The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity

Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin C Transport and Antioxidant Enzyme Function

(2013) Alexander J. Michels et al.   Annual Review of Nutrition

Parenteral Ascorbate As a Cancer Therapeutic: A Reassessment Based on Pharmacokinetics

(2013) Nermi L. Parrow et al.   ANTIOXIDANTS & REDOX SIGNALING

Induction of Cell Death in Renal Cell Carcinoma With Combination of D-Fraction and Vitamin C

(2013) Bobby Alexander et al.   INTEGRATIVE CANCER THERAPIES

Intestinal Dehydroascorbic Acid (DHA) Transport Mediated by the Facilitative Sugar Transporters, GLUT2 and GLUT8

(2013) Christopher P. Corpe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ascorbate Induces Ten-Eleven Translocation (Tet) Methylcytosine Dioxygenase-mediated Generation of 5-Hydroxymethylcytosine

(2013) Emily A. Minor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-inducible Factor 1 (HIF-1) Promotes Extracellular Matrix Remodeling under Hypoxic Conditions by InducingP4HA1, P4HA2,andPLOD2Expression in Fibroblasts

(2013) Daniele M. Gilkes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Enhanced antitumor activity of vitamin C via p53 in Cancer cells

(2012) Jinsun Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vitamin C improves the quality of somatic cell reprogramming

(2012) Miguel A Esteban et al.   NATURE GENETICS

SVCT-2 in breast cancer acts as an indicator for L-ascorbate treatment

(2012) S-W Hong et al.   ONCOGENE

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Pharmacological ascorbate induces cytotoxicity in prostate cancer cells through ATP depletion and induction of autophagy

(2011) Ping Chen et al.   ANTI-CANCER DRUGS

The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C

(2011) James M May   BRITISH JOURNAL OF PHARMACOLOGY

The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner

(2011) Tao Wang et al.   Cell Stem Cell

Suppression of Amyloid β A11 Antibody Immunoreactivity by Vitamin C

(2011) Fang Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epigenetic regulation of HIF-1α in renal cancer cells involves HIF-1α/2α binding to a reverse hypoxia-response element

(2011) J Xu et al.   ONCOGENE

Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles

(2011) Antonina I Frolova et al.   REPRODUCTION

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells

(2010) Miguel Angel Esteban et al.   Cell Stem Cell

Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer

(2010) J. Du et al.   CLINICAL CANCER RESEARCH

Oligomycin-induced Bioenergetic Adaptation in Cancer Cells with Heterogeneous Bioenergetic Organization

(2010) Wenshan Hao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VHL Inactivation Induces HEF1 and Aurora Kinase A

(2010) J. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The genetic basis of kidney cancer: a metabolic disease

(2010) W. Marston Linehan et al.   Nature Reviews Urology

Vitamin C: Intravenous Use by Complementary and Alternative Medicine Practitioners and Adverse Effects

(2010) Sebastian J. Padayatty et al.   PLoS One

Can vitamin C induce nucleotide excision repair? Support from in vitro evidence

(2009) Ruth J. Bevan et al.   BRITISH JOURNAL OF NUTRITION

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects

(2009) Julien Verrax et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of endocytosis via the oxygen-sensing pathway

(2009) Yi Wang et al.   NATURE MEDICINE

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Vitamin C Antagonizes the Cytotoxic Effects of Antineoplastic Drugs

(2008) M. L. Heaney et al.   CANCER RESEARCH

Erythrocyte Glut1 Triggers Dehydroascorbic Acid Uptake in Mammals Unable to Synthesize Vitamin C

(2008) Amélie Montel-Hagen et al.   CELL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA