The role of DNA exonucleases in protecting genome stability and their impact on ageing

Increase in mitochondrial DNA mutations impairs retinal function and renders the retina vulnerable to injury

(2011) Yu X. G. Kong et al.   AGING CELL

Caenorhabditis elegans DNA-2 helicase/endonuclease plays a vital role in maintaining genome stability, morphogenesis, and life span

(2011) Myon-Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

(2011) Kelly S. Trego et al.   CELL CYCLE

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

(2011) Li Zheng et al.   CELL RESEARCH

Accumulating Mitochondrial DNA Mutations Drive Premature Hematopoietic Aging Phenotypes Distinct from Physiological Stem Cell Aging

(2011) Gudmundur L. Norddahl et al.   Cell Stem Cell

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

Characterization of the Endonuclease and ATP-dependent Flap Endo/Exonuclease of Dna2

(2011) Barbara K. Fortini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymerase Epsilon Is Required To Maintain Replicative Senescence

(2011) A. M. Deshpande et al.   MOLECULAR AND CELLULAR BIOLOGY

Endurance exercise rescues progeroid aging and induces systemic mitochondrial rejuvenation in mtDNA mutator mice

(2011) A. Safdar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of KIAA1018/FAN1, a DNA Repair Nuclease Recruited to DNA Damage by Monoubiquitinated FANCD2

(2010) Craig MacKay et al.   CELL

Deficiency of FANCD2-Associated Nuclease KIAA1018/FAN1 Sensitizes Cells to Interstrand Crosslinking Agents

(2010) Katja Kratz et al.   CELL

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Identification of germ plasm-associated transcripts by microarray analysis of Xenopus vegetal cortex RNA

(2010) Tawny N. Cuykendall et al.   DEVELOPMENTAL DYNAMICS

Delineation of WRN helicase function with EXO1 in the replicational stress response

(2010) Monika Aggarwal et al.   DNA REPAIR

Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts

(2010) Dan Constantinescu et al.   EXPERIMENTAL CELL RESEARCH

An mre11 Mutation That Promotes Telomere Recombination and an Efficient Bypass of Senescence

(2010) I. S. Joseph et al.   GENETICS

FEN1 Functions in Long Patch Base Excision Repair Under Conditions of Oxidative Stress in Vertebrate Cells

(2010) K. Asagoshi et al.   MOLECULAR CANCER RESEARCH

A Genetic Screen Identifies FAN1, a Fanconi Anemia-Associated Nuclease Necessary for DNA Interstrand Crosslink Repair

(2010) Agata Smogorzewska et al.   MOLECULAR CELL

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

(2010) Mariela Jaskelioff et al.   NATURE

Linking functional decline of telomeres, mitochondria and stem cells during ageing

(2010) Ergün Sahin et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Three prime exonuclease I (TREX1) is Fos/AP-1 regulated by genotoxic stress and protects against ultraviolet light and benzo(a)pyrene-induced DNA damage

(2010) Markus Christmann et al.   NUCLEIC ACIDS RESEARCH

The high fidelity and unique error signature of human DNA polymerase  

(2010) D. A. Korona et al.   NUCLEIC ACIDS RESEARCH

Chemical-induced cancer incidence and underlying mechanisms in Fen1 mutant mice

(2010) H Xu et al.   ONCOGENE

Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice

(2010) Asimina Hiona et al.   PLoS One

FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair

(2010) T. Liu et al.   SCIENCE

Do mtDNA deletions drive premature aging in mtDNA mutator mice?

(2009) Yevgenya Kraytsberg et al.   AGING CELL

Increasing longevity through caloric restriction or rapamycin feeding in mammals: common mechanisms for common outcomes?

(2009) Lynne S. Cox et al.   AGING CELL

Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease: Figure 1

(2009) Tomas Lindahl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

Evidence for a role of FEN1 in maintaining mitochondrial DNA integrity

(2009) Lidza Kalifa et al.   DNA REPAIR

Structure and Functional Implications of the Human Rad9-Hus1-Rad1 Cell Cycle Checkpoint Complex

(2009) Min Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A functional EXO1 promoter variant is associated with prolonged life expectancy in centenarians

(2009) Almut Nebel et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Human Dna2 Is a Nuclear and Mitochondrial DNA Maintenance Protein

(2009) J. P. Duxin et al.   MOLECULAR AND CELLULAR BIOLOGY

Crystal Structure of the Rad9-Rad1-Hus1 DNA Damage Checkpoint Complex—Implications for Clamp Loading and Regulation

(2009) Andrew S. Doré et al.   MOLECULAR CELL

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Interplay of Mre11 Nuclease with Dna2 plus Sgs1 in Rad51-Dependent Recombinational Repair

(2009) Martin E. Budd et al.   PLoS One

Live Fast, Die Young: New Lessons in Mammalian Longevity

(2009) Lynne S. Cox   REJUVENATION RESEARCH

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair

(2009) P. Knipscheer et al.   SCIENCE

Mitofusin 2 Inhibits Mitochondrial Antiviral Signaling

(2009) K. Yasukawa et al.   Science Signaling

Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity

(2008) Robert D. C. Saunders et al.   AGING CELL

DmWRNexo is a 3′–5′ exonuclease: phenotypic and biochemical characterization of mutants of the Drosophila orthologue of human WRN exonuclease

(2008) Ivan Boubriak et al.   BIOGERONTOLOGY

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

DNA mismatch repair: Molecular mechanism, cancer, and ageing

(2008) Peggy Hsieh et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Removal of Oxidative DNA Damage via FEN1-Dependent Long-Patch Base Excision Repair in Human Cell Mitochondria

(2008) P. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA2 Resolves Expanding Flap in Mitochondrial Base Excision Repair

(2008) William C. Copeland et al.   MOLECULAR CELL

Human DNA2 Is a Mitochondrial Nuclease/Helicase for Efficient Processing of DNA Replication and Repair Intermediates

(2008) Li Zheng et al.   MOLECULAR CELL

Identification of Holliday junction resolvases from humans and yeast

(2008) Stephen C. Y. Ip et al.   NATURE

EXOG, a novel paralog of Endonuclease G in higher eukaryotes

(2008) Iwona A. Cymerman et al.   NUCLEIC ACIDS RESEARCH

p53 target gene AEN is a nuclear exonuclease required for p53-dependent apoptosis

(2008) T Kawase et al.   ONCOGENE