Article
Biophysics
Shuai Cao, Le Zhou, Chang Liu, Huacheng Zhang, Yuxin Zhao, Yanli Zhao
Summary: The ingenious design and synthesis of novel macrocycles brought renewed vigor to supramolecular chemistry in the past decade. Pillarene and pillararene-based functional materials have seen rapid growth in electrochemical studies due to their unique structures and physiochemical properties. Challenges and future developments in this field have been discussed, providing a solid foundation for further bioelectrochemical applications of pillararene systems.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Zhiguo Li, Junren Chen, Lingling Zhang, Yuge Liu, Yongmei Jia, Guohua Zhou, Liqiang Luo
Summary: In this article, a new signal amplification strategy based on signal on-off-off is proposed to improve the detection sensitivity of a breast cancer 1 (BRCA1) electrochemical sensor. The designed sensor demonstrates excellent detection sensitivity for BRCA1, capable of distinguishing single base mismatch BRCA1, two base mismatch BRCA1, and non-complementary DNA.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Priscilla B. Osei, Joshua Northcote-Smith, Jiaxin Fang, Kuldip Singh, Fabrizio Ortu, Kogularamanan Suntharalingam
Summary: The synthesis and characterization of two new binuclear copper(II)-phenanthroline complexes, 1 and 2, are reported. Complex 1 shows nanomolar toxicity towards bulk breast cancer cells and breast cancer stem cells (CSCs), with potency greater than that of cisplatin and salinomycin. Mechanistic studies reveal that complex 1 induces breast CSC apoptosis by increasing intracellular reactive oxygen species levels and damaging genomic DNA.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Analytical
Yuting Yan, Fangfang Zhou, Qian Wang, Yue Huang
Summary: A sensitive electrochemical biosensor is developed using Cu2+-modulated signal amplification for the detection of quinolones. The presence of target quinolones inhibits the activity of Cu2+-specific DNAzyme, resulting in the amplification of electrochemical signal positively correlated with the concentration of quinolones. The biosensor exhibits a good linear relationship and low limit of detection, making it suitable for the detection of quinolones in foodstuff samples.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Analytical
Liang Yuan, Lei Liu
Summary: Peptides have shown great potential in a variety of applications, particularly in the field of nanotechnology where they are used as biomaterials for constructing new nanostructures. Peptide-based biosensors are being extensively studied and are expected to play a significant role in advanced biomolecular analyses.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Qingyu Wang, Haobo Sun, Dongxiao Wen, Lei Wang, Lianzhi Li, Jinming Kong, Xueji Zhang
Summary: An electrochemical sensing platform based on ATRP signal amplification strategy has been developed for ultrasensitive determination of breast and prostate cancer marker miRNA-141, with a linear range from 10 pM to 10 aM and a detection limit of 3.23 aM, providing a new and promising path for ultrasensitive analysis of tumor-related miRNAs.
Review
Chemistry, Multidisciplinary
Jie Zhang, Lin Zhang, Zhishang Li, Qi Zhang, Yanbin Li, Yibin Ying, Yingchun Fu
Summary: This review evaluates two main types of nanoconfinement systems - confined nanochannels and planes - and summarizes the nanoconfinement effect mechanisms and applications in electrochemical analysis and sensing. It aims to help researchers deepen their understanding of nanoconfinement devices and their effects, in order to develop new analysis and sensing applications in various fields.
Article
Chemistry, Analytical
Qiong Hu, Jianwen Wan, Zhiwen Liang, Shiqi Li, Wenxing Feng, Yiyi Liang, Yilin Luo, Xiaojing Cao, Yingming Ma, Dongxue Han, Li Niu
Summary: By taking advantage of target-assisted electrochemically mediated atom transfer radical polymerization (teATRP) for signal amplification, a simple and cost-effective electrochemical aptasensor is developed for sensitive and selective detection of low-abundance endotoxin. The aptamer receptor selectively captures endotoxin, and signal amplification is achieved through the dual amplification strategy of ATRP-initiated polymer chain grafting. This aptasensor shows high sensitivity with a detection limit of 1.2 fg/mL and has great potential for detecting low-abundance endotoxin and other glycan chain containing bio-targets.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Lixia Su, Yonghuan Su, Bingqian Liu
Summary: A new strategy for immobilization-free detection of E. coli was developed using a composite as capture probes and signal amplification labels, achieving target detection through a specific sandwich format. This method showed linear detection of E. coli concentration with a low limit of detection.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Physical
Hong Yao, Qi Zhou, Xiao-Tong Kan, Yan-Bing Niu, Muhammad Naeem, Tai-Bao Wei, Qi Lin, You-Ming Zhang
Summary: In this study, a signal amplification strategy was successfully used by introducing metal ions into pillar[5]arene-based supramolecular gel to selectively and ultrasensitively detect H2PO4-. The limit of detection for H2PO4- was calculated to be 2.82 nM using the non-fluorescent metal coordinated supramolecular gel as a fluorescence turn-on sensor.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Oncology
Abdel-Rahman N. Zekri, Abeer Bahnassy, Magda Mourad, Ibrahim Malash, Ola Ahmed, Mona S. Abdellateif
Summary: This study characterized breast cancer stem cells (BCSCs) through genetic profiling, revealing specific molecular profiles that differ according to their phenotypes. These profiles could potentially impact patients' prognosis and outcome.
CANCER CELL INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Chihong Ma, Qin Zhou, Jinjin Shi, Hua Gao, Di Huang, Huimin Xue, Han Wang, Zhenzhong Zhang, Sen Yang, Junli Zhang, Kaixiang Zhang
Summary: We developed a CRISPR-empowered electrochemical biosensor, named PER-E-CRISPR, for amplification-free and sensitive detection of miR-21. The biosensor combines the advantages of CRISPR/Cas13a and primer exchange reaction (PER) for target amplification. Under optimized conditions, the PER-E-CRISPR assay exhibits a linear range from 10-13 to 10-7 M and a limit of detection of 30.2 fM. The biosensor shows excellent performance in actual plasma, indicating promising prospects for miRNA detection in molecular diagnosis.
Review
Chemistry, Multidisciplinary
Lei He, Rongrong Huang, Pengfeng Xiao, Yuan Liu, Lian Jin, Hongna Liu, Song Li, Yan Deng, Zhu Chen, Zhiyang Li, Nongyue He
Summary: Aptamers have high specificity and affinity toward various targets, making them widely used in analytical techniques. In order to improve biosensor sensitivity, different amplification strategies are being explored, such as using nanomaterials or enzyme mimics.
CHINESE CHEMICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Li Li, Zhengbo Chen
Summary: In this study, a high specificity, flexibility, and simplicity aptasensor strategy was designed using a triblock DNA probe. It was found that the polyA fragment could assemble on the gold electrode surface via polyA instead of traditional Au-S bonds, leading to improved hybridization stability. The electrochemical aptasensor showed good repeatability, stability, and specificity.
BIOELECTROCHEMISTRY
(2023)
Article
Chemistry, Analytical
Wenwen Xu, Xinyu Sun, Linyu Wang, Xianping Gao, Pei Yang, Chuanye Tang, Feng Gao, Pinghua Ling
Summary: Researchers have developed a sensitive and universal electrochemical platform for detecting targets in the cellular microenvironment. This method combines a self-serviced-track 3D DNA walker with catalytic hairpin assembly (CHA) to trigger G-Quadruplex/Hemin DNAzyme assembly signal amplification. The method showed high selectivity and sensitivity, with a detection limit of 39 cell/mL and 2.16 nM N-acetylgalactosamine using N-acetylgalactosamine as a model. This enzyme-free detection strategy has potential for early and prognostic diagnostic applications.
ANALYTICAL CHEMISTRY
(2023)
Article
Electrochemistry
Jingwen Li, Yifei Li, Xingwei Zhai, Ya Cao, Jing Zhao, Yuguo Tang, Kun Han
ELECTROCHEMISTRY COMMUNICATIONS
(2020)
Article
Nanoscience & Nanotechnology
Xiaoxia Mao, Dongsheng Mao, Tianshu Chen, Mohammed Jalalah, Mohammed S. Al-Assiri, Farid A. Harraz, Xiaoli Zhu, Genxi Li
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Chemistry, Analytical
Xiaomeng Yu, Lingjun Sha, Langjian Dong, Ya Cao, Jing Zhao
Summary: Exosomes play a crucial role in intercellular transport and communication, and have the potential to serve as biomarkers for early detection and real-time monitoring of tumors. This review provides a summary of the recent advances in tumor exosome detection and their potential applications.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Applied
Bing Han, Cheng Fang, Lingjun Sha, Mohammed Jalalah, M. S. Al-Assiri, Farid A. Harraz, Ya Cao
Summary: A new fluorescent aptasensor using cascade strand displacement reaction was proposed for the detection of ochratoxin A, achieving an improved detection limit and short assay time. The method showed potential for use in food quality control in the future.
Article
Chemistry, Analytical
Xiaoxia Mao, Shaowei Liu, Benyue Su, Dejin Wang, Zhan Huang, Jian Li, Yuanguang Zhang
Article
Biophysics
Ya Cao, Ying Wang, Xiaomeng Yu, Xihui Jiang, Gang Li, Jing Zhao
BIOSENSORS & BIOELECTRONICS
(2020)
Review
Chemistry, Analytical
Yuhao Dai, Bing Han, Langjian Dong, Jing Zhao, Ya Cao
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Bing Han, Langjian Dong, Lingling Li, Lingjun Sha, Ya Cao, Jing Zhao
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Biophysics
Bing Han, Lingjun Sha, Xiaomeng Yu, Mei Yang, Ya Cao, Jing Zhao
Summary: The study introduced a novel method for simultaneous identification of dual therapeutic targets in breast cancer using in situ automatous DNA assembly reaction and electrochemical techniques. The method demonstrated high sensitivity and specificity in identifying co-existed therapeutic targets, even in serum samples, and could potentially provide valuable information for enhancing the efficiency of combined therapy in clinic. The use of quantum dots as electrochemical labeling allowed for the creation of increased electrochemical signaling to reveal the co-expression of the two targets.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Analytical
Ying Wang, Langjian Dong, Jing Zhao, Mohammed Jalalah, M. S. Al-Assiri, Farid A. Harraz, Ya Cao
Summary: The developed dual-functional probe sensing method can specifically identify CD44 even in serum samples and breast cancer cells with broad detection range and high sensitivity. The method can monitor changes in CD44 expression, providing a new approach to study stem-like properties in breast cancer.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Shaowei Liu, Yumeng Yang, Mengqin Shi, Hai Shi, Dongsheng Mao, Xiaoxia Mao, Yuanguang Zhang
Summary: In this study, a portable smartphone-based DNAzyme hydrogel platform was developed for the detection of cfDNA. The platform showed high sensitivity and visibility, making it a promising tool for testing other nucleic acid biomarkers in the future.
Article
Nanoscience & Nanotechnology
Yingyan Zhao, Qi Liu, Yujia Qin, Yue Cao, Jing Zhao, Kai Zhang, Ya Cao
Summary: In this work, an electrochemical aptasensor was designed for the high-accuracy assay of AFP-L3 ratio. The aptasensor demonstrated the ability to accurately measure the AFP-L3 ratio in a linear range of 0.0008-40 ng mL-1, with satisfactory specificity and good recoveries in complex serum samples. This aptasensor may serve as a valuable tool for the measurement of AFP-L3 ratio and have great potential for early warning of hepatocellular carcinoma in clinical application.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Analytical
Xiaomeng Yu, Ya Cao, Yingyan Zhao, Jianan Xia, Jie Yang, Yuanyuan Xu, Jing Zhao
Summary: This study presents a universal method for accurate and sensitive analysis of tumor-associated glycoprotein biomarkers. The method utilizes dual recognition of carbohydrates and proteins to achieve amplified electrochemical responses for glycoprotein analysis. The results show high accuracy, specificity, and versatility in complex serum samples, making this method a valuable tool for the analysis of glycoprotein biomarkers.
ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Xiaoxia Mao, Dongsheng Mao, Juanjuan Jiang, Benyue Su, Guifang Chen, Xiaoli Zhu
Summary: In this study, a semi-dry smart biosensing platform was developed for the sensitive detection of metal ions using a hydrogel and intelligent image recognition. The platform demonstrated favorable operability and performance, with detection limits of 0.34 mM for potassium ions and 5.6 nM for mercury ions. It was also capable of detecting ions in serum and lake water, showing promising potential for on-site testing.
Article
Chemistry, Multidisciplinary
Xu Chen, Xianyong Wu, Ziyu He, Juan Zhang, Ya Cao, Dongsheng Mao, Chang Feng, Bo Tian, Guifang Chen
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Electrochemistry
Abdul Qayoom Mugheri, Shaista Khan, Ali Asghar Sangah, Aijaz Ahmed Bhutto, Muhammad Younis Laghari, Nadeem Ahmed Mugheri, Asif Ali Jamali, Arsalan Ahmed Mugheri, Nagji Sodho, Abdul Waheed Mastoi, Aftab Kandhro
Summary: Green hydrogen has the potential to transition to a pollution-free energy infrastructure. This study proposes a solution to produce hydrogen during the photoelectrochemical process, offering greater stability and control over chemical reactions. Techno-economic assessments show the efficiency and economic feasibility of co-producing value-added chemicals to enhance green hydrogen production.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Danpeng Cheng, Wuxin Sha, Qigao Han, Shun Tang, Jun Zhong, Jinqiao Du, Jie Tian, Yuan-Cheng Cao
Summary: LiNixCoyMn1-x-yO2 (NCM) is a critical cathode material for lithium-ion batteries in electric vehicles. The aging of cathode/electrolyte interfaces leads to capacity degradation and long-term cycle instability. A novel neural network model called ACGNet is developed to predict electrochemical stability windows of crystals, allowing for high-throughput screening of coating materials. LiPO3 is identified as a promising coating material with high oxidation voltage and low cost, which significantly improves the cycle stability of NCM batteries. This study demonstrates the accuracy and potential of machine learning in battery materials.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
P. Mohana, R. Yuvakkumar, G. Ravi, S. Arunmetha
Summary: This study successfully fabricates a non-noble CuO/NiO/rGO nanocomposite and investigates its electrocatalytic performance for oxygen evolution reaction in alkaline environment. The experimental results demonstrate that the electrocatalyst exhibits high activity and good stability, offering a new synthetic approach for sustainable energy production.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Qiong Qu, Jing Guo, Hongyu Wang, Kai Zhang, Jingde Li
Summary: In this study, a bifunctional electrode host design consisting of carbon nanofibers implanted ordered porous Co-decorated Al2O3 supported on carbon nanotube film (CNTF) was proposed to address the shuttling effect of lithium polysulfides (LiPSs) and dendrite formation of metal lithium anode in lithium-sulfur (Li-S) batteries. The electrode exhibited excellent conductivity, efficient confinement of LiPSs, and catalytic conversion performance, resulting in high initial capacity and good capacity retention during cycling. As an anode, the electrode showed excellent Li+ diffusion performance and uniform lithium growth behavior, achieving a dendrite-free lithium electrode. The flexible pack cell assembled from these electrodes delivered a specific capacity of 972 mAh g(-1) with good capacity retention.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Hong Zhang, Jin-Peng Yu, Chen Chen, Cheng-Yong Shu, Guang-Yu Xu, Jie Ren, Kai Cui, Wen-Fang Cai, Yun-Hai Wang, Kun Guo
Summary: Spray coating of acetylene black nanoparticles onto stainless steel mesh can enhance its biofilm formation ability and current density, making it a promising electrode material for microbial electrochemical systems. The spray coating method is simple, cost-effective, and suitable for large-size stainless steel electrodes.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Binpeng Hou, Jingjin Chen, Li-Hong Zhang, Xiaowen Shi, Zizhong Zhu
Summary: The electrochemical performance of Li1.20Mn0.44Ni0.32Co0.04O2 and its oxygen-deficient phase Li1.20Mn0.44Ni0.32Co0.04O1.83 was studied through first-principles calculations. The results show that the oxygen-deficient phase has a higher theoretical capacity but lower voltage platform and higher chemical activity compared to the pristine phase.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Yating Du, Sayoko Shironita, Daisuke Asakura, Eiji Hosono, Yoshitsugu Sone, Yugo Miseki, Eiichi Kobayashi, Minoru Umeda
Summary: This study investigates the effect of high- and low-temperature environments on the charge-discharge performance of a Li-ion battery. The deterioration mechanisms of the battery at different temperatures are analyzed through various characterization techniques. The results indicate that the battery performance deteriorates more significantly at a low-temperature environment of 5 degrees C compared to higher temperatures. The understanding of the deterioration mechanisms can contribute to the development of safer battery usage methods.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Si-Si Shi, Zhi-Xiang Yuan, Fei Zhang, Ping Chen
Summary: In this study, a new nano-electrocatalyst was prepared, which exhibited superior electrocatalytic activity for the reduction of NO2- to ammonia in a neutral electrolyte, potentially due to the synergistic enhancement between Co3O4-x and Co.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Berna Dalkiran, Havva Bekirog
Summary: This study reports the use of deep eutectic solvents (DES) based on ethylene glycol and urea as low-cost and green electrolytes for enhancing electrochemical detection of natural antioxidants. The study successfully developed a disposable and effective electrochemical sensing platform for simultaneous determination of ascorbic acid (AA) and gallic acid (GA) using NaOH nanorods on a pencil graphite electrode. The proposed electrode showed improved analytical performance, with higher peak currents and shifted oxidation potentials in DES compared to BR buffer medium.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Sijun Ren, Jianguo Huang
Summary: In this study, a novel bio-inspired nanofibrous WO3/carbon composite was synthesized using a facile hydrothermal method. The three-dimensional network structure of the composite alleviated the volume expansion of WO3 nanorods and enhanced the charge-transport kinetics. The optimized composite exhibited superior lithium storage properties.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Zhilong Zheng, Yu Chen, Hongxia Yin, Hengbo Xiao, Xiangji Zhou, Zhiwen Li, Ximin Li, Jin Chen, Songliu Yuan, Junjie Guo, Haibin Yu, Zhen Zhang, Lihua Qian
Summary: This study found that interstitial Zn cations in CoMoO4 can modulate the dissolution kinetics of Mo cations and improve the OER performance. The interstitial Zn cations can prevent the dissolution of Co cations at high potential, enhancing the durability of the catalyst.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Xiaobo Lin, Shern R. Tee, Debra J. Searles, Peter T. Cummings
Summary: Molecular dynamics simulations using the constant potential method were used to investigate the charging dynamics and charge storage of supercapacitors. The simulations revealed that the water-in-salt electrolyte exhibited the highest charge storage and significantly higher capacitance on the negative electrode. The varying contributions of different electrode regions to supercapacitor performance were also demonstrated.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Wiktoria Lipinska, Vita Saska, Katarzyna Siuzdak, Jakub Karczewski, Karol Zaleski, Emerson Coy, Anne de Poulpiquet, Ievgen Mazurenko, Elisabeth Lojou
Summary: The spatial distribution of enzymes on electrodes is important for bioelectrocatalysis. In this study, controlled spatial distribution of gold nanoparticles on Ti nanodimples was achieved. The efficiency of enzymatic O2 reduction was found to be influenced by the size of the gold nanoparticles and their colocalization with TiO2. The highest stability of enzymatic current was observed with the largest gold nanoparticles.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Tariq M. Al-Hejri, Zeenat A. Shaikh, Ahmed H. Al-Naggar, Siddheshwar D. Raut, Tabassum Siddiqui, Hamdan M. Danamah, Vijaykumar V. Jadhav, Abdullah M. Al-Enizi, Rajaram S. Mane
Summary: This study explores a promising self-growth approach for the synthesis of nickel hydroxide (Ni(OH)2) nanosponge-balls on the surface of a nickel-foam (NiF) electrode. The modified NiF electrode, named Ni(OH)2@NiF, shows distinctive nanosponge-ball morphology and demonstrates excellent energy storage capability and electrocatalytic performance in both hydrogen and oxygen evolution reactions.
ELECTROCHIMICA ACTA
(2024)
Article
Electrochemistry
Rafael Del Olmo, Gregorio Guzman-Gonzalez, Oihane Sanz, Maria Forsyth, Nerea Casado
Summary: The use of Lithium-Ion Batteries (LIBs) is becoming increasingly extensive, and it is important to optimize the devices to achieve their maximum practical specific capacity. In this study, mixed ionic-electronic conducting (MIEC) binders based on PEDOT:PSS and PEDOT: PDADMA-TFSI were developed for Li-ion cathodes, and their performance was compared with conventional formulations. The influence of electrode formulations, including the addition of conducting carbon and an Organic Ionic Plastic Cristal (OIPC), was also analyzed. The proposed binders showed improved performance compared to conventional formulations with different electrolyte types and active materials.
ELECTROCHIMICA ACTA
(2024)