Article
Endocrinology & Metabolism
Peng Zhou, Chao Yang, Shan Zhang, Zun-Xiang Ke, Dian-Xi Chen, Yi-Qing Li, Qin Li
Summary: The importance of early diagnosis and treatment of diabetes and its cutaneous complications is increasingly recognized. High glucose affects collagen gene expression in human dermal fibroblasts, leading to an imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Inhibiting MMP-2 and MMP-9 can alleviate collagen deposition disorder in the skin of diabetic mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Biomedical
Allison Mixon, Ahmed Suparno Bahar-Moni, Tanvir R. Faisal
Summary: Matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) subsequently damaging cartilage and altering biomechanical properties. Individually, MMP-1 and MMP-9 have minimal effect on cartilage micromechanical properties, but synergistically the two enzymes digest ECM components and result in a greater degradative effect.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Biology
Ritva Nissi, Markku Santala, Anne Talvensaari-Mattila
Summary: This study analyzed the serum levels of MMP-9, TIMP-1, and MMP-2/TIMP-2 during normal pregnancy. It was found that MMP-9 and TIMP-1 levels remained stable throughout pregnancy, while there was a slight increase in MMP-2/TIMP-2 complex after week 15 with no statistical significance.
BMC RESEARCH NOTES
(2021)
Article
Multidisciplinary Sciences
Ping Luo, Tingting Zhao, Hong He
Summary: The study demonstrates that IL-38 can alleviate inflammatory responses in chondrocytes by inhibiting the expression of inflammatory cytokines and related pathways. IL-38 limits inflammation and delays cartilage degeneration in the TMJ.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Venkatesh Sadananda Rao, Qianyu Gu, Sandra Tzschentke, Kuailu Lin, Nicole Ganig, May-Linn Thepkaysone, Fang Cheng Wong, Heike Polster, Lena Seifert, Adrian M. Seifert, Nathalie Buck, Carina Riediger, Jonas Weisse, Tony Gutschner, Susanne Michen, Achim Temme, Martin Schneider, Franziska Baenke, Juergen Weitz, Christoph Kahlert
Summary: This study reveals the important role of EV-mediated ECM remodeling in colorectal cancer liver microenvironment and identifies EV-associated TIMP1 as a potential therapeutic target and a circulating biomarker for preoperative risk stratification in patients with colorectal liver metastases.
Article
Orthopedics
Hyun Sook Hwang, Mi Hyun Lee, Dong Jin Go, Hyun Ah Kim
Summary: The study suggests that the sympathetic nervous system plays a significant role in the modulation of cartilage metabolism induced by interleukin-1beta (IL-1β). Beta-adrenergic receptors (β-ARs) exhibit a regulatory effect on cartilage catabolism induced by IL-1β, with beta-AR antagonism enhancing catabolic signals and norepinephrine antagonizing the catabolic response. Additionally, beta-AR activity affects IL-1β-stimulated signaling pathways in chondrocytes, suggesting a connection between beta-AR signaling and cartilage metabolism.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Integrative & Complementary Medicine
Guang-Yao Chen, Jia-Qi Chen, Xiao-Yu Liu, Yuan Xu, Jing Luo, Yi-Fei Wang, Tong-Liang Zhou, Ze-Ran Yan, Li Zhou, Qing-Wen Tao
Summary: TFRD showed chondroprotective effects by restoring the MMP/TIMP balance in OA models by suppressing the activation of the NF-kappa B and PI3K/AKT pathways.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Cell Biology
Benjamin Schoeps, Julian Fradrich, Achim Krueger
Summary: The original naming of proteins based on one function only may hinder the understanding of their biological impact as a whole. Tissue inhibitor of metalloproteinases-1 (TIMP-1), known for its role in inhibiting metalloproteinases, only represents a fraction of its cellular effects. TIMP-1 has recently been identified as a potent cytokine that acts through various cell-surface receptors, revealing an underappreciated role in immune cell signaling. It is important to recognize the structure-function relationships independently from names in order to properly appreciate the biological potential of TIMP-1 and other cytokines in complex physiological processes such as inflammation.
TRENDS IN CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuyang Sun, Xiaoying Gu, Jingna Peng, Liguo Yang, Xinxin Zhang, Zaohong Ran, Jiajun Xiong
Summary: PRDX2 plays a vital role in cartilage development by promoting extracellular matrix synthesis, regulating the expression of CTGF, and mediating anti-inflammatory functions through the IL-6-mediated signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Multidisciplinary
Huayue Zhang, Miaomiao Wu, Hang Thu Ta, Zhi Ping Xu, Run Zhang
Summary: This review summarizes the development and application of sensors for the detection of MMPs in the past three years. These sensors are designed mainly based on the exploration of MMPs' molecular structure and enzymatic activity, aiming to better understand the roles of MMPs in disease progression and their potential in early diagnosis and treatment monitoring. The research hotspots, current challenges, and further research directions in this field are also discussed.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Biochemistry & Molecular Biology
Maria-Elpida Christopoulou, Eleni Papakonstantinou, Daiana Stolz
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that regulate airway remodeling and may contribute to the development of emphysema in chronic obstructive pulmonary disease (COPD). This literature review examines the role of different MMPs in COPD, their regulation by tissue inhibitors, and the potential therapeutic targeting of MMPs in COPD. Recent clinical trials supporting this approach are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Aleksandr Popov, Emma Kozlovskaya, Tatyana Rutckova, Olga Styshova, Aleksey Vakhrushev, Elena Kupera, Ludmila Tekutyeva
Summary: Recent research has shown that matrix metalloproteinase-generated functional proteins (MKs) can be a valuable source of nutrition and therapy, reducing the risk of serious diseases such as cancer. MKs have antitumor properties and can be used in combination therapy without toxic side effects. This review summarizes the data on the antitumor activity of MKs from various sources and discusses their potential and challenges in therapeutic use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Luying He, Qianming Kang, Ka Iong Chan, Yang Zhang, Zhangfeng Zhong, Wen Tan
Summary: In this study, we reviewed the immunomodulatory role of matrix metalloproteinases (MMPs) in colitis-associated cancer (CAC) and discussed relevant clinical applications. We analyzed over 300 pharmacological studies retrieved from PubMed and the Web of Science, focusing on MMPs, cancer, colitis, CAC, and immunomodulation. MMPs are involved in various processes in CAC, such as cell proliferation, cell differentiation, angiogenesis, ECM remodeling, and the inflammatory response. They also affect the immune system by modulating immune cell differentiation and activity, as well as the recruitment of macrophages and neutrophils.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shriefa Almutairi, Hanin Moh'd Kalloush, Nour A. Manoon, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins in the extracellular matrix (ECM). They play a role in various biological processes and have become attractive therapeutic targets for cancer treatment.
Article
Endocrinology & Metabolism
Dylan J. J. Ritter, Dharmendra Choudhary, Gokhan Unlu, Ela W. W. Knapik
Summary: This study reveals that Rgp1 plays a crucial role in craniofacial cartilage development and the secretion of collagen II. Loss of Rgp1 leads to altered movement of Rab6a(+) vesicular compartments and activation of an Arf4b-mediated stress response in chondrocytes, resulting in cell death.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Laura Baumgartner, Karin Wuertz-Kozak, Christine L. Le Maitre, Francis Wignall, Stephen M. Richardson, Judith Hoyland, Carlos Ruiz Wills, Miguel A. Gonzalez Ballester, Michael Neidlin, Leonidas G. Alexopoulos, Jerome Noailly
Summary: Degenerative changes in the intervertebral disc are a major risk factor for low back pain, with accelerated progression in some individuals as they age. Understanding the disease requires identifying key regulatory processes at various levels, from cells to organs. Experimental research and computational modeling have contributed significantly to our understanding of cell signaling pathways and complex interactions within the intervertebral disc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Orthopedics
T. Nichol, J. Callaghan, R. Townsend, I Stockley, P. Hatton, C. Le Maitre, T. J. Smith, R. Akid
Summary: This study aimed to develop a controlled antibiotic release single-layer hybrid organic-inorganic sol-gel coating for cementless hydroxyapatite-coated titanium orthopaedic prostheses. Both laboratory and in vivo tests showed promising results in terms of antibiotic release kinetics, antibacterial activity, biocompatibility, physical bonding, and osseointegration. The sol-gel coating demonstrated rapid and effective antibiotic release, as well as successful eradication of bacterial biofilms and promotion of osteoblast differentiation in vitro and in vivo, suggesting its potential in preventing implant-related deep infection.
BONE & JOINT JOURNAL
(2021)
Article
Orthopedics
Chitra L. Dahia, Julie B. Engiles, Sarah E. Gullbrand, James C. Iatridis, Alon Lai, Christine L. Le Maitre, Jeffrey C. Lotz, Koichi Masuda, Cheryle A. Seguin, Marianna A. Tryfonidou
Summary: This perspective summarizes the genesis, development, and potential future directions of the multispecies JOR Spine histopathology series.
Article
Orthopedics
Christine L. Le Maitre, Chitra L. Dahia, Morgan Giers, Svenja Illien-Junger, Claudia Cicione, Dino Samartzis, Gianluca Vadala, Aaron Fields, Jeffrey Lotz
Summary: The study aimed to develop a standardized histopathology scoring scheme for human IVD degeneration, showing high intra-rater reliability but emphasizing the need for improved training. Future evaluation in real-world settings is necessary to further refine criteria and understand the relationship between IVD degeneration and back pain.
Review
Orthopedics
Rebecca J. Williams, Marianna A. Tryfonidou, Joseph Wiliam Snuggs, Christine Lyn Le Maitre
Summary: This article discusses cell therapy specifically targeting the restoration of the nucleus pulposus in the intervertebral disc, which is believed to be a key initiation site of disc degeneration. Various cell sources have been extensively analyzed for their regenerative potential, with induced pluripotent stem cells showing the most promising outcomes.
Article
Orthopedics
Philip Poillot, Joseph W. Snuggs, Christine L. Le Maitre, Jacques M. Huyghe
Summary: This study identifies the presence of multiple voltage-gated ion channels (VGICs) in the intervertebral disc (IVD), with evidence supporting the role of L-type voltage-gated calcium channels (VGCCs) in mechanotransduction. These findings highlight the importance of further research in this area to fully elucidate the mechanotransduction pathways in the IVD and improve treatment strategies for IVD degeneration.
Article
Orthopedics
Lisanne T. Laagland, Frances C. Bach, Laura B. Creemers, Christine L. Le Maitre, Deepani W. Poramba-Liyanage, Marianna A. Tryfonidou
Summary: Increasing medium osmolarity during expansion improves the phenotype of NPCs, enhancing their potential as cell-based therapies for intervertebral disc regeneration.
Review
Orthopedics
Shirley N. Tang, Andres F. Bonilla, Nadeen O. Chahine, Aimee C. Colbath, Jeremiah T. Easley, Sibylle Grad, Lisbet Haglund, Christine L. Le Maitre, Victor Leung, Annette M. McCoy, Devina Purmessur, Simon Y. Tang, Stephan Zeiter, Lachlan J. Smith
Summary: Intervertebral disc degeneration is a common cause of low back pain, and appropriate preclinical models are crucial for research and treatment development. This article presents contrasting arguments for in vivo animal models and ex vivo organ culture models for disc studies, aiming to reach a consensus on model selection and implementation. The authors conclude that combining multiple model types and leveraging their unique advantages can lead to high-impact research in most cases.
Article
Materials Science, Biomaterials
Joseph W. Snuggs, Kaj S. Emanuel, Christine Rustenburg, Ronak Janani, Simon Partridge, Christopher Sammon, Theo H. Smit, Christine L. Le Maitre
Summary: Back pain, mainly caused by intervertebral disc degeneration, is a leading cause of disability. However, there are currently no therapies targeting this cause. This study investigated the efficacy of an injectable hydrogel system, NPgel, in halting or reversing the degenerative processes of intervertebral disc degeneration. The results showed that NPgel administration significantly decreased the histological grade of degeneration and promoted new matrix production, highlighting its potential as a future therapy for intervertebral disc degeneration.
BIOMATERIALS SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Sonia Guarnerio, Robert Tempest, Rawan Maani, Stuart Hunt, Laura M. Cole, Christine L. Le Maitre, Keith Chapple, Nicholas Peake
Summary: This study explores the cellular responses to cancer extracellular vesicles as potential complementary biomarkers for stage separation in colorectal cancer patients. It demonstrates the potential of using a combination of plasma extracellular vesicle markers and cellular responses to separate patients according to disease stage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
C. M. E. Rustenburg, J. W. Snuggs, K. S. Emanuel, A. Thorpe, C. Sammon, C. L. Le Maitre, T. H. Smit
EUROPEAN CELLS & MATERIALS
(2020)
Article
Orthopedics
Abbie Binch, Joseph Snuggs, Christine L. Le Maitre
Review
Materials Science, Biomaterials
Paul Mardling, Andrew Alderson, Nicola Jordan-Mahy, Christine Lyn Le Maitre
BIOMATERIALS SCIENCE
(2020)
Article
Materials Science, Biomaterials
Rasha H. Dosh, Nicola Jordan-Mahy, Christopher Sammon, Christine L. Le Maitre
BIOMATERIALS SCIENCE
(2019)
Article
Orthopedics
Louise Vickers, Abbey A. Thorpe, Joseph Snuggs, Christopher Sammon, Christine L. Le Maitre
