Assisted reproductive technologies to prevent human mitochondrial disease transmission

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

Incomplete penetrance in mitochondrial optic neuropathies

(2017) Leonardo Caporali et al.   MITOCHONDRION

Genetic Counselling for Maternally Inherited Mitochondrial Disorders

(2017) Joanna Poulton et al.   Molecular Diagnosis & Therapy

First birth following spindle transfer for mitochondrial replacement therapy: hope and trepidation

(2017) Mina Alikani et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Live birth derived from oocyte spindle transfer to prevent mitochondrial disease

(2017) John Zhang et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Disruptive reproductive technologies

(2017) I. Glenn Cohen et al.   Science Translational Medicine

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

(2017) Olli Matilainen et al.   TRENDS IN CELL BIOLOGY

Mitochondrial Replacement Therapy: Are Mito-nuclear Interactions Likely To Be a Problem?

(2017) Adam Eyre-Walker   GENETICS

The Ethics of Mitochondrial Replacement

(2016) John B. Appleby et al.   BIOETHICS

Is Mitochondrial Donation Germ-Line Gene Therapy? Classifications and Ethical Implications

(2016) Ainsley J. Newson et al.   BIOETHICS

Do Mitochondrial Replacement Techniques Affect Qualitative or Numerical Identity?

(2016) S. Matthew Liao   BIOETHICS

Incompatibility between Nuclear and Mitochondrial Genomes Contributes to an Interspecies Reproductive Barrier

(2016) Hong Ma et al.   Cell Metabolism

Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes

(2016) Mitsutoshi Yamada et al.   Cell Stem Cell

Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging

(2016) Jun-Ichi Hayashi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

De novo mtDNA point mutations are common and have a low recurrence risk

(2016) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

AstraZeneca launches project to sequence 2 million genomes

(2016) Heidi Ledford   NATURE

Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease

(2016) Louise A. Hyslop et al.   NATURE

Mitochondrial replacement in human oocytes carrying pathogenic mitochondrial DNA mutations

(2016) Eunju Kang et al.   NATURE

Mitochondrial and nuclear DNA matching shapes metabolism and healthy ageing

(2016) Ana Latorre-Pellicer et al.   NATURE

Reconstitution in vitro of the entire cycle of the mouse female germ line

(2016) Orie Hikabe et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs

(2016) Payam A. Gammage et al.   NUCLEIC ACIDS RESEARCH

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

(2016) Gokhan Akman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy and ubiquitin–proteasome system contribute to sperm mitophagy after mammalian fertilization

(2016) Won-Hee Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pregnancy derived from human zygote pronuclear transfer in a patient who had arrested embryos after IVF

(2016) John Zhang et al.   REPRODUCTIVE BIOMEDICINE ONLINE

F-actin mechanics control spindle centring in the mouse zygote

(2016) Agathe Chaigne et al.   Nature Communications

Maternal Metabolic Syndrome Programs Mitochondrial Dysfunction via Germline Changes across Three Generations

(2016) Jessica L. Saben et al.   Cell Reports

Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing

(2015) Pradeep Reddy et al.   CELL

Evolutionary defined role of the mitochondrial DNA in fertility, disease and ageing

(2015) Auke B.C. Otten et al.   HUMAN REPRODUCTION UPDATE

Metabolic rescue in pluripotent cells from patients with mtDNA disease

(2015) Hong Ma et al.   NATURE

Extensive tissue-related and allele-related mtDNA heteroplasmy suggests positive selection for somatic mutations

(2015) Mingkun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient Mitochondrial Genome Editing by CRISPR/Cas9

(2015) Areum Jo et al.   Biomed Research International

Polar Body Genome Transfer for Preventing the Transmission of Inherited Mitochondrial Diseases

(2014) Tian Wang et al.   CELL

Mutation-free baby born from a mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome carrier after blastocyst trophectoderm preimplantation genetic diagnosis

(2014) Björn Heindryckx et al.   MITOCHONDRION

Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

(2014) Mitsutoshi Yamada et al.   NATURE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Potential impact of human mitochondrial replacement on global policy regarding germline gene modification

(2014) Tetsuya Ishii   REPRODUCTIVE BIOMEDICINE ONLINE

Data from Artificial Models of Mitochondrial DNA Disorders Are Not Always Applicable to Humans

(2014) Julie Steffann et al.   Cell Reports

Limitations of Preimplantation Genetic Diagnosis for Mitochondrial DNA Diseases

(2014) Shoukhrat Mitalipov et al.   Cell Reports

The Challenges of Mitochondrial Replacement

(2014) Patrick F. Chinnery et al.   PLoS Genetics

Mitochondrial genetics

(2013) P. F. Chinnery et al.   BRITISH MEDICAL BULLETIN

Biased inheritance of mitochondria during asymmetric cell division in the mouse oocyte

(2013) C. M. Dalton et al.   JOURNAL OF CELL SCIENCE

Preimplantation genetic diagnosis in mitochondrial DNA disorders: challenge and success

(2013) Suzanne C E H Sallevelt et al.   JOURNAL OF MEDICAL GENETICS

Unique insights into maternal mitochondrial inheritance in mice

(2013) S.-M. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Replacement, Evolution, and the Clinic

(2013) K. Reinhardt et al.   SCIENCE

Mitochondrial DNA Genetics and the Heteroplasmy Conundrum in Evolution and Disease

(2013) D. C. Wallace et al.   Cold Spring Harbor Perspectives in Biology

Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder

(2012) Nathan R. Treff et al.   FERTILITY AND STERILITY

Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

(2012) Daniel Paull et al.   NATURE

Towards germline gene therapy of inherited mitochondrial diseases

(2012) Masahito Tachibana et al.   NATURE

Rapid Mitochondrial DNA Segregation in Primate Preimplantation Embryos Precedes Somatic and Germline Bottleneck

(2012) Hyo-Sang Lee et al.   Cell Reports

Geminin Escapes Degradation in G1 of Mouse Pluripotent Cells and Mediates the Expression of Oct4, Sox2, and Nanog

(2011) Valerie S. Yang et al.   CURRENT BIOLOGY

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells

(2011) Alessandro Prigione et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks

(2010) Olga S. Koutsopoulos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Segregation of mtDNA throughout human embryofetal development: m.3243A>G as a model system

(2010) Sophie Monnot et al.   HUMAN MUTATION

Pronuclear transfer in human embryos to prevent transmission of mitochondrial DNA disease

(2010) Lyndsey Craven et al.   NATURE

New Evidence Confirms That the Mitochondrial Bottleneck Is Generated without Reduction of Mitochondrial DNA Content in Early Primordial Germ Cells of Mice

(2009) Liqin Cao et al.   PLoS Genetics

Spindle Positioning in Mouse Oocytes Relies on a Dynamic Meshwork of Actin Filaments

(2008) Jessica Azoury et al.   CURRENT BIOLOGY

The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes

(2008) Timothy Wai et al.   NATURE GENETICS

A reduction of mitochondrial DNA molecules during embryogenesis explains the rapid segregation of genotypes

(2008) Lynsey M Cree et al.   NATURE GENETICS