Pharmacologic ascorbate (P-AscH−) suppresses hypoxia-inducible Factor-1α (HIF-1α) in pancreatic adenocarcinoma

Peroxiporin Expression Is an Important Factor for Cancer Cell Susceptibility to Therapeutic H2O2: Implications for Pharmacological Ascorbate Therapy

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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

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Synergistic effects of ascorbate and sorafenib in hepatocellular carcinoma: New insights into ascorbate cytotoxicity

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Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

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Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner

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Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy

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Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer

(2015) J. Du et al.   CANCER RESEARCH

A Lactate-Induced Response to Hypoxia

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PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

(2015) Fanny Dupuy et al.   Cell Metabolism

Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model

(2015) Oscar K. Serrano et al.   FREE RADICAL BIOLOGY AND MEDICINE

Expression and significance of HIF-1α and HIF-2α in pancreatic cancer

(2015) Min Wang et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial

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Moles of a Substance per Cell Is a Highly Informative Dosing Metric in Cell Culture

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High Expression of HIF1a Is a Predictor of Clinical Outcome in Patients with Pancreatic Ductal Adenocarcinomas and Correlated to PDGFA, VEGF, and bFGF

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CXCL12 Chemokine Expression Suppresses Human Pancreatic Cancer Growth and Metastasis

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Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial

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Manganoporphyrins Increase Ascorbate-Induced Cytotoxicity by Enhancing H2O2 Generation

(2013) M. Rawal et al.   CANCER RESEARCH

The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

(2013) Weihua Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia inducible factor-1 alpha plays a pivotal role in hepatic metastasis of pancreatic cancer: an immunohistochemical study

(2013) Yoichiro Matsuo et al.   Journal of Hepato-Biliary-Pancreatic Sciences

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

(2012) Marco Montagner et al.   NATURE

Hypoxia-driven pathways in bone development, regeneration and disease

(2012) Christa Maes et al.   Nature Reviews Rheumatology

Inhibition of Prolyl Hydroxylase Domain-Containing Protein Downregulates Vascular Angiotensin II Type 1 Receptor

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Nuclear Factor-κB–Dependent Epithelial to Mesenchymal Transition Induced by HIF-1α Activation in Pancreatic Cancer Cells under Hypoxic Conditions

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Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

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HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase

(2010) Ataman Sendoel et al.   NATURE

Novel Agents on the Horizon for Cancer Therapy

(2009) W. W. Ma et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice

(2009) Michael P Kim et al.   Nature Protocols

Manganese Superoxide Dismutase Modulates Hypoxia-Inducible Factor-1  Induction via Superoxide

(2008) S. Kaewpila et al.   CANCER RESEARCH