HSPB8 and BAG3 cooperate to promote spatial sequestration of ubiquitinated proteins and coordinate the cellular adaptive response to proteasome insufficiency

Shaping proteostasis at the cellular, tissue, and organismal level

(2017) Ambre J. Sala et al.   JOURNAL OF CELL BIOLOGY

Conservation of the Keap1-Nrf2 System: An Evolutionary Journey through Stressful Space and Time

(2017) Yuji Fuse et al.   MOLECULES

Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination

(2017) YouJin Lee et al.   Cell Reports

L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways

(2017) Xiao-Dong Yang et al.   Frontiers in Neuroscience

Transcription factors NRF2 and HSF1 have opposing functions in autophagy

(2017) Sharadha Dayalan Naidu et al.   Scientific Reports

HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis

(2016) Yoshihisa Watanabe et al.   Autophagy

Cellular strategies to cope with protein aggregation

(2016) A. Scior et al.   Essays in Biochemistry

p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer

(2016) Koji Taniguchi et al.   FEBS LETTERS

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

(2016) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

The Chaperone Activity and Substrate Spectrum of Human Small Heat Shock Proteins

(2016) Evgeny V. Mymrikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism

(2016) Massimo Ganassi et al.   MOLECULAR CELL

Breaking BAG: The Co-Chaperone BAG3 in Health and Disease

(2016) Christian Behl   TRENDS IN PHARMACOLOGICAL SCIENCES

Small heat shock proteins sequester misfolding proteins in near-native conformation for cellular protection and efficient refolding

(2016) Sophia Ungelenk et al.   Nature Communications

Adenofection: A Method for Studying the Role of Molecular Chaperones in Cellular Morphodynamics by Depletion-Rescue Experiments

(2016) Margit Fuchs et al.   Jove-Journal of Visualized Experiments

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

(2016) Valeria Crippa et al.   Scientific Reports

Small heat shock proteins: Role in cellular functions and pathology

(2015) Raman Bakthisaran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress

(2015) Edward W.J. Wallace et al.   CELL

Compartment-specific aggregases direct distinct nuclear and cytoplasmic aggregate deposition

(2015) S. B. Miller et al.   EMBO JOURNAL

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

(2015) Yoshinori Katsuragi et al.   FEBS Journal

A First Line of Stress Defense: Small Heat Shock Proteins and Their Function in Protein Homeostasis

(2015) Martin Haslbeck et al.   JOURNAL OF MOLECULAR BIOLOGY

BAG3 myofibrillar myopathy presenting with cardiomyopathy

(2015) Chamindra G. Konersman et al.   NEUROMUSCULAR DISORDERS

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control

(2015) Irene Gallina et al.   Nature Communications

The Selective Autophagy Receptor p62 Forms a Flexible Filamentous Helical Scaffold

(2015) Rodolfo Ciuffa et al.   Cell Reports

A Role for the Chaperone Complex BAG3-HSPB8 in Actin Dynamics, Spindle Orientation and Proper Chromosome Segregation during Mitosis

(2015) Margit Fuchs et al.   PLoS Genetics

Cytoprotective Role of Nrf2 in Electrical Pulse Stimulated C2C12 Myotube

(2015) Masaki Horie et al.   PLoS One

Zebrafish models of BAG3 myofibrillar myopathy suggest a toxic gain of function leading to BAG3 insufficiency

(2014) Avnika A. Ruparelia et al.   ACTA NEUROPATHOLOGICA

BAG3 induces the sequestration of proteasomal clients into cytoplasmic puncta

(2014) Melania Minoia et al.   Autophagy

Differential Scales of Protein Quality Control

(2014) Suzanne Wolff et al.   CELL

WW Domain of BAG3 Is Required for the Induction of Autophagy in Glioma Cells

(2014) Nana Merabova et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Tension-induced autophagy

(2013) Anna Ulbricht et al.   Autophagy

Heat shock factor 1 confers resistance to Hsp90 inhibitors through p62/SQSTM1 expression and promotion of autophagic flux

(2013) Buddhini Samarasinghe et al.   BIOCHEMICAL PHARMACOLOGY

Cellular Mechanotransduction Relies on Tension-Induced and Chaperone-Assisted Autophagy

(2013) Anna Ulbricht et al.   CURRENT BIOLOGY

14-3-3 protein targets misfolded chaperone-associated proteins to aggresomes

(2013) Z. Xu et al.   JOURNAL OF CELL SCIENCE

p62/SQSTM1 regulates cellular oxygen sensing by attenuating PHD3 activity through aggregate sequestration and enhanced degradation

(2013) K. Rantanen et al.   JOURNAL OF CELL SCIENCE

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Spatial sequestration of misfolded proteins by a dynamic chaperone pathway enhances cellular fitness during stress

(2013) Stéphanie Escusa-Toret et al.   NATURE CELL BIOLOGY

Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy

(2013) Paola Rusmini et al.   NEUROBIOLOGY OF AGING

Transient Aggregation of Ubiquitinated Proteins Is a Cytosolic Unfolded Protein Response to Inflammation and Endoplasmic Reticulum Stress

(2012) Xian-De Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

(2012) Ari J. Firestone et al.   NATURE

Keap1 degradation by autophagy for the maintenance of redox homeostasis

(2012) K. Taguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62: a versatile multitasker takes on cancer

(2012) Jorge Moscat et al.   TRENDS IN BIOCHEMICAL SCIENCES

p62 Stages an Interplay Between the Ubiquitin-Proteasome System and Autophagy in the Heart of Defense Against Proteotoxic Stress

(2012) Huabo Su et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Heterooligomeric complexes of human small heat shock proteins

(2011) Evgeny V. Mymrikov et al.   CELL STRESS & CHAPERONES

BAG3-related myofibrillar myopathy in a Chinese family

(2011) HC Lee et al.   CLINICAL GENETICS

BAG3 mediates chaperone-based aggresome-targeting and selective autophagy of misfolded proteins

(2011) Martin Gamerdinger et al.   EMBO REPORTS

Hsp42 is required for sequestration of protein aggregates into deposition sites inSaccharomyces cerevisiae

(2011) Sebastian Specht et al.   JOURNAL OF CELL BIOLOGY

p62 targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding

(2011) Eisuke Itakura et al.   JOURNAL OF CELL BIOLOGY

Chaperone-mediated hierarchical control in targeting misfolded proteins to aggresomes

(2011) Xingqian Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Nrf2-mediated induction of p62 controls Toll-like receptor-4-driven aggresome-like induced structure formation and autophagic degradation

(2011) K.-i. Fujita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p62 (SQSTM1) forms part of a novel, reversible aggregate containing a specific conformer of the cAMP degrading phosphodiesterase, PDE4A4

(2010) Miles D. Houslay et al.   Autophagy

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS

p62/SQSTM1Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

(2010) Ashish Jain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inheritance patterns and phenotypic features of myofibrillar myopathy associated with a BAG3 mutation

(2010) Zagaa Odgerel et al.   NEUROMUSCULAR DISORDERS

Identification of the key structural motifs involved in HspB8/HspB6–Bag3 interaction

(2009) Margit Fuchs et al.   BIOCHEMICAL JOURNAL

Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

(2009) Martin Gamerdinger et al.   EMBO JOURNAL

Bub1 regulates chromosome segregation in a kinetochore-independent manner

(2009) Christiane Klebig et al.   JOURNAL OF CELL BIOLOGY

Mutation in BAG3 causes severe dominant childhood muscular dystrophy

(2008) Duygu Selcen et al.   ANNALS OF NEUROLOGY

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded proteins partition between two distinct quality control compartments

(2008) Daniel Kaganovich et al.   NATURE