PSD-93 Attenuates Amyloid-β-Mediated Cognitive Dysfunction by Promoting the Catabolism of Amyloid-β

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

(2016) David C. Hondius et al.   Alzheimers & Dementia

Neuronal Soluble Fas Ligand Drives M1-Microglia Polarization after Cerebral Ischemia

(2016) Hai-Lan Meng et al.   CNS Neuroscience & Therapeutics

Defining the earliest pathological changes of Alzheimer's disease

(2016) James C. Vickers et al.   Current Alzheimer Research

Stimulating the Activity of Amyloid-Beta Degrading Enzymes: A Novel Approach for the Therapeutic Manipulation of Amyloid-Beta Levels

(2016) Sanjaya Kuruppu et al.   JOURNAL OF ALZHEIMERS DISEASE

An early dysregulation of FAK and MEK/ERK signaling pathways precedes the β-amyloid deposition in the olfactory bulb of APP/PS1 mouse model of Alzheimer's disease

(2016) Mercedes Lachén-Montes et al.   Journal of Proteomics

Memory retrieval by activating engram cells in mouse models of early Alzheimer’s disease

(2016) Dheeraj S. Roy et al.   NATURE

Dopamine agonists rescue Aβ–induced LTP impairment by Src-family tyrosine kinases

(2016) PingAn Yuan Xiang et al.   NEUROBIOLOGY OF AGING

Malibatol A regulates microglia M1/M2 polarization in experimental stroke in a PPARγ-dependent manner

(2015) Jie Pan et al.   Journal of Neuroinflammation

Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease

(2015) Linjie Yu et al.   LIFE SCIENCES

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK Loss

(2015) Jonathan M. Levy et al.   NEURON

Spatial training preserves associative memory capacity with augmentation of dendrite ramification and spine generation in Tg2576 mice

(2015) Xia Jiang et al.   Scientific Reports

CART treatment improves memory and synaptic structure in APP/PS1 mice

(2015) Jia-li Jin et al.   Scientific Reports

Pathogenesis of synaptic degeneration in Alzheimer's disease and Lewy body disease

(2014) Cassia R. Overk et al.   BIOCHEMICAL PHARMACOLOGY

TL-2 attenuates β-amyloid induced neuronal apoptosis through the AKT/GSK-3β/β-catenin pathway

(2014) Xiaolei Zhu et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

PSD-93 deletion inhibits Fyn-mediated phosphorylation of NR2B and protects against focal cerebral ischemia

(2014) Meijuan Zhang et al.   NEUROBIOLOGY OF DISEASE

Methylation analysis of SST and SSTR4 promoters in the neocortex of Alzheimer's disease patients

(2014) Christian Grosser et al.   NEUROSCIENCE LETTERS

Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation of Amyloid-β Precursor Protein Processing in Alzheimer's Disease Models

(2014) Siva Sundara Kumar Durairajan et al.   PLoS One

Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models

(2014) Mathew Blurton-Jones et al.   Stem Cell Research & Therapy

Alzheimer’s disease: relevant molecular and physiopathological events affecting amyloid-β brain balance and the putative role of PPARs

(2014) Juan M. Zolezzi et al.   Frontiers in Aging Neuroscience

Potential Therapeutic Strategies for Alzheimer’s Disease Targeting or Beyondβ-Amyloid: Insights from Clinical Trials

(2014) Qiutian Jia et al.   Biomed Research International

Somatostatin receptor subtype-4 agonist NNC 26-9100 mitigates the effect of soluble Aβ42 oligomers via a metalloproteinase-dependent mechanism

(2013) Karin E. Sandoval et al.   BRAIN RESEARCH

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Altered expression of synapse and glutamate related genes in post-mortem hippocampus of depressed subjects

(2012) Vanja Duric et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Genetic insights in Alzheimer's disease

(2012) Karolien Bettens et al.   LANCET NEUROLOGY

Synaptic scaffold evolution generated components of vertebrate cognitive complexity

(2012) Jess Nithianantharajah et al.   NATURE NEUROSCIENCE

Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice

(2012) Hitoshi Nagura et al.   Molecular Brain

Are amyloid-degrading enzymes viable therapeutic targets in Alzheimer’s disease?

(2011) Natalia N. Nalivaeva et al.   JOURNAL OF NEUROCHEMISTRY

Reduced Spine Density in Specific Regions of CA1 Pyramidal Neurons in Two Transgenic Mouse Models of Alzheimer's Disease

(2011) C. Perez-Cruz et al.   JOURNAL OF NEUROSCIENCE

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

(2010) Jun Gao et al.   NATURE

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity

(2008) Holly J. Carlisle et al.   JOURNAL OF PHYSIOLOGY-LONDON

Strong association of de novo copy number mutations with sporadic schizophrenia

(2008) Bin Xu et al.   NATURE GENETICS

Rare Structural Variants Disrupt Multiple Genes in Neurodevelopmental Pathways in Schizophrenia

(2008) T. Walsh et al.   SCIENCE