Lentivirus-Mediated HDAC3 Inhibition Attenuates Oxidative Stress in APPswe/PS1dE9 Mice

The Effects of Cardiotrophin-1 on Early Synaptic Mitochondrial Dysfunction and Synaptic Pathology in APPswe/PS1dE9 Mice

(2017) Dongmei Wang et al.   JOURNAL OF ALZHEIMERS DISEASE

PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β

(2017) Linjie Yu et al.   JOURNAL OF ALZHEIMERS DISEASE

The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases

(2017) Ganggang Kong et al.   JOURNAL OF NEUROTRAUMA

Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications

(2017) Zewen Liu et al.   Oxidative Medicine and Cellular Longevity

Oxidative stress with tau hyperphosphorylation in memory impaired 1,2-diacetylbenzene-treated mice

(2017) Sin-Woo Kang et al.   TOXICOLOGY LETTERS

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe / PS1dE9 through multiple signaling pathways

(2017) Miren Ettcheto et al.   Redox Biology

NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology

(2017) Ana I. Rojo et al.   Redox Biology

Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer’s disease

(2017) Phetcharat Boonruamkaew et al.   Scientific Reports

The Role of Mitochondrial Dysfunction in the Progression of Alzheimer’s Disease

(2017) Claus Desler et al.   CURRENT MEDICINAL CHEMISTRY

2016 Alzheimer's disease facts and figures

(2016)   Alzheimers & Dementia

Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia

(2016) Hai-Lan Meng et al.   CNS Neuroscience & Therapeutics

Histone Deacetylase (HDAC) Inhibitors - emerging roles in neuronal memory, learning, synaptic plasticity and neural regeneration

(2016) Shabir Ahmad Ganai et al.   Current Neuropharmacology

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Inhibition of Histone Deacetylase 3 Restores Amyloid-β Oligomer-Induced Plasticity Deficit in Hippocampal CA1 Pyramidal Neurons

(2016) Kumar Krishna et al.   JOURNAL OF ALZHEIMERS DISEASE

CysteineS-Glutathionylation Promotes Stability and Activation of the Hippo Downstream Effector Transcriptional Co-activator with PDZ-binding Motif (TAZ)

(2016) Rajesh Kumar Gandhirajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Inhibition of Histone Deacetylase 3 (HDAC3) Mediates Ischemic Preconditioning and Protects Cortical Neurons against Ischemia in Rats

(2016) Xiaoyu Yang et al.   Frontiers in Molecular Neuroscience

Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease

(2015) Linjie Yu et al.   LIFE SCIENCES

Pharmacological Selectivity Within Class I Histone Deacetylases Predicts Effects on Synaptic Function and Memory Rescue

(2015) Gavin Rumbaugh et al.   NEUROPSYCHOPHARMACOLOGY

Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B

(2015) Mahima Sharma et al.   Scientific Reports

CART treatment improves memory and synaptic structure in APP/PS1 mice

(2015) Jia-li Jin et al.   Scientific Reports

PINK1 positively regulates HDAC3 to suppress dopaminergic neuronal cell death

(2014) Hyo-Kyoung Choi et al.   HUMAN MOLECULAR GENETICS

TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway

(2014) Xiaolei Zhu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Unspliced X-box-binding Protein 1 (XBP1) Protects Endothelial Cells from Oxidative Stress through Interaction with Histone Deacetylase 3

(2014) Daniel Martin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mst1 Promotes Cardiac Myocyte Apoptosis through Phosphorylation and Inhibition of Bcl-xL

(2014) Dominic P. Del Re et al.   MOLECULAR CELL

c-Abl Stabilizes HDAC2 Levels by Tyrosine Phosphorylation Repressing Neuronal Gene Expression in Alzheimer’s Disease

(2014) Marcelo Gonzalez-Zuñiga et al.   MOLECULAR CELL

Histone deacetylase 3 (HDAC3) plays an important role in retinal ganglion cell death after acute optic nerve injury

(2014) Heather M Schmitt et al.   Molecular Neurodegeneration

EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade Caused by Amyloid-β Oligomers

(2014) Lina M. Vargas et al.   PLoS One

Histone deacetylases in memory and cognition

(2014) J. Penney et al.   Science Signaling

Dalesconols B inhibits lipopolysaccharide induced inflammation and suppresses NF-κB and p38/JNK activation in microglial cells

(2013) Lijuan Han et al.   NEUROCHEMISTRY INTERNATIONAL

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxO3a is activated and executes neuron death via Bim in response to β-amyloid

(2013) P Sanphui et al.   Cell Death & Disease

Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1

(2012) Ji Soo Chae et al.   FREE RADICAL BIOLOGY AND MEDICINE

An epigenetic blockade of cognitive functions in the neurodegenerating brain

(2012) Johannes Gräff et al.   NATURE

Regulation of Neuronal Cell Death by c-Abl-Hippo/MST2 Signaling Pathway

(2012) Weizhe Liu et al.   PLoS One

YAP accelerates Aβ25–35-induced apoptosis through upregulation of Bax expression by interaction with p73

(2011) Heng Zhang et al.   APOPTOSIS

Inhibition of Aβ25–35-induced cell apoptosis by Low-power-laser-irradiation (LPLI) through promoting Akt-dependent YAP cytoplasmic translocation

(2011) Heng Zhang et al.   CELLULAR SIGNALLING

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

The c-Abl-MST1 Signaling Pathway Mediates Oxidative Stress-Induced Neuronal Cell Death

(2011) L. Xiao et al.   JOURNAL OF NEUROSCIENCE

Selective Toxicity by HDAC3 in Neurons: Regulation by Akt and GSK3 

(2011) F. H. Bardai et al.   JOURNAL OF NEUROSCIENCE

Differential regulation of BACE1 expression by oxidative and nitrosative signals

(2011) Young-Don Kwak et al.   Molecular Neurodegeneration

HDAC3 and the molecular brake pad hypothesis

(2011) Susan C. McQuown et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Regulation of Neuronal Cell Death by MST1-FOXO1 Signaling

(2009) Zengqiang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

(2009) Gonzalo I. Cancino et al.   NEUROBIOLOGY OF AGING

STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's β-amyloid deposits

(2008) Gonzalo I. Cancino et al.   BRAIN

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL