标题
Genetically engineered pigs as models for human disease
作者
关键词
-
出版物
Disease Models & Mechanisms
Volume 11, Issue 1, Pages dmm030783
出版商
The Company of Biologists
发表日期
2018-01-23
DOI
10.1242/dmm.030783
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni
- (2017) Eunji Kim et al. Nature Communications
- Porcine familial adenomatous polyposis model enables systematic analysis of early events in adenoma progression
- (2017) Tatiana Flisikowska et al. Scientific Reports
- Generation of germline ablated male pigs by CRISPR/Cas9 editing of the NANOS2 gene
- (2017) Ki-Eun Park et al. Scientific Reports
- Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes
- (2016) Van Trung Chu et al. BMC BIOTECHNOLOGY
- Using the mouse to model human disease: increasing validity and reproducibility
- (2016) Monica J. Justice et al. Disease Models & Mechanisms
- Expression of the Alzheimer’s Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs
- (2016) Jannik E. Jakobsen et al. JOURNAL OF ALZHEIMERS DISEASE
- Neuroimaging of a minipig model of Huntington's disease: Feasibility of volumetric, diffusion-weighted and spectroscopic assessments
- (2016) Robin Schubert et al. JOURNAL OF NEUROSCIENCE METHODS
- Defeating Alzheimer's disease and other dementias: a priority for European science and society
- (2016) Bengt Winblad et al. LANCET NEUROLOGY
- Generation of an inducible colon-specific Cre enzyme mouse line for colon cancer research
- (2016) Paul W. Tetteh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- In vitro fertilization in pigs: New molecules and protocols to consider in the forthcoming years
- (2016) Raquel Romar et al. THERIOGENOLOGY
- Generation and characterization of RAG2 knockout pigs as animal model for severe combined immunodeficiency
- (2016) Shunichi Suzuki et al. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
- A porcine model of osteosarcoma
- (2016) A Saalfrank et al. Oncogenesis
- Systematic quantification of HDR and NHEJ reveals effects of locus, nuclease, and cell type on genome-editing
- (2016) Yuichiro Miyaoka et al. Scientific Reports
- Rosa26-targeted sheep gene knock-in via CRISPR-Cas9 system
- (2016) Mingming Wu et al. Scientific Reports
- Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy
- (2016) Thomas Fröhlich et al. Scientific Reports
- Diabetes with poor glycaemic control does not promote atherosclerosis in genetically modified hypercholesterolaemic minipigs
- (2015) Rozh H. Al-Mashhadi et al. DIABETOLOGIA
- Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy
- (2015) J. W. McGreevy et al. Disease Models & Mechanisms
- Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes
- (2015) Xiaoyang Zhou et al. HUMAN MUTATION
- Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models
- (2015) Simone Renner et al. JOURNAL OF PATHOLOGY
- Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition
- (2015) Elisabeth Streckel et al. Journal of Translational Medicine
- Origins of Cystic Fibrosis Lung Disease
- (2015) David A. Stoltz et al. NEW ENGLAND JOURNAL OF MEDICINE
- Development of an intein-mediated split–Cas9 system for gene therapy
- (2015) Dong-Jiunn Jeffery Truong et al. NUCLEIC ACIDS RESEARCH
- A Genetic Porcine Model of Cancer
- (2015) Lawrence B. Schook et al. PLoS One
- Viable pigs with a conditionally-activated oncogenic KRAS mutation
- (2015) Shun Li et al. TRANSGENIC RESEARCH
- Efficient generation of gene-modified pigs via injection of zygote with Cas9/sgRNA
- (2015) Yong Wang et al. Scientific Reports
- Liraglutide Improves Pancreatic Beta Cell Mass and Function in Alloxan-Induced Diabetic Mice
- (2015) Kanako Tamura et al. PLoS One
- A new rolling culture-basedin vitrofertilization system capable of reducing polyspermy in porcine oocytes
- (2014) Hideki Kitaji et al. ANIMAL SCIENCE JOURNAL
- Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1
- (2014) Kristin M. Whitworth et al. BIOLOGY OF REPRODUCTION
- Early-Onset Familial Alzheimer's Disease (EOFAD)
- (2014) Liyong Wu et al. CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
- One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
- (2014) Tang Hai et al. CELL RESEARCH
- Increasing Efficiency in Production of Cloned Piglets
- (2014) Henrik Callesen et al. Cellular Reprogramming
- Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
- (2014) Jacques Ferlay et al. INTERNATIONAL JOURNAL OF CANCER
- Development and translational imaging of a TP53 porcine tumorigenesis model
- (2014) Jessica C. Sieren et al. JOURNAL OF CLINICAL INVESTIGATION
- Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
- (2014) Yanfang Fu et al. NATURE BIOTECHNOLOGY
- A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
- (2014) Nina Schönhuber et al. NATURE MEDICINE
- Germline transgenesis in pigs by cytoplasmic microinjection of Sleeping Beauty transposons
- (2014) Zoltán Ivics et al. Nature Protocols
- Production of Pigs Expressing a Transgene under the Control of a Tetracycline-Inducible System
- (2014) Yong-Xun Jin et al. PLoS One
- Diffuse Glomerular Nodular Lesions in Diabetic Pigs Carrying a Dominant-Negative Mutant Hepatocyte Nuclear Factor 1-Alpha, an Inheritant Diabetic Gene in Humans
- (2014) Satoshi Hara et al. PLoS One
- Targeted Disruption of LDLR Causes Hypercholesterolemia and Atherosclerosis in Yucatan Miniature Pigs
- (2014) Bryan T. Davis et al. PLoS One
- Dual Fluorescent Reporter Pig for Cre Recombination: Transgene Placement at the ROSA26 Locus
- (2014) Shun Li et al. PLoS One
- Generation of Recombination Activating Gene-1-Deficient Neonatal Piglets: A Model of T and B Cell Deficient Severe Combined Immune Deficiency
- (2014) Tetsuya Ito et al. PLoS One
- Patient-Derived Xenograft Models: An Emerging Platform for Translational Cancer Research
- (2014) M. Hidalgo et al. Cancer Discovery
- Animal Models in Osteosarcoma
- (2014) Maria V. Guijarro et al. Frontiers in Oncology
- Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set
- (2013) Mayuko Kurome et al. BMC BIOTECHNOLOGY
- A mouse model for HBV immunotolerance and immunotherapy
- (2013) Dan Yang et al. Cellular & Molecular Immunology
- Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
- (2013) S. W. Cho et al. GENOME RESEARCH
- Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle
- (2013) Nikolai Klymiuk et al. HUMAN MOLECULAR GENETICS
- Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs
- (2013) David A. Stoltz et al. JOURNAL OF CLINICAL INVESTIGATION
- Production of Diabetic Offspring Using Cryopreserved Epididymal Sperm by In Vitro Fertilization and Intrafallopian Insemination Techniques in Transgenic Pigs
- (2013) Kazuhiro UMEYAMA et al. JOURNAL OF REPRODUCTION AND DEVELOPMENT
- Use of pigs as a potential model for research into dietary modulation of the human gut microbiota
- (2013) Sonja N. Heinritz et al. NUTRITION RESEARCH REVIEWS
- CFTR-deficient pigs display peripheral nervous system defects at birth
- (2013) L. R. Reznikov et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Efficient nonmeiotic allele introgression in livestock using custom endonucleases
- (2013) W. Tan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Familial Hypercholesterolemia and Atherosclerosis in Cloned Minipigs Created by DNA Transposition of a Human PCSK9 Gain-of-Function Mutant
- (2013) R. H. Al-Mashhadi et al. Science Translational Medicine
- Generation of AQP2-Cre transgenic mini-pigs specifically expressing Cre recombinase in kidney collecting duct cells
- (2013) Weiwei Luo et al. TRANSGENIC RESEARCH
- Production of biallelic CMP-Neu5Ac hydroxylase knock-out pigs
- (2013) Deug-Nam Kwon et al. Scientific Reports
- Live pigs produced from genome edited zygotes
- (2013) Simon G. Lillico et al. Scientific Reports
- Animal Models of Alzheimer Disease
- (2013) F. M. LaFerla et al. Cold Spring Harbor Perspectives in Medicine
- A new era in the treatment of cystic fibrosis: correction of the underlying CFTR defect
- (2013) Michael P Boyle et al. Lancet Respiratory Medicine
- Production of piglets from in vitro-produced embryos following non-surgical transfer
- (2012) Koji Yoshioka et al. ANIMAL REPRODUCTION SCIENCE
- Evidence-based path to newborn screening for duchenne muscular dystrophy
- (2012) Jerry R. Mendell et al. ANNALS OF NEUROLOGY
- The use of animal models in diabetes research
- (2012) Aileen JF King BRITISH JOURNAL OF PHARMACOLOGY
- Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model With Impaired Incretin Function and Reduced -Cell Mass
- (2012) S. Renner et al. DIABETES
- Permanent Neonatal Diabetes in INSC94Y Transgenic Pigs
- (2012) S. Renner et al. DIABETES
- Diagnosis and Classification of Diabetes Mellitus
- (2012) DIABETES CARE
- A Porcine Model of Familial Adenomatous Polyposis
- (2012) Tatiana Flisikowska et al. GASTROENTEROLOGY
- Analyses of pig genomes provide insight into porcine demography and evolution
- (2012) Martien A. M. Groenen et al. NATURE
- Animal models for HIV/AIDS research
- (2012) Theodora Hatziioannou et al. NATURE REVIEWS MICROBIOLOGY
- Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs
- (2012) Simon Leuchs et al. PLoS One
- Efficient TALEN-mediated gene knockout in livestock
- (2012) D. F. Carlson et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Pluripotent cells in farm animals: state of the art and future perspectives
- (2012) Monika Nowak-Imialek et al. REPRODUCTION FERTILITY AND DEVELOPMENT
- Domestic Animal Models for Biomedical Research
- (2012) A Bähr et al. REPRODUCTION IN DOMESTIC ANIMALS
- Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT)
- (2012) Jannik Ejnar Jakobsen et al. TRANSGENIC RESEARCH
- Molecular Genetics of Colorectal Cancer
- (2011) Eric R. Fearon Annual Review of Pathology-Mechanisms of Disease
- Sarcomas in TP53 germline mutation carriers
- (2011) Simona Ognjanovic et al. CANCER
- The human glucagon-like peptide-1 analogue liraglutide preserves pancreatic beta cells via regulation of cell kinetics and suppression of oxidative and endoplasmic reticulum stress in a mouse model of diabetes
- (2011) M. Shimoda et al. DIABETOLOGIA
- First inducible transgene expression in porcine large animal models
- (2011) Nikolai Klymiuk et al. FASEB JOURNAL
- Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII
- (2011) Jingyuan Wei et al. FEBS Journal
- Mammalian Models of Duchenne Muscular Dystrophy: Pathological Characteristics and Therapeutic Applications
- (2011) Akinori Nakamura et al. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
- Mouse models of cystic fibrosis: Phenotypic analysis and research applications
- (2011) Martina Wilke et al. Journal of Cystic Fibrosis
- Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis
- (2011) N. Klymiuk et al. JOURNAL OF MOLECULAR MEDICINE-JMM
- Alzheimer's disease
- (2011) Clive Ballard et al. LANCET
- Translational research: 4 ways to fix the clinical trial
- (2011) Heidi Ledford NATURE
- A conditional knockout resource for the genome-wide study of mouse gene function
- (2011) William C. Skarnes et al. NATURE
- High drug attrition rates—where are we going wrong?
- (2011) Lisa Hutchinson et al. Nature Reviews Clinical Oncology
- Systemic Administration of PRO051 in Duchenne's Muscular Dystrophy
- (2011) Nathalie M. Goemans et al. NEW ENGLAND JOURNAL OF MEDICINE
- Efficient Immunoglobulin Gene Disruption and Targeted Replacement in Rabbit Using Zinc Finger Nucleases
- (2011) Tatiana Flisikowska et al. PLoS One
- Germline Transgenic Pigs by Sleeping Beauty Transposition in Porcine Zygotes and Targeted Integration in the Pig Genome
- (2011) Wiebke Garrels et al. PLoS One
- Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases
- (2011) J. Hauschild et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The F508 Mutation Causes CFTR Misprocessing and Cystic Fibrosis-Like Disease in Pigs
- (2011) L. S. Ostedgaard et al. Science Translational Medicine
- Loss of Cystic Fibrosis Transmembrane Conductance Regulator Function Produces Abnormalities in Tracheal Development in Neonatal Pigs and Young Children
- (2010) David K. Meyerholz et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- Atherosclerotic lesions in mouse and man: is it the same disease?
- (2010) Jacob Fog Bentzon et al. CURRENT OPINION IN LIPIDOLOGY
- Glucose Intolerance and Reduced Proliferation of Pancreatic -Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function
- (2010) S. Renner et al. DIABETES
- Preclinical PK and PD Studies on 2′-O-Methyl-phosphorothioate RNA Antisense Oligonucleotides in the mdx Mouse Model
- (2010) Hans Heemskerk et al. MOLECULAR THERAPY
- Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment
- (2010) K. E. Hung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
- (2010) M. Meyer et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer
- (2010) Yonglun Luo et al. TRANSGENIC RESEARCH
- Differential colorectal carcinogenesis: Molecular basis and clinical relevance
- (2010) Alberto Morán World Journal of Gastrointestinal Oncology
- International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons
- (2009) Lisa Mirabello et al. INTERNATIONAL JOURNAL OF CANCER
- Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer’s disease-causing dominant mutation APPsw
- (2009) Peter M. Kragh et al. TRANSGENIC RESEARCH
- Dominant-negative mutant hepatocyte nuclear factor 1α induces diabetes in transgenic-cloned pigs
- (2009) Kazuhiro Umeyama et al. TRANSGENIC RESEARCH
- Production of CFTR-null and CFTR-ΔF508 heterozygous pigs by adeno-associated virus–mediated gene targeting and somatic cell nuclear transfer
- (2008) Christopher S. Rogers et al. JOURNAL OF CLINICAL INVESTIGATION
- Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs
- (2008) C. S. Rogers et al. SCIENCE
- Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects
- (2007) Bernhard Aigner et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started