Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs

Modifying the Mitochondrial Genome

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CpG methylation patterns of human mitochondrial DNA

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Emerging concepts in the therapy of mitochondrial disease

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Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing

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Riboswitch engineering — making the all-important second and third steps

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MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases

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Mutations causing mitochondrial disease: What is new and what challenges remain?

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Fumarate induces redox-dependent senescence by modifying glutathione metabolism

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Efficient Mitochondrial Genome Editing by CRISPR/Cas9

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Genome Engineering with Targetable Nucleases

(2014) Dana Carroll   Annual Review of Biochemistry

A magic bullet to specifically eliminate mutated mitochondrial genomes from patients' cells

(2014) C. T. Moraes   EMBO Molecular Medicine

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations

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(2014) Oliver Russell et al.   EXPERIMENTAL CELL RESEARCH

Modeling of Antigenomic Therapy of Mitochondrial Diseases by Mitochondrially Addressed RNA Targeting a Pathogenic Point Mutation in Mitochondrial DNA

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MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome

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(2014) Basil J. Greber et al.   NATURE

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming

(2014) M. Picard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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Conditional Control of Mammalian Gene Expression by Tetracycline-Dependent Hammerhead Ribozymes

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Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs

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Quantitative analysis of TALE–DNA interactions suggests polarity effects

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Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

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VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

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Overcoming Transcription Activator-like Effector (TALE) DNA Binding Domain Sensitivity to Cytosine Methylation

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Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome

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Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers

(2012) Sebastian Bultmann et al.   NUCLEIC ACIDS RESEARCH

Correcting human mitochondrial mutations with targeted RNA import

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Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease

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Heritable gene targeting in zebrafish using customized TALENs

(2011) Peng Huang et al.   NATURE BIOTECHNOLOGY

Therapeutic in vivo gene transfer for genetic disease using AAV: progress and challenges

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DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease

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Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures

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Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA

(2010) Michal Minczuk et al.   Nature Protocols

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

(2010) D.-F. Suen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sequence Alignment/Map format and SAMtools

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Fast and accurate short read alignment with Burrows-Wheeler transform

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RNase P without RNA: Identification and Functional Reconstitution of the Human Mitochondrial tRNA Processing Enzyme

(2008) Johann Holzmann et al.   CELL

Selective elimination of mutant mitochondrial genomes as therapeutic strategy for the treatment of NARP and MILS syndromes

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Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA

(2008) Michal Minczuk et al.   NUCLEIC ACIDS RESEARCH

Two distinct structural elements of 5S rRNA are needed for its import into human mitochondria

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