Different in vitro and in vivo tools for elucidating the human metabolism of alpha-cathinone-derived drugs of abuse

Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples

(2017) Lilian H.J. Richter et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine

(2017) Lilian H.J. Richter et al.   TOXICOLOGY LETTERS

First metabolic profile of PV8, a novel synthetic cathinone, in human hepatocytes and urine by high-resolution mass spectrometry

(2016) Madeleine J. Swortwood et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

High-resolution mass spectrometry in toxicology: current status and future perspectives

(2016) H. H. Maurer et al.   ARCHIVES OF TOXICOLOGY

Toxicity evaluation of α-pyrrolidinovalerophenone (α-PVP): results from intoxication cases within the STRIDA project

(2016) Olof Beck et al.   CLINICAL TOXICOLOGY

A snapshot on NPS in Italy: Distribution of drugs in seized materials analysed in an Italian forensic laboratory in the period 2013–2015

(2016) Sara Odoardi et al.   FORENSIC SCIENCE INTERNATIONAL

In vitro, in vivo and in silico metabolic profiling of α-pyrrolidinopentiothiophenone, a novel thiophene stimulant

(2016) Madeleine J Swortwood et al.   Bioanalysis

Orbitrap technology for comprehensive metabolite-based liquid chromatographic–high resolution-tandem mass spectrometric urine drug screening – Exemplified for cardiovascular drugs

(2015) Andreas G. Helfer et al.   ANALYTICA CHIMICA ACTA

Studies on the metabolism and toxicological detection of the new psychoactive designer drug 2-(4-iodo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine (25I-NBOMe) in human and rat urine using GC-MS, LC-MSn, and LC-HR-MS/MS

(2015) Achim T. Caspar et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Metabolism of the designer drug α-pyrrolidinobutiophenone (α-PBP) in humans: Identification and quantification of the phase I metabolites in urine

(2015) Shuntaro Matsuta et al.   FORENSIC SCIENCE INTERNATIONAL

Urinary excretion and metabolism of the α-pyrrolidinophenone designer drug 1-phenyl-2-(pyrrolidin-1-yl)octan-1-one (PV9) in humans

(2015) Noriaki Shima et al.   Forensic Toxicology

Identification of phase I and II metabolites of the new designer drugα-pyrrolidinohexiophenone (α-PHP) in human urine by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS)

(2015) Michael Paul et al.   JOURNAL OF MASS SPECTROMETRY

A fatal case of poisoning related to new cathinone designer drugs, 4-methoxy PV8, PV9, and 4-methoxy PV9, and a dissociative agent, diphenidine

(2015) Keiko Kudo et al.   Legal Medicine

A fatal case of poisoning related to new cathinone designer drugs, 4-methoxy PV8, PV9, and 4-methoxy PV9, and a dissociative agent, diphenidine

(2015) Keiko Kudo et al.   Legal Medicine

UPLC/ESI-MS/MS-based determination of metabolism of several new illicit drugs, ADB-FUBINACA, AB-FUBINACA, AB-PINACA, QUPIC, 5F-QUPIC andα-PVT, by human liver microsome

(2014) Takahiro Takayama et al.   BIOMEDICAL CHROMATOGRAPHY

Bioactivation Potential of Thiophene-Containing Drugs

(2014) Darja Gramec et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pharmacology of novel synthetic stimulants structurally related to the “bath salts” constituent 3,4-methylenedioxypyrovalerone (MDPV)

(2014) Julie A. Marusich et al.   NEUROPHARMACOLOGY

“Deconstruction” of the Abused Synthetic Cathinone Methylenedioxypyrovalerone (MDPV) and an Examination of Effects at the Human Dopamine Transporter

(2013) Renata Kolanos et al.   ACS Chemical Neuroscience

2-Methiopropamine, a thiophene analogue of methamphetamine: studies on its metabolism and detectability in the rat and human using GC-MS and LC-(HR)-MS techniques

(2013) Jessica Welter et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Studies on the in vivo contribution of human cytochrome P450s to the hepatic metabolism of glaucine, a new drug of abuse

(2013) Golo M.J. Meyer et al.   BIOCHEMICAL PHARMACOLOGY

New cathinone-derived designer drugs 3-bromomethcathinone and 3-fluoromethcathinone: studies on their metabolism in rat urine and human liver microsomes using GC-MS and LC-high-resolution MS and their detectability in urine

(2012) Markus R. Meyer et al.   JOURNAL OF MASS SPECTROMETRY

Synthetic cathinones: Chemistry, pharmacology and toxicology of a new class of designer drugs of abuse marketed as “bath salts” or “plant food”

(2012) M. Coppola et al.   TOXICOLOGY LETTERS

In vitro approaches to studying the metabolism of new psychoactive compounds

(2011) Frank T. Peters et al.   Drug Testing and Analysis

Genetic Polymorphism of Metabolic Enzymes P450 (CYP) as a Susceptibility Factor for Drug Response, Toxicity, and Cancer Risk

(2009) Nada Božina et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology