Article
Oncology
Thomas Ollila, James Butera, Pamela Egan, John Reagan, Anthony Thomas, Inna Yakirevich, Kelsey MacKinnon, Jeannine Margolis, Jessica McMahon, Valerie Rosati, Adam J. Olszewski
Summary: This study investigated the efficacy and safety of vincristine sulfate liposomal injection in combination with bendamustine and rituximab for indolent B-cell lymphoma. The results showed that the combination therapy was safe and effective, but due to observed toxicities and recurrences, the study did not proceed with an expanded cohort.
Article
Pharmacology & Pharmacy
Xinyang Yan, Xin Gao, Xiaoya Li, Qiujun Qiu, Cong Li, Na Yan, Jie Li, Mengyang Liu, Xueying Tang, Xinrong Liu, Yanzhi Song, Yihui Deng
Summary: Studies have shown that tumor-associated macrophages (TAMs) play a crucial role in creating and maintaining an immunosuppressive tumor immune microenvironment (TIME), facilitating immune evasion and weakening antitumor therapy. TAMs express sialic acid (SA) receptors called Siglecs, which can be targeted to disrupt TIME and inhibit tumor growth. This study reported a SA-modified VCR liposome (VCR-SSAL) that demonstrated strong TAMs targeting and tumor-killing abilities. The treatment with VCR-SSAL led to the complete detachment of cancerous tissues from the growth site, followed by gradual wound healing. When the mice, whose tumors were detached, were re-inoculated after three months, the tumors detached again without treatment, with a detachment rate of 100%. This unique efficacy is speculated to be due to the ability of VCR loaded in VCR-SSAL to activate adaptive immunity, induce DNA damage, promote infiltration of cytotoxic T lymphocytes (CTLs) into tumor sites, and enhance the antitumor immune response. Thus, this study provides new insights into the application of traditional chemotherapeutic drugs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Yifan Zhang, Jingnan An, Yu Shao, Na Yu, Shujing Yue, Huanli Sun, Jubin Zhang, Wenxing Gu, Yifeng Xia, Jinping Zhang, Yang Xu, Zhiyuan Zhong
Summary: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children, and current intensive chemotherapy often leads to severe and lifelong side effects, highlighting the urgent need for more selective and less toxic treatments. DP-VCR, a CD38-directed nanotherapy, demonstrated superior efficacy and safety in treating CD38-positive ALL.
Article
Chemistry, Analytical
Yuan-Yuan Zhang, Jie Wang, Li Li, Chun-Ying Wu, Chen-Chao Chu, Hong-Li Guo, Tao Li, Feng Chen, Li Zhou, Ya-Hui Hu
Summary: This study developed a rapid, sensitive, and reproducible method for determining the plasma concentration of Vincristine, a commonly used drug in pediatric cancer treatment. The method can serve as a reliable strategy for therapeutic drug monitoring.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Multidisciplinary
A. Laura Nijstad, Wan-Yu Chu, Evelien De Vos-Kerkhof, Catherine F. Enters-Weijnen, Mirjam E. van de Velde, Gertjan J. L. Kaspers, Shelby Barnett, Gareth J. Veal, Arief Lalmohamed, C. Michel Zwaan, Alwin D. R. Huitema
Summary: This study investigated the pharmacokinetics of vincristine, a chemotherapeutic agent, in different age groups and found that the binding capacity of vincristine to beta-tubulin decreases with increasing age, suggesting that young children can tolerate higher doses of the drug.
PHARMACEUTICAL RESEARCH
(2022)
Review
Instruments & Instrumentation
Rahul Shukla, Ajit Singh, Kamalinder K. K. Singh
Summary: Vincristine (VCR), derived from the Catharanthus roseus plant, is an effective chemotherapeutic agent used in the treatment of various cancers. It inhibits cell division in cancer cells by preventing tubulin polymerization. Nanotechnological drug delivery systems, such as liposomes and nanoparticles, are being explored to improve the pharmacokinetics and tumor-specific targeting of VCR.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anfal M. M. Alkandari, Yasser M. M. Alsayed, Atallah M. M. El-Hanbaly
Summary: The aim of this study was to develop a suitable method for encapsulating a tracer in liposomes to enhance the stability and efficacy of radiopharmaceuticals. The results showed that liposomal encapsulation reduced uptake and retention of the drug in unintended organs, and also reduced its cytotoxic effect. Adding cholesterol during the formulation process enhanced the stability and specificity of the targeted organs.
Article
Chemistry, Analytical
Yuji Mano
Summary: A separate assay method was developed to determine the released and total concentrations of eribulin in dog plasma, which was successfully applied to a pharmacokinetic study. This study provides important data for further understanding the pharmacokinetic profiles of eribulin.
JOURNAL OF SEPARATION SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Pranav Ponkshe, Yingzhe Wang, Chalet Tan
Summary: By using DMPC-based liposomes and Cy5.5-labeled BSA as a model protein, we optimized the cholesterol content and surface modification of inhalable liposomes and studied their pharmacokinetics in mice. The results showed that the systemic bioavailability of inhaled liposomes was significantly higher than that of inhaled free protein. This study demonstrates the great potential of inhalable DMPC-based liposomes for non-invasive systemic protein delivery.
Article
Pharmacology & Pharmacy
Amin Mirzaaghasi, Yunho Han, So-Hee Ahn, Chulhee Choi, Ji-Ho Park
Summary: Exosomes have potential as drug delivery vehicles due to their ability to selectively deliver therapeutic cargoes to disease sites. The in vivo behaviors of exosomes are affected by pathophysiological conditions, and exosomes exhibit specific behaviors in sepsis mice compared to liposomes. This suggests that exosome-based therapeutics may be effective in managing sepsis and septic shock.
Article
Medicine, Research & Experimental
Christopher N. Subasic, Neville J. Butcher, Fiona Simpson, Rodney F. Minchin, Lisa M. Kaminskas
Summary: Dynamin II (dynII) plays a significant role in the internalization pathways of endocytic cells, by allowing membrane invaginations to bud off. However, clinically relevant doses of dynII inhibitors can inhibit the uptake of liposomes by endocytic cells in vitro, but are unlikely to significantly affect the pharmacokinetics of long-circulating, co-administered liposomes, as shown by the study that investigated the impact of phenothiazines, PCZ and thioridazine, on in vitro liposome endocytosis and in vivo liposome pharmacokinetics after PCZ infusion in rats.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemical Research Methods
Yongli Chen, Yikun Yang, Xiliu Zeng, Jing Long Feng, Ken Oakes, Xu Zhang, Shufen Cui
Summary: Although liposomes have shown significant success in clinical drug delivery, studying the pharmacokinetics of liposomal nanomedicines remains challenging due to the difficulty in accurately measuring low concentrations of free drug. This study presents a microdialysis-based microfluidic chip interfaced with mass spectrometry to address this issue. By incorporating an effective anti-foulant, PEG 20,0 0 0, the microfluidic chip demonstrated excellent drug extraction and desalting efficiency, providing a promising approach for real-time monitoring of nanomedicine pharmacokinetic profiles.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Oncology
Shelby Barnett, Farina Hellmann, Elizabeth Parke, Guy Makin, Deborah A. Tweddle, Caroline Osborne, Georg Hempel, Gareth J. Veal
Summary: This study investigated vincristine dosing, drug exposure, and the feasibility of therapeutic drug monitoring in neonate and infant patients. The results suggest that doses of <0.05mg/kg should not be used in this population due to a risk of suboptimal drug exposures, and therapeutic drug monitoring approaches are effective.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Nanoscience & Nanotechnology
Saikat Ghosh, Rohan Lalani, Kuntal Maiti, Shubhadeep Banerjee, Himanshu Bhatt, Yamini Shankar Bobde, Vivek Patel, Swati Biswas, Subhas Bhowmick, Ambikanandan Misra
Summary: This study explored the biological characteristics of co-loading vincristine with pegylated liposomal doxorubicin in non-small cell lung cancer and triple negative breast cancer. Results showed significantly increased cellular uptake, cell cycle arrest, apoptosis, and reduced cell viability with the co-loaded liposome formulation compared to doxorubicin liposome, leading to improved therapeutic efficacy in vitro and in vivo against NSCLC and TNBC.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Biophysics
Bruna G. Carvalho, Bianca B. M. Garcia, Antonio A. Malfatti-Gasperini, Sang W. Han, Lucimara G. de la Torre
Summary: The association between chondroitin sulfate (CS) and cationic liposomes (CLs)/lipoplex (CL-pDNA) was analyzed in this study. The results showed that the electrostatic interaction between CS and CL/CL-pDNA could reorganize the lipid bilayers and form nanoscale vesicles. These findings have implications for the development of novel carriers for drug and gene delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)