Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome

Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos

(2018) Vasileios I. Floros et al.   NATURE CELL BIOLOGY

Progress in mitochondrial replacement therapies

(2018) Mary Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized

(2018) Payam A. Gammage et al.   TRENDS IN GENETICS

Preimplantation genetic diagnosis for mitochondrial DNA mutations: analysis of one blastomere suffices

(2017) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

Assisted reproductive technologies to prevent human mitochondrial disease transmission

(2017) Andy Greenfield et al.   NATURE BIOTECHNOLOGY

Live birth derived from oocyte spindle transfer to prevent mitochondrial disease

(2017) John Zhang et al.   REPRODUCTIVE BIOMEDICINE ONLINE

ClickIn: a flexible protocol for quantifying mitochondrial uptake of nucleobase derivatives

(2017) Kurt Hoogewijs et al.   Interface Focus

Method of carrier-free delivery of therapeutic RNA importable into human mitochondria: Lipophilic conjugates with cleavable bonds

(2016) Ilya Dovydenko et al.   BIOMATERIALS

Modifying the Mitochondrial Genome

(2016) Alexander N. Patananan et al.   Cell Metabolism

Assessing the Delivery of Molecules to the Mitochondrial Matrix Using Click Chemistry

(2016) Kurt Hoogewijs et al.   CHEMBIOCHEM

Mitochondrial disorders in children: toward development of small-molecule treatment strategies

(2016) W. J. Koopman et al.   EMBO Molecular Medicine

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

(2016) Louise A. Hyslop et al.   NATURE

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2016) Eunju Kang et al.   NATURE

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs

(2016) Payam A. Gammage et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis

(2015) Hubert J.M. Smeets et al.   Annals of the New York Academy of Sciences

Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing

(2015) Pradeep Reddy et al.   CELL

MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

(2015) Masami Hashimoto et al.   MOLECULAR THERAPY

Concise Reviews: Assisted Reproductive Technologies to Prevent Transmission of Mitochondrial DNA Disease

(2015) Jessica Richardson et al.   STEM CELLS

Antibiotic Resistance of Bacteria

(2015) Madhab K. Chattopadhyay et al.   Biomed Research International

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

(2014) P. A. Gammage et al.   EMBO Molecular Medicine

A national perspective on prenatal testing for mitochondrial disease

(2014) Victoria Nesbitt et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Three-parent in vitro fertilization: gene replacement for the prevention of inherited mitochondrial diseases

(2014) Paula Amato et al.   FERTILITY AND STERILITY

Modeling of Antigenomic Therapy of Mitochondrial Diseases by Mitochondrially Addressed RNA Targeting a Pathogenic Point Mutation in Mitochondrial DNA

(2014) Yann Tonin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of microRNAs in Mitochondria: Small Players Acting Wide

(2014) Filipe Duarte et al.   Genes

Preimplantation genetic diagnosis in mitochondrial DNA disorders: challenge and success

(2013) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

(2013) Sandra R Bacman et al.   NATURE MEDICINE

Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder

(2012) Nathan R. Treff et al.   FERTILITY AND STERILITY

PGD and heteroplasmic mitochondrial DNA point mutations: a systematic review estimating the chance of healthy offspring

(2012) D.M.E.I. Hellebrekers et al.   HUMAN REPRODUCTION UPDATE

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease

(2011) S R Bacman et al.   GENE THERAPY

The implications of mitochondrial DNA copy number regulation during embryogenesis

(2011) Phillippa J. Carling et al.   MITOCHONDRION

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

Mitochondrial DNA mutations and human disease

(2009) Helen A.L. Tuppen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial gene replacement in primate offspring and embryonic stem cells

(2009) Masahito Tachibana et al.   NATURE

Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes

(2008) M F Alexeyev et al.   GENE THERAPY

Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA

(2008) Michal Minczuk et al.   NUCLEIC ACIDS RESEARCH