothwell, Catherine Sudlow, Yuji Ueno, Mikel Vicente-Pascual, William Whiteley, Mark Woodward, Peter J. Kelly
Summary: This study investigated the association between blood inflammatory markers (hsCRP and IL-6) and recurrent major adverse cardiovascular events (MACE) and stroke in patients with ischemic stroke/transient ischemic attack. The results showed that both hsCRP and IL-6 were independently associated with MACE and recurrent stroke. These findings strengthen the rationale for conducting randomized trials of anti-inflammatory therapies for secondary prevention after ischemic stroke/TIA.
Article
Respiratory System
Marcia Smiti Jude, Chen Xi Yang, Fernando Studart Leitao Filho, Ana I. Hernandez I. Cordero, Julia Yang, Tawimas Shaipanich, Xuan Li, David Lin, Julie MacIsaac, Michael S. Kobor, Sunita Sinha, Corey Nislow, Amrit Singh, Wan Lam, Stephen Lam, Silvia Guillemi, Marianne Harris, Julio Montaner, Raymond T. Ng, Christopher Carlsten, S. F. Paul Man, Don D. Sin, Janice M. Leung
Summary: People living with HIV (PLWH) are at increased risk of developing Chronic Obstructive Pulmonary Disease (COPD), and this is associated with dysbiosis and epigenetic and transcriptomic disruptions in the airway epithelium. Reduced diversity and altered microbial communities, particularly the decreased abundance of Prevotella, are linked with gene disruptions in PLWH with COPD.
RESPIRATORY RESEARCH
(2023)
Article
Clinical Neurology
Ana Dominguez-Mayoral, Carmen Gutierrez, Jesus Sanchez-Gomez, Soledad Perez-Sanchez, Natalia Fouz, Patricia Guerrero-Zamora, Marta Ferrer, Marfa Aguilar, Victoria Galiani, Carmen Albala, Jose Moreno, Miguel A. Gamero, Cristina Garcia-Campos, Sara Banda, Joan Montaner
Summary: This study aimed to determine the effect of obstructive sleep apnea (OSA) intervention on the quality of life and modified Rankin score of stroke patients. The results showed that a significant improvement in quality of life was observed in the intervention group, particularly among patients with good adherence to continuous positive airway pressure (CPAP) treatment. However, no significant improvement was observed in stroke patients. Therefore, OSA intervention has a significant impact on improving the quality of life in patients.
REVISTA DE NEUROLOGIA
(2023)
Article
Clinical Neurology
Francisco Moniche, Juan Antonio Cabezas-Rodriguez, Roberto Valverde, Irene Escudero-Martinez, Lucia Lebrato-Hernandez, Blanca Pardo-Galiana, Leire Ainz, Manuel Medina-Rodriguez, Javier de la Torre, Virginia Escamilla-Gomez, Joaquin Ortega-Quintanilla, Elena Zapata-Arriaza, Asier de Alboniga-Chindurza, Fernando Mancha, Miguel-Angel Gamero, Soledad Perez, Raul Espinosa-Rosso, Lucia Forero-Diaz, Miguel Moya, Pilar Pinero, Cristina Calderon-Cabrera, Sonia Nogueras, Rosario Jimenez, Vanesa Martin, Fernando Delgado, Juan-Jose Ochoa-Sepulveda, Blanca Quijano, Rosario Mata, Monica Santos-Gonzalez, Gloria Carmona-Sanchez, Concha Herrera, Alejandro Gonzalez, Joan Montaner
Summary: This study aimed to investigate the safety and efficacy of different doses of intra-arterial bone marrow mononuclear cells (BMMNCs) transplantation in patients with acute stroke. The results showed no significant improvement in the primary efficacy outcome at 180 days compared to the control group. Further clinical trials are needed to explore potential improvements at different timepoints.
