Testicular MTHFR deficiency may explain sperm DNA hypomethylation associated with high dose folic acid supplementation

Is folic acid good for everyone?

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Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development

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High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice

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A Unique Gene Regulatory Network Resets the Human Germline Epigenome for Development

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Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: Epidemiology, metabolism and the associated diseases

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High-dose folic acid supplementation alters the human sperm methylome and is influenced by theMTHFRC677T polymorphism

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MTHFR deficiency or reduced intake of folate or choline in pregnant mice results in impaired short-term memory and increased apoptosis in the hippocampus of wild-type offspring

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MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies

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Stability of DNA Methylation Patterns in Mouse Spermatogonia Under Conditions of MTHFR Deficiency and Methionine Supplementation1

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Altered DNA Methylation Patterns of the H19 Differentially Methylated Region and the DAZL Gene Promoter Are Associated with Defective Human Sperm

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Low paternal dietary folate alters the mouse sperm epigenome and is associated with negative pregnancy outcomes

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Moderately high intake of folic acid has a negative impact on mouse embryonic development

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MTHFR 677C→T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation

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High intake of folic acid disrupts embryonic development in mice

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