标题
Oligonucleotide therapeutics: chemistry, delivery and clinical progress
作者
关键词
-
出版物
Future Medicinal Chemistry
Volume 7, Issue 16, Pages 2221-2242
出版商
Future Science, LTD
发表日期
2015-10-29
DOI
10.4155/fmc.15.144
参考文献
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- (2015) Shigeo Matsuda et al. ACS Chemical Biology
- Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
- (2015) Richard S. Geary et al. ADVANCED DRUG DELIVERY REVIEWS
- Preclinical and clinical development of siRNA-based therapeutics
- (2015) Gulnihal Ozcan et al. ADVANCED DRUG DELIVERY REVIEWS
- Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides
- (2015) Michael E. Østergaard et al. BIOCONJUGATE CHEMISTRY
- Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic TrivalentN-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo
- (2015) Kallanthottathil G. Rajeev et al. CHEMBIOCHEM
- Synthetic Nucleic Acid Delivery Systems: Present and Perspectives
- (2015) Bogdan Draghici et al. JOURNAL OF MEDICINAL CHEMISTRY
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- (2015) Saúl Martínez-Montero et al. JOURNAL OF ORGANIC CHEMISTRY
- Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
- (2015) Rodolphe Barrangou et al. NUCLEIC ACIDS RESEARCH
- C5-azobenzene-functionalized locked nucleic acid uridine: isomerization properties, hybridization ability, and enzymatic stability
- (2015) K. Morihiro et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Immunomodulatory spherical nucleic acids
- (2015) Aleksandar F. Radovic-Moreno et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Chimeric Antisense Oligonucleotide Conjugated to α-Tocopherol
- (2015) Tomoko Nishina et al. Molecular Therapy-Nucleic Acids
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- (2014) Jiaxin Hu et al. BIOCHEMISTRY
- C5-Amino acid functionalized LNA: positively poised for antisense applications
- (2014) Dale C. Guenther et al. CHEMICAL COMMUNICATIONS
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- (2014) Pawan Kumar et al. JOURNAL OF ORGANIC CHEMISTRY
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- (2014) Resham J. Banga et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2014) Agop Y. Bedikian et al. MELANOMA RESEARCH
- Programmable RNA recognition and cleavage by CRISPR/Cas9
- (2014) Mitchell R. O’Connell et al. NATURE
- Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications
- (2014) Bryan R Meade et al. NATURE BIOTECHNOLOGY
- 5′-O-Methylphosphonate nucleic acids—new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes
- (2014) Hana Šípová et al. NUCLEIC ACIDS RESEARCH
- Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice
- (2014) Thazha P. Prakash et al. NUCLEIC ACIDS RESEARCH
- Carbohydrate-Functionalized Locked Nucleic Acids: Oligonucleotides with Extraordinary Binding Affinity, Target Specificity, and Enzymatic Stability
- (2014) Mamta Kaura et al. ORGANIC LETTERS
- Antisense oligonucleotides: modifications and clinical trials
- (2014) Vivek K. Sharma et al. MedChemComm
- 10th Annual Meeting of the Oligonucleotide Therapeutics Society
- (2014) Keith T. Gagnon et al. Nucleic Acid Therapeutics
- Phosphorothioates, Essential Components of Therapeutic Oligonucleotides
- (2014) Fritz Eckstein Nucleic Acid Therapeutics
- Nucleic acid therapeutics: basic concepts and recent developments
- (2014) Vivek K. Sharma et al. RSC Advances
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- (2014) Lykke Pedersen et al. Molecular Therapy-Nucleic Acids
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- (2012) Nerea Martín-Pintado et al. NUCLEIC ACIDS RESEARCH
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- (2011) Hamidreza M. Aliabadi et al. BIOMATERIALS
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- (2011) Anna Varizhuk et al. BIOORGANIC CHEMISTRY
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- (2011) Moti L. Jain et al. CHEMICAL REVIEWS
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- (2011) Thazha P. Prakash CHEMISTRY & BIODIVERSITY
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- (2011) Jonathan K Watts et al. JOURNAL OF PATHOLOGY
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- (2011) Martin Egli et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2011) Cecília Leal et al. LANGMUIR
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- (2011) Maria C Palanca-Wessels et al. MOLECULAR THERAPY
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- (2011) Mirko Trajkovski et al. NATURE
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- (2011) Susanna Obad et al. NATURE GENETICS
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- (2011) Dan Jones NATURE REVIEWS DRUG DISCOVERY
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- (2011) Natalya S. Petrova et al. NUCLEIC ACIDS RESEARCH
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- (2011) Abigail K. R. Lytton-Jean et al. Small
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- (2011) Kathryn A. Whitehead et al. Annual Review of Chemical and Biomolecular Engineering
- Gold Nanoparticles for Biology and Medicine
- (2010) David A. Giljohann et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform
- (2010) C. Frank Bennett et al. Annual Review of Pharmacology and Toxicology
- Scavenger Receptors Mediate Cellular Uptake of Polyvalent Oligonucleotide-Functionalized Gold Nanoparticles
- (2010) Pinal C. Patel et al. BIOCONJUGATE CHEMISTRY
- pH-Responsive Polymeric Micelle Carriers for siRNA Drugs
- (2010) A. J. Convertine et al. BIOMACROMOLECULES
- The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides
- (2010) Likun Fei et al. JOURNAL OF DRUG TARGETING
- Highly Efficient Gene Silencing Activity of siRNA Embedded in a Nanostructured Gyroid Cubic Lipid Matrix
- (2010) Cecília Leal et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
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- (2010) Joshua I. Cutler et al. NANO LETTERS
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Targeted Delivery Systems for Oligonucleotide Therapeutics
- (2009) Bo Yu et al. AAPS Journal
- Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics
- (2009) Frederic Heitz et al. BRITISH JOURNAL OF PHARMACOLOGY
- Antisense oligonucleotide pharmacokinetics and metabolism
- (2009) Richard S Geary Expert Opinion on Drug Metabolism & Toxicology
- Does inhibition of apolipoprotein B synthesis produce foie gras?
- (2009) Kenneth R. Feingold JOURNAL OF LIPID RESEARCH
- Strand Invasion of Extended, Mixed-Sequence B-DNA by γPNAs
- (2009) Gaofei He et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Gene Regulation with Polyvalent siRNA−Nanoparticle Conjugates
- (2009) David A. Giljohann et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The Effect of Chemical Modification and Nanoparticle Formulation on Stability and Biodistribution of siRNA in Mice
- (2009) Shan Gao et al. MOLECULAR THERAPY
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- (2009) Aurélie Goyenvalle et al. MOLECULAR THERAPY
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- (2009) Justin P Dassie et al. NATURE BIOTECHNOLOGY
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- (2009) Jiehua Zhou et al. NUCLEIC ACIDS RESEARCH
- Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents
- (2009) C. A. Stein et al. NUCLEIC ACIDS RESEARCH
- siRNA and Innate Immunity
- (2009) Marjorie Robbins et al. OLIGONUCLEOTIDES
- Improved Cellular Activity of Antisense Peptide Nucleic Acids by Conjugation to a Cationic Peptide-Lipid (CatLip) Domain
- (2008) Uffe Koppelhus et al. BIOCONJUGATE CHEMISTRY
- 2′F-Arabinonucleic acids (2′F-ANA) — History, properties, and new frontiers
- (2008) Jonathan K Watts et al. CANADIAN JOURNAL OF CHEMISTRY
- Pegaptanib sodium for the treatment of age-related macular degeneration
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- A review of stimuli-responsive nanocarriers for drug and gene delivery
- (2008) Srinivas Ganta et al. JOURNAL OF CONTROLLED RELEASE
- Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals
- (2008) Punit P. Seth et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties
- (2008) Chuanzheng Zhou et al. JOURNAL OF ORGANIC CHEMISTRY
- Design, Synthesis, and Properties of 2‘,4‘-BNANC: A Bridged Nucleic Acid Analogue
- (2008) S. M. Abdur Rahman et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol
- (2008) Kazutaka Nishina et al. MOLECULAR THERAPY
- Polyvalent DNA Nanoparticle Conjugates Stabilize Nucleic Acids
- (2008) Dwight S. Seferos et al. NANO LETTERS
- Prodrugs: design and clinical applications
- (2008) Jarkko Rautio et al. NATURE REVIEWS DRUG DISCOVERY
- OligoWalk: an online siRNA design tool utilizing hybridization thermodynamics
- (2008) Z. J. Lu et al. NUCLEIC ACIDS RESEARCH
- Triazole-Linked Analogue of Deoxyribonucleic Acid (TLDNA): Design, Synthesis, and Double-Strand Formation with Natural DNA
- (2008) Hiroyuki Isobe et al. ORGANIC LETTERS
- Complications in patients after intravitreal injection of bevacizumab
- (2007) Chiharu Shima et al. ACTA OPHTHALMOLOGICA
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