Cellular delivery of siRNA and antisense oligonucleotides via receptor-mediated endocytosis

RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

(2010) C. Frank Bennett et al.   Annual Review of Pharmacology and Toxicology

Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation

(2010) Lin Zhu et al.   BIOCONJUGATE CHEMISTRY

Breaking down the barriers: siRNA delivery and endosome escape

(2010) M. Dominska et al.   JOURNAL OF CELL SCIENCE

Targeted Intracellular Delivery of Antisense Oligonucleotides via Conjugation with Small-Molecule Ligands

(2010) Osamu Nakagawa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

(2010) Mark E. Davis et al.   NATURE

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor

(2010) Xin Ming et al.   NUCLEIC ACIDS RESEARCH

The systemic delivery of siRNAs by a cell penetrating peptide, low molecular weight protamine

(2009) Young-Suk Choi et al.   BIOMATERIALS

SnapShot: Endocytic Trafficking

(2009) Marnix Wieffer et al.   CELL

Antisense oligonucleotide pharmacokinetics and metabolism

(2009) Richard S Geary   Expert Opinion on Drug Metabolism & Toxicology

A fusion peptide directs enhanced systemic dystrophin exon skipping and functional restoration in dystrophin-deficient mdx mice

(2009) HaiFang Yin et al.   HUMAN MOLECULAR GENETICS

siRNA Targeted to p53 Attenuates Ischemic and Cisplatin-Induced Acute Kidney Injury

(2009) B. A. Molitoris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Biological Barriers to Therapy with Antisense and siRNA Oligonucleotides

(2009) R. Juliano et al.   MOLECULAR PHARMACEUTICS

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

The promises and pitfalls of RNA-interference-based therapeutics

(2009) Daniela Castanotto et al.   NATURE

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

(2009) Justin P Dassie et al.   NATURE BIOTECHNOLOGY

Efficient siRNA delivery into primary cells by a peptide transduction domain–dsRNA binding domain fusion protein

(2009) Akiko Eguchi et al.   NATURE BIOTECHNOLOGY

Knocking down barriers: advances in siRNA delivery

(2009) Kathryn A. Whitehead et al.   NATURE REVIEWS DRUG DISCOVERY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting cyclin B1 through peptide-based delivery of siRNA prevents tumour growth

(2009) L. Crombez et al.   NUCLEIC ACIDS RESEARCH

Selection, characterization and application of new RNA HIV gp 120 aptamers for facile delivery of Dicer substrate siRNAs into HIV infected cells

(2009) Jiehua Zhou et al.   NUCLEIC ACIDS RESEARCH

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

(2009) C. A. Stein et al.   NUCLEIC ACIDS RESEARCH

Therapeutic Potential of Splice-Switching Oligonucleotides

(2009) John Bauman et al.   OLIGONUCLEOTIDES

The Biological Effect of an Antisense Oligonucleotide Depends on Its Route of Endocytosis and Trafficking

(2009) Md. Rowshon Alam et al.   OLIGONUCLEOTIDES

Increased RNAi is related to intracellular release of siRNA via a covalently attached signal peptide

(2009) A. Detzer et al.   RNA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Gene Silencing of Complement C5a Receptor Using siRNA for Preventing Ischemia/Reperfusion Injury

(2008) Xiufen Zheng et al.   AMERICAN JOURNAL OF PATHOLOGY

Cellular Delivery and Biological Activity of Antisense Oligonucleotides Conjugated to a Targeted Protein Carrier

(2008) Hyunmin Kang et al.   BIOCONJUGATE CHEMISTRY

Application of an HIV gp41-Derived Peptide for Enhanced Intracellular Trafficking of Synthetic Gene and siRNA Delivery Vehicles

(2008) Ester J. Kwon et al.   BIOCONJUGATE CHEMISTRY

LHRH Receptor-Mediated Delivery of siRNA Using Polyelectrolyte Complex Micelles Self-Assembled from siRNA-PEG-LHRH Conjugate and PEI

(2008) Sun Hwa Kim et al.   BIOCONJUGATE CHEMISTRY

Self-crosslinked and reducible fusogenic peptides for intracellular delivery of siRNA

(2008) Hyejung Mok et al.   BIOPOLYMERS

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

Phosphorothioate-Stimulated Cellular Uptake of siRNA: A Cell Culture Model for Mechanistic Studies

(2008) A. Detzer et al.   CURRENT PHARMACEUTICAL DESIGN

Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo

(2008) S. Oliveira et al.   CURRENT PHARMACEUTICAL DESIGN

Cell Entry of Arginine-rich Peptides Is Independent of Endocytosis

(2008) Gohar Ter-Avetisyan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A peptide-targeted delivery system with pH-sensitive amphiphilic cell membrane disruption for efficient receptor-mediated siRNA delivery

(2008) Xu-Li Wang et al.   JOURNAL OF CONTROLLED RELEASE

A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy

(2008) Maarja Mäe et al.   JOURNAL OF CONTROLLED RELEASE

Efficient Oncogene Silencing and Metastasis Inhibition via Systemic Delivery of siRNA

(2008) Shyh-Dar Li et al.   MOLECULAR THERAPY

Novel Dual Inhibitory Function Aptamer–siRNA Delivery System for HIV-1 Therapy

(2008) Jiehua Zhou et al.   MOLECULAR THERAPY

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

(2008) Kazutaka Nishina et al.   MOLECULAR THERAPY

Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone

(2008) Yasushi Sato et al.   NATURE BIOTECHNOLOGY

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis

(2008) Md Rowshon Alam et al.   NUCLEIC ACIDS RESEARCH

Induction of Apoptosis in Murine Neuroblastoma by Systemic Delivery of Transferrin-Shielded siRNA Polyplexes for Downregulation of Ran

(2008) Nicole Tietze et al.   OLIGONUCLEOTIDES

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer

(2008) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

(2008) D. Peer et al.   SCIENCE