Fidelity of DNA replication—a matter of proofreading

Regulation and Modulation of Human DNA Polymerase δ Activity and Function

(2017) et al.   Genes

Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases

(2017) Linlin Zhao et al.   Genes

Multiple Forms of Human DNA Polymerase Delta Sub-Assembling in Cellular DNA Transactions

(2016) Qian Zhang et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Secondary Interaction Interfaces with PCNA Control Conformational Switching of DNA Polymerase PolB from Polymerization to Editing

(2016) Xiaojun Xu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular events during translocation and proofreading extracted from 200 static structures of DNA polymerase

(2016) Zhong Ren   NUCLEIC ACIDS RESEARCH

A new paradigm of DNA synthesis: three-metal-ion catalysis

(2016) Wei Yang et al.   Cell and Bioscience

Microsatellite instability: an update

(2015) Hiroyuki Yamamoto et al.   ARCHIVES OF TOXICOLOGY

Quantifying the contributions of base selectivity, proofreading and mismatch repair to nuclear DNA replication in Saccharomyces cerevisiae

(2015) Jordan A. St Charles et al.   DNA REPAIR

Genetic evidence that both dNTP-stabilized and strand slippage mechanisms may dictate DNA polymerase errors within mononucleotide microsatellites

(2015) Beverly A. Baptiste et al.   DNA REPAIR

Fidelity consequences of the impaired interaction between DNA polymerase epsilon and the GINS complex

(2015) Marta Garbacz et al.   DNA REPAIR

DNA polymerase 3′→5′ exonuclease activity: Different roles of the beta hairpin structure in family-B DNA polymerases

(2015) Hariyanto Darmawan et al.   DNA REPAIR

Eukaryotic DNA polymerase ζ

(2015) Alena V. Makarova et al.   DNA REPAIR

POLE and POLD1 mutations in 529 kindred with familial colorectal cancer and/or polyposis: review of reported cases and recommendations for genetic testing and surveillance

(2015) Fernando Bellido et al.   GENETICS IN MEDICINE

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

(2015) Adam Shlien et al.   NATURE GENETICS

Replicative DNA Polymerase δ but Not ε Proofreads Errors in Cis and in Trans

(2015) Carrie L. Flood et al.   PLoS Genetics

cryo-EM structures of the E. coli replicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease and τ

(2015) Rafael Fernandez-Leiro et al.   eLife

RB69 DNA Polymerase Structure, Kinetics, and Fidelity

(2014) Shuangluo Xia et al.   BIOCHEMISTRY

A Common Cancer-Associated DNA Polymerase   Mutation Causes an Exceptionally Strong Mutator Phenotype, Indicating Fidelity Defects Distinct from Loss of Proofreading

(2014) D. P. Kane et al.   CANCER RESEARCH

Switching between polymerase and exonuclease sites in DNA polymerase ε

(2014) Rais A. Ganai et al.   NUCLEIC ACIDS RESEARCH

Structural insights into eukaryotic DNA replication

(2014) Sylvie Doublié et al.   Frontiers in Microbiology

Architecture of the Pol III–clamp–exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair

(2013) Ana Toste Rêgo et al.   EMBO JOURNAL

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer

(2013) David N. Church et al.   HUMAN MOLECULAR GENETICS

A Substitution in the Fingers Domain of DNA Polymerase δ Reduces Fidelity by Altering Nucleotide Discrimination in the Catalytic Site

(2013) Marc J. Prindle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamics of Site Switching in DNA Polymerase

(2013) Rajan Lamichhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Structural basis for processive DNA synthesis by yeast DNA polymerase ɛ

(2013) Matthew Hogg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism for priming DNA synthesis by yeast DNA Polymerase α

(2013) Rajika L Perera et al.   eLife

The Werner Syndrome Exonuclease Facilitates DNA Degradation and High Fidelity DNA Polymerization by Human DNA Polymerase δ

(2012) Ashwini S. Kamath-Loeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

The role of DNA exonucleases in protecting genome stability and their impact on ageing

(2011) Penelope A. Mason et al.   AGE

Insights into Base Selectivity from the 1.8 Å Resolution Structure of an RB69 DNA Polymerase Ternary Complex

(2010) Mina Wang et al.   BIOCHEMISTRY

The kinetic and chemical mechanism of high-fidelity DNA polymerases

(2010) Kenneth A. Johnson   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Identification of a New Motif in Family B DNA Polymerases by Mutational Analyses of the Bacteriophage T4 DNA Polymerase

(2010) Vincent Li et al.   JOURNAL OF MOLECULAR BIOLOGY

The eukaryotic replicative DNA polymerases take shape

(2010) Erik Johansson et al.   TRENDS IN BIOCHEMICAL SCIENCES

DNA polymerase proofreading: Multiple roles maintain genome stability

(2009) Linda J. Reha-Krantz   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Structural Insight into Translesion Synthesis by DNA Pol II

(2009) Feng Wang et al.   CELL

Different Behaviors In Vivo of Mutations in the β Hairpin Loop of the DNA Polymerases of the Closely Related Phages T4 and RB69

(2009) Anna Trzemecka et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis of high-fidelity DNA synthesis by yeast DNA polymerase δ

(2009) Michael K Swan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex

(2009) H. Nishida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA polymerase   and   proofreading suppress discrete mutator and cancer phenotypes in mice

(2009) T. M. Albertson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of 2-Aminopurine Fluorescence To Study the Role of the β Hairpin in the Proofreading Pathway Catalyzed by the Phage T4 and RB69 DNA Polymerases†

(2008) Usharani Subuddhi et al.   BIOCHEMISTRY

The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases

(2008) Scott D McCulloch et al.   CELL RESEARCH