Deoxyribonucleic Acid Damage and Repair: Capitalizing on Our Understanding of the Mechanisms of Maintaining Genomic Integrity for Therapeutic Purposes

Distinct mechanistic responses to replication fork stalling induced by either nucleotide or protein deprivation

(2018) Sofia Henriksson et al.   CELL CYCLE

PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

(2018) George E. Ronson et al.   Nature Communications

Potentiation of doxorubicin efficacy in hepatocellular carcinoma by the DNA repair inhibitor DT01 in preclinical models

(2017) Nirmitha I. Herath et al.   EUROPEAN RADIOLOGY

CRISPR/Cas9-mediated gene editing ameliorates neurotoxicity in mouse model of Huntington’s disease

(2017) Su Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

(2017) Masatoshi Takagi et al.   JNCI-Journal of the National Cancer Institute

Olaparib tablets as maintenance therapy in patients with platinum-sensitive, relapsed ovarian cancer and a BRCA1/2 mutation (SOLO2/ENGOT-Ov21): a double-blind, randomised, placebo-controlled, phase 3 trial

(2017) Eric Pujade-Lauraine et al.   LANCET ONCOLOGY

The DNA Repair Inhibitor Dbait Is Specific for Malignant Hematologic Cells in Blood

(2017) Sylvain Thierry et al.   MOLECULAR CANCER THERAPEUTICS

Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome

(2017) Claudia Maletzki et al.   MOLECULAR CARCINOGENESIS

DNA Double-Strand Break Resection Occurs during Non-homologous End Joining in G1 but Is Distinct from Resection during Homologous Recombination

(2017) Ronja Biehs et al.   MOLECULAR CELL

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

(2017) Xiangyu Liu et al.   Nature Communications

AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

(2017) Jiangman Lou et al.   Nature Communications

Characterization of the interplay between DNA repair and CRISPR/Cas9-induced DNA lesions at an endogenous locus

(2017) Anne Bothmer et al.   Nature Communications

Replication fork slowing and stalling are distinct, checkpoint-independent consequences of replicating damaged DNA

(2017) Divya Ramalingam Iyer et al.   PLoS Genetics

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

(2017) Masatoshi Takagi et al.   JNCI-Journal of the National Cancer Institute

Drug-Driven Synthetic Lethality: Bypassing Tumor Cell Genetics with a Combination of AsiDNA and PARP Inhibitors

(2016) Wael Jdey et al.   CLINICAL CANCER RESEARCH

A novel small molecule inhibitor of the DNA repair protein Ku70/80

(2016) Eric Weterings et al.   DNA REPAIR

Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses

(2016) Keith M. Jacobs et al.   MOLECULAR BIOLOGY OF THE CELL

Nanoparticle formulation of small DNA molecules, Dbait, improves the sensitivity of hormone-independent prostate cancer to radiotherapy

(2016) Hong Yao et al.   Nanomedicine-Nanotechnology Biology and Medicine

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Fluorescent sensors of PARP-1 structural dynamics and allosteric regulation in response to DNA damage

(2016) Jamin D. Steffen et al.   NUCLEIC ACIDS RESEARCH

A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair

(2016) Michael Ranes et al.   NUCLEIC ACIDS RESEARCH

DNA repair targeted therapy: The past or future of cancer treatment?

(2016) Navnath S. Gavande et al.   PHARMACOLOGY & THERAPEUTICS

Genome editing: progress and challenges for medical applications

(2016) Dana Carroll   Genome Medicine

Maintenance of Genome Stability

(2016) Jiadong Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

The Combination of CRISPR/Cas9 and iPSC Technologies in the Gene Therapy of Human β-thalassemia in Mice

(2016) Zhanhui Ou et al.   Scientific Reports

Functional analysis of protein ubiquitination

(2015) Gal Levy-Cohen et al.   ANALYTICAL BIOCHEMISTRY

The role of DNA damage responses in p53 biology

(2015) Daniel Speidel   ARCHIVES OF TOXICOLOGY

BRCA1 and BARD1 colocalize mainly in the cytoplasm of breast cancer tumors, and their isoforms show differential expression

(2015) David Wiener et al.   BREAST CANCER RESEARCH AND TREATMENT

DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

(2015) S. Ying et al.   CANCER RESEARCH

FDA Approval Summary: Olaparib Monotherapy in Patients with Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer Treated with Three or More Lines of Chemotherapy

(2015) G. Kim et al.   CLINICAL CANCER RESEARCH

Replication Fork Progression during Re-replication Requires the DNA Damage Checkpoint and Double-Strand Break Repair

(2015) Jessica L. Alexander et al.   CURRENT BIOLOGY

Cell cycle regulation of human DNA repair and chromatin remodeling genes

(2015) Robin Mjelle et al.   DNA REPAIR

Understanding Xeroderma Pigmentosum Complementation Groups Using Gene Expression Profiling after UV-Light Exposure

(2015) Nikola Bowden et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma

(2015) Erika A. Newman et al.   MOLECULAR CANCER RESEARCH

The DNA Repair Inhibitor DT01 as a Novel Therapeutic Strategy for Chemosensitization of Colorectal Liver Metastasis

(2015) N. I. Herath et al.   MOLECULAR CANCER THERAPEUTICS

USP4 Auto-Deubiquitylation Promotes Homologous Recombination

(2015) Paul Wijnhoven et al.   MOLECULAR CELL

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Complementation of aprataxin deficiency by base excision repair enzymes

(2015) Melike Çağlayan et al.   NUCLEIC ACIDS RESEARCH

Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock

(2015) Leonardo Bee et al.   NUCLEIC ACIDS RESEARCH

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

(2015) T. Ochi et al.   SCIENCE

In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy

(2015) C. E. Nelson et al.   SCIENCE

DNA-Pairing and Annealing Processes in Homologous Recombination and Homology-Directed Repair

(2015) Scott W. Morrical   Cold Spring Harbor Perspectives in Biology

Mismatch Repair during Homologous and Homeologous Recombination

(2015) Maria Spies et al.   Cold Spring Harbor Perspectives in Biology

Both TALENs and CRISPR/Cas9 directly target the HBB IVS2–654 (C > T) mutation in β-thalassemia-derived iPSCs

(2015) Peng Xu et al.   Scientific Reports

The Deubiquitylating Enzyme USP4 Cooperates with CtIP in DNA Double-Strand Break End Resection

(2015) Hailong Liu et al.   Cell Reports

A Single-Strand Annealing Protein Clamps DNA to Detect and Secure Homology

(2015) Marcel Ander et al.   PLOS BIOLOGY

DNA Damage Response and Spindle Assembly Checkpoint Function throughout the Cell Cycle to Ensure Genomic Integrity

(2015) Katherine S. Lawrence et al.   PLoS Genetics

CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes

(2015) Puping Liang et al.   Protein & Cell

DNA repair mechanisms in cancer development and therapy

(2015) Alessandro Torgovnick et al.   Frontiers in Genetics

Differential Mismatch Recognition Specificities of Eukaryotic MutS Homologs, MutSα and MutSβ

(2014) Monika Sharma et al.   BIOPHYSICAL JOURNAL

DNA double-strand break repair pathway choice and cancer

(2014) Tomas Aparicio et al.   DNA REPAIR

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

(2014) Carolin Anders et al.   NATURE

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

(2014) Samuel H. Sternberg et al.   NATURE

A Data-Driven, Mathematical Model of Mammalian Cell Cycle Regulation

(2014) Michael C. Weis et al.   PLoS One

Ultrasensitive UPLC-MS-MS Method for the Quantitation of Etheno-DNA Adducts in Human Urine

(2014) Shiwei Cui et al.   International Journal of Environmental Research and Public Health

A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells

(2014) Tony Ly et al.   eLife

A Preclinical Study Combining the DNA Repair Inhibitor Dbait with Radiotherapy for the Treatment of Melanoma

(2014) Julian Biau et al.   NEOPLASIA

A Small-Molecule Inhibitor of RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to Doxorubicin

(2014) David A. Alagpulinsa et al.   Frontiers in Oncology

ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation

(2013) L. Biddlestone-Thorpe et al.   CLINICAL CANCER RESEARCH

Evaluation of the pharmacodynamics and pharmacokinetics of the PARP inhibitor olaparib: a Phase I multicentre trial in patients scheduled for elective breast cancer surgery

(2013) Nigel Bundred et al.   INVESTIGATIONAL NEW DRUGS

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

(2013) Kevin M. Foote et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Evaluation of a Novel ATM Inhibitor, KU59403, In Vitro and In Vivo in p53 Functional and Dysfunctional Models of Human Cancer

(2013) M. A. Batey et al.   MOLECULAR CANCER THERAPEUTICS

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase

(2013) E. M. Kass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protospacer recognition motifs

(2013) Shiraz A. Shah et al.   RNA Biology

DNA Damage Sensing by the ATM and ATR Kinases

(2013) A. Marechal et al.   Cold Spring Harbor Perspectives in Biology

Base Excision Repair

(2013) H. E. Krokan et al.   Cold Spring Harbor Perspectives in Biology

Oxidative Stress and DNA Lesions: The Role of 8-Oxoguanine Lesions in Trypanosoma cruzi Cell Viability

(2013) Pedro H. N. Aguiar et al.   PLoS Neglected Tropical Diseases

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

Enhanced cytotoxicity of PARP inhibition in mantle cell lymphoma harbouring mutations in both ATM and p53

(2012) Chris T. Williamson et al.   EMBO Molecular Medicine

CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination

(2012) Jacob Falck et al.   EMBO REPORTS

Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K

(2012) J. M. Munck et al.   MOLECULAR CANCER THERAPEUTICS

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

The HSV-1 Exonuclease, UL12, Stimulates Recombination by a Single Strand Annealing Mechanism

(2012) April J. Schumacher et al.   PLoS Pathogens

Defective Cell Cycle Checkpoints as Targets for Anti-Cancer Therapies

(2012) Brian Gabrielli et al.   Frontiers in Pharmacology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

γH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization

(2011) Markus Löbrich et al.   CELL CYCLE

mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

(2011) B. Ekim et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair

(2011) I. D. Odell et al.   MOLECULAR AND CELLULAR BIOLOGY

γH2Ax: Biomarker of Damage or Functional Participant in DNA Repair “All that Glitters Is not Gold!”

(2011) James E. Cleaver   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Histone  H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

(2010) C. E. Redon et al.   CLINICAL CANCER RESEARCH

Autophosphorylation and ATM Activation

(2010) Sergei V. Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Zn3 Domain of Human Poly(ADP-ribose) Polymerase-1 (PARP-1) Functions in Both DNA-dependent Poly(ADP-ribose) Synthesis Activity and Chromatin Compaction

(2010) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial

(2010) Andrew Tutt et al.   LANCET

Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

(2010) M William Audeh et al.   LANCET

Enhanced H2AX Phosphorylation, DNA Replication Fork Arrest, and Cell Death in the Absence of Chk1

(2010) Mary E. Gagou et al.   MOLECULAR BIOLOGY OF THE CELL

FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells

(2010) K. Asagoshi et al.   MOLECULAR CANCER RESEARCH

Involvement of Global Genome Repair, Transcription Coupled Repair, and Chromatin Remodeling in UV DNA Damage Response Changes during Development

(2010) Hannes Lans et al.   PLoS Genetics

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Identification of a novel pro-apopotic function of NF-κB in the DNA damage response

(2009) Sabine Karl et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comparison of nonhomologous end joining and homologous recombination in human cells

(2008) Z MAO et al.   DNA REPAIR

Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

(2008) D. Hoogstraten et al.   JOURNAL OF CELL SCIENCE

Characterization of a Highly Conserved Binding Site of Mlh1 Required for Exonuclease I-Dependent Mismatch Repair

(2008) C. Dherin et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks

(2008) Leonie Schulte-Uentrop et al.   NUCLEIC ACIDS RESEARCH