Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application
出版年份 2018 全文链接
标题
Plant Secondary Metabolites as Anticancer Agents: Successes in Clinical Trials and Therapeutic Application
作者
关键词
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出版物
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 1, Pages 263
出版商
MDPI AG
发表日期
2018-01-17
DOI
10.3390/ijms19010263
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Design, Synthesis and Biological Evaluation of Betulinic Acid Derivatives as New Antitumor Agents for Leukemia
- (2018) Fernanda Waechter et al. Anti-Cancer Agents in Medicinal Chemistry
- Evaluation of Betulin and Betulinic Acid Content in Birch Bark from Different Forestry Areas of Western Carpathians
- (2018) Liviu HOLONEC et al. Notulae Botanicae Horti Agrobotanici Cluj-Napoca
- Synthesis and biological evaluation of curcumin inspired indole analogues as tubulin polymerization inhibitors
- (2017) P.V. Sri Ramya et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Recent progress on curcumin-based therapeutics: a patent review (2012-2016). Part I: Curcumin
- (2017) Rita Maria Concetta Di Martino et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Paclitaxel: What has been done and the challenges remain ahead
- (2017) Ezequiel Bernabeu et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells
- (2017) Suzan Schwertheim et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Minimal activity of nanoparticle albumin-bound (nab) paclitaxel in relapsed or refractory lymphomas: results of a phase-I study
- (2017) Sagun Goyal et al. LEUKEMIA & LYMPHOMA
- Current approach to the treatment of chronic myeloid leukaemia
- (2017) Ivan Pasic et al. LEUKEMIA RESEARCH
- Combination of paclitaxel, bevacizumab and MEK162 in second line treatment in platinum-relapsing patient derived ovarian cancer xenografts
- (2017) Francesca Ricci et al. Molecular Cancer
- Betulinic Acid-Mediated Apoptosis in Human Prostate Cancer Cells Involves p53 and Nuclear Factor-Kappa B (NF-κB) Pathways
- (2017) Eswar Shankar et al. MOLECULES
- Emerging Cytotoxic Alkaloids in the Battle against Cancer: Overview of Molecular Mechanisms
- (2017) Zeina Habli et al. MOLECULES
- Natural products for human health: an historical overview of the drug discovery approaches
- (2017) S. Bernardini et al. NATURAL PRODUCT RESEARCH
- Traditional and complementary medicine used with curative intent in childhood cancer: A systematic review
- (2017) Caroline Diorio et al. PEDIATRIC BLOOD & CANCER
- Infantile fibrosarcoma treated with postoperative vincristine and dactinomycin
- (2017) Hiroki Yoshihara et al. PEDIATRICS INTERNATIONAL
- Quantitative Analysis of Ingenol in Euphorbia species via Validated Isotope Dilution Ultra-high Performance Liquid Chromatography Tandem Mass Spectrometry
- (2017) Tibor Béres et al. PHYTOCHEMICAL ANALYSIS
- A systematic review on ethnomedicines of anti-cancer plants
- (2017) Akash Tariq et al. PHYTOTHERAPY RESEARCH
- Taxol from Corylus avellana: paving the way for a new source of this anti-cancer drug
- (2017) Ana Gallego et al. PLANT CELL TISSUE AND ORGAN CULTURE
- A comprehensive approach to ascertain the binding mode of curcumin with DNA
- (2017) P. Haris et al. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
- Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
- (2017) Bing-Juan Li et al. Nature Communications
- Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation
- (2017) Chunguang Yang et al. Drug Design Development and Therapy
- The combination effect of homoharringtonine and ibrutinib on FLT3-ITD mutant acute myeloid leukemia
- (2017) Xia Li et al. Oncotarget
- Nanoparticle albumin-bound paclitaxel as neoadjuvant chemotherapy of breast cancer: a systematic review and meta-analysis
- (2017) Yu Zong et al. Oncotarget
- Homoharringtonine targets Smad3 and TGF-β pathway to inhibit the proliferation of acute myeloid leukemia cells
- (2017) Jian Chen et al. Oncotarget
- North African Medicinal Plants Traditionally Used in Cancer Therapy
- (2017) Jorge M. Alves-Silva et al. Frontiers in Pharmacology
- New Insights toward Colorectal Cancer Chemotherapy Using Natural Bioactive Compounds
- (2017) Saúl Redondo-Blanco et al. Frontiers in Pharmacology
- Effect of traditional Chinese medicine combined with Western therapy on primary hepatic carcinoma: a systematic review with meta-analysis
- (2017) Li Ma et al. Frontiers of Medicine
- The modification of natural products for medical use
- (2017) Zongru Guo Acta Pharmaceutica Sinica B
- Multiple molecular targets in breast cancer therapy by betulinic acid
- (2016) Runlan Luo et al. BIOMEDICINE & PHARMACOTHERAPY
- Cancer statistics, 2016
- (2016) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Search for Anti-angiogenic Substances from Natural Sources
- (2016) Naoyuki Kotoku et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Novel Soluplus ® —TPGS mixed micelles for encapsulation of paclitaxel with enhanced in vitro cytotoxicity on breast and ovarian cancer cell lines
- (2016) Ezequiel Bernabeu et al. COLLOIDS AND SURFACES B-BIOINTERFACES
- Nanocarriers Based Anticancer Drugs: Current Scenario and Future Perceptions
- (2016) Rakesh Raj et al. CURRENT DRUG TARGETS
- The structural modification of natural products for novel drug discovery
- (2016) Hong Yao et al. Expert Opinion on Drug Discovery
- A safety evaluation of omacetaxine mepesuccinate for the treatment of chronic myeloid leukemia
- (2016) Moussab Damlaj et al. Expert Opinion On Drug Safety
- Recent advances in design, synthesis and bioactivity of paclitaxel-mimics
- (2016) Guan Wen et al. FITOTERAPIA
- Use of traditional medicine in middle-income countries: a WHO-SAGE study
- (2016) Oyinlola Oyebode et al. HEALTH POLICY AND PLANNING
- Nanodiamonds coupled with 5,7-dimethoxycoumarin, a plant bioactive metabolite, interfere with the mitotic process in B16F10 cells altering the actin organization
- (2016) Angelo Gismondi et al. International Journal of Nanomedicine
- Doxorubicin enhances curcumin’s cytotoxicity in human prostate cancer cells in vitro by enhancing its cellular uptake
- (2016) Rebecca Klippstein et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- EGFR targeted delivery of paclitaxel and parthenolide co-loaded in PEG-Phospholipid micelles enhance cytotoxicity and cellular uptake in non-small cell lung cancer cells
- (2016) Kanwaldeep K. Gill et al. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
- Oral bioavailability of curcumin: problems and advancements
- (2016) Weidong Liu et al. JOURNAL OF DRUG TARGETING
- Natural product discovery: past, present, and future
- (2016) Leonard Katz et al. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
- Natural Products as Sources of New Drugs from 1981 to 2014
- (2016) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- In vivoandin vitroeffects of curcumin on head and neck carcinoma: a systematic review
- (2016) Gabriel Álvares Borges et al. JOURNAL OF ORAL PATHOLOGY & MEDICINE
- Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives
- (2016) Gaurav Kumar et al. LIFE SCIENCES
- Synthesis and antiproliferative studies of curcumin pyrazole derivatives
- (2016) Honnalagere Ramesh Puneeth et al. MEDICINAL CHEMISTRY RESEARCH
- Efficacy and Safety of Vincristine Sulfate Liposome Injection in the Treatment of Adult Acute Lymphocytic Leukemia
- (2016) Dan Douer ONCOLOGIST
- An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis
- (2016) Davies Adeloye et al. PLoS One
- Understanding taxanes in prostate cancer; importance of intratumoral drug accumulation
- (2016) Ellen de Morrée et al. PROSTATE
- Homoharringtonine (omacetaxine mepesuccinate) as an adjunct for FLT3-ITD acute myeloid leukemia
- (2016) S. S. Y. Lam et al. Science Translational Medicine
- Natural products against cancer angiogenesis
- (2016) El Bairi Khalid et al. TUMOR BIOLOGY
- nab-Paclitaxel as a potential partner with checkpoint inhibitors in solid tumors
- (2016) Hatem Soliman OncoTargets and Therapy
- Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-κB
- (2016) Helia Judith Pimentel-Gutiérrez et al. Oncology Letters
- Unraveling the Anticancer Effect of Curcumin and Resveratrol
- (2016) Aline Pavan et al. Nutrients
- Lead Phytochemicals for Anticancer Drug Development
- (2016) Sukhdev Singh et al. Frontiers in Plant Science
- Herbal Medicines: challenges in the modern world. Part 5. status and current directions of complementary and alternative herbal medicine worldwide
- (2016) Elena Yu. Enioutina et al. Expert Review of Clinical Pharmacology
- Exploring Cancer Therapeutics with Natural Products from African Medicinal Plants, Part II: Alkaloids, Terpenoids and Flavonoids
- (2015) Justina N. Nwodo et al. Anti-Cancer Agents in Medicinal Chemistry
- Cell death mechanisms of plant-derived anticancer drugs: beyond apoptosis
- (2015) Hala Gali-Muhtasib et al. APOPTOSIS
- Nanodiamonds coupled with plant bioactive metabolites: A nanotech approach for cancer therapy
- (2015) Angelo Gismondi et al. BIOMATERIALS
- Final analysis of the efficacy and safety of omacetaxine mepesuccinate in patients with chronic- or accelerated-phase chronic myeloid leukemia: Results with 24 months of follow-up
- (2015) Jorge E. Cortes et al. CANCER
- Overview of neuropathy associated with taxanes for the treatment of metastatic breast cancer
- (2015) Edgardo Rivera et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy
- (2015) Mohamed Ali-Seyed et al. Chemical Biology & Drug Design
- Curcumin, an active component of turmeric (Curcuma longa), and its effects on health
- (2015) Betül Kocaadam et al. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
- Are PEGylated liposomes better than conventional liposomes? A special case for vincristine
- (2015) Xuling Wang et al. DRUG DELIVERY
- Incidence and management of myelosuppression in patients with chronic- and accelerated-phase chronic myeloid leukemia treated with omacetaxine mepesuccinate
- (2015) Luke Akard et al. LEUKEMIA & LYMPHOMA
- Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates
- (2015) Zhiyan Xiao et al. MEDICINAL RESEARCH REVIEWS
- Betulinic Acid and its Derivatives as Potential Antitumor Agents
- (2015) Dong-Mei Zhang et al. MEDICINAL RESEARCH REVIEWS
- Indole Alkaloids from Catharanthus roseus: Bioproduction and Their Effect on Human Health
- (2015) Lorena Almagro et al. MOLECULES
- Betulinic acid induces a novel cell death pathway that depends on cardiolipin modification
- (2015) L Potze et al. ONCOGENE
- Synthesis of Paclitaxel. 2. Construction of the ABCD Ring and Formal Synthesis
- (2015) Keisuke Fukaya et al. ORGANIC LETTERS
- Effect of NF-κB inhibition on chemoresistance in biliary–pancreatic cancer
- (2015) Tadashi Uwagawa et al. SURGERY TODAY
- Biological and therapeutic activities, and anticancer properties of curcumin
- (2015) DONATELLA PERRONE et al. Experimental and Therapeutic Medicine
- Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway
- (2015) Zhongping Fu et al. Oncotarget
- Paclitaxel Through the Ages of Anticancer Therapy: Exploring Its Role in Chemoresistance and Radiation Therapy
- (2015) Anna Barbuti et al. Cancers
- Omacetaxine for treatment-resistant or treatment-intolerant adult chronic myeloid leukemia
- (2014) C. Chung AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- Betulinic Acid as a Potent and Complex Antitumor Phytochemical: A Minireview
- (2014) Dorina Gheorgheosu et al. Anti-Cancer Agents in Medicinal Chemistry
- Mechanistic Analysis of Taxol-induced Multidrug Resistance in an Ovarian Cancer Cell Line
- (2014) Ning-Ning Wang et al. Asian Pacific Journal of Cancer Prevention
- Formal Total Synthesis of (−)-Taxol through Pd-Catalyzed Eight-Membered Carbocyclic Ring Formation
- (2014) Sho Hirai et al. CHEMISTRY-A EUROPEAN JOURNAL
- Omacetaxine: A Protein Translation Inhibitor for Treatment of Chronic Myelogenous Leukemia
- (2014) V. Gandhi et al. CLINICAL CANCER RESEARCH
- The value of nature's natural product library for the discovery of New Chemical Entities: The discovery of ingenol mebutate
- (2014) Steven M. Ogbourne et al. FITOTERAPIA
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Homoharringtonine and omacetaxine for myeloid hematological malignancies
- (2014) Shuqing Lü et al. Journal of Hematology & Oncology
- Subcutaneous omacetaxine mepesuccinate in patients with chronic myeloid leukemia in tyrosine kinase inhibitor-resistant patients: Review and perspectives
- (2014) M. Heiblig et al. LEUKEMIA RESEARCH
- How Taxol/paclitaxel kills cancer cells
- (2014) Beth A. Weaver MOLECULAR BIOLOGY OF THE CELL
- Natural product and natural product derived drugs in clinical trials
- (2014) Mark S. Butler et al. NATURAL PRODUCT REPORTS
- Paclitaxel: biosynthesis, production and future prospects
- (2014) Susan Howat et al. New Biotechnology
- Updated Product Label Allows Home Administration of Omacetaxine Mepesuccinate
- (2014) A. Q. Shen et al. ONCOLOGIST
- Traditional use and safety of herbal medicines1
- (2014) Davyson de L. Moreira et al. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
- Preclinical profile of cabazitaxel
- (2014) Patricia Vrignaud et al. Drug Design Development and Therapy
- Paclitaxel Formulations: Challenges and Novel Delivery Options
- (2014) Chetan Nehate et al. Current Drug Delivery
- The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety
- (2014) Martins Ekor Frontiers in Pharmacology
- Clinical Comparison between Paclitaxel Liposome (Lipusu®) and Paclitaxel for Treatment of Patients with Metastatic Gastric Cancer
- (2013) Xu Xu et al. Asian Pacific Journal of Cancer Prevention
- Syntheses, biological evaluation and SAR of ingenol mebutate analogues for treatment of actinic keratosis and non-melanoma skin cancer
- (2013) Xifu Liang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Homoharringtonine/Omacetaxine Mepesuccinate: The Long and Winding Road to Food and Drug Administration Approval
- (2013) Hagop M. Kantarjian et al. Clinical Lymphoma Myeloma & Leukemia
- Paclitaxel Is an Inhibitor and Its Boron Dipyrromethene Derivative Is a Fluorescent Recognition Agent for Botulinum Neurotoxin Subtype A
- (2013) Saedeh Dadgar et al. JOURNAL OF MEDICINAL CHEMISTRY
- Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials
- (2012) Subash C. Gupta et al. AAPS Journal
- Negative-Pressure Cavitation Extraction of Four Main Vinca Alkaloids from Catharanthus roseus Leaves
- (2012) Fansong Mu et al. MOLECULES
- Semisynthesis of Ingenol 3-Angelate (PEP005): Efficient Stereoconservative Angeloylation of Alcohols
- (2012) Xifu Liang et al. SYNLETT
- Molecular docking and pharmacogenomics of Vinca alkaloids and their monomeric precursors, vindoline and catharanthine
- (2011) Serkan Sertel et al. BIOCHEMICAL PHARMACOLOGY
- The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers
- (2011) J.R. Ramsay et al. BRITISH JOURNAL OF DERMATOLOGY
- Combining Betulinic Acid and Mithramycin A Effectively Suppresses Pancreatic Cancer by Inhibiting Proliferation, Invasion, and Angiogenesis
- (2011) Y. Gao et al. CANCER RESEARCH
- Natural products: An evolving role in future drug discovery
- (2011) Bhuwan B. Mishra et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: Rapid lesion necrosis followed by lesion-specific immune response
- (2011) Robert H. Rosen et al. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
- Omacetaxine may have a role in chronic myeloid leukaemia eradication through downregulation of Mcl-1 and induction of apoptosis in stem/progenitor cells
- (2011) E K Allan et al. LEUKEMIA
- Vincristine: Can its therapeutic index be enhanced?
- (2009) Andrew Moore et al. PEDIATRIC BLOOD & CANCER
- Antiproliferative activity of PEP005, a novel ingenol angelate that modulates PKC functions, alone and in combination with cytotoxic agents in human colon cancer cells
- (2008) K A Benhadji et al. BRITISH JOURNAL OF CANCER
- Effects of protein kinase C modulation by PEP005, a novel ingenol angelate, on mitogen-activated protein kinase and phosphatidylinositol 3-kinase signaling in cancer cells
- (2008) M. Serova et al. MOLECULAR CANCER THERAPEUTICS
- Plant-derived compounds in clinical trials
- (2007) A SAKLANI et al. DRUG DISCOVERY TODAY
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