Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice

Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice

(2017) Patrick P. Lowe et al.   PLoS One

Changes in the Intestinal Microbiome and Alcoholic and Nonalcoholic Liver Diseases: Causes or Effects?

(2016) Naga S. Betrapally et al.   GASTROENTEROLOGY

MitoNEET Deficiency Alleviates Experimental Alcoholic Steatohepatitis in Mice by Stimulating Endocrine Adiponectin-Fgf15 Axis

(2016) Xudong Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acute-on-chronic liver failure in cirrhosis

(2016) Vicente Arroyo et al.   Nature Reviews Disease Primers

Supplementation of Saturated Long-Chain Fatty Acids Maintains Intestinal Eubiosis and Reduces Ethanol-induced Liver Injury in Mice

(2015) Peng Chen et al.   GASTROENTEROLOGY

Dysbiosis-induced intestinal inflammation activates tumor necrosis factor receptor I and mediates alcoholic liver disease in mice

(2015) Peng Chen et al.   HEPATOLOGY

Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

(2015) Brent A Neuschwander-Tetri et al.   LANCET

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Colonic inflammation and secondary bile acids in alcoholic cirrhosis

(2014) Genta Kakiyama et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Nod2 deficiency protects mice from cholestatic liver disease by increasing renal excretion of bile acids

(2014) Lirui Wang et al.   JOURNAL OF HEPATOLOGY

Intestinal transport and metabolism of bile acids

(2014) Paul A. Dawson et al.   JOURNAL OF LIPID RESEARCH

Intestinal permeability, gut-bacterial dysbiosis, and behavioral markers of alcohol-dependence severity

(2014) Sophie Leclercq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity

(2014) Sharon Manley et al.   Redox Biology

Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease

(2013) Weibin Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Metagenomic Analyses of Alcohol Induced Pathogenic Alterations in the Intestinal Microbiome and the Effect of Lactobacillus rhamnosus GG Treatment

(2013) Lara Bull-Otterson et al.   PLoS One

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

(2013) J. Petrasek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity

(2013) Fei Li et al.   Nature Communications

Colonic microbiome is altered in alcoholism

(2012) Ece A. Mutlu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential analysis of gene regulation at transcript resolution with RNA-seq

(2012) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Identification of novel transcripts in annotated genomes using RNA-Seq

(2011) A. Roberts et al.   BIOINFORMATICS

Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes

(2011) Elaine Studer et al.   HEPATOLOGY

Simultaneous characterization of bile acids and their sulfate metabolites in mouse liver, plasma, bile, and urine using LC–MS/MS

(2011) Jiangeng Huang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Dose-Response of Five Bile Acids on Serum and Liver Bile Acid Concentrations and Hepatotoxicty in Mice

(2011) Peizhen Song et al.   TOXICOLOGICAL SCIENCES

Enteric dysbiosis associated with a mouse model of alcoholic liver disease

(2010) Arthur W. Yan et al.   HEPATOLOGY

Systemic gut microbial modulation of bile acid metabolism in host tissue compartments

(2010) J. R. Swann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intestinal Dysbiosis: A Possible Mechanism of Alcohol-Induced Endotoxemia and Alcoholic Steatohepatitis in Rats

(2009) Ece Mutlu et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

The metagenomics RAST server – a public resource for the automatic phylogenetic and functional analysis of metagenomes

(2008) F Meyer et al.   BMC BIOINFORMATICS

Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice

(2008) Yongke Lu et al.   HEPATOLOGY

Quantitative-profiling of bile acids and their conjugates in mouse liver, bile, plasma, and urine using LC–MS/MS

(2008) Yazen Alnouti et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome

(2008) B. V. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA