Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium

SOXF transcription factors in cardiovascular development

(2017) Andrew J. Lilly et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Interplay between SOX7 and RUNX1 regulates hemogenic endothelial fate in the yolk sac

(2016) Andrew J. Lilly et al.   DEVELOPMENT

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation

(2016) Debbie K. Goode et al.   DEVELOPMENTAL CELL

Systematic Cellular Disease Models Reveal Synergistic Interaction of Trisomy 21 and GATA1 Mutations in Hematopoietic Abnormalities

(2016) Kimihiko Banno et al.   Cell Reports

RUNX1B Expression Is Highly Heterogeneous and Distinguishes Megakaryocytic and Erythroid Lineage Fate in Adult Mouse Hematopoiesis

(2016) Julia E. Draper et al.   PLoS Genetics

A simple and efficient method for transfecting mouse embryonic stem cells using polyethylenimine

(2015) Colleen M. Bartman et al.   EXPERIMENTAL CELL RESEARCH

GFI1 proteins orchestrate the emergence of haematopoietic stem cells through recruitment of LSD1

(2015) Roshana Thambyrajah et al.   NATURE CELL BIOLOGY

Definitive Hematopoiesis in the Yolk Sac Emerges from Wnt-Responsive Hemogenic Endothelium Independently of Circulation and Arterial Identity

(2015) Jenna M. Frame et al.   STEM CELLS

Repression of arterial genes in hemogenic endothelium is sufficient for haematopoietic fate acquisition

(2015) Carlos O. Lizama et al.   Nature Communications

A novel antibody–drug conjugate targeting SAIL for the treatment of hematologic malignancies

(2015) S Y Kim et al.   Blood Cancer Journal

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence

(2014) M. Lie-A-Ling et al.   BLOOD

CBF  and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish

(2014) E. Bresciani et al.   BLOOD

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

(2014) Anetta Ptasinska et al.   Cell Reports

Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells

(2013) Susumu Goyama et al.   JOURNAL OF CLINICAL INVESTIGATION

The expression of Sox17 identifies and regulates haemogenic endothelium

(2013) Raedun L. Clarke et al.   NATURE CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Early dynamic fate changes in haemogenic endothelium characterized at the single-cell level

(2013) Gemma Swiers et al.   Nature Communications

Addiction of t(8;21) and inv(16) Acute Myeloid Leukemia to Native RUNX1

(2013) Oren Ben-Ami et al.   Cell Reports

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment

(2012) C. Lancrin et al.   BLOOD

SOX7 regulates the expression of VE-cadherin in the haemogenic endothelium at the onset of haematopoietic development

(2012) G. Costa et al.   DEVELOPMENT

Novel function of the unique N-terminal region of RUNX1c in B cell growth regulation

(2012) G. Brady et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of a novel transcriptional target of RUNX1/AML1 at the onset of hematopoietic development

(2011) C. Ferreras et al.   BLOOD

Abrogation of RUNX1 gene expression in de novo myelodysplastic syndrome with t(4;21)(q21;q22)

(2011) A. Rio-Machin et al.   HAEMATOLOGICA

Nonredundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis

(2010) T. Bee et al.   BLOOD

Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation

(2010) R. Sood et al.   BLOOD

Live imaging of Runx1 expression in the dorsal aorta tracks the emergence of blood progenitors from endothelial cells

(2010) E. Y. N. Lam et al.   BLOOD

Runx1 isoforms show differential expression patterns during hematopoietic development but have similar functional effects in adult hematopoietic stem cells

(2010) Grant A. Challen et al.   EXPERIMENTAL HEMATOLOGY

Announcement

(2010)   GENETICS IN MEDICINE

In vivo imaging of haematopoietic cells emerging from the mouse aortic endothelium

(2010) Jean-Charles Boisset et al.   NATURE

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Haematopoietic stem cells derive directly from aortic endothelium during development

(2010) Julien Y. Bertrand et al.   NATURE

Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

(2010) S De Vita et al.   ONCOGENE

The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis

(2009) P. Sroczynska et al.   BLOOD

Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification

(2009) A. Gandillet et al.   BLOOD

Alternative Runx1 promoter usage in mouse developmental hematopoiesis

(2009) Thomas Bee et al.   BLOOD CELLS MOLECULES AND DISEASES

Blood cell generation from the hemangioblast

(2009) Christophe Lancrin et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Continuous single-cell imaging of blood generation from haemogenic endothelium

(2009) Hanna M. Eilken et al.   NATURE

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage

(2009) Christophe Lancrin et al.   NATURE

Cre recombinase expression controlled by the hematopoietic regulatory domain of Gata-1 is erythroid-specific

(2008) Donghoon Yoon et al.   BLOOD CELLS MOLECULES AND DISEASES

Genetic evidence of PEBP2β-independent activation of Runx1 in the murine embryo

(2008) Tomomasa Yokomizo et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY