Mutant ATRX: uncovering a new therapeutic target for glioma

PML protein organizes heterochromatin domains where it regulates histone H3.3 deposition by ATRX/DAXX

(2017) Erwan Delbarre et al.   GENOME RESEARCH

Diffuse intrinsic pontine gliomas—current management and new biologic insights. Is there a glimmer of hope?

(2017) Kenneth J. Cohen et al.   NEURO-ONCOLOGY

A clinical perspective on the 2016 WHO brain tumor classification and routine molecular diagnostics

(2017) Martin J. van den Bent et al.   NEURO-ONCOLOGY

Low-Grade Astrocytoma Mutations in IDH1, P53, and ATRX Cooperate to Block Differentiation of Human Neural Stem Cells via Repression of SOX2

(2017) Aram S. Modrek et al.   Cell Reports

ATRX and DAXX: Mechanisms and Mutations

(2017) Michael A. Dyer et al.   Cold Spring Harbor Perspectives in Medicine

Epigenetic Basis of Cellular Senescence and Its Implications in Aging

(2017) et al.   Genes

The Role of ATRX in Glioma Biology

(2017) Pravanya Nandakumar et al.   Frontiers in Oncology

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Epigenetic Therapeutics: A New Weapon in the War Against Cancer

(2016) Nita Ahuja et al.   Annual Review of Medicine

ATRX binds to atypical chromatin domains at the 3′ exons of zinc finger genes to preserve H3K9me3 enrichment

(2016) David Valle-García et al.   Epigenetics

Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds

(2016) Jutta Zimmer et al.   MOLECULAR CELL

ATRX loss promotes tumor growth and impairs nonhomologous end joining DNA repair in glioma

(2016) Carl Koschmann et al.   Science Translational Medicine

Stalled replication forks within heterochromatin require ATRX for protection

(2016) M S Huh et al.   Cell Death & Disease

Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells

(2016) K. M. Godek et al.   Cancer Discovery

Therapeutic Targeting of Telomerase

(2016) Kathrin Jäger et al.   Genes

The Role of ATRX in the Alternative Lengthening of Telomeres (ALT) Phenotype

(2016) João Amorim et al.   Genes

ATRX immunostaining predicts IDH and H3F3A status in gliomas

(2016) Azadeh Ebrahimi et al.   Acta Neuropathologica Communications

Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations

(2015) David A. Solomon et al.   BRAIN PATHOLOGY

Loss of ATRX Suppresses Resolution of Telomere Cohesion to Control Recombination in ALT Cancer Cells

(2015) Mahesh Ramamoorthy et al.   CANCER CELL

The Daxx/Atrx Complex Protects Tandem Repetitive Elements during DNA Hypomethylation by Promoting H3K9 Trimethylation

(2015) Quanyuan He et al.   Cell Stem Cell

Atrx promotes heterochromatin formation at retrotransposons

(2015) D. Sadic et al.   EMBO REPORTS

Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

(2015) Simon J. Elsässer et al.   NATURE

Mutational landscape and clonal architecture in grade II and III gliomas

(2015) Hiromichi Suzuki et al.   NATURE GENETICS

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Reading the unique DNA methylation landscape of the brain: Non-CpG methylation, hydroxymethylation, and MeCP2

(2015) Benyam Kinde et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

(2015) R. L. Flynn et al.   SCIENCE

Molecular Markers in Low-Grade Glioma—Toward Tumor Reclassification

(2015) Adriana Olar et al.   SEMINARS IN RADIATION ONCOLOGY

Emerging roles of ATRX in cancer

(2015) L Ashley Watson et al.   Epigenomics

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors

(2015) Jinquan Cai et al.   Oncotarget

IDH mutation, 1p19q codeletion and ATRX loss in WHO grade II gliomas

(2015) Heather E. Leeper et al.   Oncotarget

Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

(2015) Yuchen Jiao et al.   Oncotarget

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

(2015) Kasthuri Kannan et al.   Oncotarget

Epigenetic dysregulation: a novel pathway of oncogenesis in pediatric brain tumors

(2014) Adam M. Fontebasso et al.   ACTA NEUROPATHOLOGICA

ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets

(2014) Kavitha Sarma et al.   CELL

Altered global histone-trimethylation code and H3F3A-ATRX mutation in pediatric GBM

(2014) Pankaj Pathak et al.   JOURNAL OF NEURO-ONCOLOGY

The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma

(2014) Gang Wu et al.   NATURE GENETICS

Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma

(2014) Kathryn R Taylor et al.   NATURE GENETICS

Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria

(2014) Marc H. Jansen et al.   NEURO-ONCOLOGY

ATRX Dysfunction Induces Replication Defects in Primary Mouse Cells

(2014) David Clynes et al.   PLoS One

Recurrent Somatic Structural Variations Contribute to Tumorigenesis in Pediatric Osteosarcoma

(2014) Xiang Chen et al.   Cell Reports

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

(2013) Benedikt Wiestler et al.   ACTA NEUROPATHOLOGICA

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

(2013) Jeannie T. Lee et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Different flavors of X-chromosome inactivation in mammals

(2013) Cathérine Dupont et al.   CURRENT OPINION IN CELL BIOLOGY

Targeted loss of the ATR-X syndrome protein in the limb mesenchyme of mice causes brachydactyly

(2013) Lauren A. Solomon et al.   HUMAN MOLECULAR GENETICS

Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress

(2013) Justin Wai-Chung Leung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span

(2013) L. Ashley Watson et al.   JOURNAL OF CLINICAL INVESTIGATION

G-Quadruplex DNA as a Molecular Target for Induced Synthetic Lethality in Cancer Cells

(2013) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying Put

(2013) Jeffrey A. Simon et al.   MOLECULAR CELL

G-Quadruplex Structures in the Human Genome as Novel Therapeutic Targets

(2013) Joanna Bidzinska et al.   MOLECULES

The chromatin remodeller ATRX: a repeat offender in human disease

(2013) David Clynes et al.   TRENDS IN BIOCHEMICAL SCIENCES

Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

(2012) Xiao-Yang Liu et al.   ACTA NEUROPATHOLOGICA

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

ATRX-mediated chromatin association of histone variant macroH2A1 regulates  -globin expression

(2012) K. Ratnakumar et al.   GENES & DEVELOPMENT

DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin

(2012) E. Delbarre et al.   GENOME RESEARCH

Association of Age at Diagnosis and Genetic Mutations in Patients With Neuroblastoma

(2012) Nai-Kong V. Cheung   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Compromised genomic integrity impedes muscle growth after Atrx inactivation

(2012) Michael S. Huh et al.   JOURNAL OF CLINICAL INVESTIGATION

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

Loss of Atrx Sensitizes Cells to DNA Damaging Agents through p53-Mediated Death Pathways

(2012) Damiano Conte et al.   PLoS One

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

(2012) Courtney A. Lovejoy et al.   PLoS Genetics

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Genomic instability of surgical sample and cancer-initiating cell lines from human glioblastoma

(2011) Arantxa Perez-Garcia   Frontiers in Bioscience-Landmark

Defective survival of proliferating Sertoli cells and androgen receptor function in a mouse model of the ATR-X syndrome

(2011) Stefan Bagheri-Fam et al.   HUMAN MOLECULAR GENETICS

Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation

(2011) Anton Wutz   NATURE REVIEWS GENETICS

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

(2011) Shigeki Iwase et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease

(2011) Rabindranath De La Fuente et al.   REPRODUCTION

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

DAXX/ATRX, MEN1, and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors

(2011) Y. Jiao et al.   SCIENCE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

(2010) L. H. Wong et al.   GENOME RESEARCH

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA Damage Response

(2010) G. Giglia-Mari et al.   Cold Spring Harbor Perspectives in Biology

Loss of Maternal ATRX Results in Centromere Instability and Aneuploidy in the Mammalian Oocyte and Pre-Implantation Embryo

(2010) Claudia Baumann et al.   PLoS Genetics

Biochemical mechanisms of gene regulation by polycomb group protein complexes

(2009) Jürg Müller et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

A new model for random X chromosome inactivation

(2008) J. Starmer et al.   DEVELOPMENT

Mutations in the chromatin-associated protein ATRX

(2008) Richard J. Gibbons et al.   HUMAN MUTATION

Loss of ATRX leads to chromosome cohesion and congression defects

(2008) Kieran Ritchie et al.   JOURNAL OF CELL BIOLOGY

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Telomere dysfunction, genome instability and cancer

(2007) Annie et al.   Frontiers in Bioscience-Landmark