Activation of the cannabinoid receptor 1 by ACEA suppresses senescence in human primary chondrocytes through sirt1 activation

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Analysis of natural product regulation of cannabinoid receptors in the treatment of human disease

(2017) S. Badal et al.   PHARMACOLOGY & THERAPEUTICS

Mesenchymal Stem Cell-Based Cartilage Regeneration Approach and Cell Senescence: Can We Manipulate Cell Aging and Function?

(2017) Marta A. Szychlinska et al.   TISSUE ENGINEERING PART B-REVIEWS

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

(2015) Hyun Hwang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomarkers of Chondrocyte Apoptosis and Autophagy in Osteoarthritis

(2015) Giuseppe Musumeci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pinocembrin inhibits matrix metalloproteinase expression in chondrocytes

(2015) Dawei Zhang et al.   IUBMB LIFE

Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites

(2015) Caroline Turcotte et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chondrosenescence: Definition, hallmarks and potential role in the pathogenesis of osteoarthritis

(2015) Ali Mobasheri et al.   MATURITAS

The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

Dimethyl fumarate protection against collagen II degradation

(2014) Ye Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Physical activity ameliorates cartilage degeneration in a rat model of aging: A study on lubricin expression

(2014) G. Musumeci et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes

(2013) S.L. Dunn et al.   OSTEOARTHRITIS AND CARTILAGE

Cannabinoids: novel therapies for arthritis?

(2012) Sara L Dunn et al.   Future Medicinal Chemistry

DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes

(2012) J. Rose et al.   OSTEOARTHRITIS AND CARTILAGE

In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis

(2012) K.S. Santangelo et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)

(2012) F. Berenbaum   OSTEOARTHRITIS AND CARTILAGE

Role of CB1 and CB2 cannabinoid receptors in the development of joint pain induced by monosodium iodoacetate

(2012) Carmen La Porta et al.   PAIN

Why is osteoarthritis an age-related disease?

(2010) A. Shane Anderson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

SIRT1 regulation of apoptosis of human chondrocytes

(2009) Koji Takayama et al.   ARTHRITIS AND RHEUMATISM

Angiogenic growth factors inhibit chondrocyte ageing in osteoarthritis: potential involvement of catabolic stress-induced overexpression of caveolin-1 in cellular ageing

(2009) Kazuo YUDOH et al.   International Journal of Rheumatic Diseases

Biological actions of curcumin on articular chondrocytes

(2009) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Caveolin-1 expression and stress-induced premature senescence in human intervertebral disc degeneration

(2008) Sarah Heathfield et al.   ARTHRITIS RESEARCH & THERAPY

Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis

(2008) Denise Richardson et al.   ARTHRITIS RESEARCH & THERAPY